ATE43967T1 - Antitumorale arzneimittel und verbindungen fuer behandlung von tumoren unter anwendung von (alpha, omega-bis(disubstituierte phosphino) kohlenwasserstoff> digold (i), digold (iii), disilber (i) und dikupfer (i)-derivaten. - Google Patents

Antitumorale arzneimittel und verbindungen fuer behandlung von tumoren unter anwendung von (alpha, omega-bis(disubstituierte phosphino) kohlenwasserstoff> digold (i), digold (iii), disilber (i) und dikupfer (i)-derivaten.

Info

Publication number
ATE43967T1
ATE43967T1 AT85300681T AT85300681T ATE43967T1 AT E43967 T1 ATE43967 T1 AT E43967T1 AT 85300681 T AT85300681 T AT 85300681T AT 85300681 T AT85300681 T AT 85300681T AT E43967 T1 ATE43967 T1 AT E43967T1
Authority
AT
Austria
Prior art keywords
digold
dicopper
disilver
omega
alpha
Prior art date
Application number
AT85300681T
Other languages
English (en)
Inventor
David Taylor Hill
Randall Keith Johnson
Christopher Kevin Mirabelli
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Application granted granted Critical
Publication of ATE43967T1 publication Critical patent/ATE43967T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5027—Polyphosphines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5045—Complexes or chelates of phosphines with metallic compounds or metals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT85300681T 1984-02-01 1985-01-31 Antitumorale arzneimittel und verbindungen fuer behandlung von tumoren unter anwendung von (alpha, omega-bis(disubstituierte phosphino) kohlenwasserstoff> digold (i), digold (iii), disilber (i) und dikupfer (i)-derivaten. ATE43967T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57565084A 1984-02-01 1984-02-01
EP85300681A EP0151046B1 (de) 1984-02-01 1985-01-31 Antitumorale Arzneimittel und Verbindungen für Behandlung von Tumoren unter Anwendung von [alpha, omega-bis(disubstituierte phosphino) Kohlenwasserstoff] digold (I), digold (III), disilber (I) und dikupfer (I)-Derivaten

Publications (1)

Publication Number Publication Date
ATE43967T1 true ATE43967T1 (de) 1989-06-15

Family

ID=24301170

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85300681T ATE43967T1 (de) 1984-02-01 1985-01-31 Antitumorale arzneimittel und verbindungen fuer behandlung von tumoren unter anwendung von (alpha, omega-bis(disubstituierte phosphino) kohlenwasserstoff> digold (i), digold (iii), disilber (i) und dikupfer (i)-derivaten.

Country Status (9)

Country Link
EP (1) EP0151046B1 (de)
JP (1) JPS60188322A (de)
AT (1) ATE43967T1 (de)
AU (1) AU572949B2 (de)
CA (1) CA1238854A (de)
DE (1) DE3570981D1 (de)
DK (1) DK40385A (de)
IE (1) IE850226L (de)
ZA (1) ZA85755B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH21350A (en) * 1984-06-04 1987-10-13 Smithkline Beckman Corp Tumor cell growth imhibiting pharmaceutical compositions containing phosphino-hydrocarbon-gold, silver or copper complexes
US5037812A (en) * 1985-04-02 1991-08-06 Smithkline Beckman Corporation Tumor cell growth-inhibiting pharmaceutical compositions containing phosphino-hydrocarbon-gold, silver or copper complexes
DK166686A (da) * 1985-04-16 1986-10-17 Smithkline Beckman Corp Phosphinforbindelser, fremgangsmaade til fremstilling heraf samt farmaceutiske midler indeholdende disse forbindelser
US4716230A (en) * 1985-04-16 1987-12-29 Smithkline Beckman Corporation Certain bis(di-2 or 4-pyridyl-phosphino) alkanes #10 having anti-tumor properties
US4902675A (en) * 1985-05-16 1990-02-20 Smithkline Beckman Corporation "2-pyridyl and 4-pyridyl phosphine gold (I) anti tumor complexes"
EP0202854A3 (de) * 1985-05-20 1988-01-13 Smithkline Beecham Corporation Phosphin-Gold-Verbindungen
US4698422A (en) * 1985-05-20 1987-10-06 Smithkline Beckman Corporation Triphos and tetraphos gold compounds and ligands
NL8502929A (nl) * 1985-10-25 1987-05-18 Tno Groep viii-overgangsmetaal-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke groep viii-overgangsmetaal-complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
US4758589A (en) * 1985-12-23 1988-07-19 Smithkline Beckman Corporation Tetraphosphine-coordinated gold(I) complexes
US4764509A (en) * 1986-02-21 1988-08-16 Smithkline Beckman Corporation Pharmaceutical compositions containing di-gold phosphine
AU1059395A (en) * 1993-11-24 1995-06-13 Luminis Pty Limited Triorganophosphinegold (i) thionucleobases with anti-tumor activity
AU2001255125A1 (en) 2000-04-10 2001-10-23 National University Of Singapore Gold complexes
WO2001077121A1 (en) * 2000-04-10 2001-10-18 National University Of Singapore Gold complexes
DE10300097A1 (de) * 2003-01-07 2004-07-22 Bayer Ag Kupfer-Komplexe und ihre Verwendung
WO2009074305A1 (de) * 2007-12-13 2009-06-18 Biosphings Ag Gold-xanthogenate und diese enthaltende arzneimittel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3661959A (en) * 1970-07-30 1972-05-09 Du Pont Method of making organogold chloride complexes
US3676554A (en) * 1970-10-30 1972-07-11 Smith Kline French Lab Anti-arthritic compositions comprising phosphine or phosphite gold halide complexes and methods of producing anti-arthritic activity
PH21350A (en) * 1984-06-04 1987-10-13 Smithkline Beckman Corp Tumor cell growth imhibiting pharmaceutical compositions containing phosphino-hydrocarbon-gold, silver or copper complexes

Also Published As

Publication number Publication date
IE850226L (en) 1985-08-01
EP0151046A2 (de) 1985-08-07
DE3570981D1 (en) 1989-07-20
CA1238854A (en) 1988-07-05
ZA85755B (en) 1986-05-28
EP0151046B1 (de) 1989-06-14
AU572949B2 (en) 1988-05-19
EP0151046A3 (en) 1985-08-21
DK40385D0 (da) 1985-01-29
AU3812685A (en) 1985-08-29
JPS60188322A (ja) 1985-09-25
DK40385A (da) 1985-08-02

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee