ATE443775T1 - Hif-prolylhydroxylase-aktivitätstest - Google Patents

Hif-prolylhydroxylase-aktivitätstest

Info

Publication number
ATE443775T1
ATE443775T1 AT05755214T AT05755214T ATE443775T1 AT E443775 T1 ATE443775 T1 AT E443775T1 AT 05755214 T AT05755214 T AT 05755214T AT 05755214 T AT05755214 T AT 05755214T AT E443775 T1 ATE443775 T1 AT E443775T1
Authority
AT
Austria
Prior art keywords
activity test
prolyl hydroxylase
hydroxylase activity
hif prolyl
methods
Prior art date
Application number
AT05755214T
Other languages
English (en)
Inventor
Mitchell Brenner
Original Assignee
Fibrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fibrogen Inc filed Critical Fibrogen Inc
Application granted granted Critical
Publication of ATE443775T1 publication Critical patent/ATE443775T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT05755214T 2004-05-28 2005-05-26 Hif-prolylhydroxylase-aktivitätstest ATE443775T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57532404P 2004-05-28 2004-05-28
PCT/US2005/018577 WO2005118836A2 (en) 2004-05-28 2005-05-26 Hif prolyl hydroxylase activity assay

Publications (1)

Publication Number Publication Date
ATE443775T1 true ATE443775T1 (de) 2009-10-15

Family

ID=34979114

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05755214T ATE443775T1 (de) 2004-05-28 2005-05-26 Hif-prolylhydroxylase-aktivitätstest

Country Status (12)

Country Link
US (1) US20080113383A1 (de)
EP (1) EP1766047B1 (de)
JP (1) JP2008500834A (de)
AT (1) ATE443775T1 (de)
AU (1) AU2005250412B2 (de)
CA (1) CA2567619A1 (de)
DE (1) DE602005016800D1 (de)
ES (1) ES2332798T3 (de)
IL (1) IL179441A (de)
NZ (1) NZ551632A (de)
WO (1) WO2005118836A2 (de)
ZA (1) ZA200610164B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102351791B (zh) 2006-01-27 2014-10-29 菲布罗根有限公司 使低氧诱导因子(hif)稳定的氰基异喹啉化合物
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
AU2007234408B2 (en) 2006-04-04 2011-05-19 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as HIF modulators
NZ623002A (en) 2006-06-26 2015-08-28 Akebia Therapeutics Inc Prolyl hydroxylase inhibitors and methods of use
CA2774039A1 (en) 2009-11-06 2011-05-12 Aerpio Therapeutics Inc. Methods for increasing the stabilization of hypoxia inducible factor-1 alpha
EP2670750B1 (de) 2011-02-02 2016-09-14 Fibrogen, Inc. Naphthyridinderivate als hemmer von hypoxie-induzierbarem faktor (hif)-hydroxylase
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
CN103717214A (zh) 2011-06-06 2014-04-09 阿克比治疗有限公司 用于稳定低氧诱导因子-2α作为治疗癌症的方法的化合物和组合物
NO2686520T3 (de) 2011-06-06 2018-03-17
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
WO2013134660A1 (en) 2012-03-09 2013-09-12 Fibrogen, Inc. 4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors
EP3470397B1 (de) 2012-07-16 2021-12-29 Fibrogen, Inc. Kristalline formen eines prolylhydroxylaseinhibitors
SG11201500234YA (en) 2012-07-16 2015-02-27 Fibrogen Inc Process for making isoquinoline compounds
HUE066123T2 (hu) 2013-06-13 2024-07-28 Akebia Therapeutics Inc Készítmények és módszerek anémia kezelésére
CA2974691A1 (en) 2015-01-23 2016-07-28 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
NZ735973A (en) 2015-04-01 2023-06-30 Akebia Therapeutics Inc Compositions and methods for treating anemia
US11713298B2 (en) 2018-05-09 2023-08-01 Akebia Therapeutics, Inc. Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US12612367B2 (en) 2019-12-10 2026-04-28 Akebia Therapeutics, Inc. Method for producing nitrogen-containing heteroarylcarboxamide acetic acid derivative
WO2021216530A1 (en) 2020-04-20 2021-10-28 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer
CN114577945B (zh) * 2022-03-10 2023-06-02 中国科学院兰州化学物理研究所 一种从中药提取物中筛选脯氨酰羟化酶2抑制剂的胶束电动色谱方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4590157B2 (ja) * 2001-03-21 2010-12-01 アイシス イノヴェイション リミテッド アッセイ、方法および手段
HU229475B1 (en) * 2001-12-06 2014-01-28 Fibrogen Methods of increasing endogenous erythropoietin (epo)

Also Published As

Publication number Publication date
WO2005118836A3 (en) 2006-04-06
IL179441A0 (en) 2007-05-15
US20080113383A1 (en) 2008-05-15
EP1766047B1 (de) 2009-09-23
HK1102197A1 (en) 2007-11-09
AU2005250412B2 (en) 2009-09-17
CA2567619A1 (en) 2005-12-15
AU2005250412A1 (en) 2005-12-15
EP1766047A2 (de) 2007-03-28
ES2332798T3 (es) 2010-02-12
JP2008500834A (ja) 2008-01-17
NZ551632A (en) 2009-09-25
ZA200610164B (en) 2008-02-27
DE602005016800D1 (de) 2009-11-05
IL179441A (en) 2010-12-30
WO2005118836A2 (en) 2005-12-15

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