DK1896006T3 - Fremstillingmetode for entacapon-holdige granuler til orale doseringsformet - Google Patents

Fremstillingmetode for entacapon-holdige granuler til orale doseringsformet

Info

Publication number: DK1896006T3
Authority: DK; Denmark
Prior art keywords: entacapone; preparation; dosage form; oral dosage; containing granules
Prior art date: 2005-06-08

Application number

DK06755404T

Other languages

Danish (da)

English (en)

Inventor

Kari Vahervuo

Original Assignee

Orion Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-08

Filing date

2006-06-07

Publication date

2009-12-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37400847&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1896006(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-07 Application filed by Orion Corp filed Critical Orion Corp

2009-12-07 Application granted granted Critical

2009-12-07 Publication of DK1896006T3 publication Critical patent/DK1896006T3/da

Links

JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 title abstract 2
229960003337 entacapone Drugs 0.000 title abstract 2
239000006186 oral dosage form Substances 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
239000008187 granular material Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK06755404T 2005-06-08 2006-06-07 Fremstillingmetode for entacapon-holdige granuler til orale doseringsformet DK1896006T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US68833405P	2005-06-08	2005-06-08
PCT/FI2006/000182 WO2006131591A2 (en)	2005-06-08	2006-06-07	An entacapone-containing oral dosage form

Publications (1)

Publication Number	Publication Date
DK1896006T3 true DK1896006T3 (da)	2009-12-07

Family

ID=37400847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06755404T DK1896006T3 (da)	2005-06-08	2006-06-07	Fremstillingmetode for entacapon-holdige granuler til orale doseringsformet

Country Status (19)

Country	Link
US (3)	US20080187590A1 (de)
EP (5)	EP2316448A1 (de)
JP (2)	JP5336181B2 (de)
KR (2)	KR101617990B1 (de)
CN (1)	CN101184483B (de)
AT (1)	ATE444746T1 (de)
AU (1)	AU2006256724B2 (de)
CA (1)	CA2611114C (de)
CY (1)	CY1109587T1 (de)
DE (1)	DE602006009652D1 (de)
DK (1)	DK1896006T3 (de)
EA (1)	EA013161B1 (de)
ES (1)	ES2311442T3 (de)
MX (1)	MX2007015377A (de)
NO (1)	NO345046B1 (de)
PL (1)	PL1896006T3 (de)
PT (2)	PT1896006E (de)
SI (1)	SI1896006T1 (de)
WO (1)	WO2006131591A2 (de)

Families Citing this family (32)

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GB2429645A (en) *	2006-03-10	2007-03-07	Sekhsaria Chemicals Ltd	Solid pharmaceutical composition comprising a COMT inhibitor, a starch and a wetting agent
US20100104634A1 (en) *	2006-12-27	2010-04-29	Mahesh Rameshwar Kalantri	Pharmaceutical compositions of entacapone
EP1946756A1 (de) *	2007-01-17	2008-07-23	Revotar Biopharmaceuticals AG	Verwendung von Entacapon für kosmetische, dermatologische und pharmazeutische Zusammensetzungen
ATE510537T1 (de) *	2008-02-06	2011-06-15	Wockhardt Research Center	Pharmazeutische zusammensetzungen von entacapon, levodopa und carbidopa mit verbesserter bioverfügbarkeit
PT2293791E (pt) *	2008-02-06	2012-01-11	Wockhardt Ltd	Composições farmacêuticas de entacapona co-micronizada com álcoois de açúcares
RU2540465C2 (ru) *	2008-08-22	2015-02-10	Вокхардт Рисерч Сентер	Фармацевтическая композиция энтакапона или его солей пролонгрированного высвобождения
TR200806646A2 (tr) *	2008-09-03	2009-06-22	Dr. F. Fri̇k İlaç San. Ve Ti̇c. A.Ş.	Entakapon, levodopa ve karbidoba içeren farmasötik kombinasyonlar
AU2011222856B2 (en)	2010-03-04	2015-10-15	Orion Corporation	Use of levodopa, carbidopa and entacapone for treating Parkinson's disease
DE102010023828A1 (de) *	2010-06-15	2011-12-15	IIP - Institut für industrielle Pharmazie, Forschungs- und Entwicklungsgesellschaft mbH	Pharmazeutisches Präparat, welches Entacapon, Levodopa und Carbidopa enthält
US8263119B2 (en) *	2010-12-01	2012-09-11	Shire Llc	Capsule formulations containing lanthanum compounds
MX2013012429A (es) *	2011-04-26	2013-12-06	Innopharmax Inc	Una composicion de entacopone.
CN103845318A (zh) *	2012-12-07	2014-06-11	天津市汉康医药生物技术有限公司	恩他卡朋分散片
PT2968218T (pt) *	2013-03-13	2021-09-24	Neuroderm Ltd	Combinação para tratamento da doença de parkinson
KR102385603B1 (ko) *	2013-08-19	2022-04-11	타리스 바이오메디컬 엘엘씨	다중 유닛 약물 전달 장치 및 방법
US10258585B2 (en)	2014-03-13	2019-04-16	Neuroderm, Ltd.	DOPA decarboxylase inhibitor compositions
ES2967693T3 (es)	2014-03-13	2024-05-03	Neuroderm Ltd	Composiciones del inhibidor de la dopa descarboxilasa
JP2018500300A (ja)	2014-11-28	2018-01-11	ノヴィファーマ，エス．アー．	パーキンソン病を遅延させるための医薬
JP6411265B2 (ja) *	2015-03-30	2018-10-24	共和薬品工業株式会社	エンタカポン含有医薬組成物
BR112017016393A2 (pt) *	2015-05-08	2018-03-27	Wockhardt Limited	composições farmacêuticas estáveis compreendendo agente antibacteriano
WO2017028814A1 (en) *	2015-08-20	2017-02-23	Tsh Biopharm Corporation Ltd.	Pharmaceutical composition comprising amlodipine and dextromethorphan
EP3275433A1 (de) *	2016-07-29	2018-01-31	Som Innovation Biotech S.L.	Zusammensetzung mit verzögerter freisetzung mit mikronisiertem tolcapon
ES2895054T3 (es) *	2016-08-18	2022-02-17	Ilko Ilac Sanayi Ve Ticaret Anonim Sirketi	Fórmula de comprimido antiparkinson con perfil de disolución mejorado
CN106236720A (zh) *	2016-08-29	2016-12-21	海南通用康力制药有限公司	一种恩他卡朋的药物组合物及其制备方法
TWI595871B (zh) *	2016-09-22	2017-08-21	生達化學製藥股份有限公司	含有兒茶酚－ｏ－甲基轉移酶抑制劑之口服醫藥組成物及其製造方法
JP6735007B2 (ja) *	2018-09-26	2020-08-05	共和薬品工業株式会社	エンタカポン含有医薬組成物
AU2021235850A1 (en) *	2020-03-13	2022-10-06	BIAL - PORTELA & Cª, S.A.	Micronised opicapone
US11844754B2 (en)	2020-11-17	2023-12-19	Neuroderm, Ltd.	Methods for treatment of Parkinson's disease
US11213502B1 (en)	2020-11-17	2022-01-04	Neuroderm, Ltd.	Method for treatment of parkinson's disease
US11331293B1 (en)	2020-11-17	2022-05-17	Neuroderm, Ltd.	Method for treatment of Parkinson's disease
US20240300930A1 (en) *	2021-02-26	2024-09-12	Msn Laboratories Private Limited, R&D Center	Novel process for the preparation of 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine-1-oxide
CN113274362A (zh) *	2021-03-31	2021-08-20	海南通用康力制药有限公司	恩他卡朋片的生产方法
US12161612B2 (en)	2023-04-14	2024-12-10	Neuroderm, Ltd.	Methods and compositions for reducing symptoms of Parkinson's disease

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US5283352A (en)	1986-11-28	1994-02-01	Orion-Yhtyma Oy	Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
GB2238047B (en)	1989-11-03	1993-02-10	Orion Yhtymae Oy	Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation
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FI101039B (fi) *	1992-10-09	1998-04-15	Eeva Kristoffersson	Menetelmä lääkepellettien valmistamiseksi
US5562291A (en) *	1995-09-28	1996-10-08	Daniel D. Garcia	Arrow tip for shooting wooden target
US5952509A (en) *	1996-06-27	1999-09-14	Takeda Chemical Industries, Ltd.	Production of benzaldehyde compounds
AU4078997A (en) *	1996-08-22	1998-03-06	New York University	Cholinesterase inhibitors for treatment of parkinson's disease
US6599530B2 (en) *	1998-09-14	2003-07-29	Orion Corporation	Oral compacted composition comprising catechol derivatives
US20080118556A1 (en) *	1998-11-02	2008-05-22	Elan Corporation, Plc	Modified Release of Compositions Containing a Combination of Carbidopa, Levodopa and Entacapone
US7374779B2 (en) *	1999-02-26	2008-05-20	Lipocine, Inc.	Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
FI109453B (fi) *	1999-06-30	2002-08-15	Orion Yhtymae Oyj	Farmaseuttinen koostumus
BR0307331A (pt) *	2002-02-01	2004-12-07	Pfizer Prod Inc	Formulações granuladas a seco de azitromicina
US20040166159A1 (en) *	2002-05-29	2004-08-26	Chien-Hsuan Han	Pharmaceutical dosage forms having immediate and controlled release properties that contain an aromatic amino acid decarboxylase inhibitor and levodopa
WO2005063696A2 (de)	2003-12-31	2005-07-14	Cilag Ag	Neue kristalline formen von entacapone und deren herstellung
US20060222703A1 (en) *	2005-04-01	2006-10-05	Iprbox Oy	Pharmaceutical composition and preparation method thereof
CA2635313C (en) *	2005-12-29	2013-12-31	Osmotica Corp.	Triple combination release multi-layered tablet
US20090155369A1 (en) *	2007-12-13	2009-06-18	Laboratorios Lesvi, S.L.	Pharmaceutical composition containing levodopa, entacapone and carbidopa

2006
- 2006-06-07 EA EA200702616A patent/EA013161B1/ru not_active IP Right Cessation
- 2006-06-07 EP EP10011645A patent/EP2316448A1/de not_active Withdrawn
- 2006-06-07 CN CN2006800187628A patent/CN101184483B/zh not_active Ceased
- 2006-06-07 EP EP06755404A patent/EP1896006B1/de not_active Revoked
- 2006-06-07 PT PT06755404T patent/PT1896006E/pt unknown
- 2006-06-07 EP EP09000405.2A patent/EP2050447B1/de active Active
- 2006-06-07 PT PT90004052T patent/PT2050447T/pt unknown
- 2006-06-07 KR KR1020147032488A patent/KR101617990B1/ko active Active
- 2006-06-07 SI SI200630519T patent/SI1896006T1/sl unknown
- 2006-06-07 JP JP2008515235A patent/JP5336181B2/ja active Active
- 2006-06-07 AU AU2006256724A patent/AU2006256724B2/en active Active
- 2006-06-07 US US11/916,460 patent/US20080187590A1/en not_active Abandoned
- 2006-06-07 WO PCT/FI2006/000182 patent/WO2006131591A2/en not_active Ceased
- 2006-06-07 ES ES06755404T patent/ES2311442T3/es active Active
- 2006-06-07 AT AT06755404T patent/ATE444746T1/de active
- 2006-06-07 DE DE602006009652T patent/DE602006009652D1/de active Active
- 2006-06-07 PL PL06755404T patent/PL1896006T3/pl unknown
- 2006-06-07 EP EP10011858A patent/EP2308487A1/de not_active Withdrawn
- 2006-06-07 MX MX2007015377A patent/MX2007015377A/es active IP Right Grant
- 2006-06-07 CA CA2611114A patent/CA2611114C/en active Active
- 2006-06-07 EP EP10011644A patent/EP2335696A1/de not_active Withdrawn
- 2006-06-07 DK DK06755404T patent/DK1896006T3/da active
2007
- 2007-12-06 KR KR1020077028533A patent/KR101468738B1/ko active Active
- 2007-12-28 NO NO20076687A patent/NO345046B1/no unknown
2009
- 2009-12-11 CY CY20091101296T patent/CY1109587T1/el unknown
2011
- 2011-11-11 US US13/294,209 patent/US20120289594A1/en not_active Abandoned
2013
- 2013-04-10 JP JP2013082320A patent/JP2013173760A/ja active Pending
- 2013-06-06 US US13/911,185 patent/US20130274330A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2013173760A (ja)	2013-09-05
CY1109587T1 (el)	2014-08-13
NO345046B1 (no)	2020-09-07
CA2611114C (en)	2014-09-23
KR20080012945A (ko)	2008-02-12
NO20076687L (no)	2007-12-28
EA013161B1 (ru)	2010-02-26
DE602006009652D1 (de)	2009-11-19
EP2050447A1 (de)	2009-04-22
WO2006131591A3 (en)	2007-03-01
AU2006256724A1 (en)	2006-12-14
ES2311442T3 (es)	2010-01-07
KR101468738B1 (ko)	2014-12-03
EP1896006B1 (de)	2009-10-07
CA2611114A1 (en)	2006-12-14
MX2007015377A (es)	2008-02-14
EA200702616A1 (ru)	2008-04-28
US20080187590A1 (en)	2008-08-07
PT1896006E (pt)	2009-10-19
AU2006256724B2 (en)	2012-06-07
EP2316448A1 (de)	2011-05-04
US20120289594A1 (en)	2012-11-15
CN101184483A (zh)	2008-05-21
CN101184483B (zh)	2011-08-10
KR101617990B1 (ko)	2016-05-03
EP2308487A1 (de)	2011-04-13
JP5336181B2 (ja)	2013-11-06
JP2008542434A (ja)	2008-11-27
ATE444746T1 (de)	2009-10-15
SI1896006T1 (sl)	2010-02-26
EP2335696A1 (de)	2011-06-22
PL1896006T3 (pl)	2010-03-31
ES2311442T1 (es)	2009-02-16
KR20150001843A (ko)	2015-01-06
US20130274330A1 (en)	2013-10-17
EP2050447B1 (de)	2017-10-11
EP1896006A2 (de)	2008-03-12
WO2006131591A2 (en)	2006-12-14
PT2050447T (pt)	2018-01-17

Publication	Publication Date	Title
DK1896006T3 (da)	2009-12-07	Fremstillingmetode for entacapon-holdige granuler til orale doseringsformet
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