ATE443527T1 - 5-cnac zur oralen verabreichung von parathormonfragmenten - Google Patents

5-cnac zur oralen verabreichung von parathormonfragmenten

Info

Publication number
ATE443527T1
ATE443527T1 AT02794796T AT02794796T ATE443527T1 AT E443527 T1 ATE443527 T1 AT E443527T1 AT 02794796 T AT02794796 T AT 02794796T AT 02794796 T AT02794796 T AT 02794796T AT E443527 T1 ATE443527 T1 AT E443527T1
Authority
AT
Austria
Prior art keywords
parathormone
cnac
fragments
oral administration
methods
Prior art date
Application number
AT02794796T
Other languages
English (en)
Inventor
Moise Azria
Simon Bateman
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE443527T1 publication Critical patent/ATE443527T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT02794796T 2001-08-17 2002-08-16 5-cnac zur oralen verabreichung von parathormonfragmenten ATE443527T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31304801P 2001-08-17 2001-08-17
PCT/EP2002/009181 WO2003015822A1 (en) 2001-08-17 2002-08-16 5-cnac as oral delivery agent for parathyroid hormone fragments

Publications (1)

Publication Number Publication Date
ATE443527T1 true ATE443527T1 (de) 2009-10-15

Family

ID=23214149

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02794796T ATE443527T1 (de) 2001-08-17 2002-08-16 5-cnac zur oralen verabreichung von parathormonfragmenten

Country Status (26)

Country Link
US (4) US20040242478A1 (de)
EP (1) EP1420827B8 (de)
JP (2) JP4959917B2 (de)
KR (1) KR20040030120A (de)
CN (1) CN1279981C (de)
AT (1) ATE443527T1 (de)
AU (1) AU2002333443C1 (de)
BR (1) BRPI0211932B1 (de)
CA (1) CA2453646C (de)
CO (1) CO5560586A2 (de)
CY (1) CY1109661T1 (de)
DE (1) DE60233803D1 (de)
DK (1) DK1420827T3 (de)
EC (1) ECSP044961A (de)
ES (1) ES2333587T3 (de)
HU (1) HUP0401441A3 (de)
IL (2) IL159714A0 (de)
MX (1) MXPA04001418A (de)
NO (1) NO328069B1 (de)
NZ (1) NZ531018A (de)
PL (1) PL210258B1 (de)
PT (1) PT1420827E (de)
RU (1) RU2322256C2 (de)
SI (1) SI1420827T1 (de)
WO (1) WO2003015822A1 (de)
ZA (1) ZA200400242B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL211976B1 (pl) * 2001-06-01 2012-07-31 Novartis Ag Kompozycja farmaceutyczna do podawania doustnego oraz zastosowanie kompozycji
EP1420827B8 (de) * 2001-08-17 2009-12-23 Novartis AG 5-cnac zur oralen verabreichung von parathormonfragmenten
AU2003234716A1 (en) * 2002-04-10 2003-10-27 Joel M. Linden Use of a2a adenosine receptor agonists for the treatment of inflammatory diseases
US20050054557A1 (en) * 2002-05-09 2005-03-10 Goldberg Michael M. Compositions for delivering parathyroid hormone and calcitonin
MXPA06000807A (es) 2003-07-23 2006-08-23 Novartis Ag Uso de calcitonina en osteoartritis.
GB0427600D0 (en) * 2004-12-16 2005-01-19 Novartis Ag Organic compounds
WO2006076692A1 (en) * 2005-01-12 2006-07-20 Emisphere Technologies, Inc. Compositions for buccal delivery of parathyroid hormone
EP1896134A2 (de) * 2005-06-13 2008-03-12 Rigel Pharmaceuticals, Inc. Verfahren und zusammensetzungen zur behandlung degenerativer knochenerkrankungen
PE20100241A1 (es) 2005-09-19 2010-04-16 Emisphere Tech Inc Formas cristalinas de la sal di-sodio del acido n-(5-clorosaliciloil)-8-aminocaprilico
GB0522566D0 (en) * 2005-11-04 2005-12-14 Novartis Ag Organic compounds
CN101355959B (zh) * 2005-11-10 2013-02-27 密歇根理工大学管理委员会 黑熊甲状旁腺素和使用黑熊甲状旁腺素的方法
AU2007289344B2 (en) * 2006-08-31 2011-04-14 Novartis Ag Pharmaceutical compositions comprising hGH for oral delivery
KR20150091536A (ko) * 2007-03-02 2015-08-11 노파르티스 아게 칼시토닌의 경구 투여
NZ585080A (en) 2007-11-02 2012-05-25 Emisphere Tech Inc Composition comprising Vitamin B12 and N-[8-(2-hydroxybenzoyl) amino ]caprylic acid and salts thereof for treating Vitamin B12 deficiency
EP2509996A1 (de) 2009-12-07 2012-10-17 Michigan Technological University Schwarzbär-parathyroid-hormon und verfahren zur verwendung des schwarzbär-parathyroid-hormons
WO2012130193A1 (en) 2011-03-31 2012-10-04 Zentiva, K.S. Non-covalent soluble complexes of teriparatide with polysaccharides and a dosage form of teriparatide for oral administration
CN113713090B (zh) 2015-02-09 2023-06-02 安特拉贝欧有限公司 骨质疏松症的治疗
IL264880B2 (en) 2016-08-17 2024-09-01 Entera Bio Ltd Preparations for oral administration of active substances
KR101796604B1 (ko) * 2016-08-30 2017-11-10 목포대학교 산학협력단 위장관 흡수증진제를 함유하는 부갑상선 호르몬의 경구 투여 제형

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692433A (en) * 1983-10-12 1987-09-08 The Regents Of The University Of California Method and composition for regulating serum calcium levels of mammals
JPH07502507A (ja) * 1991-12-17 1995-03-16 プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド ビスホスホネート類及び副甲状腺ホルモンを用いた骨粗鬆症の治療方法
ES2179831T3 (es) * 1992-09-29 2003-02-01 Inhale Therapeutic Syst Liberacion en los pulmones de fragmentos activos de hormona paratiroidiana.
DK0915911T3 (da) * 1996-08-02 2004-03-08 Ca Nat Research Council Analoger til parathyreoideahormon til behandling af osteoporose
US5773647A (en) * 1997-02-07 1998-06-30 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
CA2319680C (en) * 1997-02-07 2010-04-20 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6537965B1 (en) * 1998-11-25 2003-03-25 The General Hospital Corporation Amino-terminal modified parathyroid hormone (PTH) analogs
EP1175390B1 (de) * 1999-04-05 2005-02-02 Emisphere Technologies, Inc. Dinatrium-salze, monohydrate und ethanol-solvate
ES2386263T3 (es) * 2000-03-21 2012-08-14 Emisphere Technologies, Inc. Método de preparación de salicilamidas alquiladas mediante un producto intermedio de dicarboxilato
PL211976B1 (pl) * 2001-06-01 2012-07-31 Novartis Ag Kompozycja farmaceutyczna do podawania doustnego oraz zastosowanie kompozycji
EP1420827B8 (de) * 2001-08-17 2009-12-23 Novartis AG 5-cnac zur oralen verabreichung von parathormonfragmenten
ES2330638T3 (es) * 2003-07-11 2009-12-14 Novartis Ag Composiciones farmaceuticas dosificadas en forma oral que contienen un agente de suministro en forma micronizada.

Also Published As

Publication number Publication date
KR20040030120A (ko) 2004-04-08
ECSP044961A (es) 2004-03-23
PL365388A1 (en) 2005-01-10
CA2453646C (en) 2008-09-30
MXPA04001418A (es) 2004-05-27
EP1420827A1 (de) 2004-05-26
PT1420827E (pt) 2009-12-15
HUP0401441A2 (hu) 2004-12-28
NO328069B1 (no) 2009-11-23
JP2005501852A (ja) 2005-01-20
US20120088725A1 (en) 2012-04-12
NZ531018A (en) 2006-03-31
AU2002333443B2 (en) 2006-06-29
IL159714A0 (en) 2004-06-20
US20090264367A1 (en) 2009-10-22
WO2003015822A1 (en) 2003-02-27
DK1420827T3 (da) 2009-12-21
US9272040B2 (en) 2016-03-01
NO20040598L (no) 2004-02-10
US20060217313A1 (en) 2006-09-28
US20040242478A1 (en) 2004-12-02
BR0211932A (pt) 2004-10-26
PL210258B1 (pl) 2011-12-30
EP1420827B1 (de) 2009-09-23
CA2453646A1 (en) 2003-02-27
RU2004107899A (ru) 2005-05-10
CY1109661T1 (el) 2014-08-13
DE60233803D1 (de) 2009-11-05
SI1420827T1 (sl) 2010-01-29
CN1543357A (zh) 2004-11-03
ES2333587T3 (es) 2010-02-24
CN1279981C (zh) 2006-10-18
BRPI0211932B1 (pt) 2016-12-06
CO5560586A2 (es) 2005-09-30
JP4959917B2 (ja) 2012-06-27
ZA200400242B (en) 2004-11-18
EP1420827B8 (de) 2009-12-23
RU2322256C2 (ru) 2008-04-20
JP2009242410A (ja) 2009-10-22
AU2002333443C1 (en) 2009-10-08
HUP0401441A3 (en) 2012-09-28
IL159714A (en) 2010-12-30

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