ATE44280T1 - Trizyklische verbindungen, verfahren zur herstellung derselben, pharmazeutische praeparate und behandlungsmethode. - Google Patents

Trizyklische verbindungen, verfahren zur herstellung derselben, pharmazeutische praeparate und behandlungsmethode.

Info

Publication number: ATE44280T1
Authority: AT; Austria
Prior art keywords: sup; hydrogen; compounds; lower alkyl; same
Prior art date: 1985-01-22

Application number

AT86100324T

Other languages

English (en)

Inventor

Nils-Erik Willman

Bengt Christer Hans Sjoegren

Lennart Gustav Nordh

Gustav Lennart Persson

Goeran Henry Sjoeholm

Original Assignee

Leo Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-22

Filing date

1986-01-11

Publication date

1989-07-15

1986-01-11 Application filed by Leo Ab filed Critical Leo Ab

1989-07-15 Application granted granted Critical

1989-07-15 Publication of ATE44280T1 publication Critical patent/ATE44280T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 3
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
-1 nitro, hydroxy, cyano, carbamyl Chemical group 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
ATYBXHSAIOKLMG-UHFFFAOYSA-N oxepin Chemical compound O1C=CC=CC=C1 ATYBXHSAIOKLMG-UHFFFAOYSA-N 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/12—[b,e]-condensed

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

AT86100324T 1985-01-22 1986-01-11 Trizyklische verbindungen, verfahren zur herstellung derselben, pharmazeutische praeparate und behandlungsmethode. ATE44280T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8500273A SE8500273D0 (sv)	1985-01-22	1985-01-22	Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder
EP86100324A EP0189078B1 (de)	1985-01-22	1986-01-11	Trizyklische Verbindungen, Verfahren zur Herstellung derselben, pharmazeutische Präparate und Behandlungsmethode

Publications (1)

Publication Number	Publication Date
ATE44280T1 true ATE44280T1 (de)	1989-07-15

Family

ID=20358842

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86100324T ATE44280T1 (de)	1985-01-22	1986-01-11	Trizyklische verbindungen, verfahren zur herstellung derselben, pharmazeutische praeparate und behandlungsmethode.

Country Status (12)

Country	Link
US (1)	US4645758A (de)
EP (1)	EP0189078B1 (de)
JP (1)	JPH0798817B2 (de)
AT (1)	ATE44280T1 (de)
AU (1)	AU587597B2 (de)
CA (1)	CA1309409C (de)
DE (1)	DE3664136D1 (de)
DK (1)	DK31486A (de)
FI (1)	FI860199A7 (de)
IE (1)	IE59600B1 (de)
NO (1)	NO855373L (de)
SE (1)	SE8500273D0 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0560831B1 (de) *	1986-06-17	1993-09-03	Dainippon Pharmaceutical Co
GB9318935D0 (en) *	1992-10-20	1993-10-27	Zeneca Ltd	Heterocyclic derivatives
US5340826A (en) *	1993-02-04	1994-08-23	Pfizer Inc.	Pharmaceutical agents for treatment of urinary incontinence
US5574173A (en) *	1993-12-06	1996-11-12	Schering Corporation	Tricyclic derivatives, compositions and methods of use
ES2214532T3 (es)	1995-03-03	2004-09-16	Endo Pharmaceuticals Inc.	Uso de dextrorfano o dextrometorfano para el tratamiento de la incontinencia urinaria.
BR9608502A (pt) *	1995-06-07	1999-07-06	Nippon Shinyaku Co Ltd	Derivado da pirrola e composição medicinal
US6323206B1 (en)	1996-07-12	2001-11-27	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
KR100447674B1 (ko) *	1997-04-15	2004-09-08	교와 핫꼬 고교 가부시끼가이샤	삼환식 화합물
CN1289336A (zh)	1998-01-21	2001-03-28	千禧药品公司	趋化因子受体拮抗剂和其使用方法
US6613905B1 (en)	1998-01-21	2003-09-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en)	1998-01-21	2003-01-21	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) *	1998-09-04	2007-09-18	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en) *	2001-11-21	2009-06-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US7378408B2 (en) *	2001-11-30	2008-05-27	Pfizer Inc.	Methods of treatment and formulations of cephalosporin
TWI291467B (en) *	2002-11-13	2007-12-21	Millennium Pharm Inc	CCR1 antagonists and methods of use therefor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL279409A (de) *	1961-06-08
NL300844A (de) *	1962-11-24
NL130988C (de) *	1966-07-21		Boehringer Mannheim Gmbh
US3876659A (en) *	1970-09-18	1975-04-08	Sandoz Ag	Spiro tricyclic isoindolines
FR2512024A1 (fr) *	1981-08-27	1983-03-04	Adir	Ethers tricycliques, leur preparation et les compositions pharmaceutiques les contenant
JPS6147466A (ja) *	1984-08-10	1986-03-07	Dainippon Pharmaceut Co Ltd	アミン誘導体

1985
- 1985-01-22 SE SE8500273A patent/SE8500273D0/xx unknown
- 1985-12-30 NO NO855373A patent/NO855373L/no unknown
- 1985-12-30 IE IE332585A patent/IE59600B1/en not_active IP Right Cessation
1986
- 1986-01-10 AU AU52171/86A patent/AU587597B2/en not_active Ceased
- 1986-01-11 AT AT86100324T patent/ATE44280T1/de not_active IP Right Cessation
- 1986-01-11 EP EP86100324A patent/EP0189078B1/de not_active Expired
- 1986-01-11 DE DE8686100324T patent/DE3664136D1/de not_active Expired
- 1986-01-16 FI FI860199A patent/FI860199A7/fi not_active Application Discontinuation
- 1986-01-17 US US06/820,428 patent/US4645758A/en not_active Expired - Fee Related
- 1986-01-21 DK DK31486A patent/DK31486A/da not_active Application Discontinuation
- 1986-01-21 JP JP61010959A patent/JPH0798817B2/ja not_active Expired - Lifetime
- 1986-01-21 CA CA000500044A patent/CA1309409C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA1309409C (en)	1992-10-27
EP0189078A1 (de)	1986-07-30
DK31486D0 (da)	1986-01-21
FI860199A7 (fi)	1986-07-23
DK31486A (da)	1986-07-23
US4645758A (en)	1987-02-24
DE3664136D1 (en)	1989-08-03
JPH0798817B2 (ja)	1995-10-25
IE853325L (en)	1986-07-22
NO855373L (no)	1986-07-23
AU587597B2 (en)	1989-08-24
EP0189078B1 (de)	1989-06-28
JPS61172871A (ja)	1986-08-04
FI860199A0 (fi)	1986-01-16
SE8500273D0 (sv)	1985-01-22
IE59600B1 (en)	1994-03-09
AU5217186A (en)	1986-07-31

Legal Events

Date	Code	Title
1989-12-15	UEP	Publication of translation of european patent specification
1996-06-15	EEIH	Change in the person of patent owner
1997-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE44280T1 (de)	1989-07-15	Trizyklische verbindungen, verfahren zur herstellung derselben, pharmazeutische praeparate und behandlungsmethode.
ATE185807T1 (de)	1999-11-15	Thiazolylbenzofuranderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die sie enthalten
HUT56370A (en)	1991-08-28	Process for producing tricyclic carbapenem derivatives and pharmaceutical compositions comprising such compounds as active ingredient
YU115688A (en)	1988-10-31	Process for obtaining derivatives of imidazole as calcium independent camp inhibtors of phosphodiestheraze
HUP9900351A2 (hu)	1999-06-28	2-(4-Helyettesített)-benzilamino-2-metil-propánamidszármazékok, előállításuk és a vegyületeket tartalmazó gyógyszerkészítmények
HUT67283A (en)	1995-03-28	Method for producing n-containing fused heterocyclic ketone derivatives and medical preparatives containing them
NZ232283A (en)	1991-08-27	Substituted imidazo(1,2-b)pyridazine derivatives; pharmaceutical compositions and preparatory processes
IL76538A (en)	1989-09-10	1-piperazino-3-phenylindane derivatives and methods of preparation and pharmaceutical compositions containing them
LV10235A (lv)	1994-10-20	Jauni esteri to iegusanas panemiens farmaceitiska kompozicija arstesanas metode
ZA815043B (en)	1983-03-30	Diazepine derivatives,process for their preparation,and pharmaceutical compositions thereof
IE822310L (en)	1983-03-24	Triazoloquinazolone derivatives
AU1491092A (en)	1992-10-22	3-aryl oxazolidinone derivatives, a method of preparing them and therapeutic use thereof
DE68905363D1 (de)	1993-04-22	Heterotetracyclische laktamderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
AU4583489A (en)	1990-06-14	New indole derivatives, process for preparing them and pharmaceutical compositions containing them
PT83924A (en)	1987-01-01	Process for the preparation of tricyclic pyridazopyridone derivatives and of pharmaceutical compositions containing the same
GR3017801T3 (en)	1996-01-31	Flavone derivatives.
KR890002148A (ko)	1989-04-08	융합된 방향족 테트라하이드로 아제피논(및 티온)
DE69018352D1 (de)	1995-05-11	N-hydroxy-dibenz[b,e]oxepin-alkylamine und -alkanoische Säureamide, verwandte heterocyclische Analoge, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Medikamenten.
NO165593C (no)	1991-03-06	Analogifremgangsmaate ved fremstilling av nye tetracykliske indolderivater.
DE3767533D1 (de)	1991-02-28	D-nor-7-ergolinderivate, verfahren zu ihrer herstellung, pharmazeutische zubereitung und verwendung.
AU657423B2 (en)	1995-03-09	Novel piperidine derivatives and process for preparation thereof
ES2040629A1 (es)	1993-10-16	Procedimiento de obtencion de derivados triciclicos de la benzotiazepina farmacologicamente activos.
AU586089B2 (en)	1989-06-29	Phosphodiesterace type 111 inhibitors having a thiadiazinone ring as part of a tricyclic structure
IE44349L (en)	1977-01-10	DERIVATIVES OF 4H-THIENO [3,2-b] [1] BENZAZEPINES