ATE439430T1 - Mutanten für die herstellung von d-aminosäuren - Google Patents

Mutanten für die herstellung von d-aminosäuren

Info

Publication number
ATE439430T1
ATE439430T1 AT03775186T AT03775186T ATE439430T1 AT E439430 T1 ATE439430 T1 AT E439430T1 AT 03775186 T AT03775186 T AT 03775186T AT 03775186 T AT03775186 T AT 03775186T AT E439430 T1 ATE439430 T1 AT E439430T1
Authority
AT
Austria
Prior art keywords
production
amino acids
mutants
acids
hydratase
Prior art date
Application number
AT03775186T
Other languages
English (en)
Inventor
Oliver May
Stefan Buchholz
Michael Schwarm
Karlheinz Drauz
Robert J Turner
Ian Fotheringham
Original Assignee
Evonik Degussa Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa Gmbh filed Critical Evonik Degussa Gmbh
Application granted granted Critical
Publication of ATE439430T1 publication Critical patent/ATE439430T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/009—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving hydantoins or carbamoylamino compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03775186T 2002-11-04 2003-10-15 Mutanten für die herstellung von d-aminosäuren ATE439430T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10251184A DE10251184A1 (de) 2002-11-04 2002-11-04 Mutanten zur Herstellung von D-Aminosäuren
PCT/EP2003/011432 WO2004042047A1 (en) 2002-11-04 2003-10-15 Mutants for the preparation of d-amino acids

Publications (1)

Publication Number Publication Date
ATE439430T1 true ATE439430T1 (de) 2009-08-15

Family

ID=32103290

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03775186T ATE439430T1 (de) 2002-11-04 2003-10-15 Mutanten für die herstellung von d-aminosäuren

Country Status (9)

Country Link
US (2) US20060228787A1 (de)
EP (1) EP1558727B1 (de)
JP (1) JP2006504428A (de)
CN (1) CN100510052C (de)
AT (1) ATE439430T1 (de)
AU (1) AU2003283269A1 (de)
CA (1) CA2511751A1 (de)
DE (2) DE10251184A1 (de)
WO (1) WO2004042047A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012016869A2 (pt) 2010-01-08 2015-09-01 President And Fellows Harvard College Método e revestimentos para tratar biofilmes.
WO2012151554A1 (en) 2011-05-04 2012-11-08 President And Fellows Of Harvard College Polyamines for treating biofilms
KR102027201B1 (ko) * 2011-11-16 2019-10-01 에보닉 테크노케미 게엠베하 히단토이나제의 돌연변이체
CN107937377A (zh) * 2017-11-09 2018-04-20 江南大学 一种d‑n‑氨甲酰水解酶及应用
US20210106708A1 (en) 2018-03-21 2021-04-15 Case Western Reserve University Thermoresponsive compositions and methods for preventing and disrupting biofilms
CN110699396B (zh) * 2019-11-15 2022-03-01 江南大学 一种级联反应制备d-芳香族氨基酸的方法
EP4105335A1 (de) 2021-06-16 2022-12-21 Evonik Operations GmbH Enzymatisches verfahren zur herstellung von l-glufosinat-p-alkylestern
EP4493709A1 (de) 2022-03-14 2025-01-22 Evonik Operations GmbH Enzymatisches verfahren zur herstellung von l-glufosinat p-estern
CN116926139A (zh) * 2022-04-12 2023-10-24 元素驱动(杭州)生物科技有限公司 一种n-乙酰-d-氨基酸、d-氨基酸、d-氨基酸衍生物的制备方法
WO2023232225A1 (en) 2022-05-31 2023-12-07 Evonik Operations Gmbh Enzymatic method for the diastereoselective production of l-glufosinate p-esters

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1277125B1 (it) * 1995-12-21 1997-11-04 Eniricerche Spa Mutanti termostabili della d-n-alfa-carbamilasi
US5728555A (en) * 1996-09-30 1998-03-17 Monsanto Company Preparation of d-amino acids by direct fermentative means
DE59915086D1 (de) * 1998-04-02 2009-11-05 Evonik Degussa Gmbh Rekombinante l-n-carbamoylase aus arthrobacter aurescens, verfahren zur herstellung von l-aminosäuren mittels dieser
DE10114999A1 (de) * 2001-03-26 2002-10-10 Degussa D-Carbamoylase aus Arthrobacter crystallopoietes DSM 20117

Also Published As

Publication number Publication date
WO2004042047A1 (en) 2004-05-21
US20090203091A1 (en) 2009-08-13
JP2006504428A (ja) 2006-02-09
AU2003283269A1 (en) 2004-06-07
EP1558727B1 (de) 2009-08-12
CN1708583A (zh) 2005-12-14
CN100510052C (zh) 2009-07-08
US20060228787A1 (en) 2006-10-12
DE10251184A1 (de) 2004-05-13
EP1558727A1 (de) 2005-08-03
CA2511751A1 (en) 2004-05-21
DE60328813D1 (de) 2009-09-24
US9194009B2 (en) 2015-11-24

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