ATE443706T1 - Pyrrolotriazinverbindungen als kinaseinhibitoren - Google Patents

Pyrrolotriazinverbindungen als kinaseinhibitoren

Info

Publication number: ATE443706T1
Authority: AT; Austria
Prior art keywords: kinase inhibitors; pyrrolotriazine compounds; pyrrolotriazine; compounds; kinase
Prior art date: 2003-12-29

Application number

AT04815269T

Other languages

English (en)

Inventor

Brian Fink

Ashvinikumar Gavai

Gregory Vite

Ping Chen

Harold Mastalerz

Derek Norris

John Tokarski

Yufen Zhao

Wen-Ching Han

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-29

Filing date

2004-12-23

Publication date

2009-10-15

2004-12-23 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2009-10-15 Application granted granted Critical

2009-10-15 Publication of ATE443706T1 publication Critical patent/ATE443706T1/de

Links

229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
150000003921 pyrrolotriazines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT04815269T 2003-12-29 2004-12-23 Pyrrolotriazinverbindungen als kinaseinhibitoren ATE443706T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53333503P	2003-12-29	2003-12-29
PCT/US2004/043169 WO2005066176A1 (en)	2003-12-29	2004-12-23	Pyrrolotriazine compounds as kinase inhibitors

Publications (1)

Publication Number	Publication Date
ATE443706T1 true ATE443706T1 (de)	2009-10-15

Family

ID=34748887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04815269T ATE443706T1 (de)	2003-12-29	2004-12-23	Pyrrolotriazinverbindungen als kinaseinhibitoren

Country Status (31)

Country	Link
US (4)	US7141571B2 (de)
EP (2)	EP2058314A1 (de)
JP (1)	JP4740878B2 (de)
KR (1)	KR100839716B1 (de)
CN (1)	CN1922182B (de)
AR (1)	AR047076A1 (de)
AT (1)	ATE443706T1 (de)
AU (1)	AU2004312413C1 (de)
BR (1)	BRPI0418231A (de)
CA (1)	CA2552107C (de)
CL (1)	CL2009001492A1 (de)
CY (1)	CY1109662T1 (de)
DE (1)	DE602004023324D1 (de)
DK (1)	DK1699797T3 (de)
ES (1)	ES2331842T3 (de)
GE (1)	GEP20105081B (de)
HR (1)	HRP20090601T1 (de)
IL (1)	IL176450A0 (de)
MX (1)	MXPA06007038A (de)
MY (1)	MY145634A (de)
NO (1)	NO20062763L (de)
NZ (2)	NZ548070A (de)
PE (1)	PE20050679A1 (de)
PL (1)	PL1699797T3 (de)
PT (1)	PT1699797E (de)
RU (1)	RU2373209C2 (de)
SI (1)	SI1699797T1 (de)
TW (1)	TWI332840B (de)
UA (1)	UA89038C2 (de)
WO (1)	WO2005066176A1 (de)
ZA (1)	ZA200605160B (de)

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PT1497019E (pt) *	2002-04-23	2015-09-10	Bristol Myers Squibb Co	Compostos de pirrolotriazina anilina úteis como inibidores de quinase
US20060014741A1 (en) *	2003-12-12	2006-01-19	Dimarco John D	Synthetic process, and crystalline forms of a pyrrolotriazine compound
MY145634A (en) *	2003-12-29	2012-03-15	Bristol Myers Squibb Co	Pyrrolotriazine compounds as kinase inhibitors
US7102002B2 (en)	2004-06-16	2006-09-05	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
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US7253167B2 (en) *	2004-06-30	2007-08-07	Bristol-Myers Squibb Company	Tricyclic-heteroaryl compounds useful as kinase inhibitors
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US7504521B2 (en) *	2004-08-05	2009-03-17	Bristol-Myers Squibb Co.	Methods for the preparation of pyrrolotriazine compounds
TW200618803A (en)	2004-08-12	2006-06-16	Bristol Myers Squibb Co	Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
TW200635927A (en) *	2004-12-22	2006-10-16	Bristol Myers Squibb Co	Synthetic process
WO2006104971A1 (en)	2005-03-28	2006-10-05	Bristol-Myers Squibb Company	Atp competitive kinase inhibitors
US20060235020A1 (en) *	2005-04-18	2006-10-19	Soojin Kim	Process for preparing salts of 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide and novel stable forms produced therein
MY150958A (en)	2005-06-16	2014-03-31	Astrazeneca Ab	Compounds for the treatment of multi-drug resistant bacterial infections
WO2007064932A2 (en) *	2005-12-02	2007-06-07	Bayer Healthcare Llc.	Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
US8063208B2 (en) *	2006-02-16	2011-11-22	Bristol-Myers Squibb Company	Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
US20100136137A1 (en) *	2006-11-01	2010-06-03	Bristol-Meyers Squibb Company	Therapeutic combination of a panher/vegfr2 kinase inhibitor and a platinum compound
EP2115130B1 (de)	2007-02-08	2011-08-03	Codexis, Inc.	Ketoreduktasen und anwendungen davon
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JP2010209058A (ja) *	2008-09-29	2010-09-24	Sumitomo Chemical Co Ltd	１−置換−トランス−４−（置換アミノ）ピペリジン−３−オールの製造方法
CN102245610B (zh) *	2008-10-08	2014-04-30	百时美施贵宝公司	吡咯并三嗪激酶抑制剂
ES2539620T3 (es)	2008-12-19	2015-07-02	Cephalon, Inc.	Pirrolotriazina como inhibidor de ALK y de JAK2
AU2010206161B2 (en)	2009-01-21	2014-08-07	Basilea Pharmaceutica Ag	Novel bicyclic antibiotics
IN2012DN01251A (de) *	2009-07-28	2015-05-15	Ube Industries
WO2011103091A1 (en)	2010-02-18	2011-08-25	Transtech Pharma, Inc.	Phenyl-heteroaryl derivatives and methods of use thereof
ES2689103T3 (es)	2010-06-30	2018-11-08	Fujifilm Corporation	Nuevo derivado de nicotinamida o sal del mismo
CN102153558B (zh) *	2011-02-23	2012-11-21	扬州永济医药新技术有限公司	多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
DE102011119127A1 (de) *	2011-11-22	2013-05-23	Merck Patent Gmbh	3-Cyanaryl-1H-pyrrolo[2.3-b]pyridin-Derivate
US9724352B2 (en)	2012-05-31	2017-08-08	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
CN103450204B (zh)	2012-05-31	2016-08-17	中国科学院上海药物研究所	吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途
TW201414737A (zh)	2012-07-13	2014-04-16	必治妥美雅史谷比公司	作爲激酶抑制劑之咪唑并三□甲腈
EP3054955B1 (de)	2013-10-11	2018-05-30	Bristol-Myers Squibb Company	Pyrrolotriazin-kinasehemmer
LT3466955T (lt) *	2014-01-13	2021-02-25	Aurigene Discovery Technologies Limited	Oksazol[4,5-b]piridino ir tiazol[4,5-b]piridino darinių, kaip irak4 inhibitorių, skirtų vėžio gydymui, gamybos būdas
WO2015175561A1 (en) *	2014-05-12	2015-11-19	Quest Diagnostics Investments Incorporated	Quantitation of tamoxifen and metabolites thereof by mass spectrometry
AR112027A1 (es)	2017-06-15	2019-09-11	Biocryst Pharm Inc	Inhibidores de alk 2 quinasa que contienen imidazol
WO2019214651A1 (zh) *	2018-05-08	2019-11-14	南京明德新药研发有限公司	作为选择性HER2抑制剂的吡咯并[2,1-f][1,2,4]三嗪类衍生物及其应用
BR112021020441A2 (pt)	2019-04-12	2021-12-14	Blueprint Medicines Corp	Derivados de pirrolotriazina para tratar doenças mediadas por kit e pdgfra
WO2021088987A1 (zh) *	2019-11-08	2021-05-14	南京明德新药研发有限公司	作为选择性her2抑制剂的盐型、晶型及其应用
IL300412A (en) *	2020-08-24	2023-04-01	Gilead Sciences Inc	Phospholipid compounds and their uses
US20240132521A1 (en) *	2022-08-22	2024-04-25	Iambic Therapeutics, Inc.	Compounds and methods for modulating her2
WO2025178975A1 (en) *	2024-02-20	2025-08-28	Iambic Therapeutics, Inc.	Doses and regimens of her2 inhibitors
CN120271495B (zh) *	2025-06-12	2025-09-19	成都道合尔医药技术有限公司	一种(3r,4r)-n-pg-4-氨基-3-甲基哌啶的合成方法

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2004
- 2004-12-09 MY MYPI20045093A patent/MY145634A/en unknown
- 2004-12-22 TW TW093140035A patent/TWI332840B/zh not_active IP Right Cessation
- 2004-12-22 US US11/019,901 patent/US7141571B2/en not_active Expired - Lifetime
- 2004-12-23 WO PCT/US2004/043169 patent/WO2005066176A1/en not_active Ceased
- 2004-12-23 KR KR1020067012936A patent/KR100839716B1/ko not_active Expired - Fee Related
- 2004-12-23 UA UAA200608400A patent/UA89038C2/ru unknown
- 2004-12-23 DK DK04815269T patent/DK1699797T3/da active
- 2004-12-23 SI SI200431286T patent/SI1699797T1/sl unknown
- 2004-12-23 JP JP2006547328A patent/JP4740878B2/ja not_active Expired - Fee Related
- 2004-12-23 PL PL04815269T patent/PL1699797T3/pl unknown
- 2004-12-23 NZ NZ548070A patent/NZ548070A/en unknown
- 2004-12-23 DE DE602004023324T patent/DE602004023324D1/de not_active Expired - Lifetime
- 2004-12-23 ES ES04815269T patent/ES2331842T3/es not_active Expired - Lifetime
- 2004-12-23 GE GEAP20049544A patent/GEP20105081B/en unknown
- 2004-12-23 MX MXPA06007038A patent/MXPA06007038A/es active IP Right Grant
- 2004-12-23 EP EP09153694A patent/EP2058314A1/de not_active Withdrawn
- 2004-12-23 PT PT04815269T patent/PT1699797E/pt unknown
- 2004-12-23 NZ NZ573544A patent/NZ573544A/en unknown
- 2004-12-23 HR HR20090601T patent/HRP20090601T1/hr unknown
- 2004-12-23 EP EP04815269A patent/EP1699797B1/de not_active Expired - Lifetime
- 2004-12-23 CA CA2552107A patent/CA2552107C/en not_active Expired - Fee Related
- 2004-12-23 BR BRPI0418231-6A patent/BRPI0418231A/pt not_active IP Right Cessation
- 2004-12-23 AT AT04815269T patent/ATE443706T1/de active
- 2004-12-23 CN CN2004800421984A patent/CN1922182B/zh not_active Expired - Fee Related
- 2004-12-23 AU AU2004312413A patent/AU2004312413C1/en not_active Ceased
- 2004-12-23 RU RU2006127396/04A patent/RU2373209C2/ru not_active IP Right Cessation
- 2004-12-29 AR ARP040104947A patent/AR047076A1/es not_active Application Discontinuation
2005
- 2005-01-03 PE PE2005000015A patent/PE20050679A1/es not_active Application Discontinuation
2006
- 2006-06-13 NO NO20062763A patent/NO20062763L/no not_active Application Discontinuation
- 2006-06-20 IL IL176450A patent/IL176450A0/en unknown
- 2006-06-22 ZA ZA200605160A patent/ZA200605160B/en unknown
- 2006-06-26 US US11/426,479 patent/US7297695B2/en not_active Expired - Lifetime
2008
- 2008-09-24 US US11/869,910 patent/US7846931B2/en not_active Expired - Lifetime
2009
- 2009-06-26 CL CL2009001492A patent/CL2009001492A1/es unknown
- 2009-12-21 CY CY20091101326T patent/CY1109662T1/el unknown
2010
- 2010-10-25 US US12/911,299 patent/US20110039838A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20090048244A1 (en)	2009-02-19
TW200526226A (en)	2005-08-16
MY145634A (en)	2012-03-15
HRP20090601T1 (hr)	2009-12-31
WO2005066176A1 (en)	2005-07-21
PL1699797T3 (pl)	2010-02-26
RU2373209C2 (ru)	2009-11-20
US20110039838A1 (en)	2011-02-17
PE20050679A1 (es)	2005-09-25
ZA200605160B (en)	2007-12-27
CA2552107C (en)	2011-10-18
AR047076A1 (es)	2006-01-04
CN1922182B (zh)	2010-08-18
CL2009001492A1 (es)	2010-01-15
GEP20105081B (en)	2010-09-27
JP2007518721A (ja)	2007-07-12
MXPA06007038A (es)	2006-08-31
CA2552107A1 (en)	2005-07-21
AU2004312413A1 (en)	2005-07-21
IL176450A0 (en)	2006-10-05
TWI332840B (en)	2010-11-11
JP4740878B2 (ja)	2011-08-03
NZ548070A (en)	2009-02-28
EP1699797A1 (de)	2006-09-13
DK1699797T3 (da)	2010-01-04
US7141571B2 (en)	2006-11-28
NZ573544A (en)	2010-04-30
UA89038C2 (en)	2009-12-25
PT1699797E (pt)	2009-12-29
RU2006127396A (ru)	2008-02-10
AU2004312413B2 (en)	2010-07-22
US20050182058A1 (en)	2005-08-18
US7846931B2 (en)	2010-12-07
US7297695B2 (en)	2007-11-20
NO20062763L (no)	2006-09-11
CY1109662T1 (el)	2014-08-13
EP1699797B1 (de)	2009-09-23
SI1699797T1 (sl)	2010-04-30
AU2004312413C1 (en)	2011-01-27
DE602004023324D1 (de)	2009-11-05
EP2058314A1 (de)	2009-05-13
BRPI0418231A (pt)	2007-04-27
HK1088332A1 (en)	2006-11-03
KR20060107828A (ko)	2006-10-16
CN1922182A (zh)	2007-02-28
ES2331842T3 (es)	2010-01-18
US20060264438A1 (en)	2006-11-23
KR100839716B1 (ko)	2008-06-19

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2010-03-15

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