DK1211243T3 - Polymorfer af donepezilhydrochlorid og fremgangsmåder til fremstilling deraf - Google Patents
Polymorfer af donepezilhydrochlorid og fremgangsmåder til fremstilling derafInfo
- Publication number
- DK1211243T3 DK1211243T3 DK02005248.6T DK02005248T DK1211243T3 DK 1211243 T3 DK1211243 T3 DK 1211243T3 DK 02005248 T DK02005248 T DK 02005248T DK 1211243 T3 DK1211243 T3 DK 1211243T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymorphs
- donepezil hydrochloride
- preparation
- methods
- peaks
- Prior art date
Links
- 229960003135 donepezil hydrochloride Drugs 0.000 title abstract 2
- XWAIAVWHZJNZQQ-UHFFFAOYSA-N donepezil hydrochloride Chemical compound [H+].[Cl-].O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 XWAIAVWHZJNZQQ-UHFFFAOYSA-N 0.000 title abstract 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 abstract 2
- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000000862 absorption spectrum Methods 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14629396 | 1996-06-07 | ||
| PCT/JP1996/003881 WO1997046526A1 (en) | 1996-06-07 | 1996-12-27 | Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production |
| US08/774,802 US6140321A (en) | 1996-06-07 | 1996-12-30 | Polymorphs of donepezil hydrochloride and process for production |
| EP97924337A EP1019374B1 (en) | 1996-06-07 | 1997-06-06 | Polymorphs of donepezil hydrochloride and process for production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1211243T3 true DK1211243T3 (da) | 2010-02-08 |
Family
ID=15404413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02005248.6T DK1211243T3 (da) | 1996-06-07 | 1997-06-06 | Polymorfer af donepezilhydrochlorid og fremgangsmåder til fremstilling deraf |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6140321A (da) |
| JP (2) | JP2005015486A (da) |
| KR (1) | KR100545851B1 (da) |
| CN (1) | CN1312129C (da) |
| AT (1) | ATE445603T1 (da) |
| AU (1) | AU1153097A (da) |
| CA (1) | CA2516108C (da) |
| DE (1) | DE69739622D1 (da) |
| DK (1) | DK1211243T3 (da) |
| ES (1) | ES2330997T3 (da) |
| HU (1) | HUP0900417A3 (da) |
| PT (1) | PT1211243E (da) |
| SI (1) | SI22888B (da) |
| UA (1) | UA60307C2 (da) |
| WO (1) | WO1997046526A1 (da) |
| ZA (1) | ZA975064B (da) |
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| WO2020240505A1 (en) | 2019-05-31 | 2020-12-03 | TECNIMEDE - Sociedade Técnico-medicinal, SA | Immediate release fixed-dose combination of memantine and donepezil |
| JP2025542471A (ja) | 2022-12-28 | 2025-12-25 | コリウム， エルエルシー | 経皮送達システムを調製することの予混合方法 |
| CN120513081A (zh) | 2022-12-28 | 2025-08-19 | 考里安有限责任公司 | 制备透皮递送系统的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
-
1996
- 1996-12-27 WO PCT/JP1996/003881 patent/WO1997046526A1/en not_active Ceased
- 1996-12-27 AU AU11530/97A patent/AU1153097A/en not_active Abandoned
- 1996-12-30 US US08/774,802 patent/US6140321A/en not_active Expired - Fee Related
-
1997
- 1997-06-06 AT AT02005248T patent/ATE445603T1/de active
- 1997-06-06 PT PT02005248T patent/PT1211243E/pt unknown
- 1997-06-06 HU HU0900417A patent/HUP0900417A3/hu unknown
- 1997-06-06 CN CNB200510075915XA patent/CN1312129C/zh not_active Expired - Fee Related
- 1997-06-06 DK DK02005248.6T patent/DK1211243T3/da active
- 1997-06-06 CA CA002516108A patent/CA2516108C/en not_active Expired - Fee Related
- 1997-06-06 KR KR1020047017860A patent/KR100545851B1/ko not_active Expired - Fee Related
- 1997-06-06 SI SI9720102A patent/SI22888B/sl not_active IP Right Cessation
- 1997-06-06 ES ES02005248T patent/ES2330997T3/es not_active Expired - Lifetime
- 1997-06-06 UA UA99010107A patent/UA60307C2/uk unknown
- 1997-06-06 DE DE69739622T patent/DE69739622D1/de not_active Expired - Lifetime
- 1997-06-09 ZA ZA9705064A patent/ZA975064B/xx unknown
-
2004
- 2004-07-12 JP JP2004205012A patent/JP2005015486A/ja active Pending
-
2008
- 2008-08-04 JP JP2008201060A patent/JP2009040783A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU1153097A (en) | 1998-01-05 |
| HK1080078A1 (en) | 2006-04-21 |
| SI22888B (sl) | 2010-06-30 |
| ZA975064B (en) | 1998-04-01 |
| JP2005015486A (ja) | 2005-01-20 |
| HU0900417D0 (en) | 2009-08-28 |
| JP2009040783A (ja) | 2009-02-26 |
| WO1997046526A1 (en) | 1997-12-11 |
| UA60307C2 (uk) | 2003-10-15 |
| ES2330997T3 (es) | 2009-12-18 |
| ATE445603T1 (de) | 2009-10-15 |
| DE69739622D1 (de) | 2009-11-26 |
| CA2516108A1 (en) | 1997-12-11 |
| KR20040104707A (ko) | 2004-12-10 |
| KR100545851B1 (ko) | 2006-01-24 |
| PT1211243E (pt) | 2009-11-06 |
| HUP0900417A3 (en) | 2012-12-28 |
| CN1312129C (zh) | 2007-04-25 |
| SI22888A (sl) | 2010-04-30 |
| CN1699343A (zh) | 2005-11-23 |
| CA2516108C (en) | 2008-12-02 |
| US6140321A (en) | 2000-10-31 |
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