ATE446745T1 - Antikörper mit t-zell-rezeptor-artiger spezifität,aber höherer affinität und seine verwendung zum nachweis und zur behandlung von krebs, virusinfektionen und autoimmunkrankheiten - Google Patents
Antikörper mit t-zell-rezeptor-artiger spezifität,aber höherer affinität und seine verwendung zum nachweis und zur behandlung von krebs, virusinfektionen und autoimmunkrankheitenInfo
- Publication number
- ATE446745T1 ATE446745T1 AT03706876T AT03706876T ATE446745T1 AT E446745 T1 ATE446745 T1 AT E446745T1 AT 03706876 T AT03706876 T AT 03706876T AT 03706876 T AT03706876 T AT 03706876T AT E446745 T1 ATE446745 T1 AT E446745T1
- Authority
- AT
- Austria
- Prior art keywords
- specificity
- antibodies
- detecting
- autoimmune diseases
- cell receptor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/073,301 US6992176B2 (en) | 2002-02-13 | 2002-02-13 | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| PCT/IL2003/000105 WO2003068201A2 (en) | 2002-02-13 | 2003-02-11 | High affinity antibody having a tcr-like specificity and use in detection and treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE446745T1 true ATE446745T1 (de) | 2009-11-15 |
Family
ID=27732335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03706876T ATE446745T1 (de) | 2002-02-13 | 2003-02-11 | Antikörper mit t-zell-rezeptor-artiger spezifität,aber höherer affinität und seine verwendung zum nachweis und zur behandlung von krebs, virusinfektionen und autoimmunkrankheiten |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6992176B2 (de) |
| EP (3) | EP2329814B1 (de) |
| JP (1) | JP4272535B2 (de) |
| AT (1) | ATE446745T1 (de) |
| AU (3) | AU2003208582C1 (de) |
| CA (1) | CA2474782C (de) |
| DE (1) | DE60329823D1 (de) |
| ES (2) | ES2425539T3 (de) |
| IL (1) | IL193376A (de) |
| WO (1) | WO2003068201A2 (de) |
Families Citing this family (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004527449A (ja) * | 2000-02-15 | 2004-09-09 | リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | テロメラーゼ逆転写酵素を用いる癌を治療するための万能ワクチンと方法 |
| US20040191260A1 (en) | 2003-03-26 | 2004-09-30 | Technion Research & Development Foundation Ltd. | Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof |
| US6992176B2 (en) * | 2002-02-13 | 2006-01-31 | Technion Research & Development Foundation Ltd. | Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease |
| AU2003216341A1 (en) * | 2002-02-20 | 2003-09-09 | Dyax Corporation | Mhc-peptide complex binding ligands |
| US20040072262A1 (en) * | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
| CA2570458C (en) * | 2004-06-09 | 2014-05-20 | Technion Research & Development Foundation Ltd. | Antibodies for selective apoptosis of cells |
| CA2571168A1 (en) * | 2004-06-17 | 2006-01-26 | Mannkind Corporation | Mhc i-binding ssx-241-49 variants |
| KR101442209B1 (ko) * | 2006-05-19 | 2014-11-18 | 테크니온 리서치 엔드 디벨로프먼트 화운데이션 엘티디. | 융합 단백질, 이의 용도 및 이의 제조방법 |
| US8361473B2 (en) * | 2007-03-29 | 2013-01-29 | Technion Research & Development Foundation Ltd. | Antibodies and their uses for diagnosis and treatment of cytomegalovirus infection and associated diseases |
| EP2144935A2 (de) | 2007-03-29 | 2010-01-20 | Technion Research & Development Foundation Ltd. | Antikörper, methoden und kits zur diagnose und behandlung von melanomen |
| WO2009125395A1 (en) * | 2008-04-09 | 2009-10-15 | Technion Research & Development Foundation Ltd. | Anti influenza antibodies and uses thereof |
| EP2280731A1 (de) * | 2008-04-09 | 2011-02-09 | Technion Research and Development Foundation, Ltd. | Anti-human-immunschwäche-antikörper und ihre verwendung |
| EP2508325A3 (de) * | 2008-04-10 | 2013-05-22 | Objet Ltd. | System und verfahren für dreidimensionalen Modelldruck |
| ES2532896T5 (es) | 2008-05-14 | 2018-03-20 | Immatics Biotechnologies Gmbh | Péptidos del MHC de clase II novedosos y potentes derivados de survivina y neurocan |
| RS53782B1 (sr) | 2008-10-01 | 2015-06-30 | Immatics Biotechnologies Gmbh | Preparati tumor-asociranih peptida i odgovarajuća antikancerska vakcina za tretman glioblastoma (gbm) i drugih kancera |
| US20120077696A1 (en) | 2009-03-15 | 2012-03-29 | Technion Research And Development Foundation Ltd. | Soluble hla complexes for use in disease diagnosis |
| SG177025A1 (en) | 2010-06-21 | 2012-01-30 | Agency Science Tech & Res | Hepatitis b virus specific antibody and uses thereof |
| JP2013541937A (ja) * | 2010-08-05 | 2013-11-21 | エフ．ホフマン−ラ ロシュ アーゲー | 抗ｍｈｃ抗体−抗ウイルス性サイトカイン融合タンパク質 |
| WO2012129520A1 (en) | 2011-03-24 | 2012-09-27 | Texas Tech University System | Tcr mimic antibodies as vascular targeting tools |
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| WO2013048243A1 (en) | 2011-09-29 | 2013-04-04 | Apo-T B.V. | Multi-specific binding molecules targeting aberrant cells |
| CA2860914A1 (en) * | 2012-01-13 | 2013-07-18 | Apo-T B.V. | Aberrant cell-restricted immunoglobulins provided with a toxic moiety |
| UA114108C2 (uk) | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
| TWI636065B (zh) | 2013-08-05 | 2018-09-21 | 伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物 |
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- 2003-02-11 JP JP2003567383A patent/JP4272535B2/ja not_active Expired - Fee Related
- 2003-02-11 AU AU2003208582A patent/AU2003208582C1/en not_active Ceased
- 2003-02-11 ES ES10011766T patent/ES2425539T3/es not_active Expired - Lifetime
- 2003-02-11 ES ES03706876T patent/ES2332175T3/es not_active Expired - Lifetime
- 2003-02-11 AT AT03706876T patent/ATE446745T1/de not_active IP Right Cessation
- 2003-02-11 WO PCT/IL2003/000105 patent/WO2003068201A2/en not_active Ceased
- 2003-02-11 EP EP10011766.2A patent/EP2329814B1/de not_active Expired - Lifetime
- 2003-02-11 CA CA2474782A patent/CA2474782C/en not_active Expired - Lifetime
- 2003-02-11 DE DE60329823T patent/DE60329823D1/de not_active Expired - Lifetime
- 2003-02-11 EP EP03706876A patent/EP1474120B1/de not_active Expired - Lifetime
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2005
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- 2008-08-11 IL IL193376A patent/IL193376A/en active IP Right Grant
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| HK1068810A1 (en) | 2005-05-06 |
| ES2425539T3 (es) | 2013-10-16 |
| AU2003208582B2 (en) | 2007-12-06 |
| US6992176B2 (en) | 2006-01-31 |
| EP2072045A2 (de) | 2009-06-24 |
| AU2010214669B2 (en) | 2012-01-12 |
| US20110318369A1 (en) | 2011-12-29 |
| AU2008201062B2 (en) | 2010-10-28 |
| EP2329814A1 (de) | 2011-06-08 |
| JP4272535B2 (ja) | 2009-06-03 |
| AU2010214669A1 (en) | 2010-09-16 |
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| WO2003068201A3 (en) | 2003-12-04 |
| ES2332175T3 (es) | 2010-01-28 |
| IL193376A (en) | 2013-11-28 |
| EP1474120B1 (de) | 2009-10-28 |
| CA2474782C (en) | 2017-05-30 |
| CA2474782A1 (en) | 2003-08-21 |
| EP1474120A4 (de) | 2005-10-12 |
| EP2072045A3 (de) | 2010-09-22 |
| EP2072045B1 (de) | 2012-08-15 |
| EP1474120A2 (de) | 2004-11-10 |
| AU2003208582C1 (en) | 2008-08-07 |
| DE60329823D1 (de) | 2009-12-10 |
| EP2329814B1 (de) | 2013-05-29 |
| US20050287141A1 (en) | 2005-12-29 |
| IL193376A0 (en) | 2009-02-11 |
| AU2003208582A1 (en) | 2003-09-04 |
| US20050255101A1 (en) | 2005-11-17 |
| AU2008201062A1 (en) | 2008-04-03 |
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