ATE443723T1 - Monoklonale antikörper, kreuz-reaktive antikörper und deren produktionsverfahren - Google Patents

Monoklonale antikörper, kreuz-reaktive antikörper und deren produktionsverfahren

Info

Publication number
ATE443723T1
ATE443723T1 AT99928574T AT99928574T ATE443723T1 AT E443723 T1 ATE443723 T1 AT E443723T1 AT 99928574 T AT99928574 T AT 99928574T AT 99928574 T AT99928574 T AT 99928574T AT E443723 T1 ATE443723 T1 AT E443723T1
Authority
AT
Austria
Prior art keywords
antibodies
cross
production processes
monoclonal antibodies
reactive
Prior art date
Application number
AT99928574T
Other languages
English (en)
Inventor
Avi Ashkenazi
Anan Chuntharapai
K Kim
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE443723T1 publication Critical patent/ATE443723T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT99928574T 1998-06-12 1999-06-10 Monoklonale antikörper, kreuz-reaktive antikörper und deren produktionsverfahren ATE443723T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9663798A 1998-06-12 1998-06-12
PCT/US1999/013197 WO1999064461A2 (en) 1998-06-12 1999-06-10 Monoclonal antibodies, cross-reactive antibodies and method for producing the same

Publications (1)

Publication Number Publication Date
ATE443723T1 true ATE443723T1 (de) 2009-10-15

Family

ID=22258333

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99928574T ATE443723T1 (de) 1998-06-12 1999-06-10 Monoklonale antikörper, kreuz-reaktive antikörper und deren produktionsverfahren

Country Status (11)

Country Link
US (1) US20060177456A1 (de)
EP (2) EP2058334B1 (de)
JP (2) JP2002517223A (de)
AT (1) ATE443723T1 (de)
AU (1) AU4561199A (de)
CA (1) CA2328498A1 (de)
DE (1) DE69941453D1 (de)
ES (2) ES2395693T3 (de)
IL (3) IL139419A0 (de)
PT (1) PT1086138E (de)
WO (1) WO1999064461A2 (de)

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US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
US6252050B1 (en) 1998-06-12 2001-06-26 Genentech, Inc. Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
EP1181319B1 (de) * 1999-05-28 2009-04-22 Genentech, Inc. Chimärische dr4 antikörper und ihre verwendung
JP2003531588A (ja) 2000-04-11 2003-10-28 ジェネンテック・インコーポレーテッド 多価抗体とその用途
WO2002079377A2 (en) * 2000-11-08 2002-10-10 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
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US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
US7115717B2 (en) 2001-05-18 2006-10-03 Kirin Beer Kabushiki Kaisha Anti-TRAIL-R antibodies
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US7361341B2 (en) 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
EP1409544B1 (de) 2001-07-03 2009-06-17 Genentech, Inc. Humane dr4-antikörper und deren anwendungen
KR20060132006A (ko) 2004-03-23 2006-12-20 비오겐 아이덱 엠에이 아이엔씨. 수용체 커플링제 및 이의 치료적 용도
US8029783B2 (en) 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
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AU2011352207B2 (en) * 2010-12-31 2016-03-03 Bioatla, Llc Comprehensive monoclonal antibody generation
EP2914629A1 (de) 2012-11-05 2015-09-09 MAB Discovery GmbH Verfahren zur herstellung multispezifischer antikörper
EP2727941A1 (de) 2012-11-05 2014-05-07 MAB Discovery GmbH Verfahren zur Herstellung multispezifischer Antikörper
EP2727943A1 (de) 2012-11-05 2014-05-07 MAB Discovery GmbH Trispezifische Antikörper gegen menschliche EGFR, HER2 und HER3
EP2727942A1 (de) 2012-11-05 2014-05-07 MAB Discovery GmbH Bispezifische Antikörper gegen menschliche EGFR, HER2 und HER3

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Also Published As

Publication number Publication date
IL200056A (en) 2010-12-30
WO1999064461A3 (en) 2000-04-20
WO1999064461A9 (en) 2001-06-28
DE69941453D1 (de) 2009-11-05
ES2331901T3 (es) 2010-01-19
JP2009112318A (ja) 2009-05-28
HK1132750A1 (en) 2010-03-05
EP2058334A3 (de) 2009-05-20
CA2328498A1 (en) 1999-12-16
IL139419A0 (en) 2001-11-25
EP2058334A2 (de) 2009-05-13
ES2395693T3 (es) 2013-02-14
IL139419A (en) 2010-12-30
PT1086138E (pt) 2010-01-04
US20060177456A1 (en) 2006-08-10
WO1999064461A2 (en) 1999-12-16
EP1086138B1 (de) 2009-09-23
EP1086138A2 (de) 2001-03-28
JP2002517223A (ja) 2002-06-18
AU4561199A (en) 1999-12-30
EP2058334B1 (de) 2012-10-31

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