ATE440151T1 - Verfahren zur beurteilung eines krankheitzustandes mittels nachweis von partikel- und nicht partikelgebundenen nukleinsäuren in blutplasma und -serum - Google Patents
Verfahren zur beurteilung eines krankheitzustandes mittels nachweis von partikel- und nicht partikelgebundenen nukleinsäuren in blutplasma und -serumInfo
- Publication number
- ATE440151T1 ATE440151T1 AT03722865T AT03722865T ATE440151T1 AT E440151 T1 ATE440151 T1 AT E440151T1 AT 03722865 T AT03722865 T AT 03722865T AT 03722865 T AT03722865 T AT 03722865T AT E440151 T1 ATE440151 T1 AT E440151T1
- Authority
- AT
- Austria
- Prior art keywords
- particle
- bond
- serum
- nucleic acids
- blood plasma
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 210000002381 plasma Anatomy 0.000 title abstract 2
- 210000002966 serum Anatomy 0.000 title abstract 2
- 239000002245 particle Substances 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38070802P | 2002-05-14 | 2002-05-14 | |
| PCT/GB2003/002081 WO2003095674A2 (en) | 2002-05-14 | 2003-05-14 | Methods for evaluating a disease condition by detection of particle and non-particle bound nucleic acids in blood plasma and serum |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE440151T1 true ATE440151T1 (de) | 2009-09-15 |
Family
ID=29420628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03722865T ATE440151T1 (de) | 2002-05-14 | 2003-05-14 | Verfahren zur beurteilung eines krankheitzustandes mittels nachweis von partikel- und nicht partikelgebundenen nukleinsäuren in blutplasma und -serum |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20040009518A1 (de) |
| EP (1) | EP1504120B1 (de) |
| JP (1) | JP4327714B2 (de) |
| CN (2) | CN100529100C (de) |
| AT (1) | ATE440151T1 (de) |
| AU (1) | AU2003230025B2 (de) |
| DE (1) | DE60328885D1 (de) |
| WO (1) | WO2003095674A2 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004065629A1 (en) * | 2003-01-17 | 2004-08-05 | The Chinese University Of Hong Kong | Circulating mrna as diagnostic markers for pregnancy-related disorders |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| TW200729050A (en) * | 2005-09-22 | 2007-08-01 | China Synthetic Rubber Corp | Gene expression profiling for identification of prognostic subclasses in nasopharyngeal carcinomas |
| EP3260556B1 (de) | 2006-05-31 | 2019-07-31 | Sequenom, Inc. | Verfahren zur nukleinsäureextraktion aus einer probe |
| AU2007260750A1 (en) * | 2006-06-16 | 2007-12-21 | Sequenom, Inc. | Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample |
| TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
| AU2008230813B2 (en) | 2007-03-26 | 2014-01-30 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| CA2984820C (en) * | 2007-04-04 | 2021-12-07 | Ande Corporation | Plastic microfluidic separation and detection platforms |
| DK2240781T3 (en) | 2008-01-18 | 2018-03-26 | Harvard College | METHODS FOR DETECTING DISEASE OR STATE SIGNATURES IN BODY FLUIDS |
| WO2009120808A2 (en) | 2008-03-26 | 2009-10-01 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| WO2010079118A1 (en) * | 2009-01-07 | 2010-07-15 | Michael Roth-Chiarello | Use of rna obtained from proteolipid complexes circulating in blood for diagnosis and treatment of tumors |
| EP3514244B1 (de) | 2009-04-03 | 2021-07-07 | Sequenom, Inc. | Verfahren für die herstellung von nukleinsäuren |
| EP2443254A2 (de) | 2009-06-15 | 2012-04-25 | NetBio, Inc. | Verbesserte verfahren für forensische dna-quantifizierung |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| EP2572003A4 (de) | 2010-05-18 | 2016-01-13 | Natera Inc | Verfahren zur nichtinvasiven pränatalen ploidiezuordnung |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US12545960B2 (en) | 2010-05-18 | 2026-02-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| WO2012012693A2 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods for detecting signatures of disease or conditions in bodily fluids |
| AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| EP2596134B1 (de) | 2010-07-23 | 2020-04-08 | President and Fellows of Harvard College | Verfahren zur erkennung von erkrankungen oder leiden mit phagozytischen zellen |
| CA2806304A1 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting prenatal or pregnancy-related diseases or conditions |
| US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US20140342940A1 (en) | 2011-01-25 | 2014-11-20 | Ariosa Diagnostics, Inc. | Detection of Target Nucleic Acids using Hybridization |
| US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
| US10167508B2 (en) | 2010-08-06 | 2019-01-01 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
| US11031095B2 (en) | 2010-08-06 | 2021-06-08 | Ariosa Diagnostics, Inc. | Assay systems for determination of fetal copy number variation |
| WO2012088456A2 (en) | 2010-12-22 | 2012-06-28 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
| US9994897B2 (en) | 2013-03-08 | 2018-06-12 | Ariosa Diagnostics, Inc. | Non-invasive fetal sex determination |
| US11270781B2 (en) | 2011-01-25 | 2022-03-08 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
| US8756020B2 (en) | 2011-01-25 | 2014-06-17 | Ariosa Diagnostics, Inc. | Enhanced risk probabilities using biomolecule estimations |
| CA2826111A1 (en) * | 2011-01-31 | 2012-08-09 | Esoterix Genetic Laboratories, Llc | Methods for enriching microparticles or nucleic acids in a complex mixture using size exclusion filtration |
| AU2011358564B9 (en) | 2011-02-09 | 2017-07-13 | Natera, Inc | Methods for non-invasive prenatal ploidy calling |
| EP2518160A1 (de) * | 2011-04-29 | 2012-10-31 | Universitätsklinikum Freiburg | Mitochondriale Nukleinsäure als Marker für Autoimmun- und Autoentzündungskrankheiten |
| US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
| US20130280704A9 (en) * | 2011-09-16 | 2013-10-24 | Frederick S. Wreford | Enhanced detection of non-somatic circulating nucleic acids |
| US10289800B2 (en) | 2012-05-21 | 2019-05-14 | Ariosa Diagnostics, Inc. | Processes for calculating phased fetal genomic sequences |
| JP2015522293A (ja) | 2012-07-19 | 2015-08-06 | アリオサ ダイアグノスティックス インコーポレイテッドＡｒｉｏｓａ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． | 多重化連続ライゲーションに基づく遺伝子変異体の検出 |
| US20140045702A1 (en) * | 2012-08-13 | 2014-02-13 | Synapdx Corporation | Systems and methods for distinguishing between autism spectrum disorders (asd) and non-asd development delay |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| ES2482866B1 (es) * | 2012-11-22 | 2015-05-12 | Consejo Superior De Investigaciones Científicas (Csic) | Método de diagnóstico y/o pronóstico de enfermedades neurodegenerativas. |
| EP2965077B1 (de) | 2013-03-09 | 2022-07-13 | Harry Stylli | Verfahren zur krebserkennung |
| US11585814B2 (en) | 2013-03-09 | 2023-02-21 | Immunis.Ai, Inc. | Methods of detecting prostate cancer |
| CN106068455B (zh) | 2013-07-12 | 2018-05-11 | 权宁娥 | 使用Luterial的形态特征用于诊断疾病的方法 |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP3957749A1 (de) | 2014-04-21 | 2022-02-23 | Natera, Inc. | Nachweis von tumorspezifischen mutationen in biopsien mittels sequenzierung des gesamten exoms und in zellfreien proben |
| US20180173845A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| MA40636A (fr) | 2014-09-11 | 2015-09-11 | Colleen Kelly | Procédés pour détecter le cancer de la prostate |
| WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
| AU2016382837B2 (en) | 2015-12-30 | 2019-08-08 | Ventana Medical Systems, Inc. | System and method for real time assay monitoring |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| US11485996B2 (en) | 2016-10-04 | 2022-11-01 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| CN109406785A (zh) | 2017-08-18 | 2019-03-01 | 山东泽济生物科技有限公司 | 肿瘤血液标志物及其应用 |
| JP2021506342A (ja) | 2017-12-14 | 2021-02-22 | ティーエーアイ ダイアグノスティックス インコーポレイテッドＴａｉ Ｄｉａｇｎｏｓｔｉｃｓ，Ｉｎｃ． | 移植のための移植片適合性の評価 |
| WO2019195975A1 (zh) * | 2018-04-09 | 2019-10-17 | 深圳华大生命科学研究院 | 基因文库的构建方法及其应用 |
| CA3090426A1 (en) | 2018-04-14 | 2019-10-17 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| EP3980559A1 (de) | 2019-06-06 | 2022-04-13 | Natera, Inc. | Verfahren zur detektion von immunzellen-dna und zur überwachung des immunsystems |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86202908U (zh) * | 1986-05-06 | 1987-09-30 | 四川大学 | 蚕丝匀度及毛疵光电自动检验仪 |
| ATE471150T1 (de) * | 1996-03-26 | 2010-07-15 | Kopreski Michael S | Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden |
| US6664056B2 (en) * | 2000-10-17 | 2003-12-16 | The Chinese University Of Hong Kong | Non-invasive prenatal monitoring |
| WO2004065629A1 (en) * | 2003-01-17 | 2004-08-05 | The Chinese University Of Hong Kong | Circulating mrna as diagnostic markers for pregnancy-related disorders |
-
2003
- 2003-05-13 US US10/437,500 patent/US20040009518A1/en not_active Abandoned
- 2003-05-14 CN CNB038109514A patent/CN100529100C/zh not_active Expired - Lifetime
- 2003-05-14 WO PCT/GB2003/002081 patent/WO2003095674A2/en not_active Ceased
- 2003-05-14 JP JP2004503664A patent/JP4327714B2/ja not_active Expired - Lifetime
- 2003-05-14 CN CN200910150245A patent/CN101613760A/zh active Pending
- 2003-05-14 AT AT03722865T patent/ATE440151T1/de not_active IP Right Cessation
- 2003-05-14 DE DE60328885T patent/DE60328885D1/de not_active Expired - Lifetime
- 2003-05-14 AU AU2003230025A patent/AU2003230025B2/en not_active Expired
- 2003-05-14 EP EP03722865A patent/EP1504120B1/de not_active Expired - Lifetime
-
2010
- 2010-11-08 US US12/941,855 patent/US20110086357A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60328885D1 (de) | 2009-10-01 |
| AU2003230025B8 (en) | 2003-11-24 |
| EP1504120B1 (de) | 2009-08-19 |
| EP1504120A2 (de) | 2005-02-09 |
| CN1653192A (zh) | 2005-08-10 |
| JP2005525124A (ja) | 2005-08-25 |
| US20110086357A1 (en) | 2011-04-14 |
| US20040009518A1 (en) | 2004-01-15 |
| WO2003095674A3 (en) | 2004-02-26 |
| WO2003095674A2 (en) | 2003-11-20 |
| JP4327714B2 (ja) | 2009-09-09 |
| CN101613760A (zh) | 2009-12-30 |
| AU2003230025B2 (en) | 2008-01-24 |
| AU2003230025A1 (en) | 2003-11-11 |
| CN100529100C (zh) | 2009-08-19 |
| HK1077602A1 (zh) | 2006-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |