ATE447611T1 - Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon - Google Patents

Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon

Info

Publication number
ATE447611T1
ATE447611T1 AT04816813T AT04816813T ATE447611T1 AT E447611 T1 ATE447611 T1 AT E447611T1 AT 04816813 T AT04816813 T AT 04816813T AT 04816813 T AT04816813 T AT 04816813T AT E447611 T1 ATE447611 T1 AT E447611T1
Authority
AT
Austria
Prior art keywords
disclosed
production
display libraries
polypeptide display
expression vectors
Prior art date
Application number
AT04816813T
Other languages
English (en)
Inventor
Patrick Daugherty
Paul Bessette
Jeffrey Rice
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE447611T1 publication Critical patent/ATE447611T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT04816813T 2003-08-18 2004-08-18 Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon ATE447611T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49569803P 2003-08-18 2003-08-18
PCT/US2004/026873 WO2005047461A2 (en) 2003-08-18 2004-08-18 Polypeptide display libraries and methods of making and using thereof

Publications (1)

Publication Number Publication Date
ATE447611T1 true ATE447611T1 (de) 2009-11-15

Family

ID=34590081

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04816813T ATE447611T1 (de) 2003-08-18 2004-08-18 Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon

Country Status (6)

Country Link
US (8) US7256038B2 (de)
EP (1) EP1668114B1 (de)
JP (1) JP4809767B2 (de)
AT (1) ATE447611T1 (de)
DE (1) DE602004023956D1 (de)
WO (1) WO2005047461A2 (de)

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AU2013201000B2 (en) * 2005-08-31 2016-05-12 The Regents Of The University Of California Cellular libraries of peptide sequences (CLiPS) and methods of using the same
AU2006284651C1 (en) 2005-08-31 2013-09-12 The Regents Of The University Of California Cellular libraries of peptide sequences (CLiPS) and methods of using the same
AU2016205006C1 (en) * 2005-08-31 2018-11-01 The Regents Of The University Of California Cellular libraries of peptide sequences (CLiPS) and methods of using the same
JP5571955B2 (ja) * 2006-10-13 2014-08-13 アーチャー−ダニエルズ−ミッドランド カンパニー 酵母細胞触媒支持体における細胞表面ディスプレイの使用
WO2008067547A2 (en) 2006-11-30 2008-06-05 Research Development Foundation Improved immunoglobulin libraries
US20090035317A1 (en) * 2007-01-12 2009-02-05 Daugherty Patrick S Peptides binding to vascular endothelial growth factor
WO2008118392A2 (en) * 2007-03-22 2008-10-02 The Regents Of The University Of California Synthetic cell platforms and methods of use thereof
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US20090304719A1 (en) 2007-08-22 2009-12-10 Patrick Daugherty Activatable binding polypeptides and methods of identification and use thereof
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
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US8399219B2 (en) * 2009-02-23 2013-03-19 Cytomx Therapeutics, Inc. Protease activatable interferon alpha proprotein
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EP2882844B1 (de) 2012-08-10 2018-10-03 Cytomx Therapeutics Inc. Protease-resistente systeme für polypeptiddisplay sowie verfahren zu ihrer herstellung und verwendung
WO2014063012A1 (en) 2012-10-19 2014-04-24 The Board Of Trustees Of The Leland Stanford Junior University Conjugated knottin mini-proteins containing non-natural amino acids
CN113150164A (zh) 2013-07-25 2021-07-23 西托姆克斯治疗公司 多特异性抗体、多特异性可活化抗体及其使用方法
US20170029812A1 (en) * 2014-01-28 2017-02-02 Los Alamos National Security, Llc Genetically engineered polymer libraries and methods of using them
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CA2956265C (en) * 2014-08-04 2023-03-21 Oncotherapy Science, Inc. Urlc10-derived peptide and vaccine containing same
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AU2017326338A1 (en) 2016-09-15 2019-01-31 Augmenta Bioworks, Inc. Immune repertoire sequence amplification methods and applications
CA3071799C (en) * 2017-07-31 2022-12-13 The University Of Tokyo Super versatile method for presenting cyclic peptide motif on protein structure
IL321773A (en) 2017-10-14 2025-08-01 Cytomx Therapeutics Inc Activatable antibodies and methods for preparing them
WO2019104529A1 (zh) * 2017-11-29 2019-06-06 深圳琅技生命科技有限公司 均相检测方法
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US12460317B2 (en) 2019-05-20 2025-11-04 The Texas A&M University System Genetically encoded, phage-displayed cyclic peptide library and methods of making the same
CN111088254B (zh) * 2019-11-05 2021-11-23 中国农业科学院生物技术研究所 一种内源搭载的外源基因高效可控表达系统
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AU2021320360B2 (en) * 2020-08-05 2025-07-10 National Institute Of Advanced Industrial Science And Technology Method for screening for polypeptide that acts on target protein
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IT202300021963A1 (it) 2023-10-20 2025-04-20 Univ Ca Foscari Di Venezia Librerie peptidiche in lievito

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Also Published As

Publication number Publication date
WO2005047461A3 (en) 2006-05-11
JP4809767B2 (ja) 2011-11-09
EP1668114B1 (de) 2009-11-04
US20050196406A1 (en) 2005-09-08
US10544410B2 (en) 2020-01-28
US20200318099A1 (en) 2020-10-08
WO2005047461A2 (en) 2005-05-26
US20100113303A1 (en) 2010-05-06
US8361933B2 (en) 2013-01-29
EP1668114A2 (de) 2006-06-14
US20220119802A1 (en) 2022-04-21
US20070099247A1 (en) 2007-05-03
US7612019B2 (en) 2009-11-03
EP1668114A4 (de) 2007-02-28
JP2007513602A (ja) 2007-05-31
US10041063B2 (en) 2018-08-07
US7256038B2 (en) 2007-08-14
US20160032279A1 (en) 2016-02-04
US20190264194A1 (en) 2019-08-29
US9134309B2 (en) 2015-09-15
US11078479B2 (en) 2021-08-03
DE602004023956D1 (de) 2009-12-17
US20130210673A1 (en) 2013-08-15

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