ATE447611T1 - Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon - Google Patents

Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon

Info

Publication number
ATE447611T1
ATE447611T1 AT04816813T AT04816813T ATE447611T1 AT E447611 T1 ATE447611 T1 AT E447611T1 AT 04816813 T AT04816813 T AT 04816813T AT 04816813 T AT04816813 T AT 04816813T AT E447611 T1 ATE447611 T1 AT E447611T1
Authority
AT
Austria
Prior art keywords
disclosed
production
display libraries
polypeptide display
expression vectors
Prior art date
Application number
AT04816813T
Other languages
English (en)
Inventor
Patrick Daugherty
Paul Bessette
Jeffrey Rice
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE447611T1 publication Critical patent/ATE447611T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT04816813T 2003-08-18 2004-08-18 Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon ATE447611T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49569803P 2003-08-18 2003-08-18
PCT/US2004/026873 WO2005047461A2 (en) 2003-08-18 2004-08-18 Polypeptide display libraries and methods of making and using thereof

Publications (1)

Publication Number Publication Date
ATE447611T1 true ATE447611T1 (de) 2009-11-15

Family

ID=34590081

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04816813T ATE447611T1 (de) 2003-08-18 2004-08-18 Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon

Country Status (6)

Country Link
US (8) US7256038B2 (de)
EP (1) EP1668114B1 (de)
JP (1) JP4809767B2 (de)
AT (1) ATE447611T1 (de)
DE (1) DE602004023956D1 (de)
WO (1) WO2005047461A2 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7256038B2 (en) 2003-08-18 2007-08-14 Regents Of The University Of California Polypeptide display libraries and methods of making and using thereof
AU2005291011B2 (en) * 2004-10-08 2011-10-13 Affitech Research As Methods for antibody library screening
AU2016205006C1 (en) * 2005-08-31 2018-11-01 The Regents Of The University Of California Cellular libraries of peptide sequences (CLiPS) and methods of using the same
AU2013201000B2 (en) * 2005-08-31 2016-05-12 The Regents Of The University Of California Cellular libraries of peptide sequences (CLiPS) and methods of using the same
EP2535346B1 (de) * 2005-08-31 2017-08-02 The Regents of The University of California Zelluläre Peptidsequenzbibliotheken (CLiPS) und Verwendungsverfahren dafür
CA2666336C (en) * 2006-10-13 2014-01-28 Archer Daniels Midland Company Use of surface display proteins to display inorganic catalysts on the surface of a yeast, bacterium or virion
ATE555128T1 (de) 2006-11-30 2012-05-15 Res Dev Foundation Verbesserte immunglobulin-bibliotheken
US20090035317A1 (en) * 2007-01-12 2009-02-05 Daugherty Patrick S Peptides binding to vascular endothelial growth factor
WO2008118392A2 (en) 2007-03-22 2008-10-02 The Regents Of The University Of California Synthetic cell platforms and methods of use thereof
WO2009014726A1 (en) * 2007-07-26 2009-01-29 The Regents Of The University Of California Methods for enhancing bacterial cell display of proteins and peptides
WO2009021052A1 (en) * 2007-08-06 2009-02-12 University Of Kentucky Research Foundation Polypeptides, systems, and methods useful for detecting glucose
US20090304719A1 (en) 2007-08-22 2009-12-10 Patrick Daugherty Activatable binding polypeptides and methods of identification and use thereof
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
EP2071952A1 (de) * 2007-12-21 2009-06-24 Bayer CropScience AG Verwendung von Tetramsäurederivaten zur Bekämpfung von Schaderregern durch Angiessen oder Tröpfchenapplikation
EP2263089B1 (de) * 2008-03-03 2015-01-28 GlycoFi, Inc. Oberflächenanzeige rekombinanter proteine bei niederen eukaryoten
WO2010081173A2 (en) 2009-01-12 2010-07-15 Cytomx Therapeutics, Llc Modified antibody compositions, methods of making and using thereof
US8399219B2 (en) 2009-02-23 2013-03-19 Cytomx Therapeutics, Inc. Protease activatable interferon alpha proprotein
JP5863045B2 (ja) * 2010-03-11 2016-02-16 国立研究開発法人理化学研究所 ポリペプチド配列の選択方法、並びに金属酸化物または含珪素化合物結合ペプチドおよびその利用
US9309510B2 (en) 2012-08-10 2016-04-12 Cytomx Therapeutics, Inc. Protease-resistant systems for polypeptide display and methods of making and using thereof
WO2014063012A1 (en) 2012-10-19 2014-04-24 The Board Of Trustees Of The Leland Stanford Junior University Conjugated knottin mini-proteins containing non-natural amino acids
JP6693872B2 (ja) 2013-07-25 2020-05-13 シトムクス セラピューティクス，インコーポレイティド 多重特異性抗体、多重特異性活性化可能抗体、及びそれらの使用方法
WO2015116665A2 (en) * 2014-01-28 2015-08-06 Los Alamos National Security, Llc Genetically engineered polymer libraries and methods of using them
EP2933263A1 (de) * 2014-04-17 2015-10-21 Universität Zu Köln Vektor und Verfahren zur Expression von Molekülen von Interesse in einer bakteriellen Zelle
WO2016014974A2 (en) 2014-07-25 2016-01-28 Cytomx Therapeutics, Inc. Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same
RU2700881C2 (ru) * 2014-08-04 2019-09-23 Онкотерапи Сайенс, Инк. Пептид, полученный из urlc10, и содержащая его вакцина
AU2016353453B2 (en) 2015-11-11 2022-08-11 Serimmune Inc. Methods and compositions for assessing antibody specificities
CN110225972A (zh) 2016-09-15 2019-09-10 奥明塔生物技术公司 免疫组库序列扩增方法及应用
JP6598344B2 (ja) * 2017-07-31 2019-10-30 国立大学法人 東京大学 環状ペプチドをタンパク質構造に提示させる超汎用法
US11472889B2 (en) 2017-10-14 2022-10-18 Cytomx Therapeutics, Inc. Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof
WO2019104529A1 (zh) * 2017-11-29 2019-06-06 深圳琅技生命科技有限公司 均相检测方法
WO2020077017A2 (en) * 2018-10-10 2020-04-16 Augmenta Bioworks, Inc. Methods for isolating immune binding proteins
EP3972625A4 (de) 2019-05-20 2023-04-12 The Texas A&M University System Genetisch codierte, durch phagen angezeigte zyklische peptidbibliothek und verfahren zu deren herstellung
CN111088254B (zh) * 2019-11-05 2021-11-23 中国农业科学院生物技术研究所 一种内源搭载的外源基因高效可控表达系统
EP4171604A4 (de) * 2020-06-24 2024-10-09 Serimmune Inc. Sars-cov-2-serumantikörperprofilierung
JP7412043B2 (ja) * 2020-08-05 2024-01-12 国立研究開発法人産業技術総合研究所 標的タンパク質に作用するポリペプチドのスクリーニング方法
KR102779639B1 (ko) * 2021-02-05 2025-03-10 중앙대학교 산학협력단 C-반응성 단백질에 특이적으로 결합하는 펩타이드 및 이의 용도
IT202300021963A1 (it) 2023-10-20 2025-04-20 Univ Ca Foscari Di Venezia Librerie peptidiche in lievito
WO2026006835A1 (en) * 2024-06-28 2026-01-02 The Medical College Of Wisconsin, Inc. Omvogenic outer membrane protein engineering for outer membrane vesicle production

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US827952A (en) 1906-05-01 1906-08-07 Leo H Battalia Piano-action.
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP0474891A1 (de) * 1990-09-08 1992-03-18 BEHRINGWERKE Aktiengesellschaft Vektoren für die Expression malarialer Antigene an der Oberfläche von Salmonella Vakzinstämmen
DE59008773D1 (de) 1990-09-10 1995-04-27 Asea Brown Boveri Gasturbinenanordnung.
US5962255A (en) * 1992-03-24 1999-10-05 Cambridge Antibody Technology Limited Methods for producing recombinant vectors
US6492160B1 (en) * 1991-05-15 2002-12-10 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
AU5670194A (en) * 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
US6335160B1 (en) * 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6300065B1 (en) * 1996-05-31 2001-10-09 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6696251B1 (en) * 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6699658B1 (en) * 1996-05-31 2004-03-02 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
RO120919B1 (ro) 1996-10-25 2006-09-29 G.D. Searle & Co. Proteină hematopoietină, moleculă de acid nucleiccare o codifică, compoziţie farmaceutică şi utilizarea proteinei
US6660257B1 (en) * 1996-10-25 2003-12-09 Pharmacia Corporation Circular permuteins of flt3 ligand
US6723512B2 (en) * 1997-08-29 2004-04-20 Selective Genetics Inc. Methods using genetic package display for detecting and identifying protein-protein interactions that facilitate internalization and transgene expression and cells or tissues competent for the same and methods for evolving gene delivery vectors
EP0922957B1 (de) * 1997-12-05 2000-03-29 von Gabain, Alexander Verfahren zum Biomolekularinteraktionsnachweis
US6180343B1 (en) * 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US7087412B2 (en) * 2000-11-14 2006-08-08 Boehringer Ingelheim International Gmbh Methods for large scale protein production in prokaryotes
US6955910B2 (en) * 2000-11-14 2005-10-18 Boehringer Ingelheim International Gmbh Method for large scale production of recombinant DNA-derived TPA or K2S molecules
IL158418A0 (en) * 2001-04-19 2004-05-12 Scripps Research Inst In vivo incorporation of unnatural amino acids
WO2004039962A2 (en) * 2002-10-30 2004-05-13 Pointilliste, Inc. Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides
US7218657B2 (en) 2003-07-09 2007-05-15 Sumitomo Electric Industries, Ltd. Optical transmitting module having a can type package and providing a temperature sensor therein
US7256038B2 (en) 2003-08-18 2007-08-14 Regents Of The University Of California Polypeptide display libraries and methods of making and using thereof
EP1725112A4 (de) * 2004-02-05 2007-10-24 Massachusetts Inst Technology Zellen-display-bibliotheken
CA2560074A1 (en) * 2004-03-18 2005-11-03 Board Of Regents, The University Of Texas System Combinatorial protein library screening by periplasmic expression
EP2535346B1 (de) * 2005-08-31 2017-08-02 The Regents of The University of California Zelluläre Peptidsequenzbibliotheken (CLiPS) und Verwendungsverfahren dafür
US20090035317A1 (en) 2007-01-12 2009-02-05 Daugherty Patrick S Peptides binding to vascular endothelial growth factor
WO2009014726A1 (en) 2007-07-26 2009-01-29 The Regents Of The University Of California Methods for enhancing bacterial cell display of proteins and peptides
US9309510B2 (en) 2012-08-10 2016-04-12 Cytomx Therapeutics, Inc. Protease-resistant systems for polypeptide display and methods of making and using thereof

Also Published As

Publication number Publication date
US20160032279A1 (en) 2016-02-04
EP1668114A2 (de) 2006-06-14
US7612019B2 (en) 2009-11-03
US10041063B2 (en) 2018-08-07
US20190264194A1 (en) 2019-08-29
US20130210673A1 (en) 2013-08-15
US20100113303A1 (en) 2010-05-06
DE602004023956D1 (de) 2009-12-17
US10544410B2 (en) 2020-01-28
US11078479B2 (en) 2021-08-03
JP2007513602A (ja) 2007-05-31
US20220119802A1 (en) 2022-04-21
US8361933B2 (en) 2013-01-29
US7256038B2 (en) 2007-08-14
WO2005047461A2 (en) 2005-05-26
US20070099247A1 (en) 2007-05-03
US20200318099A1 (en) 2020-10-08
US9134309B2 (en) 2015-09-15
WO2005047461A3 (en) 2006-05-11
EP1668114A4 (de) 2007-02-28
US20050196406A1 (en) 2005-09-08
JP4809767B2 (ja) 2011-11-09
EP1668114B1 (de) 2009-11-04

Similar Documents

Publication Publication Date Title
DE602004023956D1 (de) Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon
DE60208450D1 (de) Verfahren zur Herstellung von L-Glutamin mittels Fermentation und ein L-Glutamin produzierendes Bakterium
ATE353921T1 (de) Chimäre polypeptide, verfahren zur herstellung und verwendung dafür
DE60117008D1 (de) Giessform und verfahren zur herstellung von ophthalmischen linsen
DE60314865D1 (de) Verfahren zur herstellung von modifiziertem polymer, danach erhaltenes modifiziertes polymer und kautschukzusammensetzung
DE60206031D1 (de) Verfahren zur herstellung von seltenerdlegierungs sinterformteilen
DE602004004615D1 (de) Verfahren zur Herstellung von Fluoropolymerdispersionen
DE50303749D1 (de) Verfahren zur herstellung von phthalocyaninpigmentzubereitungen
AT4947U3 (de) Vollnarbiges rindnappaleder und verfahren zur herstellung desselben
DE60204296D1 (de) Verfahren zur herstellung von einstückigen kolben
DE602004020476D1 (de) Verfahren zur herstellung von thermoplastischen vulkanisaten und thermoplastischen vulkanisaten
DE60333291D1 (de) Verfahren zur herstellung von flachglas
DE60324813D1 (de) Verfahren zur Herstellung von Wellenleitern
DE60213444D1 (de) Fluorpolymerlaminate und verfahren zur herstellung derselben
DE602006019835D1 (de) Genexpressionskassette und transformante sowie verfahren zur herstellung von 2-desoxyscylloinosose unter verwendung der transformante
DE10390418D2 (de) Verfahren zur Herstellung von rekombinanten Proteinen in Mikroorganismen
DE502006006803D1 (de) Verfahren zur herstellung von leder
ATE506370T1 (de) Reagenzien und verfahren zur bildung von disulfid-bindungen und glykosylierung von proteinen
DE60212024D1 (de) Strahlungsempfindliche Harzzusammensetzung, Rippe und Verfahren zur Herstellung derselben und Anzeigeelement
DE50200467D1 (de) SPM-Sensor und Verfahren zur Herstellung desselben
DE60300144D1 (de) Verfahren zur Herstellung von Al-Sinterlegierung
DE60325869D1 (de) Dreidimensionales konstruktionselement und verfahren zur herstellung des elements, optischer schalter und mikrovorrichtung
DE602004026157D1 (de) Proteinkomplex, verfahren zu dessen herstellung und verwendung davon
DE502004011774D1 (de) Verfahren zur herstellung von leder
DE60212363D1 (de) Verfahren zur herstellung von verstärktem platinmaterial

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties