ATE448258T1 - Befestigung von molekülen auf oberflächen - Google Patents

Befestigung von molekülen auf oberflächen

Info

Publication number
ATE448258T1
ATE448258T1 AT04789464T AT04789464T ATE448258T1 AT E448258 T1 ATE448258 T1 AT E448258T1 AT 04789464 T AT04789464 T AT 04789464T AT 04789464 T AT04789464 T AT 04789464T AT E448258 T1 ATE448258 T1 AT E448258T1
Authority
AT
Austria
Prior art keywords
present
relates
molecules
attachment
methods
Prior art date
Application number
AT04789464T
Other languages
English (en)
Inventor
Ronald Ofstead
Melvin Swanson
Dale Swan
Original Assignee
Surmodics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surmodics Inc filed Critical Surmodics Inc
Application granted granted Critical
Publication of ATE448258T1 publication Critical patent/ATE448258T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
    • C08F2800/10—Copolymer characterised by the proportions of the comonomers expressed as molar percentages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
    • C08F2800/20—Copolymer characterised by the proportions of the comonomers expressed as weight or mass percentages
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Laminated Bodies (AREA)
  • Paints Or Removers (AREA)
AT04789464T 2003-10-01 2004-09-30 Befestigung von molekülen auf oberflächen ATE448258T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/677,022 US7309593B2 (en) 2003-10-01 2003-10-01 Attachment of molecules to surfaces
PCT/US2004/032443 WO2005033158A2 (en) 2003-10-01 2004-09-30 Attachment of molecules to surfaces

Publications (1)

Publication Number Publication Date
ATE448258T1 true ATE448258T1 (de) 2009-11-15

Family

ID=34393654

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04789464T ATE448258T1 (de) 2003-10-01 2004-09-30 Befestigung von molekülen auf oberflächen

Country Status (8)

Country Link
US (3) US7309593B2 (de)
EP (1) EP1668050B1 (de)
JP (1) JP4741499B2 (de)
AT (1) ATE448258T1 (de)
AU (1) AU2004278408B2 (de)
CA (1) CA2536303C (de)
DE (1) DE602004024095D1 (de)
WO (1) WO2005033158A2 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6433154B1 (en) * 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
AU2001261625B2 (en) 2000-05-16 2006-04-06 Regents Of The University Of Minnesota High mass throughput particle generation using multiple nozzle spraying
US7247338B2 (en) * 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
JP4630817B2 (ja) * 2003-03-31 2011-02-09 独立行政法人理化学研究所 物質固定化剤、それを用いた物質固定化方法及びそれを用いた物質固定化基体
US7309593B2 (en) * 2003-10-01 2007-12-18 Surmodics, Inc. Attachment of molecules to surfaces
DE602005016402D1 (de) 2004-05-24 2009-10-15 Genvault Corp Stabile lagerung von protein und stabile lagerung von nukleinsäure in wiedergewinnbarer form
US7846676B2 (en) * 2004-07-19 2010-12-07 Cell Biosciences, Inc. Methods and devices for analyte detection
US7935479B2 (en) 2004-07-19 2011-05-03 Cell Biosciences, Inc. Methods and devices for analyte detection
EP1776581B1 (de) * 2004-07-19 2015-05-06 ProteinSimple Verfahren zum Nachweis von Proteinen
EP1872139A2 (de) 2005-04-09 2008-01-02 Cell Biosciences, Inc. Automatisches mikrovolumen-assaysystem
WO2007035864A2 (en) 2005-09-20 2007-03-29 Cell Biosciences, Inc. Electrophoresis standards, methods and kits
US8117902B2 (en) * 2005-11-03 2012-02-21 University Of Massachusetts Nanopatterned surfaces and related methods for selective adhesion, sensing and separation
CN1962155A (zh) * 2005-11-10 2007-05-16 鸿富锦精密工业（深圳）有限公司 一种二氧化碳激光焊接装置
US9108217B2 (en) 2006-01-31 2015-08-18 Nanocopoeia, Inc. Nanoparticle coating of surfaces
WO2007089883A2 (en) * 2006-01-31 2007-08-09 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US7951428B2 (en) * 2006-01-31 2011-05-31 Regents Of The University Of Minnesota Electrospray coating of objects
US20080017512A1 (en) * 2006-07-24 2008-01-24 Bordunov Andrei V Coatings for capillaries capable of capturing analytes
US9040816B2 (en) * 2006-12-08 2015-05-26 Nanocopoeia, Inc. Methods and apparatus for forming photovoltaic cells using electrospray
JP5423965B2 (ja) * 2007-05-30 2014-02-19 Ｊｓｒ株式会社 非特異吸着防止剤
US20090022805A1 (en) * 2007-06-28 2009-01-22 Joram Slager Polypeptide microparticles having sustained release characteristics, methods and uses
US20100209957A1 (en) * 2008-06-20 2010-08-19 Genvault Corporation Biosample storage devices and methods of use thereof
US8382858B2 (en) 2008-06-25 2013-02-26 University Of Massachusetts Nanoparticle-textured surfaces and related methods for selective adhesion, sensing and separation
WO2010031007A2 (en) 2008-09-12 2010-03-18 Genvault Corporation Matrices and media for storage and stabilization of biomolecules
CN102427834A (zh) 2009-04-28 2012-04-25 苏尔莫迪克斯公司 用于递送生物活性剂的装置和方法
WO2011072199A2 (en) * 2009-12-10 2011-06-16 Surmodics, Inc. Water-soluble degradable photo-crosslinker
US10315987B2 (en) 2010-12-13 2019-06-11 Surmodics, Inc. Photo-crosslinker
US9861814B2 (en) 2010-12-23 2018-01-09 Medtronic, Inc. Medical electrical lead having biological surface and methods of making and using same
HUE041353T2 (hu) 2011-02-15 2019-05-28 Elanco Us Inc Eljárás fájdalom csillapítására kutyafélékben fentanil transzdermális oldatának alkalmazásával
US9757497B2 (en) 2011-05-20 2017-09-12 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
US10213529B2 (en) 2011-05-20 2019-02-26 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
US9861727B2 (en) 2011-05-20 2018-01-09 Surmodics, Inc. Delivery of hydrophobic active agent particles
EP2724163B1 (de) * 2011-06-24 2017-08-09 The Regents of The University of California Mikrofluidische vorrichtungen und verfahren zur trennung und detektion von komponenten einer flüssigkeitsprobe
WO2013123409A1 (en) 2012-02-17 2013-08-22 NVS Technologies, Inc. Polymer scaffolds for assay applications
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
SG11201502786TA (en) * 2012-10-12 2015-05-28 Nvs Technologies Inc Polymers having orthogonal reactive groups and uses thereof
US11246963B2 (en) 2012-11-05 2022-02-15 Surmodics, Inc. Compositions and methods for delivery of hydrophobic active agents
EP2914297B1 (de) 2012-11-05 2019-01-09 SurModics, Inc. Zusammensetzung und verfahren zur freisetzung von hydrophoben wirkstoffen
EP2965083B1 (de) 2013-03-07 2019-07-03 The Regents of The University of California Elektrophoretische trennvorrichtungen und verfahren zur verwendung davon
JP2016517465A (ja) * 2013-03-14 2016-06-16 エヌブイエス テクノロジーズ，インコーポレイティド 生体分子を封鎖するための表面酸化および関連する方法
WO2016123480A1 (en) 2015-01-29 2016-08-04 Surmodics, Inc. Delivery of hydrophobic active agent particles
US10478546B2 (en) 2015-09-15 2019-11-19 Surmodics, Inc. Hemodialysis catheter sleeve
US10377928B2 (en) 2015-12-10 2019-08-13 Ppg Industries Ohio, Inc. Structural adhesive compositions
US10918835B2 (en) 2016-03-31 2021-02-16 Surmodics, Inc. Delivery system for active agent coated balloon
US10806904B2 (en) 2016-03-31 2020-10-20 Surmodics, Inc. Two-part insertion tool and methods
US20170281914A1 (en) 2016-03-31 2017-10-05 Surmodics, Inc. Localized treatment of tissues through transcatheter delivery of active agents
US10391292B2 (en) 2016-06-15 2019-08-27 Surmodics, Inc. Hemostasis sealing device with constriction ring
AU2017325722B2 (en) 2016-09-16 2023-11-30 Surmodics, Inc. Lubricious insertion tools for medical devices and methods for using
US10758719B2 (en) 2016-12-15 2020-09-01 Surmodics, Inc. Low-friction sealing devices
US10898446B2 (en) 2016-12-20 2021-01-26 Surmodics, Inc. Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces
US12226552B2 (en) 2019-09-30 2025-02-18 Surmodics, Inc. Active agent depots formed in situ
TWI899211B (zh) 2020-04-17 2025-10-01 小利蘭史丹佛大學董事會 用於生物醫藥調配物之聚合物賦形劑
WO2022147139A1 (en) 2020-12-30 2022-07-07 10X Genomics, Inc. Methods and compositions for light-controlled surface patterning using a polymer
EP4271511B1 (de) 2020-12-30 2024-10-09 10X Genomics, Inc. Erzeugung einer molekülmatrix unter verwendung von fotoresist
US20220228201A1 (en) 2020-12-30 2022-07-21 10X Genomics, Inc. Molecular arrays and methods for generating and using the arrays
CN117999086A (zh) * 2021-05-24 2024-05-07 普利纳斯技术公司 使用dna酶的治疗方案
WO2023211937A1 (en) 2022-04-25 2023-11-02 Surmodics, Inc. Medical device coatings with microcrystalline active agents
TW202410920A (zh) 2022-05-23 2024-03-16 小利蘭史丹佛大學董事會 包括聚合物賦形劑之抗體生物醫藥調配物
US20240076656A1 (en) 2022-06-29 2024-03-07 10X Genomics, Inc. High definition molecular array feature generation using photoresist
WO2024006799A1 (en) 2022-06-29 2024-01-04 10X Genomics, Inc. Covalent attachment of splint oligonucleotides for molecular array generation using ligation
US20240060127A1 (en) 2022-06-29 2024-02-22 10X Genomics, Inc. Methods and systems for light-controlled surface patterning using photomasks
WO2025090490A1 (en) * 2023-10-24 2025-05-01 Promega Corporation Polymers, compositions, and methods for isolation of nucleic acids
WO2025101377A1 (en) 2023-11-09 2025-05-15 10X Genomics, Inc. Matrix-assisted spatial analysis of biological samples
DE102023136339A1 (de) 2023-12-21 2025-06-26 Schott Technical Glass Solutions Gmbh Verfahren und Beschichtungssystem zur Immobilisierung von Biomolekülen

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073484A (en) * 1982-03-09 1991-12-17 Bio-Metric Systems, Inc. Quantitative analysis apparatus and method
US5002582A (en) * 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US4722906A (en) * 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US5217492A (en) * 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US5512329A (en) * 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
US4542102A (en) * 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4582860A (en) * 1983-12-15 1986-04-15 Rohm And Haas Company Oxirane resins for enzyme immobilization
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
WO1991016425A1 (de) 1990-04-12 1991-10-31 Hans Sigrist Verfahren zur lichtinduzierten immobilisierung von biomolekülen an chemisch 'inerten' oberflächen
FR2679255B1 (fr) * 1991-07-17 1993-10-22 Bio Merieux Procede d'immobilisation d'un fragment nucleique par fixation passive sur un support solide, support solide ainsi obtenu et son utilisation.
EP0585436B1 (de) * 1992-02-13 2000-05-03 SurModics, Inc. Immobilisierung eines chemischen spezies in einer vernetzten matrix
US5512474A (en) * 1992-05-29 1996-04-30 Bsi Corporation Cell culture support containing a cell adhesion factor and a positively-charged molecule
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification
CA2154444A1 (en) * 1993-01-21 1994-08-04 John F. W. Keana Chemical functionalization of surfaces
US5610287A (en) * 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US5643580A (en) * 1994-10-17 1997-07-01 Surface Genesis, Inc. Biocompatible coating, medical device using the same and methods
US5707818A (en) * 1994-12-13 1998-01-13 Bsi Corporation Device and method for simultaneously performing multiple competitive immunoassays
CA2222136C (en) * 1995-05-26 2005-04-05 Bsi Corporation Method and implantable article for promoting endothelialization
US5783502A (en) * 1995-06-07 1998-07-21 Bsi Corporation Virus inactivating coatings
DE19533682A1 (de) * 1995-09-12 1997-03-13 Biotronik Mess & Therapieg Verfahren zum Anlagern und Immobilisieren von Heparin auf anorganischen Substratoberflächen von kardiovaskulären Implantanten
US5714360A (en) * 1995-11-03 1998-02-03 Bsi Corporation Photoactivatable water soluble cross-linking agents containing an onium group
US5942555A (en) * 1996-03-21 1999-08-24 Surmodics, Inc. Photoactivatable chain transfer agents and semi-telechelic photoactivatable polymers prepared therefrom
US6057100A (en) * 1996-06-07 2000-05-02 Eos Biotechnology, Inc. Oligonucleotide arrays
US5981734A (en) * 1997-07-17 1999-11-09 University Of Chicago Methods for immobilizing nucleic acids on a gel substrate
US5858653A (en) * 1997-09-30 1999-01-12 Surmodics, Inc. Reagent and method for attaching target molecules to a surface
US6465178B2 (en) 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
DE19804518C2 (de) 1998-02-05 2000-10-05 Roehm Gmbh Verfahren zur Herstellung von perlförmigen Mischpolymerisaten auf Acrylatbasis, danach hergestellte Trägerpolymermaterialien und deren Verwendung
US6410044B1 (en) * 1998-03-19 2002-06-25 Surmodics, Inc. Crosslinkable macromers
US6376619B1 (en) 1998-04-13 2002-04-23 3M Innovative Properties Company High density, miniaturized arrays and methods of manufacturing same
AU3628999A (en) 1998-05-08 1999-11-29 Kyowa Medex Co., Ltd. Method for quantitating specific gene sequence and quantitating reagent
US6254634B1 (en) * 1998-06-10 2001-07-03 Surmodics, Inc. Coating compositions
JP4560260B2 (ja) * 1999-07-01 2010-10-13 旭化成ケミカルズ株式会社 低分子量オキシメチレン重合体及びその組成物
DE60027309T2 (de) 1999-07-02 2006-08-31 Symyx Technologies, Inc., Santa Clara Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen
US6250044B1 (en) * 2000-01-13 2001-06-26 Kohler Co. Shower door bar with recessed grip
US6410643B1 (en) * 2000-03-09 2002-06-25 Surmodics, Inc. Solid phase synthesis method and reagent
AU2002368411A1 (en) 2002-11-29 2004-06-23 Marcella Chiari Method for immobilizing biologic molecules on solid surfaces
US7820158B2 (en) 2003-04-10 2010-10-26 Surmodics, Inc. Ligand-coupled initiator polymers and methods of use
US7309593B2 (en) * 2003-10-01 2007-12-18 Surmodics, Inc. Attachment of molecules to surfaces

Also Published As

Publication number Publication date
EP1668050B1 (de) 2009-11-11
CA2536303C (en) 2014-11-18
US7309593B2 (en) 2007-12-18
WO2005033158A2 (en) 2005-04-14
US7829317B2 (en) 2010-11-09
US8129159B2 (en) 2012-03-06
US20050074478A1 (en) 2005-04-07
DE602004024095D1 (de) 2009-12-24
EP1668050A2 (de) 2006-06-14
WO2005033158A3 (en) 2005-06-02
AU2004278408A1 (en) 2005-04-14
US20090042742A1 (en) 2009-02-12
JP2007510889A (ja) 2007-04-26
AU2004278408B2 (en) 2009-12-03
CA2536303A1 (en) 2005-04-14
US20110009292A1 (en) 2011-01-13
JP4741499B2 (ja) 2011-08-03

Similar Documents

Publication Publication Date Title
ATE448258T1 (de) Befestigung von molekülen auf oberflächen
DE60328885D1 (de) Verfahren zur Beurteilung eines Krankheitzustandes mittels Nachweis von partikel- und nicht partikelgebundenen Nukleinsäuren in Blutplasma und -serum
DE69739898D1 (de) Tests auf proteinkinasen mit fluoreszierenden proteinsubstraten
ATE202148T1 (de) Verfahren zur entdeckung von liganden
DE19782097T1 (de) Zusammensetzungen und Verfahren zur Immobilisierung von Nucleinsäuren an feste Träger
DE59906513D1 (de) Verfahren zur vernetzung von hydrogelen mit bis- und poly-2-oxazolidinonen
DE60300734D1 (de) Anordnungen zur Vorbehandlung von Proben
WO1998031839A3 (en) Electronic-property probing of biological molecules at surfaces
ATE530633T1 (de) Verfahren und vorrichtung zur bildung von biologischem zellmaterial
DE60137203D1 (de) Poröse ferro- oder ferrimagnetische glasteilchen für molekültrennung
ATE515488T1 (de) Click-chemie zur herstellung von reportermolekülen
NO20054790L (no) Anvendelse av B7-113 som et immunoregulatorisk middel
ATE466283T1 (de) Zentrifugalvorrichtung und verfahren zur durchführung von bindungsversuchen
ATE402198T1 (de) Verfahren zur immobilisierung biologischer moleküle an feste oberflächen
DE602006011525D1 (de) Verfahren zur Isolierung von Nukleinsäuren mit bifunktionalen Material mit Amino- und Carboxylgruppen
DE602004002271D1 (de) Biologischer abbau von oxyanionen-wie perchlorat an ionenaustauscherharzen
ATE457799T1 (de) Verfahren und vorrichtungen, die die adsorption von chiralen molekülen an einer oberfläche oder grenzfläche verwendenden
ATE340634T1 (de) Verfahren zur verringerung einer adsorptionsneigung von molekülen oder biologischen zellen an einer materialoberfläche
AU2002229977A1 (en) Biochemical method and apparatus for detecting genetic characteristics
WO2009026546A3 (en) Methods of modifying support surfaces for the immobilization of particles and the use of the immobilized particles for analyzing nucleic acids
DE602005017252D1 (de) Verfahren zur amplifikation von nukleinsäuren mittels promotor-templates
ATE359512T1 (de) Biochemisches verfahren und vorrichtung zur bestimmung von eigenschaften von proteinen
DE60239808D1 (de) Verfahren zur isomerisierung von c5-c8 kohlenwasserstofffreaktionen mit zwei parallelreaktoren
WO2007112007A3 (en) Immobilized proteins and methods and uses thereof
ATE368451T1 (de) Verfahren zum überziehen von feststoffteilchen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties