ATE448231T1 - Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen - Google Patents

Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen

Info

Publication number
ATE448231T1
ATE448231T1 AT07751984T AT07751984T ATE448231T1 AT E448231 T1 ATE448231 T1 AT E448231T1 AT 07751984 T AT07751984 T AT 07751984T AT 07751984 T AT07751984 T AT 07751984T AT E448231 T1 ATE448231 T1 AT E448231T1
Authority
AT
Austria
Prior art keywords
products
alpha
morphinan
beta
unsaturated ketone
Prior art date
Application number
AT07751984T
Other languages
English (en)
Inventor
Henry Buehler
William Dummitt
Anthony Mannino
Dennis Aubuchon
Hong Gu
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38326629&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE448231(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE448231T1 publication Critical patent/ATE448231T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT07751984T 2006-03-02 2007-03-02 Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen ATE448231T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77825806P 2006-03-02 2006-03-02
PCT/US2007/005256 WO2007103105A2 (en) 2006-03-02 2007-03-02 Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds

Publications (1)

Publication Number Publication Date
ATE448231T1 true ATE448231T1 (de) 2009-11-15

Family

ID=38326629

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07751984T ATE448231T1 (de) 2006-03-02 2007-03-02 Verfahren zur herstellung von morphinan-6-on- produkten mit geringen konzentrationen von alpha-,beta-ungesättigten ketonverbindungen

Country Status (10)

Country Link
US (8) US8871779B2 (de)
EP (1) EP1994034B1 (de)
JP (2) JP5695296B2 (de)
CN (1) CN101395159A (de)
AT (1) ATE448231T1 (de)
AU (1) AU2007224221B2 (de)
CA (1) CA2644095A1 (de)
DE (1) DE602007003197D1 (de)
MX (1) MX2008010921A (de)
WO (1) WO2007103105A2 (de)

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EP2588481B1 (de) 2010-07-02 2017-11-15 Johnson Matthey Public Limited Company Verfahren für die synthese und reinigung von oxycodon
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CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
PL2736497T3 (pl) 2011-07-29 2018-01-31 Gruenenthal Gmbh Tabletka odporna na ingerencję, zapewniająca natychmiastowe uwalnianie leku
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US10624862B2 (en) 2013-07-12 2020-04-21 Grünenthal GmbH Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
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JP2017502991A (ja) 2014-01-15 2017-01-26 ローズ テクノロジーズ 改良されたオキシコドン合成のための方法
US20150320690A1 (en) 2014-05-12 2015-11-12 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
EP3148512A1 (de) 2014-05-26 2017-04-05 Grünenthal GmbH Gegen entsorgung von ethanolischer dosis gesicherte mehrfachpartikel
MA40332A (fr) * 2014-07-09 2021-04-28 Rhodes Tech Réduction des niveaux de cétone alpha, beta-insaturée dans des compositions de dérivés de morphinane
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Also Published As

Publication number Publication date
DE602007003197D1 (de) 2009-12-24
JP5695296B2 (ja) 2015-04-01
JP2009528366A (ja) 2009-08-06
WO2007103105A3 (en) 2007-11-22
EP1994034B1 (de) 2009-11-11
CN101395159A (zh) 2009-03-25
US8748611B2 (en) 2014-06-10
US8871779B2 (en) 2014-10-28
AU2007224221A1 (en) 2007-09-13
US20220079938A1 (en) 2022-03-17
US20190381033A1 (en) 2019-12-19
CA2644095A1 (en) 2007-09-13
US20120059167A1 (en) 2012-03-08
US20150148365A1 (en) 2015-05-28
EP1994034A2 (de) 2008-11-26
US20200338068A1 (en) 2020-10-29
WO2007103105A2 (en) 2007-09-13
US20160243113A1 (en) 2016-08-25
US20080312442A1 (en) 2008-12-18
US20180008596A1 (en) 2018-01-11
JP2013173765A (ja) 2013-09-05
MX2008010921A (es) 2008-09-03
AU2007224221B2 (en) 2013-02-14

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