ATE441418T1 - Verwendung von treprostinil zur verbesserung der nierenfunktion - Google Patents

Verwendung von treprostinil zur verbesserung der nierenfunktion

Info

Publication number: ATE441418T1
Authority: AT; Austria
Prior art keywords: treprostinil; kidney; kidney function; improve kidney; derivative
Prior art date: 2003-12-16

Application number

AT04814318T

Other languages

English (en)

Inventor

Michael Wade

Roger Jeffs

Kathryn Bronstein

Deborah Strootman

Original Assignee

United Therapeutics Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-16

Filing date

2004-12-16

Publication date

2009-09-15

2004-12-16 Application filed by United Therapeutics Corp filed Critical United Therapeutics Corp

2009-09-15 Application granted granted Critical

2009-09-15 Publication of ATE441418T1 publication Critical patent/ATE441418T1/de

Links

230000003907 kidney function Effects 0.000 title abstract 3
PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 title abstract 3
229960005032 treprostinil Drugs 0.000 title abstract 3
210000003734 kidney Anatomy 0.000 abstract 2
230000007257 malfunction Effects 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
208000024891 symptom Diseases 0.000 abstract 2
210000002700 urine Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
External Artificial Organs (AREA)

AT04814318T 2003-12-16 2004-12-16 Verwendung von treprostinil zur verbesserung der nierenfunktion ATE441418T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US52962103P	2003-12-16	2003-12-16
PCT/US2004/042119 WO2005058329A1 (en)	2003-12-16	2004-12-16	Use of treprostinil to improve kidney functions

Publications (1)

Publication Number	Publication Date
ATE441418T1 true ATE441418T1 (de)	2009-09-15

Family

ID=34700010

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04814318T ATE441418T1 (de)	2003-12-16	2004-12-16	Verwendung von treprostinil zur verbesserung der nierenfunktion

Country Status (10)

Country	Link
US (1)	US7199157B2 (de)
EP (1)	EP1696932B1 (de)
JP (1)	JP4906514B2 (de)
KR (1)	KR20060123482A (de)
CN (1)	CN1917883B (de)
AT (1)	ATE441418T1 (de)
CA (1)	CA2549801C (de)
DE (1)	DE602004022982D1 (de)
ES (1)	ES2331187T3 (de)
WO (1)	WO2005058329A1 (de)

Families Citing this family (44)

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DE602005020269D1 (de) *	2004-04-12	2010-05-12	United Therapeutics Corp	Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren
CA2654492C (en)	2006-05-15	2017-06-27	United Therapeutics Corporation	Treprostinil administration using a metered dose inhaler
DE102006026786A1 (de)	2006-06-07	2007-12-13	Joachim Kern	Dosierinhalator
WO2009078965A1 (en)	2007-12-17	2009-06-25	United Therapeutics Corporation	An improved process to prepare treprostinil, the active ingredient in remodulin
JP6219016B2 (ja) *	2008-05-08	2017-10-25	ユナイテッドセラピューティクスコーポレーション	トレプロスチニル一水和物
US8575175B2 (en)	2008-07-23	2013-11-05	Toray Industries, Inc.	Therapeutic agent for chronic renal failure
CN102271685A (zh) *	2008-12-30	2011-12-07	斯若姆博洛捷克有限公司	鉴定发展成器官功能衰竭的风险提高的危重患者的方法及用于其治疗的化合物
CN102421288B (zh) *	2009-05-07	2015-04-22	联合治疗公司	前列环素类似物的固体剂型
KR20160132501A (ko)	2010-03-15	2016-11-18	유나이티드 세러퓨틱스 코오포레이션	폐고혈압의 치료
CN103261142B (zh)	2010-06-03	2014-12-10	联合治疗公司	曲前列环素的制备
ES2581762T3 (es)	2011-03-02	2016-09-07	United Therapeutics Corporation	Síntesis de producto intermedio para la producción de treprostinil
BR112014003225A2 (pt)	2011-08-12	2017-03-01	Ascendis Pharma As	profármacos de treprostinil ligados a veículo
CN103193626B (zh) *	2012-01-10	2016-05-11	上海天伟生物制药有限公司	一种前列腺素类似物的晶型及其制备方法和用途
CN103193627B (zh)	2012-01-10	2016-04-20	上海天伟生物制药有限公司	一种前列腺素类似物的晶型及其制备方法和用途
US9505737B2 (en)	2013-01-11	2016-11-29	Corsair Pharma, Inc.	Treprostinil derivative compounds and methods of using same
EP3712142B1 (de)	2013-01-11	2022-07-06	Corsair Pharma, Inc.	Prodrugs von treprostinil
WO2014159050A1 (en) *	2013-03-14	2014-10-02	United Therapeutics Corporation	Solid forms of treprostinil
EP2970081A4 (de)	2013-03-15	2016-10-12	United Therapeutics Corp	Salze von treprostinil
WO2014160638A1 (en)	2013-03-25	2014-10-02	United Therapeutics Corporation	Process of making prostacyclin compounds with linker thiol and pegylated forms
US9469600B2 (en)	2013-10-25	2016-10-18	Insmed Incorporated	Prostacyclin compounds, compositions and methods of use thereof
ES2908142T3 (es)	2014-06-13	2022-04-27	United Therapeutics Corp	Formulaciones de treprostinil
CN107108427A (zh)	2014-10-20	2017-08-29	联合治疗学有限公司	用于制备前列环素衍生物的中间体的合成
US10343979B2 (en)	2014-11-18	2019-07-09	Insmed Incorporated	Methods of manufacturing treprostinil and treprostinil derivative prodrugs
CA2967899C (en)	2014-12-03	2023-09-19	Steadymed Ltd	Preservative-free treprostinil formulations and methods and devices for use with same
US9643911B2 (en)	2015-06-17	2017-05-09	Corsair Pharma, Inc.	Treprostinil derivatives and compositions and uses thereof
US9394227B1 (en)	2015-06-17	2016-07-19	Corsair Pharma, Inc.	Treprostinil derivatives and compositions and uses thereof
EP3452170A4 (de)	2016-05-05	2020-04-01	Liquidia Technologies, Inc.	Treprostinil in pulverform zur behandlung von pulmonaler hypertonie
WO2018058124A1 (en)	2016-09-26	2018-03-29	United Therapeutics Corporation	Treprostinil prodrugs
US10799653B2 (en)	2017-01-09	2020-10-13	United Therapeutics Corporation	Aerosol delivery device and method for manufacturing and operating the same
CN112739679B (zh)	2018-09-18	2024-03-12	伊莱利利公司	曲前列环素的特丁胺盐
CN119632930A (zh)	2019-04-29	2025-03-18	英斯梅德股份有限公司	曲前列素前药的干粉组合物及其使用方法
WO2020236748A1 (en) *	2019-05-17	2020-11-26	NXT Biomedical	Urine collecting system interventions for improving kidney function
CN114616225A (zh)	2019-08-23	2022-06-10	联合治疗公司	曲前列环素前药
IL296567A (en)	2020-04-17	2022-11-01	United Therapeutics Corp	Terfostinil for use in the treatment of interstitial lung disease
AU2021289336B2 (en)	2020-06-09	2025-08-28	Mannkind Corporation	Fumaryl diketopiperidine prodrugs of treprostinil
KR102849520B1 (ko)	2020-12-14	2025-08-25	유나이티드 쎄러퓨틱스 코포레이션	트레프로스티닐 프로드러그로 질환을 치료하는 방법
WO2022187352A1 (en)	2021-03-03	2022-09-09	United Therapeutics Corporation	A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp)
WO2023154705A1 (en)	2022-02-08	2023-08-17	United Therapeutics Corporation	Treprostinil iloprost combination therapy
EP4516297A4 (de)	2022-04-29	2026-02-25	Zhaoke pharmaceutical guangzhou co ltd	Treprostinil-weichnebelinhalationsmittel
EP4651879A1 (de)	2023-01-18	2025-11-26	United Therapeutics Corporation	Behandlung von pulmonaler arterieller hypertonie
CN121241041A (zh)	2023-01-19	2025-12-30	联合治疗公司	曲前列尼尔类似物及相关制备和使用方法
CN122514512A (zh)	2023-11-09	2026-08-04	联合治疗公司	可用于生产曲前列尼尔的化合物的合成
WO2026035705A1 (en)	2024-08-06	2026-02-12	United Therapeutics Corporation	Treating pulmonary hypertension based on novel biomarker
US20260166056A1 (en)	2024-12-13	2026-06-18	United Therapeutics Corporation	Treprostinil formulations and their uses

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4306075A (en) *	1980-03-28	1981-12-15	The Upjohn Company	Composition and process
GB8814438D0 (en) *	1988-06-17	1988-07-20	Wellcome Found	Compounds for use in medicine
US6441245B1 (en) *	1997-10-24	2002-08-27	United Therapeutics Corporation	Process for stereoselective synthesis of prostacyclin derivatives
ES2214753T3 (es) *	1997-11-14	2004-09-16	United Therapeutics Corporation	Uso de 9-desoxi-2',9-alfa-metano-3-oxa-4,5,6-trinor-3,7-(1',3'-interfenilen)-13,14-dihidro-prostaglandina f1 para tratar la enfermedad vascular periferica.
US6521212B1 (en) *	1999-03-18	2003-02-18	United Therapeutics Corporation	Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
CN102697790A (zh) *	2003-05-22	2012-10-03	联合治疗公司	化合物和释放前列环素类似物的方法
JP2005120069A (ja) *	2003-10-13	2005-05-12	Anges Mg Inc	炎症性疾患治療薬
CN1917866B (zh) *	2003-12-16	2010-12-15	联合治疗公司	曲前列环素或它的衍生物，或其药学上可接受的盐在制备治疗和预防缺血性损害的药物中的用途

2004
- 2004-12-16 US US11/012,722 patent/US7199157B2/en not_active Expired - Lifetime
- 2004-12-16 ES ES04814318T patent/ES2331187T3/es not_active Expired - Lifetime
- 2004-12-16 WO PCT/US2004/042119 patent/WO2005058329A1/en not_active Ceased
- 2004-12-16 AT AT04814318T patent/ATE441418T1/de not_active IP Right Cessation
- 2004-12-16 DE DE602004022982T patent/DE602004022982D1/de not_active Expired - Lifetime
- 2004-12-16 KR KR1020067013987A patent/KR20060123482A/ko not_active Ceased
- 2004-12-16 EP EP04814318A patent/EP1696932B1/de not_active Expired - Lifetime
- 2004-12-16 CN CN2004800417620A patent/CN1917883B/zh not_active Expired - Fee Related
- 2004-12-16 CA CA2549801A patent/CA2549801C/en not_active Expired - Fee Related
- 2004-12-16 JP JP2006545379A patent/JP4906514B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR20060123482A (ko)	2006-12-01
WO2005058329A1 (en)	2005-06-30
ES2331187T3 (es)	2009-12-23
US20050165110A1 (en)	2005-07-28
CA2549801A1 (en)	2005-06-30
JP2007513999A (ja)	2007-05-31
DE602004022982D1 (de)	2009-10-15
EP1696932A1 (de)	2006-09-06
CN1917883B (zh)	2011-05-11
JP4906514B2 (ja)	2012-03-28
CA2549801C (en)	2012-10-16
US7199157B2 (en)	2007-04-03
EP1696932B1 (de)	2009-09-02
CN1917883A (zh)	2007-02-21

Legal Events

Date	Code	Title	Description
2010-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602004022982D1 (de)	2009-10-15	Verwendung von treprostinil zur verbesserung der nierenfunktion
ATE462427T1 (de)	2010-04-15	Verwendung von treprostinil zur behandlung von neuropathischen diabetischen fussgeschwüren
EA200802213A1 (ru)	2009-10-30	Способы лечения заболеваний крови
EA200401198A1 (ru)	2005-04-28	АНТИТЕЛА ПРОТИВ αvβ6
DE602004014117D1 (de)	2008-07-10	Thiazole zur verwendung als inhibitoren von protein-kinasen
EA200700175A1 (ru)	2007-08-31	Композиции и способы лечения воспалительных заболеваний
EA200900802A1 (ru)	2010-04-30	Способы и композиции для лечения амилоидных заболеваний
PT1543011E (pt)	2006-08-31	Composto de tienopirrolilo e furanopirrolilo e sua utilizacao como ligandos do receptor h4 da histamina
EA200600078A1 (ru)	2006-08-25	Способы и композиции для лечения амилоидных заболеваний
EA200300528A1 (ru)	2003-10-30	1-арил-или 1-алкилсульфонилгетероциклилбензазолы в качестве лигандов 5-гидрокситриптамина-6
TW200716624A (en)	2007-05-01	Compounds for modulating TRPV3 function
UA92355C2 (en)	2010-10-25	urn:schemas-microsoft-com:office:smarttags2,4-DIAMINO-PYRIMIDINES USED AS AURORAINHIBITORS
EA200300829A1 (ru)	2003-12-25	Производные 1-арил- или 1-алкилсульфонилбензазола в качестве лигандов 5-гидрокситриптамина-6
EA200501771A1 (ru)	2006-06-30	Лиганды каннабиноидных рецепторов и их применения
EA200500856A1 (ru)	2005-10-27	Новые химические соединения
UA85559C2 (en)	2009-02-10	Aminobenzophenone compounds
DE60122337D1 (de)	2006-09-28	Verwendung von taci als antitumormittel
MXPA06012500A (es)	2007-07-11	Compuestos para el tratamiento de la enfermedad de alzheimer y para la inhibicion de la produccion del peptido beta-amiloideo.
BRPI0513149A (pt)	2008-04-29	uso de 2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituìdas no tratamento de náuseas e vÈmito
DE60328603D1 (de)	2009-09-10	Prodrugs von imidazol-derivaten, zur verwendung als protonenpumpen-hemmer zur behandlung von z.b. peptischen magengeschwüren
WO2007028088A3 (en)	2009-04-23	Methods for enhancing the dewaterability of sludge with alpha-amylase treatment
ATE549024T1 (de)	2012-03-15	Chinazolin-kaliumkanalhemmer
TNSN06138A1 (fr)	2007-11-15	Inhibitors of the mutant form of kit
DE602005018181D1 (de)	2010-01-21	Materialien und methoden zur behandlung von koagulationsstörungen
EA200700407A1 (ru)	2007-08-31	Производные хиназолина и их использования при лечении тромбоцитемии