ATE447967T1 - Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung - Google Patents
Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendungInfo
- Publication number
- ATE447967T1 ATE447967T1 AT02777600T AT02777600T ATE447967T1 AT E447967 T1 ATE447967 T1 AT E447967T1 AT 02777600 T AT02777600 T AT 02777600T AT 02777600 T AT02777600 T AT 02777600T AT E447967 T1 ATE447967 T1 AT E447967T1
- Authority
- AT
- Austria
- Prior art keywords
- vlps
- cpg
- antigens
- virus
- particles
- Prior art date
Links
- 230000003308 immunostimulating effect Effects 0.000 title abstract 2
- 239000002245 particle Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000004806 packaging method and process Methods 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 230000005867 T cell response Effects 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31899401P | 2001-09-14 | 2001-09-14 | |
| US37414502P | 2002-04-22 | 2002-04-22 | |
| PCT/IB2002/004132 WO2003024481A2 (en) | 2001-09-14 | 2002-09-16 | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE447967T1 true ATE447967T1 (de) | 2009-11-15 |
Family
ID=26981773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02777600T ATE447967T1 (de) | 2001-09-14 | 2002-09-16 | Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20030099668A1 (de) |
| EP (2) | EP1450856B1 (de) |
| JP (2) | JP4516748B2 (de) |
| CN (1) | CN1599623B (de) |
| AT (1) | ATE447967T1 (de) |
| AU (2) | AU2002339224B2 (de) |
| CA (1) | CA2492826C (de) |
| CY (1) | CY1110585T1 (de) |
| DE (1) | DE60234375D1 (de) |
| DK (1) | DK1450856T3 (de) |
| ES (1) | ES2335979T3 (de) |
| WO (1) | WO2003024481A2 (de) |
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- 2002-09-16 DK DK02777600.4T patent/DK1450856T3/da active
- 2002-09-16 JP JP2003528575A patent/JP4516748B2/ja not_active Expired - Lifetime
- 2002-09-16 DE DE60234375T patent/DE60234375D1/de not_active Expired - Lifetime
- 2002-09-16 AU AU2002339224A patent/AU2002339224B2/en not_active Expired
- 2002-09-16 ES ES02777600T patent/ES2335979T3/es not_active Expired - Lifetime
- 2002-09-16 EP EP09014047A patent/EP2196217A1/de not_active Withdrawn
- 2002-09-16 WO PCT/IB2002/004132 patent/WO2003024481A2/en not_active Ceased
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- 2002-09-16 CN CN028179358A patent/CN1599623B/zh not_active Expired - Lifetime
- 2002-09-16 AT AT02777600T patent/ATE447967T1/de active
- 2002-09-16 US US10/244,065 patent/US20030099668A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| CN1599623A (zh) | 2005-03-23 |
| CN1599623B (zh) | 2011-05-11 |
| EP2196217A1 (de) | 2010-06-16 |
| JP2009197001A (ja) | 2009-09-03 |
| JP4516748B2 (ja) | 2010-08-04 |
| US9950055B2 (en) | 2018-04-24 |
| AU2002339224B2 (en) | 2008-10-09 |
| EP1450856A2 (de) | 2004-09-01 |
| US20030099668A1 (en) | 2003-05-29 |
| AU2009200115B2 (en) | 2012-05-03 |
| CA2492826A1 (en) | 2003-03-27 |
| DK1450856T3 (da) | 2010-05-31 |
| JP2005517632A (ja) | 2005-06-16 |
| EP1450856B1 (de) | 2009-11-11 |
| AU2009200115A1 (en) | 2009-02-05 |
| CA2492826C (en) | 2016-12-13 |
| US20150030620A1 (en) | 2015-01-29 |
| WO2003024481A3 (en) | 2004-06-03 |
| DE60234375D1 (de) | 2009-12-24 |
| US8691209B2 (en) | 2014-04-08 |
| CY1110585T1 (el) | 2015-04-29 |
| WO2003024481A2 (en) | 2003-03-27 |
| US20120301499A1 (en) | 2012-11-29 |
| JP4749475B2 (ja) | 2011-08-17 |
| ES2335979T3 (es) | 2010-04-07 |
| HK1067058A1 (en) | 2005-04-01 |
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