ATE441418T1 - Verwendung von treprostinil zur verbesserung der nierenfunktion - Google Patents
Verwendung von treprostinil zur verbesserung der nierenfunktionInfo
- Publication number
- ATE441418T1 ATE441418T1 AT04814318T AT04814318T ATE441418T1 AT E441418 T1 ATE441418 T1 AT E441418T1 AT 04814318 T AT04814318 T AT 04814318T AT 04814318 T AT04814318 T AT 04814318T AT E441418 T1 ATE441418 T1 AT E441418T1
- Authority
- AT
- Austria
- Prior art keywords
- treprostinil
- kidney
- kidney function
- improve kidney
- derivative
- Prior art date
Links
- 230000003907 kidney function Effects 0.000 title abstract 3
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 title abstract 3
- 229960005032 treprostinil Drugs 0.000 title abstract 3
- 210000003734 kidney Anatomy 0.000 abstract 2
- 230000007257 malfunction Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- 210000002700 urine Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52962103P | 2003-12-16 | 2003-12-16 | |
| PCT/US2004/042119 WO2005058329A1 (en) | 2003-12-16 | 2004-12-16 | Use of treprostinil to improve kidney functions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE441418T1 true ATE441418T1 (de) | 2009-09-15 |
Family
ID=34700010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04814318T ATE441418T1 (de) | 2003-12-16 | 2004-12-16 | Verwendung von treprostinil zur verbesserung der nierenfunktion |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7199157B2 (de) |
| EP (1) | EP1696932B1 (de) |
| JP (1) | JP4906514B2 (de) |
| KR (1) | KR20060123482A (de) |
| CN (1) | CN1917883B (de) |
| AT (1) | ATE441418T1 (de) |
| CA (1) | CA2549801C (de) |
| DE (1) | DE602004022982D1 (de) |
| ES (1) | ES2331187T3 (de) |
| WO (1) | WO2005058329A1 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2562614C (en) * | 2004-04-12 | 2013-09-17 | United Therapeutics, Inc. | Use of treprostinil to treat neuropathic diabetic foot ulcers |
| JP5797376B2 (ja) | 2006-05-15 | 2015-10-21 | ユナイテッド セラピューティクス コーポレーション | 定量吸入器を用いたトレプロスチニル投与 |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| WO2009078965A1 (en) | 2007-12-17 | 2009-06-25 | United Therapeutics Corporation | An improved process to prepare treprostinil, the active ingredient in remodulin |
| KR20110010753A (ko) * | 2008-05-08 | 2011-02-07 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐 일수화물 |
| CA2730599C (en) | 2008-07-23 | 2016-09-13 | Toray Industries, Inc. | Therapeutic agent for chronic renal failure |
| JP5851246B2 (ja) * | 2008-12-30 | 2016-02-03 | リグスホスピタルＲｉｇｓｈｏｓｐｉｔａｌｅｔ | 臓器不全の発生リスクが上昇した重篤患者を識別する方法およびその治療のための化合物 |
| EP2427054A4 (de) * | 2009-05-07 | 2014-01-15 | United Therapeutics Corp | Feste formulierungen aus prostacyclin-analogen |
| JP5681276B2 (ja) | 2010-03-15 | 2015-03-04 | ユナイテッド セラピューティクス コーポレイション | 肺高血圧症のための治療 |
| US8481782B2 (en) | 2010-06-03 | 2013-07-09 | United Therapeutics Corporation | Treprostinil production |
| KR101454571B1 (ko) | 2011-03-02 | 2014-10-23 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐 생산을 위한 중간체 합성 |
| EP2741781A1 (de) * | 2011-08-12 | 2014-06-18 | Ascendis Pharma A/S | Trägerverknüpfte treprostinil-prodrugs |
| CN103193626B (zh) | 2012-01-10 | 2016-05-11 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| CN103193627B (zh) | 2012-01-10 | 2016-04-20 | 上海天伟生物制药有限公司 | 一种前列腺素类似物的晶型及其制备方法和用途 |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| ES2927844T3 (es) | 2013-01-11 | 2022-11-11 | Corsair Pharma Inc | Profármacos de treprostinil |
| CA3125504C (en) * | 2013-03-14 | 2023-10-24 | United Therapeutics Corporation | Solid forms of treprostinil |
| KR20150128903A (ko) | 2013-03-15 | 2015-11-18 | 유나이티드 세러퓨틱스 코오포레이션 | 트레프로스티닐의 염 |
| WO2014160638A1 (en) | 2013-03-25 | 2014-10-02 | United Therapeutics Corporation | Process of making prostacyclin compounds with linker thiol and pegylated forms |
| SI3060041T1 (sl) | 2013-10-25 | 2021-04-30 | Insmed Incorporated | Spojine prostaciklina |
| ES2908142T3 (es) | 2014-06-13 | 2022-04-27 | United Therapeutics Corp | Formulaciones de treprostinil |
| US9593061B2 (en) | 2014-10-20 | 2017-03-14 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
| EP3904326A1 (de) | 2014-11-18 | 2021-11-03 | Insmed Incorporated | Verfahren zur herstellung von treprostinil und treprostinilderivat-prodrugs |
| EP3226838A1 (de) | 2014-12-03 | 2017-10-11 | Steadymed Ltd. | Konservierungsmittelfreie treprostinilformulierungen sowie verfahren und vorrichtungen zur verwendung damit |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US10898494B2 (en) | 2016-05-05 | 2021-01-26 | Liquidia Technologies, Inc. | Dry powder treprostinil for the treatment of pulmonary hypertension |
| CA3038276A1 (en) | 2016-09-26 | 2018-03-29 | United Therapeutics Corporation | Treprostinil prodrugs |
| US10799653B2 (en) | 2017-01-09 | 2020-10-13 | United Therapeutics Corporation | Aerosol delivery device and method for manufacturing and operating the same |
| EP3853200B1 (de) | 2018-09-18 | 2024-01-24 | Eli Lilly and Company | Erbumine salz von treprostinil |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| WO2020236748A1 (en) * | 2019-05-17 | 2020-11-26 | NXT Biomedical | Urine collecting system interventions for improving kidney function |
| WO2021041320A1 (en) | 2019-08-23 | 2021-03-04 | United Therapeutics Corporation | Treprostinil prodrugs |
| IL296567A (en) | 2020-04-17 | 2022-11-01 | United Therapeutics Corp | Terfostinil for use in the treatment of interstitial lung disease |
| US11793780B2 (en) | 2020-06-09 | 2023-10-24 | United Therapeutics Corporation | Prodrugs of treprosiinil |
| KR20250133451A (ko) | 2020-12-14 | 2025-09-05 | 유나이티드 쎄러퓨틱스 코포레이션 | 트레프로스티닐 프로드러그로 질환을 치료하는 방법 |
| AU2022229367A1 (en) | 2021-03-03 | 2023-09-14 | United Therapeutics Corporation | A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp) |
| US20230263807A1 (en) | 2022-02-08 | 2023-08-24 | United Therapeutics Corporation | Treprostinil iloprost combination therapy |
| KR20250002687A (ko) | 2022-04-29 | 2025-01-07 | 자오커 파마슈티컬 (광저우) 컴퍼니., 리미티드 | 트레프로스티닐 소프트 미스트 흡입제 |
| EP4651879A1 (de) | 2023-01-18 | 2025-11-26 | United Therapeutics Corporation | Behandlung von pulmonaler arterieller hypertonie |
| AU2024208919A1 (en) | 2023-01-19 | 2025-07-17 | United Therapeutics Corporation | Treprostinil analogs |
| US20250197338A1 (en) | 2023-11-09 | 2025-06-19 | United Therapeutics Corporation | Syntheses of compounds useful for producing treprostinil |
| US20260041656A1 (en) | 2024-08-06 | 2026-02-12 | United Therapeutics Corporation | Treating pulmonary hypertension based on novel biomarker |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| GB8814438D0 (en) | 1988-06-17 | 1988-07-20 | Wellcome Found | Compounds for use in medicine |
| US6441245B1 (en) | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| KR100638684B1 (ko) * | 1997-11-14 | 2006-10-27 | 유나이티드 세러퓨틱스 코오포레이션 | 말초 혈관 질환의 치료를 위한 9-데옥시-2',9-알파-메타노-3-옥사-4,5,6-트리노르-3,7-(1',3'-인터페닐렌)-13,14-디하이드로-프로스타글란딘 에프1의 용도 |
| US6521212B1 (en) | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| ES2670872T3 (es) * | 2003-05-22 | 2018-06-01 | United Therapeutics Corporation | Polimorfo de una sal de dietanolamina de treprostinil |
| JP2005120069A (ja) * | 2003-10-13 | 2005-05-12 | Anges Mg Inc | 炎症性疾患治療薬 |
| US8765813B2 (en) * | 2003-12-16 | 2014-07-01 | United Therapeutics Corporation | Use of treprostinil to treat and prevent ischemic lesions |
-
2004
- 2004-12-16 JP JP2006545379A patent/JP4906514B2/ja not_active Expired - Fee Related
- 2004-12-16 KR KR1020067013987A patent/KR20060123482A/ko not_active Ceased
- 2004-12-16 DE DE602004022982T patent/DE602004022982D1/de not_active Expired - Lifetime
- 2004-12-16 WO PCT/US2004/042119 patent/WO2005058329A1/en not_active Ceased
- 2004-12-16 CN CN2004800417620A patent/CN1917883B/zh not_active Expired - Fee Related
- 2004-12-16 EP EP04814318A patent/EP1696932B1/de not_active Expired - Lifetime
- 2004-12-16 US US11/012,722 patent/US7199157B2/en not_active Expired - Lifetime
- 2004-12-16 CA CA2549801A patent/CA2549801C/en not_active Expired - Fee Related
- 2004-12-16 AT AT04814318T patent/ATE441418T1/de not_active IP Right Cessation
- 2004-12-16 ES ES04814318T patent/ES2331187T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2331187T3 (es) | 2009-12-23 |
| JP2007513999A (ja) | 2007-05-31 |
| US7199157B2 (en) | 2007-04-03 |
| JP4906514B2 (ja) | 2012-03-28 |
| KR20060123482A (ko) | 2006-12-01 |
| CA2549801C (en) | 2012-10-16 |
| EP1696932B1 (de) | 2009-09-02 |
| WO2005058329A1 (en) | 2005-06-30 |
| US20050165110A1 (en) | 2005-07-28 |
| CN1917883A (zh) | 2007-02-21 |
| DE602004022982D1 (de) | 2009-10-15 |
| CN1917883B (zh) | 2011-05-11 |
| CA2549801A1 (en) | 2005-06-30 |
| EP1696932A1 (de) | 2006-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602004022982D1 (de) | Verwendung von treprostinil zur verbesserung der nierenfunktion | |
| ATE462427T1 (de) | Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren | |
| EA200802213A1 (ru) | Способы лечения заболеваний крови | |
| EA200401198A1 (ru) | АНТИТЕЛА ПРОТИВ αvβ6 | |
| DE602004014117D1 (de) | Thiazole zur verwendung als inhibitoren von protein-kinasen | |
| EA200700175A1 (ru) | Композиции и способы лечения воспалительных заболеваний | |
| PT1543011E (pt) | Composto de tienopirrolilo e furanopirrolilo e sua utilizacao como ligandos do receptor h4 da histamina | |
| EA200900802A1 (ru) | Способы и композиции для лечения амилоидных заболеваний | |
| EA200600078A1 (ru) | Способы и композиции для лечения амилоидных заболеваний | |
| EA200300528A1 (ru) | 1-арил-или 1-алкилсульфонилгетероциклилбензазолы в качестве лигандов 5-гидрокситриптамина-6 | |
| TW200716624A (en) | Compounds for modulating TRPV3 function | |
| UA92355C2 (en) | urn:schemas-microsoft-com:office:smarttags2,4-DIAMINO-PYRIMIDINES USED AS AURORAINHIBITORS | |
| EA200300829A1 (ru) | Производные 1-арил- или 1-алкилсульфонилбензазола в качестве лигандов 5-гидрокситриптамина-6 | |
| EA200501771A1 (ru) | Лиганды каннабиноидных рецепторов и их применения | |
| EA200500856A1 (ru) | Новые химические соединения | |
| UA85559C2 (en) | Aminobenzophenone compounds | |
| DE60122337D1 (de) | Verwendung von taci als antitumormittel | |
| MXPA06012500A (es) | Compuestos para el tratamiento de la enfermedad de alzheimer y para la inhibicion de la produccion del peptido beta-amiloideo. | |
| BRPI0513149A (pt) | uso de 2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituìdas no tratamento de náuseas e vÈmito | |
| DE60328603D1 (de) | Prodrugs von imidazol-derivaten, zur verwendung als protonenpumpen-hemmer zur behandlung von z.b. peptischen magengeschwüren | |
| WO2007028088A3 (en) | Methods for enhancing the dewaterability of sludge with alpha-amylase treatment | |
| ATE549024T1 (de) | Chinazolin-kaliumkanalhemmer | |
| TNSN06138A1 (fr) | Inhibitors of the mutant form of kit | |
| DE602005018181D1 (de) | Materialien und methoden zur behandlung von koagulationsstörungen | |
| EA200700407A1 (ru) | Производные хиназолина и их использования при лечении тромбоцитемии |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |