ATE426599T1 - Thiazolylpiperidin derivate als mtp inhibitoren - Google Patents

Thiazolylpiperidin derivate als mtp inhibitoren

Info

Publication number
ATE426599T1
ATE426599T1 AT04735742T AT04735742T ATE426599T1 AT E426599 T1 ATE426599 T1 AT E426599T1 AT 04735742 T AT04735742 T AT 04735742T AT 04735742 T AT04735742 T AT 04735742T AT E426599 T1 ATE426599 T1 AT E426599T1
Authority
AT
Austria
Prior art keywords
mtp inhibitors
thiazolylpiperidine derivatives
thiazolylpiperidine
derivatives
mtp
Prior art date
Application number
AT04735742T
Other languages
English (en)
Inventor
Philippe Guedat
Francois Collonges
Herve Dumas
Jean-Yves Ortholand
Jacques Decerprit
Jacques Barbanton
Richard Foster
Peter Kane
Bernd Wendt
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE426599T1 publication Critical patent/ATE426599T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT04735742T 2003-06-25 2004-06-02 Thiazolylpiperidin derivate als mtp inhibitoren ATE426599T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0307670A FR2856685B1 (fr) 2003-06-25 2003-06-25 Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ATE426599T1 true ATE426599T1 (de) 2009-04-15

Family

ID=33515396

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04735742T ATE426599T1 (de) 2003-06-25 2004-06-02 Thiazolylpiperidin derivate als mtp inhibitoren

Country Status (18)

Country Link
US (1) US7674803B2 (de)
EP (1) EP1636218B1 (de)
JP (1) JP4629666B2 (de)
KR (1) KR20060024812A (de)
CN (1) CN1809560A (de)
AR (1) AR044909A1 (de)
AT (1) ATE426599T1 (de)
AU (1) AU2004253649B2 (de)
BR (1) BRPI0411721A (de)
CA (1) CA2531011C (de)
DE (1) DE602004020223D1 (de)
ES (1) ES2323463T3 (de)
FR (1) FR2856685B1 (de)
MX (1) MXPA05013521A (de)
RU (1) RU2006101890A (de)
TW (1) TW200518751A (de)
WO (1) WO2005003128A1 (de)
ZA (1) ZA200600690B (de)

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JP2009504707A (ja) 2005-08-18 2009-02-05 エフ．ホフマン−ラ ロシュ アーゲー Ｈ３受容体調節剤として有用なチアゾリルピペリジン誘導体
EP1832586A1 (de) * 2006-03-10 2007-09-12 Oridis Biomed Forschungs- und Entwicklungs GmbH Thiazolpiperidinderivate zur Behandlung von Erkrankungen der Leber und des Pankreas
EP1834954A1 (de) * 2006-03-15 2007-09-19 4Sc Ag Thiazole als NF-kB Hemmer (Proteasom-Hemmer)
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WO2009058728A1 (en) * 2007-10-29 2009-05-07 Schering Corporation Thiazole derivatives as protein kinase inhibitors
BRPI0905759A2 (pt) * 2008-01-25 2015-07-14 Du Pont Composto selecionado a partir dos compostos de fórmula 1 e n óxidos e sais dos mesmos, método para controlar doenças de planta causadas por patógenos de planta fúngicos oomycota e composição fungicida
BRPI0910837B1 (pt) 2008-04-30 2017-03-07 Bayer Cropscience Ag ésteres e tioésteres tiazol-4-carboxílicos, seus usos, e método e composição para controlar fungos fitopatogênicos prejudiciais
CN102216296B (zh) * 2008-10-01 2015-03-18 拜耳作物科学公司 作为作物保护剂的杂环取代的噻唑类
UY32285A (es) 2008-12-02 2010-06-30 Du Pont Compuestos heterocíclicos fungicidas
US8889674B2 (en) * 2009-03-05 2014-11-18 Shionogi & Co., Ltd. Piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonism
EP2272846A1 (de) * 2009-06-23 2011-01-12 Bayer CropScience AG Thiazolylpiperidin Derivate als Fungizide
JP2013501744A (ja) * 2009-08-12 2013-01-17 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 殺微生物複素環
WO2011051243A1 (en) 2009-10-29 2011-05-05 Bayer Cropscience Ag Active compound combinations
BR112012010242B1 (pt) * 2009-10-30 2018-03-20 Bayer Intellectual Property Gmbh Derivados de heteroarilpiperidina e heteroarilpiperazina
US8629286B2 (en) * 2009-12-22 2014-01-14 Syngenta Crop Protection, Llc Pyrazole derivatives
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Also Published As

Publication number Publication date
JP4629666B2 (ja) 2011-02-09
EP1636218A1 (de) 2006-03-22
AU2004253649B2 (en) 2009-09-24
AU2004253649A1 (en) 2005-01-13
MXPA05013521A (es) 2006-03-09
JP2007506651A (ja) 2007-03-22
FR2856685B1 (fr) 2005-09-23
ZA200600690B (en) 2007-05-30
KR20060024812A (ko) 2006-03-17
US7674803B2 (en) 2010-03-09
ES2323463T3 (es) 2009-07-16
BRPI0411721A (pt) 2006-05-23
TW200518751A (en) 2005-06-16
CN1809560A (zh) 2006-07-26
CA2531011C (en) 2012-10-09
RU2006101890A (ru) 2007-07-27
CA2531011A1 (en) 2005-01-13
EP1636218B1 (de) 2009-03-25
DE602004020223D1 (de) 2009-05-07
AR044909A1 (es) 2005-10-05
US20070054939A1 (en) 2007-03-08
FR2856685A1 (fr) 2004-12-31
WO2005003128A1 (en) 2005-01-13

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