ATE446105T1 - Trna-synthetase-fragmente - Google Patents

Trna-synthetase-fragmente

Info

Publication number
ATE446105T1
ATE446105T1 AT05759912T AT05759912T ATE446105T1 AT E446105 T1 ATE446105 T1 AT E446105T1 AT 05759912 T AT05759912 T AT 05759912T AT 05759912 T AT05759912 T AT 05759912T AT E446105 T1 ATE446105 T1 AT E446105T1
Authority
AT
Austria
Prior art keywords
trna synthetase
synthetase fragments
fragments
relates
present
Prior art date
Application number
AT05759912T
Other languages
English (en)
Inventor
Paul Glidden
Original Assignee
Angiosyn Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/961,526 external-priority patent/US20060079672A1/en
Priority claimed from US10/962,375 external-priority patent/US20060078553A1/en
Priority claimed from US10/961,529 external-priority patent/US20060079441A1/en
Priority claimed from US10/962,171 external-priority patent/US20060079473A1/en
Priority claimed from US10/962,058 external-priority patent/US20060079472A1/en
Priority claimed from US10/961,486 external-priority patent/US20060078886A1/en
Priority claimed from US10/962,218 external-priority patent/US20060079474A1/en
Priority claimed from US10/962,062 external-priority patent/US20060078556A1/en
Priority claimed from US10/961,528 external-priority patent/US20060078887A1/en
Priority claimed from US10/980,866 external-priority patent/US20060024286A1/en
Priority claimed from US11/019,969 external-priority patent/US20060024287A1/en
Application filed by Angiosyn Inc filed Critical Angiosyn Inc
Application granted granted Critical
Publication of ATE446105T1 publication Critical patent/ATE446105T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/53—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
AT05759912T 2004-08-02 2005-07-21 Trna-synthetase-fragmente ATE446105T1 (de)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US59801904P 2004-08-02 2004-08-02
US10/962,171 US20060079473A1 (en) 2004-10-07 2004-10-07 Multi-unit complexes and uses thereof
US10/962,058 US20060079472A1 (en) 2004-10-07 2004-10-07 Methods for treating angiogenesis
US10/961,486 US20060078886A1 (en) 2004-10-07 2004-10-07 Business methods for modulating angiogenesis
US10/961,526 US20060079672A1 (en) 2004-10-07 2004-10-07 Kits for modulating angiogenesis
US10/961,529 US20060079441A1 (en) 2004-10-07 2004-10-07 Methods of modulating angiogenesis
US10/962,218 US20060079474A1 (en) 2004-10-07 2004-10-07 Analogs of tRNA synthetase fragments and uses thereof
US10/961,528 US20060078887A1 (en) 2004-10-07 2004-10-07 Methods for screening for anti-angiogenic agents
US10/962,217 US20060079673A1 (en) 2004-08-02 2004-10-07 Polynucleotides encoding tRNA synthetase fragments and uses thereof
US10/962,375 US20060078553A1 (en) 2004-10-07 2004-10-07 Diverse multi-unit complexes including a tRNA synthetase fragment
US10/962,062 US20060078556A1 (en) 2004-10-07 2004-10-07 Antibodies and epitopes specific to tRNA synthetase fragments
US62465604P 2004-11-02 2004-11-02
US10/980,866 US20060024286A1 (en) 2004-08-02 2004-11-02 Variants of tRNA synthetase fragments and uses thereof
US11/019,969 US20060024287A1 (en) 2004-08-02 2004-12-20 Compositions and methods for modulating angiogenesis
PCT/IB2005/002180 WO2006016217A1 (en) 2004-08-02 2005-07-21 tRNA SYNTHETASE FRAGMENTS

Publications (1)

Publication Number Publication Date
ATE446105T1 true ATE446105T1 (de) 2009-11-15

Family

ID=35839163

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05759912T ATE446105T1 (de) 2004-08-02 2005-07-21 Trna-synthetase-fragmente

Country Status (8)

Country Link
US (1) US20060079673A1 (de)
EP (1) EP1776138B1 (de)
JP (1) JP4938661B2 (de)
AT (1) ATE446105T1 (de)
CA (1) CA2575694C (de)
ES (1) ES2332799T3 (de)
MX (1) MX2007001505A (de)
WO (1) WO2006016217A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8282921B2 (en) * 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
JP4777225B2 (ja) * 2006-12-04 2011-09-21 キヤノン株式会社 吐出用液体及び吐出方法
CN102105164A (zh) 2008-06-11 2011-06-22 Atyr医药公司 酪氨酰-trna合成酶多肽的血小板生成活性
EP2310498A1 (de) 2008-06-26 2011-04-20 Atyr Pharma, Inc. Glycyl-trna-synthetasen mit nichtkanonischen biologischen aktivitäten umfassende zusammensetzungen und verfahren
ES2552773T3 (es) 2009-02-27 2015-12-02 Atyr Pharma, Inc. Motivos estructurales de polipéptidos asociados con la actividad de señalización celular
JP5730280B2 (ja) 2009-03-16 2015-06-03 パング バイオファーマ リミテッド 非カノニカル生物学的活性を有するヒスチジル−ｔＲＮＡシンテターゼスプライスバリアントを含む組成物および方法
WO2010120509A2 (en) * 2009-03-31 2010-10-21 Atyr Pharma, Inc. Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities
US20120252718A1 (en) * 2009-10-06 2012-10-04 The Trustees Of The University Of Pennsylvania Compositions and Methods for Regulating Cytochrome c-Mediated Apoptosis by tRNA
US8828395B2 (en) 2009-12-11 2014-09-09 Atyr Pharma, Inc. Antibodies that bind tyrosyl-tRNA synthetases
ES2535951T3 (es) 2009-12-11 2015-05-19 Atyr Pharma, Inc. Histidil ARNt sintetasas para reducir la inflamación
CA2797093C (en) 2010-04-26 2019-10-29 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
CA2797362C (en) 2010-04-27 2020-12-08 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases
CA2797259C (en) 2010-04-27 2020-09-29 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl trna synthetases
WO2011139853A2 (en) 2010-04-28 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases
US8986680B2 (en) 2010-04-29 2015-03-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
EP2563383B1 (de) 2010-04-29 2017-03-01 Atyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von valyl-trna-synthetasen
WO2011139986A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
CA2797977C (en) 2010-05-03 2019-08-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
CN103140233B (zh) 2010-05-03 2017-04-05 Atyr 医药公司 与甲硫氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
AU2011248357B2 (en) 2010-05-03 2017-02-23 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases
EP2566499B1 (de) 2010-05-04 2017-01-25 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten aus einem p38-multi-trna-synthetase-komplex
US9062301B2 (en) 2010-05-04 2015-06-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases
CA2799197C (en) 2010-05-14 2019-10-29 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases
US9034598B2 (en) 2010-05-17 2015-05-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
AU2011258106B2 (en) 2010-05-27 2017-02-23 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
CN103118694B (zh) 2010-06-01 2016-08-03 Atyr医药公司 与赖氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
EP2593126B1 (de) 2010-07-12 2017-09-20 aTyr Pharma, Inc. Innovative erkennung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen in zusammenhang mit proteinfragmenten von histidyl-trna-synthetasen
US8999321B2 (en) 2010-07-12 2015-04-07 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
JP6116479B2 (ja) 2010-07-12 2017-04-19 エータイアー ファーマ， インコーポレイテッド グリシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CA2804278C (en) 2010-07-12 2021-07-13 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases
JP5964304B2 (ja) 2010-08-25 2016-08-03 エータイアー ファーマ， インコーポレイテッド チロシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CA2812795C (en) 2010-10-06 2021-08-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases
WO2013022982A2 (en) 2011-08-09 2013-02-14 Atyr Pharma, Inc. Pegylated tyrosyl-trna synthetase polypeptides
US9816084B2 (en) 2011-12-06 2017-11-14 Atyr Pharma, Inc. Aspartyl-tRNA synthetases
WO2013086228A1 (en) 2011-12-06 2013-06-13 Atyr Pharma, Inc. Pegylated aspartyl-trna synthetase polypeptides
CN104220461A (zh) 2011-12-29 2014-12-17 Atyr医药公司 天冬氨酰-tRNA合成酶-FC缀合物
EP2814514B1 (de) 2012-02-16 2017-09-13 Atyr Pharma, Inc. Histidyl-trna-synthetasen zur behandlung von autoimmun- und entzündungserkrankungen
CN114717206A (zh) 2013-03-15 2022-07-08 Atyr 医药公司 组氨酰-trna合成酶-fc缀合物
ES2994451T3 (en) 2017-04-20 2025-01-24 Atyr Pharma Inc Compositions for treating lung inflammation
KR102478445B1 (ko) * 2019-07-18 2022-12-20 주식회사 큐어바이오테라퓨틱스 Wrs 단백질에 특이적으로 결합하는 항체 및 이의 용도

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JPH01196295A (ja) * 1988-01-30 1989-08-08 Tosoh Corp プロウロキナーゼからの発熱性物質除去方法
JPH01196294A (ja) * 1988-01-30 1989-08-08 Tosoh Corp スーパーオキサイド・ジムスターゼから発熱性物質を除去する方法
JPH01242105A (ja) * 1988-03-18 1989-09-27 Toray Ind Inc エンドトキシン除去材
JPH04197436A (ja) * 1990-11-29 1992-07-17 Terumo Corp エンドトキシン吸着フィルター
GB9601068D0 (en) * 1996-01-19 1996-03-20 Smithkline Beecham Plc Novel compounds
GB2327945A (en) * 1997-07-31 1999-02-10 Medeva Europ Ltd Removal of endotoxin from vaccines
JP4868681B2 (ja) * 2000-03-31 2012-02-01 ザ スクリプス リサーチ インスティチュート 血管新生の調節のために有用なヒトアミノアシル−ｔＲＮＡシンテターゼポリペプチド
CN100486992C (zh) * 2001-02-23 2009-05-13 斯克里普斯研究学院 用于调节血管发生的色氨酰-tRNA合成酶衍生的多肽
US6903189B2 (en) * 2001-03-21 2005-06-07 The Scripps Research Institute Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
WO2003009813A2 (en) * 2001-07-26 2003-02-06 Novartis Ag Methods of treating neuropilin-mediated diseases

Also Published As

Publication number Publication date
CA2575694C (en) 2012-07-10
EP1776138A1 (de) 2007-04-25
CA2575694A1 (en) 2006-02-16
JP2008508349A (ja) 2008-03-21
EP1776138B1 (de) 2009-10-21
US20060079673A1 (en) 2006-04-13
WO2006016217A1 (en) 2006-02-16
JP4938661B2 (ja) 2012-05-23
MX2007001505A (es) 2007-06-11
ES2332799T3 (es) 2010-02-12

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