ATE450274T1 - Konjugate von n-hydroxypropymethacrylamid- methacrylat-copolymeren mit nuklidaktivierungsagentien und/oder antikrebs- verbindungen - Google Patents
Konjugate von n-hydroxypropymethacrylamid- methacrylat-copolymeren mit nuklidaktivierungsagentien und/oder antikrebs- verbindungenInfo
- Publication number
- ATE450274T1 ATE450274T1 AT03738319T AT03738319T ATE450274T1 AT E450274 T1 ATE450274 T1 AT E450274T1 AT 03738319 T AT03738319 T AT 03738319T AT 03738319 T AT03738319 T AT 03738319T AT E450274 T1 ATE450274 T1 AT E450274T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxypropymethacrylamide
- conjugates
- nuclide activation
- methacrylate copolymers
- anticancer compounds
- Prior art date
Links
- 230000004913 activation Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000001093 anti-cancer Effects 0.000 title abstract 2
- 229920001577 copolymer Polymers 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 4
- 125000005647 linker group Chemical group 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
- A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02255107 | 2002-07-22 | ||
| PCT/GB2003/002919 WO2004009136A2 (en) | 2002-07-22 | 2003-07-04 | Conjugates of n-hydroxypropymethacrylamide-methacrylate copolymer with nuclide activation agent and/or anti-cancer compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE450274T1 true ATE450274T1 (de) | 2009-12-15 |
Family
ID=30470320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03738319T ATE450274T1 (de) | 2002-07-22 | 2003-07-04 | Konjugate von n-hydroxypropymethacrylamid- methacrylat-copolymeren mit nuklidaktivierungsagentien und/oder antikrebs- verbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7662360B2 (de) |
| EP (1) | EP1534347B1 (de) |
| JP (1) | JP2006502993A (de) |
| CN (2) | CN1678353A (de) |
| AT (1) | ATE450274T1 (de) |
| AU (2) | AU2003250391A1 (de) |
| CA (1) | CA2493252A1 (de) |
| DE (1) | DE60330355D1 (de) |
| WO (2) | WO2004009136A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005115457A2 (en) * | 2004-05-10 | 2005-12-08 | University Of Utah Research Foundation | Combined active and passive targeting of biologically active agents |
| EP1797427A4 (de) * | 2004-09-22 | 2009-04-08 | Odyssey Thera Inc | Verfahren zur identifizierung neuer arzneimittel-leads und neuer therapeutischer verwendungen für bekannte arzneimittel |
| CA2739757C (en) * | 2008-10-07 | 2016-07-05 | Rexahn Pharmaceuticals, Inc. | Hpma - docetaxel or gemcitabine conjugates and uses therefore |
| WO2011008863A2 (en) * | 2009-07-14 | 2011-01-20 | Lucia Irene Gonzalez | Stereoisomer peptides and their polymer conjugates for hiv disease |
| CA2779290A1 (en) * | 2009-10-29 | 2011-05-19 | Lucia Irene Gonzalez | Ligand-targeted multi-stereoisomer peptide polymer conjugates and uses thereof |
| AU2012305327B2 (en) * | 2011-09-05 | 2016-07-14 | Hiroshi Maeda | Polymer-type fluorescent molecule probe |
| JP6253008B2 (ja) * | 2013-08-27 | 2017-12-27 | 国立大学法人 筑波大学 | 高分子化ホウ素化合物及びその使用 |
| JP6281991B2 (ja) * | 2014-04-11 | 2018-02-21 | 国立研究開発法人産業技術総合研究所 | ホウ素化合物を内包および外壁に担持するカーボンナノホーン及びその製造方法 |
| CZ308807B6 (cs) * | 2015-01-14 | 2021-06-02 | Ústav Organické Chemie A Biochemie Av Čr, V.V.I. | Makromolekulární konjugáty pro vizualizaci a separaci proteinů a buněk |
| CZ308742B6 (cs) * | 2015-01-14 | 2021-04-21 | Ústav Organické Chemie A Biochemie Av Čr, V.V.I. | Makromolekulární konjugáty pro izolaci, imobilizaci a vizualizaci proteinů |
| CN105503918A (zh) * | 2015-12-08 | 2016-04-20 | 南京林业大学 | 一种含二氧杂戊硼基卟啉锌配合物及其制备方法 |
| CN105777790B (zh) * | 2016-05-17 | 2017-11-14 | 南京远淑医药科技有限公司 | 一种邻碳硼烷苯酚衍生物及其制备方法和应用 |
| WO2018071767A1 (en) * | 2016-10-14 | 2018-04-19 | University Of Utah Research Foundation | Antibody-polymer-drug conjugates |
| CN107163097B (zh) * | 2017-04-20 | 2020-04-14 | 童永彭 | 环磷酸腺苷硼酸络合物及其制备方法，以及抗肿瘤药物和中子俘获治疗的硼剂 |
| WO2019163790A1 (ja) * | 2018-02-20 | 2019-08-29 | 国立大学法人東京工業大学 | ｐ－ボロノフェニルアラニン誘導体及びそれを含む組成物、並びにそれらを製造するためのキット |
| CN112334158B (zh) * | 2018-06-20 | 2023-10-13 | 国立大学法人弘前大学 | 用于硼中子俘获疗法的能够在短时间内选择性地或局部地靶向肿瘤组织的聚集性硼10药剂 |
| WO2020061430A1 (en) * | 2018-09-20 | 2020-03-26 | Glyscend, Inc. | Boronic acid polymers and methods of use |
| MX2022003384A (es) | 2019-09-20 | 2022-06-27 | Glyscend Inc | Polimeros que contienen acido fenil boronico sustituido y metodos de uso. |
| JP2021063033A (ja) * | 2019-10-11 | 2021-04-22 | 国立大学法人 東京大学 | 環状ペプチド |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5856551A (en) * | 1993-03-12 | 1999-01-05 | The Regents Of The University Of California | Macromolecular structure for boron neutron-capture therapy |
| US6180766B1 (en) | 1993-12-02 | 2001-01-30 | Raymond F. Schinazi | Nucleosides and oligonucleotides containing boron clusters |
| JPH07206690A (ja) * | 1994-01-14 | 1995-08-08 | Seitai Kagaku Kenkyusho:Kk | 癌治療薬およびその中間体 |
| US6017902A (en) | 1999-02-25 | 2000-01-25 | Brookhaven Science Associates | Boron containing amino acid compounds and methods for their use |
-
2003
- 2003-07-04 US US10/521,814 patent/US7662360B2/en not_active Expired - Fee Related
- 2003-07-04 JP JP2004522288A patent/JP2006502993A/ja active Pending
- 2003-07-04 WO PCT/GB2003/002919 patent/WO2004009136A2/en not_active Ceased
- 2003-07-04 WO PCT/GB2003/002898 patent/WO2004009135A2/en not_active Ceased
- 2003-07-04 EP EP03738319A patent/EP1534347B1/de not_active Expired - Lifetime
- 2003-07-04 CA CA002493252A patent/CA2493252A1/en not_active Abandoned
- 2003-07-04 CN CNA038207419A patent/CN1678353A/zh active Pending
- 2003-07-04 AU AU2003250391A patent/AU2003250391A1/en not_active Abandoned
- 2003-07-04 DE DE60330355T patent/DE60330355D1/de not_active Expired - Lifetime
- 2003-07-04 AT AT03738319T patent/ATE450274T1/de not_active IP Right Cessation
- 2003-07-04 CN CNA2009101184891A patent/CN101524549A/zh active Pending
- 2003-07-04 AU AU2003244843A patent/AU2003244843B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003244843B2 (en) | 2008-06-19 |
| AU2003250391A8 (en) | 2004-02-09 |
| CN1678353A (zh) | 2005-10-05 |
| DE60330355D1 (de) | 2010-01-14 |
| WO2004009135A2 (en) | 2004-01-29 |
| WO2004009136A2 (en) | 2004-01-29 |
| US7662360B2 (en) | 2010-02-16 |
| HK1077513A1 (en) | 2006-02-17 |
| CA2493252A1 (en) | 2004-01-29 |
| JP2006502993A (ja) | 2006-01-26 |
| AU2003244843A1 (en) | 2004-02-09 |
| EP1534347A2 (de) | 2005-06-01 |
| WO2004009136A3 (en) | 2004-04-08 |
| US20070258891A1 (en) | 2007-11-08 |
| WO2004009135A3 (en) | 2004-05-06 |
| CN101524549A (zh) | 2009-09-09 |
| AU2003250391A1 (en) | 2004-02-09 |
| EP1534347B1 (de) | 2009-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |