ATE441702T1 - Verfahren zur herstellung eines hmg-coa reduktase hemmers - Google Patents

Verfahren zur herstellung eines hmg-coa reduktase hemmers

Info

Publication number: ATE441702T1
Authority: AT; Austria
Prior art keywords: substituted; hmg; producing; coa reductase; reductase inhibitor
Prior art date: 1999-01-29

Application number

AT00901980T

Other languages

English (en)

Inventor

Hirofumi Endo

Yoshiyuki Yonetani

Hiroshi Mizoguchi

Shin-Ichi Hashimoto

Akio Ozaki

Original Assignee

Kyowa Hakko Bio Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-29

Filing date

2000-01-28

Publication date

2009-09-15

2000-01-28 Application filed by Kyowa Hakko Bio Co Ltd filed Critical Kyowa Hakko Bio Co Ltd

2009-09-15 Application granted granted Critical

2009-09-15 Publication of ATE441702T1 publication Critical patent/ATE441702T1/de

Links

229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
108020004414 DNA Proteins 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
241000193830 Bacillus <bacterium> Species 0.000 abstract 1
108020004511 Recombinant DNA Proteins 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000000640 hydroxylating effect Effects 0.000 abstract 1
125000000686 lactone group Chemical group 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Plant Substances (AREA)

AT00901980T 1999-01-29 2000-01-28 Verfahren zur herstellung eines hmg-coa reduktase hemmers ATE441702T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2170799		1999-01-29
PCT/JP2000/000472 WO2000044886A1 (en)	1999-01-29	2000-01-28	PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITOR

Publications (1)

Publication Number	Publication Date
ATE441702T1 true ATE441702T1 (de)	2009-09-15

Family

ID=12062541

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00901980T ATE441702T1 (de)	1999-01-29	2000-01-28	Verfahren zur herstellung eines hmg-coa reduktase hemmers

Country Status (14)

Country	Link
US (4)	US7049111B1 (de)
EP (1)	EP1148122B1 (de)
JP (1)	JP4668420B2 (de)
KR (1)	KR20010108139A (de)
CN (1)	CN1329508C (de)
AT (1)	ATE441702T1 (de)
AU (1)	AU2321600A (de)
CA (1)	CA2360080A1 (de)
CZ (1)	CZ20012728A3 (de)
DE (1)	DE60042879D1 (de)
HK (1)	HK1040530A1 (de)
HU (1)	HUP0105145A3 (de)
IL (1)	IL144526A0 (de)
WO (1)	WO2000044886A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1146126B1 (de) *	1999-01-20	2007-04-25	Kyowa Hakko Kogyo Co., Ltd.	Verfahren zur herstellung von hemmern der hmg-coa reduktase
KR20010108139A (ko)	1999-01-29	2001-12-07	히라타 다다시	히드록시메틸글루타릴 코에이 환원효소 저해제의 제조방법
CN101351551A (zh)	2005-11-29	2009-01-21	协和发酵工业株式会社	新型蛋白质和编码该蛋白质的dna
DK2094841T3 (da) *	2006-12-13	2012-05-29	Dsm Sinochem Pharm Nl Bv	Fremgangsmåde til fremstilling af pravastatin
US8383381B2 (en)	2007-09-27	2013-02-26	Shjonogi & Co., Ltd.	Method for producing hydroxylated adaivjantane using cytochrome P450
CN120283054A (zh)	2022-12-09	2025-07-08	麒麟控股株式会社	具有聚对苯二甲酸乙二醇酯分解活性的蛋白质和分解聚对苯二甲酸乙二醇酯的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5750894A (en)	1980-09-08	1982-03-25	Sankyo Co Ltd	Preparation of ml-236b derivative
MX7065E (es)	1980-06-06	1987-04-10	Sankyo Co	Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5720894A (en)	1980-07-15	1982-02-03	Nippon Keibi Hosho Kk	Fault diagnozing method for ultrasonic alarm unit
US4356621A (en)	1980-07-25	1982-11-02	Toyoda Koki Kabushiki Kaisha	Machine tool with automatic tool change
JPS5889191A (ja)	1981-11-20	1983-05-27	Sankyo Co Ltd	３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JP2672551B2 (ja)	1987-03-02	1997-11-05	三共株式会社	チトクロームｐ−４５０遺伝子を含有するｄｎａ
US6043064A (en)	1993-10-22	2000-03-28	Bristol-Myers Squibb Company	Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US5942423A (en)	1995-06-07	1999-08-24	Massachusetts Institute Of Technology	Conversion of compactin to pravastatin by actinomadura
JP4162848B2 (ja)	1997-08-07	2008-10-08	協和醗酵工業株式会社	ＨＭＧ−ＣｏＡレダクターゼ阻害剤の製造法
AU9264598A (en)	1997-08-22	1999-03-16	Gist-Brocades B.V.	Statin production by fermentation
SI9800144A (sl)	1998-05-21	1999-12-31	LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d.	Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
EP1146126B1 (de)	1999-01-20	2007-04-25	Kyowa Hakko Kogyo Co., Ltd.	Verfahren zur herstellung von hemmern der hmg-coa reduktase
KR20010108139A (ko)	1999-01-29	2001-12-07	히라타 다다시	히드록시메틸글루타릴 코에이 환원효소 저해제의 제조방법

2000
- 2000-01-28 KR KR1020017009457A patent/KR20010108139A/ko not_active Abandoned
- 2000-01-28 CN CNB008056293A patent/CN1329508C/zh not_active Expired - Fee Related
- 2000-01-28 EP EP00901980A patent/EP1148122B1/de not_active Expired - Lifetime
- 2000-01-28 JP JP2000596130A patent/JP4668420B2/ja not_active Expired - Lifetime
- 2000-01-28 DE DE60042879T patent/DE60042879D1/de not_active Expired - Lifetime
- 2000-01-28 US US09/869,334 patent/US7049111B1/en not_active Expired - Fee Related
- 2000-01-28 HU HU0105145A patent/HUP0105145A3/hu not_active Application Discontinuation
- 2000-01-28 AU AU23216/00A patent/AU2321600A/en not_active Abandoned
- 2000-01-28 IL IL14452600A patent/IL144526A0/xx unknown
- 2000-01-28 CZ CZ20012728A patent/CZ20012728A3/cs unknown
- 2000-01-28 CA CA002360080A patent/CA2360080A1/en not_active Abandoned
- 2000-01-28 AT AT00901980T patent/ATE441702T1/de not_active IP Right Cessation
- 2000-01-28 HK HK02101906.9A patent/HK1040530A1/en unknown
- 2000-01-28 WO PCT/JP2000/000472 patent/WO2000044886A1/ja not_active Ceased
2006
- 2006-02-13 US US11/352,308 patent/US7470528B2/en not_active Expired - Fee Related
2008
- 2008-05-22 US US12/125,569 patent/US20080261273A1/en not_active Abandoned
- 2008-11-17 US US12/272,448 patent/US7897370B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US7897370B2 (en)	2011-03-01
US20090148916A1 (en)	2009-06-11
CZ20012728A3 (cs)	2002-02-13
WO2000044886A1 (en)	2000-08-03
IL144526A0 (en)	2002-05-23
US7470528B2 (en)	2008-12-30
KR20010108139A (ko)	2001-12-07
EP1148122A4 (de)	2008-02-13
US7049111B1 (en)	2006-05-23
DE60042879D1 (de)	2009-10-15
EP1148122A1 (de)	2001-10-24
US20060154348A1 (en)	2006-07-13
HUP0105145A3 (en)	2006-02-28
HK1040530A1 (en)	2002-06-14
CN1329508C (zh)	2007-08-01
AU2321600A (en)	2000-08-18
CA2360080A1 (en)	2000-08-03
HUP0105145A2 (hu)	2002-04-29
US20080261273A1 (en)	2008-10-23
CN1345371A (zh)	2002-04-17
JP4668420B2 (ja)	2011-04-13
EP1148122B1 (de)	2009-09-02

Legal Events

Date	Code	Title	Description
2010-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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DE60042879D1 (de)	2009-10-15	Verfahren zur herstellung eines hmg-coa reduktase hemmers
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ATE360703T1 (de)	2007-05-15	Verfahren zur herstellung von hemmern der hmg-coa reduktase
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DE69839248D1 (de)	2008-04-24	VERFAHREN FÜR DIE HERSTELLUNG VON INHIBITOREN DER HMG-CoA-REDUKTASE.
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DK0963998T3 (da)	2004-08-16	Azasteroidforbindelse til behandling eller prævention af prostatacancer
WO2001025215A3 (de)	2001-10-25	Verfahren zur selektiven spaltung cyclischer carbonsäureanhydride
ATE358180T1 (de)	2007-04-15	Verfahren zur herstellung von trifluor-3(r)- hydroxybuttersäurederivaten
ATE319722T1 (de)	2006-03-15	Verfahren zur herstellung von vitamin-d analogen
AU2001250386A1 (en)	2001-09-24	Method for producing 1,1' binaphthalenylidene-4,4'-diones
EP0934936A4 (de)	2001-02-28	Oxazolidinverbindungen und verfahren zu ihrer herstellung