ATE440151T1 - Verfahren zur beurteilung eines krankheitzustandes mittels nachweis von partikel- und nicht partikelgebundenen nukleinsäuren in blutplasma und -serum - Google Patents
Verfahren zur beurteilung eines krankheitzustandes mittels nachweis von partikel- und nicht partikelgebundenen nukleinsäuren in blutplasma und -serumInfo
- Publication number
- ATE440151T1 ATE440151T1 AT03722865T AT03722865T ATE440151T1 AT E440151 T1 ATE440151 T1 AT E440151T1 AT 03722865 T AT03722865 T AT 03722865T AT 03722865 T AT03722865 T AT 03722865T AT E440151 T1 ATE440151 T1 AT E440151T1
- Authority
- AT
- Austria
- Prior art keywords
- particle
- bond
- serum
- nucleic acids
- blood plasma
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 210000002381 plasma Anatomy 0.000 title abstract 2
- 210000002966 serum Anatomy 0.000 title abstract 2
- 239000002245 particle Substances 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38070802P | 2002-05-14 | 2002-05-14 | |
| PCT/GB2003/002081 WO2003095674A2 (en) | 2002-05-14 | 2003-05-14 | Methods for evaluating a disease condition by detection of particle and non-particle bound nucleic acids in blood plasma and serum |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE440151T1 true ATE440151T1 (de) | 2009-09-15 |
Family
ID=29420628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03722865T ATE440151T1 (de) | 2002-05-14 | 2003-05-14 | Verfahren zur beurteilung eines krankheitzustandes mittels nachweis von partikel- und nicht partikelgebundenen nukleinsäuren in blutplasma und -serum |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20040009518A1 (de) |
| EP (1) | EP1504120B1 (de) |
| JP (1) | JP4327714B2 (de) |
| CN (2) | CN101613760A (de) |
| AT (1) | ATE440151T1 (de) |
| AU (1) | AU2003230025B2 (de) |
| DE (1) | DE60328885D1 (de) |
| WO (1) | WO2003095674A2 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004065629A1 (en) * | 2003-01-17 | 2004-08-05 | The Chinese University Of Hong Kong | Circulating mrna as diagnostic markers for pregnancy-related disorders |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| JP2009516501A (ja) * | 2005-09-22 | 2009-04-23 | チャイナ シンセティック ラバー コーポレーション | 鼻咽腔癌の予後的サブクラスの同定のための遺伝子発現プロファイリング |
| EP3260556B1 (de) | 2006-05-31 | 2019-07-31 | Sequenom, Inc. | Verfahren zur nukleinsäureextraktion aus einer probe |
| AU2007260750A1 (en) * | 2006-06-16 | 2007-12-21 | Sequenom, Inc. | Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample |
| TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
| AU2008230813B2 (en) | 2007-03-26 | 2014-01-30 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| EP2137523A1 (de) * | 2007-04-04 | 2009-12-30 | Network Biosystems, Inc. | Kunststoff-mikrofluid-trenn- und -nachweisplattformen |
| EP3358354B1 (de) | 2008-01-18 | 2020-07-15 | President and Fellows of Harvard College | Verfahren zur detektion von anzeichen einer krankheit oder eines leidens in körperflüssigkeiten |
| US8206926B2 (en) | 2008-03-26 | 2012-06-26 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| WO2010079118A1 (en) * | 2009-01-07 | 2010-07-15 | Michael Roth-Chiarello | Use of rna obtained from proteolipid complexes circulating in blood for diagnosis and treatment of tumors |
| EP2414545B1 (de) | 2009-04-03 | 2017-01-11 | Sequenom, Inc. | Zusammensetzungen und verfahren für die herstellung von nukleinsäuren |
| WO2010147654A2 (en) * | 2009-06-15 | 2010-12-23 | Netbio Inc. | Improved methods for forensic dna quantitation |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US12545960B2 (en) | 2010-05-18 | 2026-02-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US8825412B2 (en) | 2010-05-18 | 2014-09-02 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| MX382244B (es) | 2010-07-23 | 2025-03-13 | Harvard College | Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales |
| SG10201505724SA (en) | 2010-07-23 | 2015-09-29 | Harvard College | Methods of detecting diseases or conditions using phagocytic cells |
| CA2806293A1 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| US20130203624A1 (en) | 2010-07-23 | 2013-08-08 | President And Fellows Of Harvard College | Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions |
| US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US10167508B2 (en) | 2010-08-06 | 2019-01-01 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US11031095B2 (en) | 2010-08-06 | 2021-06-08 | Ariosa Diagnostics, Inc. | Assay systems for determination of fetal copy number variation |
| US20140342940A1 (en) | 2011-01-25 | 2014-11-20 | Ariosa Diagnostics, Inc. | Detection of Target Nucleic Acids using Hybridization |
| US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
| EP2656263B1 (de) | 2010-12-22 | 2019-11-06 | Natera, Inc. | Verfahren für nichtinvasiven pränatalen vaterschaftstest |
| US9994897B2 (en) | 2013-03-08 | 2018-06-12 | Ariosa Diagnostics, Inc. | Non-invasive fetal sex determination |
| US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
| US8756020B2 (en) | 2011-01-25 | 2014-06-17 | Ariosa Diagnostics, Inc. | Enhanced risk probabilities using biomolecule estimations |
| US11270781B2 (en) | 2011-01-25 | 2022-03-08 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
| WO2012106338A1 (en) * | 2011-01-31 | 2012-08-09 | Esoterix Genetic Laboratories, Llc | Methods for enriching microparticles or nucleic acids in a complex mixture using size exclusion filtration |
| JP6153874B2 (ja) | 2011-02-09 | 2017-06-28 | ナテラ， インコーポレイテッド | 非侵襲的出生前倍数性呼び出しのための方法 |
| EP2518160A1 (de) * | 2011-04-29 | 2012-10-31 | Universitätsklinikum Freiburg | Mitochondriale Nukleinsäure als Marker für Autoimmun- und Autoentzündungskrankheiten |
| US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
| US20130280704A9 (en) * | 2011-09-16 | 2013-10-24 | Frederick S. Wreford | Enhanced detection of non-somatic circulating nucleic acids |
| US10289800B2 (en) | 2012-05-21 | 2019-05-14 | Ariosa Diagnostics, Inc. | Processes for calculating phased fetal genomic sequences |
| AU2013292287A1 (en) | 2012-07-19 | 2015-02-19 | Ariosa Diagnostics, Inc. | Multiplexed sequential ligation-based detection of genetic variants |
| US20140045702A1 (en) * | 2012-08-13 | 2014-02-13 | Synapdx Corporation | Systems and methods for distinguishing between autism spectrum disorders (asd) and non-asd development delay |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| ES2482866B1 (es) * | 2012-11-22 | 2015-05-12 | Consejo Superior De Investigaciones Científicas (Csic) | Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas. |
| WO2014164362A1 (en) | 2013-03-09 | 2014-10-09 | Harry Stylli | Methods of detecting prostate cancer |
| EP4202441A3 (de) | 2013-03-09 | 2023-07-26 | Immunis.AI, Inc. | Genexpressionsprofil in makrophagen zur diagnose von krebs |
| CN106068455B (zh) | 2013-07-12 | 2018-05-11 | 权宁娥 | 使用Luterial的形态特征用于诊断疾病的方法 |
| CN113774132A (zh) | 2014-04-21 | 2021-12-10 | 纳特拉公司 | 检测染色体片段中的突变和倍性 |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| US10626464B2 (en) | 2014-09-11 | 2020-04-21 | Cell Mdx, Llc | Methods of detecting prostate cancer |
| DK3294906T3 (en) | 2015-05-11 | 2024-08-05 | Natera Inc | Methods for determining ploidy |
| CA3007159C (en) | 2015-12-30 | 2022-08-23 | Ventana Medical Systems, Inc. | System and method for real time assay monitoring |
| DK3443119T3 (da) | 2016-04-15 | 2022-05-23 | Natera Inc | Fremgangsmåde til bestemmelse af lunge cancer |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| CN109406785A (zh) | 2017-08-18 | 2019-03-01 | 山东泽济生物科技有限公司 | 肿瘤血液标志物及其应用 |
| WO2019118926A1 (en) | 2017-12-14 | 2019-06-20 | Tai Diagnostics, Inc. | Assessing graft suitability for transplantation |
| WO2019195975A1 (zh) * | 2018-04-09 | 2019-10-17 | 深圳华大生命科学研究院 | 基因文库的构建方法及其应用 |
| DK3781714T3 (da) | 2018-04-14 | 2026-03-30 | Natera Inc | Fremgangsmåder til cancerpåvisning og -overvågning ved personlig påvisning af cirkulerende tumor-dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| EP3980559A1 (de) | 2019-06-06 | 2022-04-13 | Natera, Inc. | Verfahren zur detektion von immunzellen-dna und zur überwachung des immunsystems |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86202908U (zh) * | 1986-05-06 | 1987-09-30 | 四川大学 | 蚕丝匀度及毛疵光电自动检验仪 |
| ES2347854T5 (es) * | 1996-03-26 | 2014-07-24 | Michael S. Kopreski | Método que permite el uso de RNA extracelular extraído de plasma o suero para detectar, monitorizar o evaluar un cáncer |
| US6664056B2 (en) * | 2000-10-17 | 2003-12-16 | The Chinese University Of Hong Kong | Non-invasive prenatal monitoring |
| WO2004065629A1 (en) * | 2003-01-17 | 2004-08-05 | The Chinese University Of Hong Kong | Circulating mrna as diagnostic markers for pregnancy-related disorders |
-
2003
- 2003-05-13 US US10/437,500 patent/US20040009518A1/en not_active Abandoned
- 2003-05-14 CN CN200910150245A patent/CN101613760A/zh active Pending
- 2003-05-14 WO PCT/GB2003/002081 patent/WO2003095674A2/en not_active Ceased
- 2003-05-14 AU AU2003230025A patent/AU2003230025B2/en not_active Expired
- 2003-05-14 AT AT03722865T patent/ATE440151T1/de not_active IP Right Cessation
- 2003-05-14 EP EP03722865A patent/EP1504120B1/de not_active Expired - Lifetime
- 2003-05-14 DE DE60328885T patent/DE60328885D1/de not_active Expired - Lifetime
- 2003-05-14 JP JP2004503664A patent/JP4327714B2/ja not_active Expired - Lifetime
- 2003-05-14 CN CNB038109514A patent/CN100529100C/zh not_active Expired - Lifetime
-
2010
- 2010-11-08 US US12/941,855 patent/US20110086357A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110086357A1 (en) | 2011-04-14 |
| US20040009518A1 (en) | 2004-01-15 |
| AU2003230025B8 (en) | 2003-11-24 |
| WO2003095674A3 (en) | 2004-02-26 |
| CN100529100C (zh) | 2009-08-19 |
| EP1504120B1 (de) | 2009-08-19 |
| AU2003230025A1 (en) | 2003-11-11 |
| HK1077602A1 (zh) | 2006-02-17 |
| CN1653192A (zh) | 2005-08-10 |
| JP4327714B2 (ja) | 2009-09-09 |
| DE60328885D1 (de) | 2009-10-01 |
| WO2003095674A2 (en) | 2003-11-20 |
| AU2003230025B2 (en) | 2008-01-24 |
| JP2005525124A (ja) | 2005-08-25 |
| CN101613760A (zh) | 2009-12-30 |
| EP1504120A2 (de) | 2005-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |