ATE440966T1 - Mobilitätsmodifizierte nukleobasenpolymere und verfahren zu deren verwendung - Google Patents

Mobilitätsmodifizierte nukleobasenpolymere und verfahren zu deren verwendung

Info

Publication number
ATE440966T1
ATE440966T1 AT02731376T AT02731376T ATE440966T1 AT E440966 T1 ATE440966 T1 AT E440966T1 AT 02731376 T AT02731376 T AT 02731376T AT 02731376 T AT02731376 T AT 02731376T AT E440966 T1 ATE440966 T1 AT E440966T1
Authority
AT
Austria
Prior art keywords
mobility
polymers
oligonucleobase
modifying
present
Prior art date
Application number
AT02731376T
Other languages
English (en)
Inventor
Sam Woo
Ron Graham
Jing Tian
Original Assignee
Applied Biosystems Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Biosystems Llc filed Critical Applied Biosystems Llc
Application granted granted Critical
Publication of ATE440966T1 publication Critical patent/ATE440966T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polyethers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT02731376T 2001-04-16 2002-04-15 Mobilitätsmodifizierte nukleobasenpolymere und verfahren zu deren verwendung ATE440966T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/836,704 US6743905B2 (en) 2001-04-16 2001-04-16 Mobility-modified nucleobase polymers and methods of using same
PCT/US2002/011824 WO2002083954A1 (en) 2001-04-16 2002-04-15 Mobility-modified nucleobase polymers and methods of using same

Publications (1)

Publication Number Publication Date
ATE440966T1 true ATE440966T1 (de) 2009-09-15

Family

ID=25272541

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02731376T ATE440966T1 (de) 2001-04-16 2002-04-15 Mobilitätsmodifizierte nukleobasenpolymere und verfahren zu deren verwendung

Country Status (7)

Country Link
US (4) US6743905B2 (de)
EP (1) EP1379698B1 (de)
JP (2) JP4452445B2 (de)
AT (1) ATE440966T1 (de)
CA (1) CA2443122A1 (de)
DE (1) DE60233477D1 (de)
WO (1) WO2002083954A1 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US7537938B2 (en) 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US6743905B2 (en) * 2001-04-16 2004-06-01 Applera Corporation Mobility-modified nucleobase polymers and methods of using same
WO2002095356A2 (en) 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
US20060003333A1 (en) * 2002-11-19 2006-01-05 Singulex, Inc. Preparation of defined highly labeled probes
US20040126765A1 (en) * 2002-12-27 2004-07-01 Adams Craig W. Method and compositions for sequencing nucleic acid molecules
US20050239089A1 (en) * 2003-06-06 2005-10-27 Johnson Martin D Mobility cassettes
EP1704245A1 (de) * 2003-12-31 2006-09-27 Applera Corporation Multiplex-proteaseprofilerstellung
US20080103053A1 (en) * 2005-11-22 2008-05-01 Helicos Biosciences Corporation Methods and compositions for sequencing a nucleic acid
AU2007221315B2 (en) * 2006-02-22 2013-03-14 Covidien Lp Biodegradable phosphoester polyamines
US9677123B2 (en) * 2006-03-15 2017-06-13 Siemens Healthcare Diagnostics Inc. Degenerate nucleobase analogs
CN101517091B (zh) * 2006-06-01 2013-02-13 垂林克生物技术公司 用于核酸扩增的化学修饰的寡核苷酸引物
EP3543357A1 (de) 2007-05-08 2019-09-25 Trustees of Boston University Chemische funktionalisierung von festkörpernanoporen und nanoporenarrays und anwendungen davon
US8097712B2 (en) 2007-11-07 2012-01-17 Beelogics Inc. Compositions for conferring tolerance to viral disease in social insects, and the use thereof
WO2010046829A1 (en) * 2008-10-20 2010-04-29 Koninklijke Philips Electronics N.V. Separation free ser(r)s assay
WO2011027966A2 (en) * 2009-09-03 2011-03-10 Seegene, Inc. Td probe and its uses
EP2483680A4 (de) 2009-09-30 2014-01-01 Quantapore Inc Ultraschnelle sequenzierung biologischer polymere mithilfe einer markierten nanopore
US8962584B2 (en) 2009-10-14 2015-02-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Compositions for controlling Varroa mites in bees
PE20130649A1 (es) 2010-03-08 2013-07-13 Monsanto Technology Llc Moleculas polinucleotidicas para regulacion genetica en plantas
CA3140885A1 (en) 2010-12-13 2012-06-21 Quiapeg Pharmaceuticals Ab Functionalized polymers
CN103930549B (zh) 2011-09-13 2020-09-18 孟山都技术公司 用于杂草控制的方法和组合物
US10829828B2 (en) 2011-09-13 2020-11-10 Monsanto Technology Llc Methods and compositions for weed control
WO2013040116A1 (en) 2011-09-13 2013-03-21 Monsanto Technology Llc Methods and compositions for weed control
EP2755466A4 (de) 2011-09-13 2015-04-15 Monsanto Technology Llc Verfahren und zusammensetzungen zur unkrautbekämpfung
AU2012308737B2 (en) 2011-09-13 2018-06-14 Monsanto Technology Llc Methods and compositions for weed control
US10760086B2 (en) 2011-09-13 2020-09-01 Monsanto Technology Llc Methods and compositions for weed control
EP3434779A1 (de) 2011-09-13 2019-01-30 Monsanto Technology LLC Verfahren und zusammensetzungen zur unkrautbekämpfung
CN103957697B (zh) 2011-09-13 2017-10-24 孟山都技术公司 用于杂草控制的方法和组合物
US9840715B1 (en) 2011-09-13 2017-12-12 Monsanto Technology Llc Methods and compositions for delaying senescence and improving disease tolerance and yield in plants
MX343072B (es) 2011-09-13 2016-10-21 Monsanto Technology Llc Metodos y composiciones para controlar malezas.
US10806146B2 (en) 2011-09-13 2020-10-20 Monsanto Technology Llc Methods and compositions for weed control
CA2848669A1 (en) 2011-09-13 2013-03-21 Monsanto Technology Llc Methods and compositions for weed control targeting epsps
US9920326B1 (en) 2011-09-14 2018-03-20 Monsanto Technology Llc Methods and compositions for increasing invertase activity in plants
US20150018579A1 (en) * 2012-02-22 2015-01-15 Suresh C. Srivastava Synthesis of high purity dmt-c3-disulfide phosphoramidite
US10240162B2 (en) 2012-05-24 2019-03-26 A.B. Seeds Ltd. Compositions and methods for silencing gene expression
CA2876315C (en) * 2012-06-12 2021-05-25 Marek Kwiatkowski Conjugates of biologically active molecules to functionalized polymers
WO2014039092A1 (en) 2012-09-06 2014-03-13 Life Technologies Corporation Multiplex y-str analysis
FI3622810T3 (fi) 2012-09-24 2024-03-21 Seminis Vegetable Seeds Inc Menetelmät ja koostumukset kasvituotteiden säilyvyyden pidentämiseksi
AR093058A1 (es) 2012-10-18 2015-05-13 Monsanto Technology Llc Metodos y composiciones para el control de pestes en plantas
US9651539B2 (en) 2012-10-28 2017-05-16 Quantapore, Inc. Reducing background fluorescence in MEMS materials by low energy ion beam treatment
UA118841C2 (uk) 2013-01-01 2019-03-25 Ей.Бі. СІДС ЛТД. Спосіб формування рослини, яка має підвищену стійкість до комахи-шкідника
US10683505B2 (en) 2013-01-01 2020-06-16 Monsanto Technology Llc Methods of introducing dsRNA to plant seeds for modulating gene expression
US20150342192A1 (en) 2013-01-15 2015-12-03 Monsanto Technology Llc Methods and Compositions for Plant Pest Control
US10000767B2 (en) 2013-01-28 2018-06-19 Monsanto Technology Llc Methods and compositions for plant pest control
EP2967082A4 (de) 2013-03-13 2016-11-02 Monsanto Technology Llc Verfahren und zusammensetzungen zur unkrautbekämpfung
WO2014164761A1 (en) 2013-03-13 2014-10-09 Monsanto Technology Llc Methods and compositions for weed control
US20140283211A1 (en) 2013-03-14 2014-09-18 Monsanto Technology Llc Methods and Compositions for Plant Pest Control
US10568328B2 (en) 2013-03-15 2020-02-25 Monsanto Technology Llc Methods and compositions for weed control
EP3004385B1 (de) 2013-05-24 2018-11-28 Quantapore Inc. Nanoporenbasierte nukleinsäureanalyse mit gemischtem fret-nachweis
US9850496B2 (en) 2013-07-19 2017-12-26 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
JP6668236B2 (ja) 2013-07-19 2020-03-18 モンサント テクノロジー エルエルシー Ｌｅｐｔｉｎｏｔａｒｓａ防除用組成物及びその方法
JP6190534B2 (ja) 2013-08-22 2017-08-30 ソニー株式会社 水溶性蛍光染料又は有色染料及びその使用方法
MX390055B (es) 2013-11-04 2025-03-20 Monsanto Technology Llc Composiciones y metodos para controlar infestaciones de plagas y parasitos de los artropodos.
UA119253C2 (uk) 2013-12-10 2019-05-27 Біолоджикс, Інк. Спосіб боротьби із вірусом у кліща varroa та у бджіл
CN105979770B (zh) 2014-01-15 2019-07-05 孟山都技术公司 用于使用epsps多核苷酸的杂草控制的方法和组合物
BR112016022711A2 (pt) 2014-04-01 2017-10-31 Monsanto Technology Llc composições e métodos para controle de pragas de inseto
WO2015200223A1 (en) 2014-06-23 2015-12-30 Monsanto Technology Llc Compositions and methods for regulating gene expression via rna interference
US11807857B2 (en) 2014-06-25 2023-11-07 Monsanto Technology Llc Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression
AU2015296700B2 (en) 2014-07-29 2021-10-21 Monsanto Technology Llc Compositions and methods for controlling insect pests
ES2789000T3 (es) 2014-10-10 2020-10-23 Quantapore Inc Análisis de polinucleótidos basado en nanoporos con marcadores fluorescentes que se inactivan mutuamente
CA2964790C (en) 2014-10-24 2023-02-21 Quantapore, Inc. Efficient optical analysis of polymers using arrays of nanostructures
US10968449B2 (en) 2015-01-22 2021-04-06 Monsanto Technology Llc Compositions and methods for controlling Leptinotarsa
KR102676814B1 (ko) 2015-02-26 2024-06-21 소니그룹주식회사 접합 그룹을 포함하는 수용성 형광 또는 착색 염료
US10883103B2 (en) 2015-06-02 2021-01-05 Monsanto Technology Llc Compositions and methods for delivery of a polynucleotide into a plant
EP3302030A4 (de) 2015-06-03 2019-04-24 Monsanto Technology LLC Verfahren und zusammensetzungen zum einführen von nukleinsäuren in pflanzen
EP3408390A4 (de) 2016-01-26 2019-10-09 Monsanto Technology LLC Zusammensetzungen und verfahren zur bekämpfung von insektenbefall
CN107580618A (zh) 2016-04-01 2018-01-12 索尼公司 超亮二聚或多聚染料
JP7069033B2 (ja) 2016-04-06 2022-05-17 ソニーグループ株式会社 スペーシングリンカー基を有する超明色ダイマーまたはポリマー染料
AU2017264861B2 (en) 2016-05-11 2021-09-23 Sony Group Corporation Ultra bright dimeric or polymeric dyes
US10823721B2 (en) 2016-07-05 2020-11-03 Quantapore, Inc. Optically based nanopore sequencing
US10822647B2 (en) 2016-07-12 2020-11-03 Biodynamics S.R.L. Methods for using long ssDNA polynucleotides as primers (superprimers) in PCR assays
US10465242B2 (en) 2016-07-14 2019-11-05 University Of Utah Research Foundation Multi-sequence capture system
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
AU2018231832A1 (en) 2017-03-10 2019-08-08 Quiapeg Pharmaceuticals Ab Releasable conjugates
EP3691689A1 (de) 2017-10-05 2020-08-12 Sony Corporation Programmierbare dendritische arzneimittel
JP7551056B2 (ja) 2017-10-05 2024-09-17 ソニーグループ株式会社 プログラマブルなポリマー薬物
JP2021503450A (ja) 2017-11-16 2021-02-12 ソニー株式会社 プログラム可能なポリマー薬
JP7813098B2 (ja) 2018-01-12 2026-02-12 ソニーグループ株式会社 生物学的に活性な化合物を含む剛性間隔基を有するポリマー
CN111565757A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的磷酸烷基聚合物
JP2021510698A (ja) 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含むホスホアルキルリボースポリマー
KR102742386B1 (ko) 2018-03-19 2024-12-16 소니그룹주식회사 형광 신호 향상을 위한 2가 금속의 사용
WO2019182766A1 (en) 2018-03-21 2019-09-26 Sony Corporation Polymeric tandem dyes with linker groups
KR102854332B1 (ko) 2018-06-27 2025-09-03 소니그룹주식회사 디옥시리보오스를 포함하는 링커 군을 갖는 중합체성 염료
EP3820944A1 (de) 2018-07-13 2021-05-19 Sony Corporation Polymere farbstoffe mit einem gerüst mit organophosphateinheiten
EP3849660A1 (de) 2018-09-12 2021-07-21 QuiaPEG Pharmaceuticals AB Lösbare glp-1-konjugate
WO2021062176A2 (en) 2019-09-26 2021-04-01 Sony Corporation Polymeric tandem dyes with linker groups
JP7816141B2 (ja) 2019-09-30 2026-02-18 ソニーグループ株式会社 ヌクレオチドプローブ
EP4150116A2 (de) 2020-05-11 2023-03-22 Illumina, Inc. Vorrichtungen mit an elektroden gekoppelten partikeln und verfahren zur herstellung und verwendung davon
US20230295711A1 (en) * 2020-06-30 2023-09-21 Illumina, Inc. Compositions and methods for sequencing using at least electrical characteristics
JP2023550791A (ja) * 2020-11-25 2023-12-05 ソニーグループ株式会社 ポリマー色素
EP4256078A1 (de) * 2020-12-07 2023-10-11 Sony Group Corporation Abstandslinkergruppendesign zur helligkeitsverstärkung in dimeren oder polymeren farbstoffen
KR20220087091A (ko) * 2020-12-17 2022-06-24 오토텔릭바이오 주식회사 고순도 안티센스 올리고뉴클레오타이드의 제조방법
EP4074839A1 (de) * 2021-04-16 2022-10-19 Biotype GmbH Optimierte oligonukleotid-tx-sonde für eine multiplexing-analyse von nukleinsäuren und ein multiplexing-verfahren

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1218721B (de) * 1960-07-20 1966-06-08 Bayer Ag Stabilisieren chlorhaltiger Polymerisate
US3172871A (en) * 1960-02-26 1965-03-09 Ch3 chj
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5470974A (en) 1985-03-15 1995-11-28 Neu-Gene Development Group Uncharged polynucleotide-binding polymers
US4914210A (en) 1987-10-02 1990-04-03 Cetus Corporation Oligonucleotide functionalizing reagents
US5470967A (en) 1990-04-10 1995-11-28 The Dupont Merck Pharmaceutical Company Oligonucleotide analogs with sulfamate linkages
DE69322266T2 (de) 1992-04-03 1999-06-02 Perkin-Elmer Corp., Foster City, Calif. Proben zusammensetzung und verfahren
US5470705A (en) * 1992-04-03 1995-11-28 Applied Biosystems, Inc. Probe composition containing a binding domain and polymer chain and methods of use
US5696253A (en) 1994-06-30 1997-12-09 The Regents Of The University Of California Polynucleoside chain with 3'→5' guanidyl linkages
WO1996040709A1 (en) 1995-06-07 1996-12-19 Perseptive Biosystems, Inc. Pna-dna chimeras and pna synthons for their preparation
EP0964690B1 (de) 1996-10-15 2003-07-09 The Liposome Company, Inc. Peptid-lipid konjugate, liposomen und liposomale arzneimittelverabreichung
US6339069B1 (en) 1996-10-15 2002-01-15 Elan Pharmaceuticalstechnologies, Inc. Peptide-lipid conjugates, liposomes and lipsomal drug delivery
WO2000055368A2 (en) * 1999-03-15 2000-09-21 Pe Corporation (Ny) Probe/mobility modifier complexes for multiplex nucleic acid detection
US6743905B2 (en) 2001-04-16 2004-06-01 Applera Corporation Mobility-modified nucleobase polymers and methods of using same

Also Published As

Publication number Publication date
US20110160082A1 (en) 2011-06-30
JP2009240332A (ja) 2009-10-22
EP1379698A4 (de) 2007-04-25
US20070026434A1 (en) 2007-02-01
US20020182602A1 (en) 2002-12-05
US7897338B2 (en) 2011-03-01
EP1379698B1 (de) 2009-08-26
US6743905B2 (en) 2004-06-01
US7074569B2 (en) 2006-07-11
CA2443122A1 (en) 2002-10-24
JP4452445B2 (ja) 2010-04-21
US20050042644A1 (en) 2005-02-24
JP2004535382A (ja) 2004-11-25
DE60233477D1 (de) 2009-10-08
EP1379698A1 (de) 2004-01-14
WO2002083954A1 (en) 2002-10-24

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