ATE445603T1 - Polymorphe von donepezil-hydrochlorid und verfahren zur herstellung - Google Patents
Polymorphe von donepezil-hydrochlorid und verfahren zur herstellungInfo
- Publication number
- ATE445603T1 ATE445603T1 AT02005248T AT02005248T ATE445603T1 AT E445603 T1 ATE445603 T1 AT E445603T1 AT 02005248 T AT02005248 T AT 02005248T AT 02005248 T AT02005248 T AT 02005248T AT E445603 T1 ATE445603 T1 AT E445603T1
- Authority
- AT
- Austria
- Prior art keywords
- polymorphs
- donepezil hydrochloride
- production
- peaks
- hydrochloride
- Prior art date
Links
- 229960003135 donepezil hydrochloride Drugs 0.000 title abstract 2
- XWAIAVWHZJNZQQ-UHFFFAOYSA-N donepezil hydrochloride Chemical compound [H+].[Cl-].O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 XWAIAVWHZJNZQQ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 abstract 2
- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000000862 absorption spectrum Methods 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14629396 | 1996-06-07 | ||
| PCT/JP1996/003881 WO1997046526A1 (en) | 1996-06-07 | 1996-12-27 | Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production |
| US08/774,802 US6140321A (en) | 1996-06-07 | 1996-12-30 | Polymorphs of donepezil hydrochloride and process for production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE445603T1 true ATE445603T1 (de) | 2009-10-15 |
Family
ID=15404413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02005248T ATE445603T1 (de) | 1996-06-07 | 1997-06-06 | Polymorphe von donepezil-hydrochlorid und verfahren zur herstellung |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6140321A (de) |
| JP (2) | JP2005015486A (de) |
| KR (1) | KR100545851B1 (de) |
| CN (1) | CN1312129C (de) |
| AT (1) | ATE445603T1 (de) |
| AU (1) | AU1153097A (de) |
| CA (1) | CA2516108C (de) |
| DE (1) | DE69739622D1 (de) |
| DK (1) | DK1211243T3 (de) |
| ES (1) | ES2330997T3 (de) |
| HU (1) | HUP0900417A3 (de) |
| PT (1) | PT1211243E (de) |
| SI (1) | SI22888B (de) |
| UA (1) | UA60307C2 (de) |
| WO (1) | WO1997046526A1 (de) |
| ZA (1) | ZA975064B (de) |
Families Citing this family (95)
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| DE60124730T2 (de) | 2000-03-03 | 2007-10-04 | Eisai R&D Management Co., Ltd. | Neue methoden unter verwendung von cholinesteraseinhibitoren |
| US20060183776A9 (en) * | 2000-03-03 | 2006-08-17 | Eisai Co., Ltd. | Liquid dosage formulations of donepezil |
| ES2288984T3 (es) | 2000-09-25 | 2008-02-01 | EISAI R&D MANAGEMENT CO., LTD. | Procedimiento para producir un cristal polimorfico de hidrocloruro de donepezilo. |
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| US6878693B2 (en) * | 2001-09-28 | 2005-04-12 | Solubest Ltd. | Hydrophilic complexes of lipophilic materials and an apparatus and method for their production |
| US20050249786A1 (en) * | 2001-09-28 | 2005-11-10 | Solubest Ltd. | Hydrophilic dispersions of nanoparticles of inclusion complexes of amorphous compounds |
| US20050191359A1 (en) * | 2001-09-28 | 2005-09-01 | Solubest Ltd. | Water soluble nanoparticles and method for their production |
| US7700851B2 (en) * | 2001-11-13 | 2010-04-20 | U.S. Smokeless Tobacco Company | Tobacco nicotine demethylase genomic clone and uses thereof |
| AU2003207184B2 (en) * | 2002-02-07 | 2008-02-14 | Eisai R And D Management Co., Ltd. | Hair growth stimulants, percutaneous preparations and method of stimulating hair growth |
| ATE429452T1 (de) * | 2002-05-01 | 2009-05-15 | San Ei Gen Ffi Inc | Verfahren zur modifizierung von gummi arabicum |
| IL150509A (en) * | 2002-07-01 | 2007-07-04 | Joseph Kaspi | Pharmaceutical preparations containing donafazil hydrochloride |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US20060014801A1 (en) * | 2002-11-22 | 2006-01-19 | The Johns Hopkins University | Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs |
| IL154370A0 (en) * | 2003-02-10 | 2003-09-17 | Chemagis Ltd | Solid amorphous mixtures, processes for the preparation thereof and pharmaceutical compositions containing the same |
| US20050288330A1 (en) * | 2004-06-29 | 2005-12-29 | Avinash Naidu | Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride) |
| US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| US7560560B2 (en) * | 2003-04-16 | 2009-07-14 | Hetero Drugs Limited | Crystalline forms of donepezil hydrochloride |
| WO2004099142A1 (en) * | 2003-05-05 | 2004-11-18 | Ranbaxy Laboratories Limited | Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs |
| UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| WO2005065645A2 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Donepezil formulations |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
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| US7371906B2 (en) * | 2004-08-24 | 2008-05-13 | Eastman Kodak Company | Process for photo-oxidative stability improvements |
| AU2005289100B2 (en) * | 2004-09-29 | 2011-11-03 | Bayer Healthcare Llc | Thermodynamically stable form of bay 43-9006 tosylate |
| AU2005288521A1 (en) * | 2004-09-29 | 2006-04-06 | Chemagis Ltd. | Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride |
| EP2039349A1 (de) * | 2004-10-19 | 2009-03-25 | KRKA, tovarna zdravil, d.d., Novo mesto | Feste pharmazeutische Zusammensetzung mit Donepezilhydrochlorid |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
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| EP2425846A1 (de) * | 2004-12-23 | 2012-03-07 | Voyager Pharmaceutical Corporation | Acetylcholinesterasehemmer und Leuprolidacetat zur Behandlung von Alzheimer-Krankheit |
| JP5180816B2 (ja) * | 2005-04-04 | 2013-04-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経変性疾患および認知症のためのジヒドロピリジン化合物 |
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| EA034167B8 (ru) | 2015-05-22 | 2021-04-27 | Эйджинбайо, Инк. | Фармацевтические композиции леветирацетама пролонгированного высвобождения |
| CN109310697A (zh) | 2016-06-10 | 2019-02-05 | 勃林格殷格翰国际有限公司 | 利格列汀和二甲双胍的组合 |
| CN106397306B (zh) * | 2016-10-20 | 2019-03-08 | 山东罗欣药业集团股份有限公司 | 一种盐酸多奈哌齐晶型化合物及其制备方法 |
| US10369187B2 (en) | 2017-02-09 | 2019-08-06 | Vanderbilt University | Peptide regulators of JNK family kinases |
| IL288505B1 (en) | 2019-05-31 | 2026-07-01 | Tecnimede Sociedade Tecnico Medicinal Sa | Immediate release fixed dose memantine and donepezil |
| CN120513081A (zh) | 2022-12-28 | 2025-08-19 | 考里安有限责任公司 | 制备透皮递送系统的方法 |
| EP4642432A1 (de) | 2022-12-28 | 2025-11-05 | Corium, LLC | Vormischungsverfahren zur herstellung eines transdermalen abgabesystems |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
-
1996
- 1996-12-27 WO PCT/JP1996/003881 patent/WO1997046526A1/en not_active Ceased
- 1996-12-27 AU AU11530/97A patent/AU1153097A/en not_active Abandoned
- 1996-12-30 US US08/774,802 patent/US6140321A/en not_active Expired - Fee Related
-
1997
- 1997-06-06 CA CA002516108A patent/CA2516108C/en not_active Expired - Fee Related
- 1997-06-06 UA UA99010107A patent/UA60307C2/uk unknown
- 1997-06-06 CN CNB200510075915XA patent/CN1312129C/zh not_active Expired - Fee Related
- 1997-06-06 DE DE69739622T patent/DE69739622D1/de not_active Expired - Lifetime
- 1997-06-06 AT AT02005248T patent/ATE445603T1/de active
- 1997-06-06 ES ES02005248T patent/ES2330997T3/es not_active Expired - Lifetime
- 1997-06-06 DK DK02005248.6T patent/DK1211243T3/da active
- 1997-06-06 PT PT02005248T patent/PT1211243E/pt unknown
- 1997-06-06 HU HU0900417A patent/HUP0900417A3/hu unknown
- 1997-06-06 SI SI9720102A patent/SI22888B/sl not_active IP Right Cessation
- 1997-06-06 KR KR1020047017860A patent/KR100545851B1/ko not_active Expired - Fee Related
- 1997-06-09 ZA ZA9705064A patent/ZA975064B/xx unknown
-
2004
- 2004-07-12 JP JP2004205012A patent/JP2005015486A/ja active Pending
-
2008
- 2008-08-04 JP JP2008201060A patent/JP2009040783A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| UA60307C2 (uk) | 2003-10-15 |
| JP2009040783A (ja) | 2009-02-26 |
| WO1997046526A1 (en) | 1997-12-11 |
| US6140321A (en) | 2000-10-31 |
| SI22888B (sl) | 2010-06-30 |
| DE69739622D1 (de) | 2009-11-26 |
| ZA975064B (en) | 1998-04-01 |
| DK1211243T3 (da) | 2010-02-08 |
| HUP0900417A3 (en) | 2012-12-28 |
| HU0900417D0 (en) | 2009-08-28 |
| PT1211243E (pt) | 2009-11-06 |
| SI22888A (sl) | 2010-04-30 |
| CA2516108A1 (en) | 1997-12-11 |
| JP2005015486A (ja) | 2005-01-20 |
| HK1080078A1 (en) | 2006-04-21 |
| CN1312129C (zh) | 2007-04-25 |
| CN1699343A (zh) | 2005-11-23 |
| AU1153097A (en) | 1998-01-05 |
| ES2330997T3 (es) | 2009-12-18 |
| KR100545851B1 (ko) | 2006-01-24 |
| KR20040104707A (ko) | 2004-12-10 |
| CA2516108C (en) | 2008-12-02 |
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