ATE450274T1 - Konjugate von n-hydroxypropymethacrylamid- methacrylat-copolymeren mit nuklidaktivierungsagentien und/oder antikrebs- verbindungen - Google Patents
Konjugate von n-hydroxypropymethacrylamid- methacrylat-copolymeren mit nuklidaktivierungsagentien und/oder antikrebs- verbindungenInfo
- Publication number
- ATE450274T1 ATE450274T1 AT03738319T AT03738319T ATE450274T1 AT E450274 T1 ATE450274 T1 AT E450274T1 AT 03738319 T AT03738319 T AT 03738319T AT 03738319 T AT03738319 T AT 03738319T AT E450274 T1 ATE450274 T1 AT E450274T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxypropymethacrylamide
- conjugates
- nuclide activation
- methacrylate copolymers
- anticancer compounds
- Prior art date
Links
- 230000004913 activation Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 230000001093 anti-cancer Effects 0.000 title abstract 2
- 229920001577 copolymer Polymers 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 4
- 125000005647 linker group Chemical group 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
- A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02255107 | 2002-07-22 | ||
| PCT/GB2003/002919 WO2004009136A2 (en) | 2002-07-22 | 2003-07-04 | Conjugates of n-hydroxypropymethacrylamide-methacrylate copolymer with nuclide activation agent and/or anti-cancer compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE450274T1 true ATE450274T1 (de) | 2009-12-15 |
Family
ID=30470320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03738319T ATE450274T1 (de) | 2002-07-22 | 2003-07-04 | Konjugate von n-hydroxypropymethacrylamid- methacrylat-copolymeren mit nuklidaktivierungsagentien und/oder antikrebs- verbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7662360B2 (de) |
| EP (1) | EP1534347B1 (de) |
| JP (1) | JP2006502993A (de) |
| CN (2) | CN1678353A (de) |
| AT (1) | ATE450274T1 (de) |
| AU (2) | AU2003250391A1 (de) |
| CA (1) | CA2493252A1 (de) |
| DE (1) | DE60330355D1 (de) |
| WO (2) | WO2004009136A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005115457A2 (en) * | 2004-05-10 | 2005-12-08 | University Of Utah Research Foundation | Combined active and passive targeting of biologically active agents |
| EP1797427A4 (de) * | 2004-09-22 | 2009-04-08 | Odyssey Thera Inc | Verfahren zur identifizierung neuer arzneimittel-leads und neuer therapeutischer verwendungen für bekannte arzneimittel |
| CN102264396A (zh) * | 2008-10-07 | 2011-11-30 | 瑞沙恩医药公司 | Hpma-多西他赛或吉西他滨缀合物及其用途 |
| WO2011008863A2 (en) * | 2009-07-14 | 2011-01-20 | Lucia Irene Gonzalez | Stereoisomer peptides and their polymer conjugates for hiv disease |
| US8715986B2 (en) * | 2009-10-29 | 2014-05-06 | Lucia Irene Gonzalez | Stereoisomer peptides, ligand-targeted multi- stereoisomer peptide polymer conjugates, and uses thereof |
| HUE032791T2 (en) * | 2011-09-05 | 2017-11-28 | Hiroshi Maeda | Polymer-type fluorescent molecule probe |
| JP6253008B2 (ja) * | 2013-08-27 | 2017-12-27 | 国立大学法人 筑波大学 | 高分子化ホウ素化合物及びその使用 |
| JP6281991B2 (ja) * | 2014-04-11 | 2018-02-21 | 国立研究開発法人産業技術総合研究所 | ホウ素化合物を内包および外壁に担持するカーボンナノホーン及びその製造方法 |
| CZ308742B6 (cs) * | 2015-01-14 | 2021-04-21 | Ústav Organické Chemie A Biochemie Av Čr, V.V.I. | Makromolekulární konjugáty pro izolaci, imobilizaci a vizualizaci proteinů |
| CZ308807B6 (cs) | 2015-01-14 | 2021-06-02 | Ústav Organické Chemie A Biochemie Av Čr, V.V.I. | Makromolekulární konjugáty pro vizualizaci a separaci proteinů a buněk |
| CN105503918A (zh) * | 2015-12-08 | 2016-04-20 | 南京林业大学 | 一种含二氧杂戊硼基卟啉锌配合物及其制备方法 |
| CN105777790B (zh) * | 2016-05-17 | 2017-11-14 | 南京远淑医药科技有限公司 | 一种邻碳硼烷苯酚衍生物及其制备方法和应用 |
| EP3525808A4 (de) | 2016-10-14 | 2020-06-24 | University of Utah Research Foundation | Antikörper-polymer-wirkstoffkonjugate |
| CN107163097B (zh) * | 2017-04-20 | 2020-04-14 | 童永彭 | 环磷酸腺苷硼酸络合物及其制备方法，以及抗肿瘤药物和中子俘获治疗的硼剂 |
| EP3757137B1 (de) * | 2018-02-20 | 2022-09-07 | Tokyo Institute of Technology | P-borophenylalaninderivat und zusammensetzung damit und kit zur herstellung des derivats und der zusammensetzung |
| US20210138274A1 (en) * | 2018-06-20 | 2021-05-13 | Hirosaki University | Accumulative boron 10 medicine for boron neutron capture therapy for selectively or locally targeting tumor tissues in short time |
| US20210403625A1 (en) * | 2018-09-20 | 2021-12-30 | Glyscend, Inc. | Boronic acid polymers and methods of use |
| EP4031553A4 (de) | 2019-09-20 | 2023-11-01 | Glyscend, Inc. | Polymere mit substituierter phenylboronsäure und verwendungsverfahren |
| JP2021063033A (ja) * | 2019-10-11 | 2021-04-22 | 国立大学法人 東京大学 | 環状ペプチド |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5856551A (en) * | 1993-03-12 | 1999-01-05 | The Regents Of The University Of California | Macromolecular structure for boron neutron-capture therapy |
| US6180766B1 (en) * | 1993-12-02 | 2001-01-30 | Raymond F. Schinazi | Nucleosides and oligonucleotides containing boron clusters |
| JPH07206690A (ja) * | 1994-01-14 | 1995-08-08 | Seitai Kagaku Kenkyusho:Kk | 癌治療薬およびその中間体 |
| US6017902A (en) * | 1999-02-25 | 2000-01-25 | Brookhaven Science Associates | Boron containing amino acid compounds and methods for their use |
-
2003
- 2003-07-04 AT AT03738319T patent/ATE450274T1/de not_active IP Right Cessation
- 2003-07-04 AU AU2003250391A patent/AU2003250391A1/en not_active Abandoned
- 2003-07-04 EP EP03738319A patent/EP1534347B1/de not_active Expired - Lifetime
- 2003-07-04 US US10/521,814 patent/US7662360B2/en not_active Expired - Fee Related
- 2003-07-04 DE DE60330355T patent/DE60330355D1/de not_active Expired - Lifetime
- 2003-07-04 CN CNA038207419A patent/CN1678353A/zh active Pending
- 2003-07-04 JP JP2004522288A patent/JP2006502993A/ja active Pending
- 2003-07-04 WO PCT/GB2003/002919 patent/WO2004009136A2/en not_active Ceased
- 2003-07-04 AU AU2003244843A patent/AU2003244843B2/en not_active Ceased
- 2003-07-04 CA CA002493252A patent/CA2493252A1/en not_active Abandoned
- 2003-07-04 WO PCT/GB2003/002898 patent/WO2004009135A2/en not_active Ceased
- 2003-07-04 CN CNA2009101184891A patent/CN101524549A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004009136A2 (en) | 2004-01-29 |
| AU2003250391A1 (en) | 2004-02-09 |
| DE60330355D1 (de) | 2010-01-14 |
| US20070258891A1 (en) | 2007-11-08 |
| WO2004009136A3 (en) | 2004-04-08 |
| CA2493252A1 (en) | 2004-01-29 |
| AU2003250391A8 (en) | 2004-02-09 |
| CN101524549A (zh) | 2009-09-09 |
| AU2003244843B2 (en) | 2008-06-19 |
| AU2003244843A1 (en) | 2004-02-09 |
| WO2004009135A3 (en) | 2004-05-06 |
| CN1678353A (zh) | 2005-10-05 |
| WO2004009135A2 (en) | 2004-01-29 |
| HK1077513A1 (en) | 2006-02-17 |
| JP2006502993A (ja) | 2006-01-26 |
| US7662360B2 (en) | 2010-02-16 |
| EP1534347B1 (de) | 2009-12-02 |
| EP1534347A2 (de) | 2005-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |