ATE444096T1 - Verfahren zur herstellung von geformten mikronadeln - Google Patents

Verfahren zur herstellung von geformten mikronadeln

Info

Publication number
ATE444096T1
ATE444096T1 AT05776430T AT05776430T ATE444096T1 AT E444096 T1 ATE444096 T1 AT E444096T1 AT 05776430 T AT05776430 T AT 05776430T AT 05776430 T AT05776430 T AT 05776430T AT E444096 T1 ATE444096 T1 AT E444096T1
Authority
AT
Austria
Prior art keywords
projections
micro
mold
molds
positive
Prior art date
Application number
AT05776430T
Other languages
English (en)
Inventor
Goeran Stemme
Patrick Griss
Original Assignee
Bonsens Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonsens Ab filed Critical Bonsens Ab
Application granted granted Critical
Publication of ATE444096T1 publication Critical patent/ATE444096T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/2628—Moulds with mould parts forming holes in or through the moulded article, e.g. for bearing cages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C99/00—Subject matter not provided for in other groups of this subclass
    • B81C99/0075—Manufacture of substrate-free structures
    • B81C99/0085—Manufacture of substrate-free structures using moulds and master templates, e.g. for hot-embossing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C2045/0094—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor injection moulding of small-sized articles, e.g. microarticles, ultra thin articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2203/00—Basic microelectromechanical structures
    • B81B2203/03—Static structures
    • B81B2203/0361—Tips, pillars
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/03—Processes for manufacturing substrate-free structures
    • B81C2201/034—Moulding

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
  • Medicinal Preparation (AREA)
AT05776430T 2004-08-30 2005-08-30 Verfahren zur herstellung von geformten mikronadeln ATE444096T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0402100A SE0402100D0 (sv) 2004-08-30 2004-08-30 Molded micro-needles
PCT/SE2005/001260 WO2006025786A1 (en) 2004-08-30 2005-08-30 Molded micro-needles

Publications (1)

Publication Number Publication Date
ATE444096T1 true ATE444096T1 (de) 2009-10-15

Family

ID=33096051

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05776430T ATE444096T1 (de) 2004-08-30 2005-08-30 Verfahren zur herstellung von geformten mikronadeln

Country Status (7)

Country Link
US (1) US7981346B2 (de)
EP (1) EP1796778B1 (de)
JP (1) JP2008511382A (de)
AT (1) ATE444096T1 (de)
DE (1) DE602005016951D1 (de)
SE (1) SE0402100D0 (de)
WO (1) WO2006025786A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005087305A1 (en) * 2004-03-12 2005-09-22 Agency For Science, Technology And Research Methods and moulds for use in fabricating side-ported microneedles
GB0616411D0 (en) * 2006-08-18 2006-09-27 Renishaw Plc Neurosurgical instruments
US20090326415A1 (en) * 2006-08-28 2009-12-31 Agency For Science ,Technology And Research Microneedles and methods for fabricating microneedles
US20090318833A1 (en) * 2006-09-18 2009-12-24 Agency For Science Technology And Research Needle Structures and Methods for Fabricating Needle Structures
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
DE102008052749B4 (de) * 2008-10-22 2012-01-12 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Nadel, Nadelanordnung, Spritzgussform und Verfahren zum Herstellen
FI20095433A0 (fi) 2009-04-20 2009-04-20 Valtion Teknillinen Mikroneula
EP2275164A1 (de) * 2009-07-15 2011-01-19 Debiotech S.A. Mikronadeln mit mehreren Kanälen
PT2563450T (pt) 2010-04-28 2017-08-28 Kimberly Clark Co Dispositivo para entrega de medicação para a artrite reumatóide
RU2570280C2 (ru) 2010-04-28 2015-12-10 Кимберли-Кларк Ворлдвайд, Инк. Композитная матрица микроигл, содержащая на поверхности наноструктуры
US9522262B2 (en) 2010-04-28 2016-12-20 Kimberly-Clark Worldwide, Inc. Medical devices for delivery of siRNA
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
CN104039382B (zh) 2011-10-27 2018-01-12 金伯利-克拉克环球有限公司 高粘度生物活性剂的经皮递送
PL3542851T3 (pl) 2011-10-27 2022-04-25 Sorrento Therapeutics, Inc. Wszczepialne urządzenia do dostarczania środków biologicznie czynnych
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
JP6155539B2 (ja) * 2011-12-02 2017-07-05 凸版印刷株式会社 針状体の製造方法および針状体の転写版
JP5856475B2 (ja) * 2011-12-28 2016-02-09 Ａｓｔｉ株式会社 マイクロニードルの製造方法
EP2662110A1 (de) 2012-05-10 2013-11-13 Debiotech S.A. Vorrichtung und Methode für das Einsetzen von Nadeln
WO2015009524A1 (en) 2013-07-16 2015-01-22 3M Innovative Properties Company Hollow microneedle with beveled tip
US10384047B2 (en) 2013-07-16 2019-08-20 3M Innovative Properties Company Hollow microneedle with bevel opening
SG10201710909YA (en) 2013-07-16 2018-02-27 3M Innovative Properties Co Article comprising a microneedle
EP3021931B1 (de) 2013-07-16 2021-09-01 Kindeva Drug Delivery L.P. Hohlmikronadelfeldartikel
KR102012241B1 (ko) 2017-08-30 2019-08-21 한국기계연구원 마이크로니들 구조체, 이의 제조방법 및 장치
KR102240614B1 (ko) * 2018-06-22 2021-04-16 주식회사 에스엔비아 화살촉 형상의 마이크로니들
WO2020256198A1 (ko) * 2019-06-21 2020-12-24 주식회사 에스엔비아 화살촉 형상의 마이크로니들 및 그 제조장치와 제조방법

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4838877A (en) 1985-08-06 1989-06-13 Massau Bruce A Polymeric hypodermic device
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6719719B2 (en) 1998-11-13 2004-04-13 Elan Pharma International Limited Spike for liquid transfer device, liquid transfer device including spike, and method of transferring liquids using the same
JP2002532165A (ja) * 1998-12-18 2002-10-02 メドトロニック ミニメド インコーポレイテッド 医療装置と共に使われる、微小突刺し部材を備える挿入セット及びそのような挿入セットの使用方法
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6629949B1 (en) * 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US6767341B2 (en) * 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US6749792B2 (en) * 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
SE0102736D0 (sv) * 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
WO2003024507A2 (en) * 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
EP1439870B1 (de) * 2001-10-29 2009-01-14 Becton, Dickinson and Company Vorrichtung für die abgabe einer substanz
AU2002352978A1 (en) * 2001-11-30 2003-06-17 Alza Corporation Methods and apparatuses for forming microprojection arrays
EP1483019A4 (de) * 2002-03-11 2007-07-04 Altea Therapeutics Corp Transdermales arzneimittelabgabe-pflastersystem, verfahren zu seiner herstellung und anwendungsverfahren dafür
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
WO2004033021A1 (en) * 2002-10-07 2004-04-22 Biovalve Technologies, Inc. Microneedle array patch
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
ES2290738T3 (es) * 2003-06-30 2008-02-16 Alza Corporation Procedimiento para revestir microproyecciones de perforacion de la piel.

Also Published As

Publication number Publication date
EP1796778B1 (de) 2009-09-30
JP2008511382A (ja) 2008-04-17
DE602005016951D1 (de) 2009-11-12
US7981346B2 (en) 2011-07-19
WO2006025786A1 (en) 2006-03-09
EP1796778A1 (de) 2007-06-20
SE0402100D0 (sv) 2004-08-30
US20070255205A1 (en) 2007-11-01

Similar Documents

Publication Publication Date Title
ATE444096T1 (de) Verfahren zur herstellung von geformten mikronadeln
BRPI0509773A (pt) preformas, garrafas e método para fabricar as preformas e as garrafas
WO2012106512A3 (en) Nozzle and method of making same
DE602008005989D1 (de) Formelement zum Ausformen dreidimensionaler Produkte, System und Verfahren zum Herstellen eines Formelements
MX378475B (es) Pieza de plástico moldeada y método para la producción del mismo.
ATE496754T1 (de) Verfahren zur herstellung eines kunststoffhohlkörpers aus einem vorformling
WO2012000621A3 (de) Verfahren zur herstellung eines kunststoffartikels sowie blasformwerkzeug zur durchführung des verfahrens
TW200720053A (en) Manufacturing process of suction cup, suction cup and in-vehicle instrument
ATE301037T1 (de) Verfahren zur herstellung eines kunststoff- kraftstofftanks
BRPI0515214A (pt) molde para moldagem por injeção, processo para fabricar uma peça de matéria plástica e peça de matéria plástica
DE10337559A1 (de) Formwerkzeug zur Herstellung von Formschaumkörpern
WO2011061593A8 (en) Method for manufacturing monolithic hollow bodies by means of a casting or injection molding process
DE602004029427D1 (de) Blasformverfahren
DE502004010319D1 (de) Verfahren und vorrichtung zur herstellung von hohlkörpern
BRPI0509395A (pt) conjunto de preformado, conjunto de recipiente, e método de fabricação
DE50306776D1 (de) Verfahren zum herstellen von hinterspritzten kunststoffformteilen
WO2006039309A3 (en) A molded, plastic container and a method for making the same
PL4185448T3 (pl) Forma wtryskowa do tworzyw sztucznych, przeznaczona do wytwarzania zakrętki oraz sposób wytwarzania zakrętki
PL1888316T3 (pl) Sposób kontroli procesu wtryskiwania we wtryskarce
CN110450350A (zh) 制造模型车身的方法
CN104015306B (zh) Pcr板注塑成型模具及其方法
SE0200195D0 (sv) Förfarande och anordning för framställning av plastdetaljer
EP1508427A3 (de) Blasformverfahren
WO2005084487A3 (en) Injection moulding process
CN105800916B (zh) 一种生产玻璃制品的模具结构

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties