ATE507818T1 - Orale verabreichung eines calcitonins - Google Patents

Orale verabreichung eines calcitonins

Info

Publication number: ATE507818T1
Authority: AT; Austria
Prior art keywords: calcitonin; peptide drugs; oral administration; oral; bioavailability
Prior art date: 2007-03-02

Application number

AT08743617T

Other languages

English (en)

Inventor

Yatindra Joshi

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-02

Filing date

2008-02-29

Publication date

2011-05-15

2008-02-29 Application filed by Novartis Ag filed Critical Novartis Ag

2011-05-15 Application granted granted Critical

2011-05-15 Publication of ATE507818T1 publication Critical patent/ATE507818T1/de

Links

102000055006 Calcitonin Human genes 0.000 title abstract 5
108060001064 Calcitonin Proteins 0.000 title abstract 5
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 title abstract 5
229960004015 calcitonin Drugs 0.000 title abstract 5
238000000034 method Methods 0.000 abstract 4
239000003814 drug Substances 0.000 abstract 3
229940079593 drug Drugs 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
238000010521 absorption reaction Methods 0.000 abstract 1
229940124447 delivery agent Drugs 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Zoology (AREA)
Orthopedic Medicine & Surgery (AREA)
General Chemical & Material Sciences (AREA)
Rheumatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oil, Petroleum & Natural Gas (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nutrition Science (AREA)
Physiology (AREA)

AT08743617T 2007-03-02 2008-02-29 Orale verabreichung eines calcitonins ATE507818T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US89259407P	2007-03-02	2007-03-02
PCT/US2008/055399 WO2008109385A2 (en)	2007-03-02	2008-02-29	Oral administration of a calcitonin

Publications (1)

Publication Number	Publication Date
ATE507818T1 true ATE507818T1 (de)	2011-05-15

Family

ID=39496395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08743617T ATE507818T1 (de)	2007-03-02	2008-02-29	Orale verabreichung eines calcitonins

Country Status (16)

Country	Link
US (1)	US8410052B2 (de)
EP (1)	EP2131810B1 (de)
JP (1)	JP5249246B2 (de)
KR (2)	KR20150091536A (de)
CN (2)	CN107050433A (de)
AT (1)	ATE507818T1 (de)
AU (1)	AU2008223108B2 (de)
BR (1)	BRPI0808517A2 (de)
CA (1)	CA2679782C (de)
DE (1)	DE602008006700D1 (de)
ES (1)	ES2365648T3 (de)
MX (1)	MX2009009243A (de)
PL (1)	PL2131810T3 (de)
PT (1)	PT2131810E (de)
RU (2)	RU2009136303A (de)
WO (1)	WO2008109385A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL2651398T3 (pl)	2010-12-16	2018-05-30	Novo Nordisk A/S	Stałe kompozycje zawierające agonistę GLP-1 i sól kwasu N-(8-(2-hydroksybenzoilo)amino)kaprylowego
DK2696687T3 (en)	2011-04-12	2017-02-06	Novo Nordisk As	Double-acylated GLP-1 derivatives
GEP201606523B (en) *	2011-09-22	2016-08-10	Exelixis Inc	Method for treating osteoporosis
HUE042757T2 (hu)	2012-03-22	2019-07-29	Novo Nordisk As	Szállító szert tartalmazó készítmények és elõállításuk
PL3542790T3 (pl)	2012-03-22	2024-02-26	Novo Nordisk A/S	Kompozycje zawierające substancję dostarczającą i ich przygotowanie
EP4324475A1 (de)	2012-03-22	2024-02-21	Novo Nordisk A/S	Zusammensetzungen von glp-1-peptiden und herstellung davon
JP6517690B2 (ja) *	2012-06-20	2019-05-22	ノヴォノルディスクアー／エス	ペプチド及び送達剤を含む錠剤製剤
KR20210086717A (ko)	2013-05-02	2021-07-08	노보 노르디스크 에이/에스	Glp-1 화합물의 경구 투여
CN104961687B (zh) *	2015-06-03	2017-07-25	苏州维泰生物技术有限公司	1,2‑二嗪衍生物及其制剂、用途
WO2019149880A1 (en)	2018-02-02	2019-08-08	Novo Nordisk A/S	Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant
AU2021259683A1 (en)	2020-04-22	2022-11-17	Hadasit Medical Research Services & Development Limited	Bioactive phenolate ionic complexes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5629020A (en) *	1994-04-22	1997-05-13	Emisphere Technologies, Inc.	Modified amino acids for drug delivery
NZ534409A (en) *	1999-04-05	2006-03-31	Emisphere Tech Inc	Disodium salts, monohydrates, and ethanol solvates for delivering active agents
AU4218400A (en)	1999-04-05	2000-10-23	Emisphere Technologies, Inc.	Lyophilized solid dosage forms and methods of making
US7049283B2 (en) *	2000-12-06	2006-05-23	Novartis Ag	Pharmaceutical compositions for the oral delivery of pharmacologically active agents
MXPA04001418A (es)	2001-08-17	2004-05-27	Novartis Ag	Acido n-(5-clorosalociloil)-8-aminocaprilico como agente de suministro oral para fragmentos de hormona paratiroides.
US20050054557A1 (en) *	2002-05-09	2005-03-10	Goldberg Michael M.	Compositions for delivering parathyroid hormone and calcitonin
AR040737A1 (es) *	2002-08-01	2005-04-20	Novartis Ag	Administracion oral de calcitonina
JP4716987B2 (ja) *	2003-07-23	2011-07-06	ノバルティスアーゲー	骨関節症におけるカルシトニンの使用

2008
- 2008-02-29 KR KR1020157020307A patent/KR20150091536A/ko not_active Ceased
- 2008-02-29 CA CA2679782A patent/CA2679782C/en not_active Expired - Fee Related
- 2008-02-29 KR KR1020097018236A patent/KR101564114B1/ko not_active Expired - Fee Related
- 2008-02-29 JP JP2009551864A patent/JP5249246B2/ja not_active Expired - Fee Related
- 2008-02-29 US US12/529,371 patent/US8410052B2/en not_active Expired - Fee Related
- 2008-02-29 DE DE602008006700T patent/DE602008006700D1/de active Active
- 2008-02-29 WO PCT/US2008/055399 patent/WO2008109385A2/en not_active Ceased
- 2008-02-29 ES ES08743617T patent/ES2365648T3/es active Active
- 2008-02-29 CN CN201710436918.4A patent/CN107050433A/zh active Pending
- 2008-02-29 AT AT08743617T patent/ATE507818T1/de active
- 2008-02-29 PT PT08743617T patent/PT2131810E/pt unknown
- 2008-02-29 EP EP08743617A patent/EP2131810B1/de not_active Not-in-force
- 2008-02-29 AU AU2008223108A patent/AU2008223108B2/en not_active Ceased
- 2008-02-29 BR BRPI0808517-0A patent/BRPI0808517A2/pt not_active IP Right Cessation
- 2008-02-29 CN CN200880006790A patent/CN101621991A/zh active Pending
- 2008-02-29 RU RU2009136303/15A patent/RU2009136303A/ru unknown
- 2008-02-29 PL PL08743617T patent/PL2131810T3/pl unknown
- 2008-02-29 MX MX2009009243A patent/MX2009009243A/es active IP Right Grant
2013
- 2013-11-13 RU RU2013150659/15A patent/RU2013150659A/ru not_active Application Discontinuation

Also Published As

Publication number	Publication date
US8410052B2 (en)	2013-04-02
ES2365648T3 (es)	2011-10-07
AU2008223108B2 (en)	2013-10-10
CA2679782A1 (en)	2008-09-12
RU2013150659A (ru)	2015-05-20
EP2131810B1 (de)	2011-05-04
BRPI0808517A2 (pt)	2014-08-19
JP2010520221A (ja)	2010-06-10
KR20150091536A (ko)	2015-08-11
JP5249246B2 (ja)	2013-07-31
CN107050433A (zh)	2017-08-18
PL2131810T3 (pl)	2011-09-30
KR101564114B1 (ko)	2015-10-28
AU2008223108A2 (en)	2009-09-10
DE602008006700D1 (de)	2011-06-16
CA2679782C (en)	2015-02-17
CN101621991A (zh)	2010-01-06
AU2008223108A1 (en)	2008-09-12
PT2131810E (pt)	2011-08-03
EP2131810A2 (de)	2009-12-16
WO2008109385A2 (en)	2008-09-12
RU2009136303A (ru)	2011-04-10
WO2008109385A3 (en)	2009-04-09
US20100210526A1 (en)	2010-08-19
KR20090116772A (ko)	2009-11-11
MX2009009243A (es)	2009-09-08

Legal Events

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2011-12-15

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