ATE449861T1 - Verfahren zur fermentativen herstellung von heterologen genprodukten in milchsäurebakterien - Google Patents

Verfahren zur fermentativen herstellung von heterologen genprodukten in milchsäurebakterien

Info

Publication number
ATE449861T1
ATE449861T1 AT01978228T AT01978228T ATE449861T1 AT E449861 T1 ATE449861 T1 AT E449861T1 AT 01978228 T AT01978228 T AT 01978228T AT 01978228 T AT01978228 T AT 01978228T AT E449861 T1 ATE449861 T1 AT E449861T1
Authority
AT
Austria
Prior art keywords
lactic acid
acid bacteria
heterologue
gene products
fermentative production
Prior art date
Application number
AT01978228T
Other languages
English (en)
Inventor
Astrid Vrang
Soeren Madsen
Lars Bredmose
Peter Ravn
Jose Arnau
Mads Johnsen
Anne Steenberg
Hans Israelsen
Original Assignee
Bioneer As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioneer As filed Critical Bioneer As
Application granted granted Critical
Publication of ATE449861T1 publication Critical patent/ATE449861T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT01978228T 2000-10-20 2001-10-19 Verfahren zur fermentativen herstellung von heterologen genprodukten in milchsäurebakterien ATE449861T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69220500A 2000-10-20 2000-10-20
PCT/DK2001/000693 WO2002033109A2 (en) 2000-10-20 2001-10-19 Fermentation method for production of heterologous gene products in lactic acid bacteria

Publications (1)

Publication Number Publication Date
ATE449861T1 true ATE449861T1 (de) 2009-12-15

Family

ID=24779648

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01978228T ATE449861T1 (de) 2000-10-20 2001-10-19 Verfahren zur fermentativen herstellung von heterologen genprodukten in milchsäurebakterien

Country Status (12)

Country Link
US (1) US7358067B2 (de)
EP (1) EP1356073B1 (de)
JP (1) JP4399158B2 (de)
AT (1) ATE449861T1 (de)
AU (2) AU1040102A (de)
CA (1) CA2426084C (de)
DE (1) DE60140626D1 (de)
DK (1) DK1356073T3 (de)
ES (1) ES2336647T3 (de)
NZ (1) NZ525394A (de)
PT (1) PT1356073E (de)
WO (1) WO2002033109A2 (de)

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GB9521568D0 (en) * 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
EP1239032A1 (de) * 2001-03-02 2002-09-11 Société des Produits Nestlé S.A. Milchsäurebakterien als Mitteln zur Behandlung und Vorbeugung von Allergie
US7780961B2 (en) * 2001-05-03 2010-08-24 Actogenix N.V. Self-containing Lactococcus strain
CA2506031A1 (en) * 2002-11-15 2004-06-03 Vib Vzw Self-containing lactobacillus strain comprising a thya mutation and therapeutic applications thereof
US7842289B2 (en) 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
WO2005071088A2 (en) * 2003-12-24 2005-08-04 Cerus Corporation Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof
JP2009505652A (ja) * 2005-08-26 2009-02-12 セレニス セラピューティクス ホールディング エスア 乳酸菌においてアポリポタンパク質遺伝子生成物を生成するための組成物および方法
GB0522303D0 (en) * 2005-11-01 2005-12-07 Chiron Srl Culture method
AU2006319216B2 (en) 2005-11-29 2012-09-13 Intrexon Actobiotics Nv Induction of mucosal tolerance to antigens
EP1984514A4 (de) * 2006-01-27 2010-09-01 Univ Massachusetts Systeme und verfahren zur herstellung von biokraftstoffen und entsprechende materialien
US7935804B2 (en) 2006-03-01 2011-05-03 Aduro Biotech Engineered Listeria and methods of use thereof
ES2595729T3 (es) * 2007-01-12 2017-01-03 Intrexon Actobiotics Nv Promotores de Lactococcus y usos de los mismos
EP3351268B1 (de) 2007-01-25 2020-08-05 Intrexon Actobiotics NV Behandlung von immunerkrankungen durch mukosale abgabe von antigenen
JP5576115B2 (ja) * 2007-04-26 2014-08-20 中外製薬株式会社 高濃度アミノ酸含有培地を用いた細胞の培養方法
AU2009219150A1 (en) * 2008-02-27 2009-09-03 Qteros, Inc. Methods for the conversion of plant materials into fuels and chemicals by sequential action of two microorganisms
US20090286294A1 (en) * 2008-04-04 2009-11-19 University Of Massachusetts Methods and Compositions for Improving the Production of Fuels in Microorganisms
US20100105114A1 (en) * 2008-06-11 2010-04-29 University Of Massachusetts Methods and Compositions for Regulating Sporulation
NZ591781A (en) * 2008-09-08 2013-01-25 Jurag Separation As Process for controlling the ph and level of target ions of a liquid composition
US20100086981A1 (en) * 2009-06-29 2010-04-08 Qteros, Inc. Compositions and methods for improved saccharification of biomass
EP2421984A1 (de) * 2009-04-20 2012-02-29 Qteros, Inc. Zusammensetzungen und verfahren zur fermentation von biomasse
EP2275527A1 (de) 2009-07-17 2011-01-19 ActoGeniX NV Kulturmedium zur Fermentation von Bakterien welches frei von tierischen Bestandteilen ist
CN104928336B (zh) 2009-10-26 2020-05-08 弗·哈夫曼-拉罗切有限公司 用于生产糖基化免疫球蛋白的方法
WO2011081658A2 (en) * 2009-12-15 2011-07-07 Qteros, Inc. Methods and compositions for producing chemical products from c. phytofermentants
GB2478791A (en) * 2010-03-19 2011-09-21 Qteros Inc Ethanol production by genetically-modified bacteria
WO2012045769A1 (en) 2010-10-05 2012-04-12 Novo Nordisk Health Care Ag Process for protein production
JP5979684B2 (ja) * 2011-12-15 2016-08-24 セラム インスティチュート オブ インディア プライベイト リミテッド 莢膜多糖の収量向上のための細菌培養方法
EP4276180B1 (de) 2012-01-12 2026-04-22 Endo Biologics Limited Clostridium histolyticum enzym
BR112015032960B1 (pt) 2013-07-04 2021-01-05 F. Hoffmann-La Roche Ag imunoensaio suprimido por interferência para detectar anticorpos anti-fármaco em amostras de soro
CN104988107B (zh) * 2015-05-19 2018-06-08 中国农业科学院兰州兽医研究所 一种高效表达口蹄疫病毒抗原基因的重组乳酸杆菌及其制备方法和应用
US11473074B2 (en) 2017-03-28 2022-10-18 Endo Global Aesthetics Limited Method of producing collagenase
KR101915950B1 (ko) * 2018-01-09 2018-11-07 주식회사 쎌바이오텍 시스타틴을 발현 및 분비하는 위장관 질환 치료 약물 전달용 미생물 및 그를 포함하는 위장관 질환 예방 또는 치료용 약제학적 조성물
KR101915951B1 (ko) * 2018-01-09 2018-11-07 주식회사 쎌바이오텍 P8 단백질을 발현 및 분비하는 위장관 질환 치료 약물 전달용 미생물 및 그를 포함하는 위장관 질환 예방 또는 치료용 약제학적 조성물
KR102281858B1 (ko) 2019-09-11 2021-07-26 주식회사 쎌바이오텍 유산균 유래 p8 단백질의 발현 컨스트럭트를 포함하는 대장 질환의 치료 또는 예방용 조성물
CN111254103B (zh) * 2019-11-19 2023-06-02 河南省生物工程技术研究中心 一种非洲猪瘟基因工程疫苗高密度发酵补料培养基及发酵工艺
CN112813085B (zh) * 2021-03-05 2023-03-31 昆明理工大学 焦磷酸酶基因的用途
CN112795527A (zh) * 2021-03-05 2021-05-14 昆明理工大学 二氢蝶呤醛缩酶基因的用途
CN115343746A (zh) * 2022-05-09 2022-11-15 浙江省肿瘤医院 一种测量工业辐照剂量二维分布的方法和胶片

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PT677110E (pt) 1992-12-30 2005-05-31 Chr Hansen As Bacteria lactica recombinante contendo um promotor inserido
NZ334521A (en) 1996-09-06 2000-03-27 Bioteknologisk Inst A lactic acid bacterial regulatable expression system
CA2381184C (en) 1999-08-06 2011-08-02 Bioteknologisk Institut Method of isolating secretion signals in lactic acid bacteria and novel secretion signals isolated from lactococcus lactis

Also Published As

Publication number Publication date
CA2426084C (en) 2013-12-10
US20020137140A1 (en) 2002-09-26
JP2004511248A (ja) 2004-04-15
CA2426084A1 (en) 2002-04-25
NZ525394A (en) 2005-12-23
DK1356073T3 (da) 2010-04-06
AU1040102A (en) 2002-04-29
EP1356073B1 (de) 2009-11-25
JP4399158B2 (ja) 2010-01-13
DE60140626D1 (de) 2010-01-07
US7358067B2 (en) 2008-04-15
ES2336647T3 (es) 2010-04-15
AU2002210401B2 (en) 2006-07-20
PT1356073E (pt) 2010-02-15
WO2002033109A2 (en) 2002-04-25
WO2002033109A3 (en) 2003-09-04
EP1356073A2 (de) 2003-10-29

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