ATE442841T1 - Pegylierte nanoteilchen - Google Patents
Pegylierte nanoteilchenInfo
- Publication number
- ATE442841T1 ATE442841T1 AT05745586T AT05745586T ATE442841T1 AT E442841 T1 ATE442841 T1 AT E442841T1 AT 05745586 T AT05745586 T AT 05745586T AT 05745586 T AT05745586 T AT 05745586T AT E442841 T1 ATE442841 T1 AT E442841T1
- Authority
- AT
- Austria
- Prior art keywords
- nanoparticles
- administration
- polyethylene glycol
- pegylation
- type
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6933—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained by reactions only involving carbon to carbon, e.g. poly(meth)acrylate, polystyrene, polyvinylpyrrolidone or polyvinylalcohol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/04—Anhydrides, e.g. cyclic anhydrides
- C08F222/06—Maleic anhydride
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Biological Depolymerization Polymers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200401022A ES2246694B1 (es) | 2004-04-29 | 2004-04-29 | Nanoparticulas pegiladas. |
| PCT/ES2005/000226 WO2005104648A2 (es) | 2004-04-29 | 2005-04-28 | Nanopartículas pegiladas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442841T1 true ATE442841T1 (de) | 2009-10-15 |
Family
ID=35242088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05745586T ATE442841T1 (de) | 2004-04-29 | 2005-04-28 | Pegylierte nanoteilchen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8628801B2 (de) |
| EP (1) | EP1752142B1 (de) |
| JP (1) | JP2007534729A (de) |
| CN (1) | CN1976688A (de) |
| AT (1) | ATE442841T1 (de) |
| AU (1) | AU2005237270B2 (de) |
| BR (1) | BRPI0509827B8 (de) |
| CA (1) | CA2564982C (de) |
| DE (1) | DE602005016674D1 (de) |
| ES (2) | ES2246694B1 (de) |
| MX (1) | MXPA06012583A (de) |
| RU (1) | RU2400215C2 (de) |
| WO (1) | WO2005104648A2 (de) |
Families Citing this family (83)
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| EP1713514B1 (de) | 2004-01-28 | 2021-11-24 | Johns Hopkins University | Arzneimittel und genträgerteilchen, die sich schnell durch schleimhautbarrieren bewegen |
| EP2061433B1 (de) * | 2006-09-08 | 2011-02-16 | Johns Hopkins University | Zusammensetzungen zur transportintensivierung durch die schleimhaut |
| ES2310122B1 (es) | 2007-04-20 | 2009-10-30 | Instituto Cientifico Y Tecnologico De Navarra, S.A | Nanoparticulas que comprenden una ciclodextrina y una molecula biologicamente activa y sus aplicaciones. |
| CA2699172C (en) * | 2007-09-03 | 2016-05-17 | Nanotherapeutics, Inc | Compositions and methods for delivery of poorly soluble drugs |
| ES2358493B1 (es) * | 2008-04-05 | 2012-06-13 | Instituto Cientifico Y Tecnologico De Navarra, S.A | Nanopartículas pegiladas que comprenden una molécula biológicamente activa y sus aplicaciones. |
| WO2011106702A2 (en) | 2010-02-25 | 2011-09-01 | The Johns Hopkins University | Sustained delivery of therapeutic agents to an eye compartment |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| EP2625189B1 (de) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Manipulierte nukleinsäuren und anwendungsverfahren dafür |
| WO2012059936A1 (en) | 2010-11-03 | 2012-05-10 | Padma Venkitachalam Devarajan | Pharmaceutical compositions for colloidal drug delivery |
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| EP2510930A1 (de) | 2011-04-15 | 2012-10-17 | Bionanoplus, S.L. | Nanopartikel mit Halbestern aus Poly(Methylvinylether-Co-Maleinsäureanhydrid) und Verwendungen davon |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
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| EP2804632B1 (de) | 2012-01-19 | 2019-09-18 | The Johns Hopkins University | Nanopartikelformulierungen mit verbesserter mukosaler penetration |
| JP6138904B2 (ja) | 2012-03-16 | 2017-05-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート |
| US8962577B2 (en) | 2012-03-16 | 2015-02-24 | The Johns Hopkins University | Controlled release formulations for the delivery of HIF-1 inhibitors |
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| US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| JP6360039B2 (ja) | 2012-05-03 | 2018-07-18 | カラ ファーマシューティカルズ インコーポレイテッド | 複数の被覆された粒子を含む組成物、医薬組成物、医薬製剤、及び当該粒子の形成方法 |
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| AU2013256008B2 (en) | 2012-05-04 | 2016-02-25 | The Johns Hopkins University | Lipid-based drug carriers for rapid penetration through mucus linings |
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| CN116437913A (zh) | 2020-09-23 | 2023-07-14 | 艾其林医药公司 | 用于治疗补体介导的病症的药物化合物 |
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| EP0752245B1 (de) * | 1995-07-05 | 2002-05-22 | European Community | Biokompatibele und biodegradierbare Nanokapseln zur Absorption und Verabreichung von proteinischen Arzneimitteln |
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| WO1999018934A1 (en) | 1997-10-09 | 1999-04-22 | Vanderbilt University | Micro-particulate and nano-particulate polymeric delivery system |
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| CN1507357A (zh) * | 2000-10-31 | 2004-06-23 | PRҩƷ����˾ | 提高生物活性分子传递的方法和组合物 |
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-
2004
- 2004-04-29 ES ES200401022A patent/ES2246694B1/es not_active Expired - Fee Related
-
2005
- 2005-04-28 BR BRPI0509827A patent/BRPI0509827B8/pt not_active IP Right Cessation
- 2005-04-28 US US11/568,454 patent/US8628801B2/en not_active Expired - Fee Related
- 2005-04-28 AU AU2005237270A patent/AU2005237270B2/en not_active Expired
- 2005-04-28 DE DE602005016674T patent/DE602005016674D1/de not_active Expired - Lifetime
- 2005-04-28 WO PCT/ES2005/000226 patent/WO2005104648A2/es not_active Ceased
- 2005-04-28 MX MXPA06012583A patent/MXPA06012583A/es active IP Right Grant
- 2005-04-28 RU RU2006142100/15A patent/RU2400215C2/ru active
- 2005-04-28 JP JP2007510054A patent/JP2007534729A/ja active Pending
- 2005-04-28 AT AT05745586T patent/ATE442841T1/de not_active IP Right Cessation
- 2005-04-28 ES ES05745586T patent/ES2333659T3/es not_active Expired - Lifetime
- 2005-04-28 CN CNA2005800218392A patent/CN1976688A/zh active Pending
- 2005-04-28 EP EP05745586A patent/EP1752142B1/de not_active Expired - Lifetime
- 2005-04-28 CA CA2564982A patent/CA2564982C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2246694A1 (es) | 2006-02-16 |
| RU2006142100A (ru) | 2008-06-20 |
| EP1752142A2 (de) | 2007-02-14 |
| JP2007534729A (ja) | 2007-11-29 |
| CN1976688A (zh) | 2007-06-06 |
| BRPI0509827B8 (pt) | 2021-05-25 |
| WO2005104648A2 (es) | 2005-11-10 |
| AU2005237270B2 (en) | 2011-02-17 |
| DE602005016674D1 (de) | 2009-10-29 |
| ES2246694B1 (es) | 2007-05-01 |
| BRPI0509827B1 (pt) | 2020-11-03 |
| ES2333659T3 (es) | 2010-02-25 |
| CA2564982A1 (en) | 2005-11-10 |
| AU2005237270A1 (en) | 2005-11-10 |
| CA2564982C (en) | 2015-04-21 |
| RU2400215C2 (ru) | 2010-09-27 |
| US8628801B2 (en) | 2014-01-14 |
| WO2005104648A3 (es) | 2005-12-08 |
| BRPI0509827A (pt) | 2007-10-23 |
| US20080248125A1 (en) | 2008-10-09 |
| MXPA06012583A (es) | 2007-03-21 |
| EP1752142B1 (de) | 2009-09-16 |
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