ATE445647T1 - Nicht-humaner säuger, welcher transgen ist für die konstante region der schweren kette vom humanem klasse a immunoglobulin und verwendung dafür - Google Patents

Nicht-humaner säuger, welcher transgen ist für die konstante region der schweren kette vom humanem klasse a immunoglobulin und verwendung dafür

Info

Publication number
ATE445647T1
ATE445647T1 AT04805265T AT04805265T ATE445647T1 AT E445647 T1 ATE445647 T1 AT E445647T1 AT 04805265 T AT04805265 T AT 04805265T AT 04805265 T AT04805265 T AT 04805265T AT E445647 T1 ATE445647 T1 AT E445647T1
Authority
AT
Austria
Prior art keywords
human
immunoglobulin
transgenic
heavy chain
constant region
Prior art date
Application number
AT04805265T
Other languages
English (en)
Inventor
Michel Cogne
Christophe Sirac
Micael Bardel
Catherine Decourt
Morvan Caroline Le
Original Assignee
Centre Nat Rech Scient
Univ Limoges
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Univ Limoges filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE445647T1 publication Critical patent/ATE445647T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Animal Husbandry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04805265T 2003-10-24 2004-10-21 Nicht-humaner säuger, welcher transgen ist für die konstante region der schweren kette vom humanem klasse a immunoglobulin und verwendung dafür ATE445647T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0312502A FR2861255B1 (fr) 2003-10-24 2003-10-24 Mammifere non-humain transgenique pour la region constante de la chaine lourde des immunoglobulines humaines de classe a et ses applications.
PCT/FR2004/002701 WO2005047333A1 (fr) 2003-10-24 2004-10-21 Mammifere non-humain transgenique pour la region constante de la chaine lourde des immunoglobulines humaines de classe a et ses applications.

Publications (1)

Publication Number Publication Date
ATE445647T1 true ATE445647T1 (de) 2009-10-15

Family

ID=34400790

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04805265T ATE445647T1 (de) 2003-10-24 2004-10-21 Nicht-humaner säuger, welcher transgen ist für die konstante region der schweren kette vom humanem klasse a immunoglobulin und verwendung dafür

Country Status (8)

Country Link
US (1) US8629317B2 (de)
EP (1) EP1680449B1 (de)
JP (1) JP2008501303A (de)
AT (1) ATE445647T1 (de)
DE (1) DE602004023637D1 (de)
ES (1) ES2335018T3 (de)
FR (1) FR2861255B1 (de)
WO (1) WO2005047333A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2926438B1 (fr) * 2008-01-22 2013-01-11 Univ Limoges Mammifere non-humain transgenique pour la region constante de la chaine lourde des immunoglobulines humaines de classe g et ses applications
KR102362774B1 (ko) 2008-09-30 2022-02-15 아블렉시스, 엘엘씨 키메라 항체의 제조를 위한 인간 이외의 포유동물
AU2010217934A1 (en) * 2009-02-27 2011-08-18 Genentech, Inc. Hyper IgE animal model with enhanced immunoglobulin heavy chain class switching to c-epsilon
PL2954779T3 (pl) * 2009-12-10 2019-07-31 Regeneron Pharmaceuticals, Inc. Myszy wytwarzające przeciwciała ciężkołańcuchowe
KR20210010942A (ko) 2010-03-31 2021-01-28 아블렉시스, 엘엘씨 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작
EP2947151A1 (de) 2010-08-02 2015-11-25 Regeneron Pharmaceuticals, Inc. Bindeproteine mit vl-domänen
EP2820947A1 (de) 2013-07-05 2015-01-07 B Cell Design Transgenes nichtmenschliches Säugetier zur Herstellung chimärer humaner Immunglobulin-E-Antikörper
EP2905031A1 (de) 2014-02-10 2015-08-12 B Cell Design Neues, nicht-HIV-Impfstoff-Antigen aus der vaginalen Mikrobiota zur Induzierung einer mukosalen, neutralisierenden, schützenden Antikörperreaktion gegen eine HIV-Infektion
RU2016141123A (ru) 2014-03-21 2018-04-23 Регенерон Фармасьютикалз, Инк. Антигенсвязывающие белки vl, проявляющие различные связывающие характеристики
RU2016141307A (ru) 2014-03-21 2018-04-24 Регенерон Фармасьютикалз, Инк. Отличные от человека животные, которые вырабатывают однодоменные связывающие белки
CA2944647C (en) 2014-04-03 2025-07-08 Igm Biosciences, Inc. Modified j-chain
DK3265575T3 (da) 2015-03-04 2021-05-31 Igm Biosciences Inc Cd20-bindende molekyler og anvendelser deraf
HK1250038A1 (zh) 2015-03-19 2018-11-23 瑞泽恩制药公司 选择结合抗原的轻链可变区的非人动物
US11639389B2 (en) 2015-09-30 2023-05-02 Igm Biosciences, Inc. Binding molecules with modified J-chain
AU2016329197B2 (en) 2015-09-30 2021-01-21 Igm Biosciences, Inc. Binding molecules with modified J-chain
EP3398967A1 (de) 2017-05-04 2018-11-07 B Cell Design Antikörper gegen karzinoembryonisches antigen zur krebstherapie und -diagnose
CN108486126A (zh) * 2018-03-27 2018-09-04 重庆金迈博生物科技有限公司 一种核酸分子及其在人源化抗体中的应用
EP3844290A4 (de) * 2018-09-13 2022-07-06 Ramot at Tel-Aviv University Ltd. Genetische manipulation eines b-zell-rezeptors und verwendung davon in der antigen-induzierten antikörpersekretion
WO2020240876A1 (ja) * 2019-05-27 2020-12-03 株式会社トランスジェニック エクソンヒト化マウス
CN115197942A (zh) * 2021-04-09 2022-10-18 北京大学第一医院 一种可表达人源IgA1蛋白的鼠模型及其构建方法和应用
WO2025257185A1 (en) 2024-06-11 2025-12-18 Abcely Humanized anti-human-carcinoembryonic antigen antibody
WO2026035843A2 (en) * 2024-08-06 2026-02-12 Regeneron Pharmaceuticals, Inc. Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
JPH08140528A (ja) * 1993-12-03 1996-06-04 Genpharm Internatl Inc 異種抗体を産生することができるトランスジェニック非ヒト動物
US5714352A (en) * 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
US6833268B1 (en) * 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
CA2436091A1 (en) * 2001-01-26 2002-08-01 Abgenix, Inc. Neutralizing human monoclonal antibodies against hiv-1, their production and uses

Also Published As

Publication number Publication date
US8629317B2 (en) 2014-01-14
JP2008501303A (ja) 2008-01-24
ES2335018T3 (es) 2010-03-18
FR2861255A1 (fr) 2005-04-29
DE602004023637D1 (de) 2009-11-26
EP1680449B1 (de) 2009-10-14
EP1680449A1 (de) 2006-07-19
FR2861255B1 (fr) 2006-02-17
WO2005047333A1 (fr) 2005-05-26
US20070248601A1 (en) 2007-10-25

Similar Documents

Publication Publication Date Title
ATE445647T1 (de) Nicht-humaner säuger, welcher transgen ist für die konstante region der schweren kette vom humanem klasse a immunoglobulin und verwendung dafür
AU2020286186B2 (en) Humanized il-15 animals
Taniguchi et al. Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection
CA2376299A1 (en) Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
PT1597382E (pt) Células e mamíferos não humanos geneticamente modificados
BR122020013427B1 (pt) Método para fazer um camundongo, uma célula ou tecido derivado de um camundongo e um hibridoma
RU2011102962A (ru) Продуцирующие антитела млекопитающие, не являющиеся человеком
ATE405154T1 (de) Verfahren zur erschaffung transgener nicht- menschlicher tiere
ZA200802561B (en) Novel gene disruptions, compositions and methods relating thereto
JP3765574B2 (ja) 逆向き反復配列を含む組み換え遺伝子及びその利用
AU2005213965B2 (en) Gene disruptions, compositions and methods relating thereto
KR20150126867A (ko) 조건적 Acvr1 돌연변이체 대립형질을 갖는 설치류
AU2005224992B2 (en) Transgenic model for Alzheimer's disease
KR20210020018A (ko) 진행성 골화성 섬유이형성증의 설치류 모델
US20250134079A1 (en) Genetically modified non-human animal with human or chimeric genes
JP2004523234A5 (de)
DE60118913T2 (de) Transgenes tiermodell für neurodegenerative erkrankungen
JP4171256B2 (ja) パピローマウイルスベクターを用いたＲＮＡｉ表現型を有する非ヒト哺乳動物の作製方法
US20240090480A1 (en) Split-intein methods and compositions for generation of single sex offspring
US20060265772A1 (en) Histamine hyperproductive animal
RU2795136C2 (ru) Модель прогрессирующей оссифицирующей фибродисплазии на грызунах
EP1859676A1 (de) Haarloses transgenes tier
JPWO2021216505A5 (de)
HK1210659B (en) Humanized il-15 animals
Iyadurai et al. 13 Creating APP Transgenic

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties