ATE507845T1 - Polyacetal-arzneimittelkonjugate als freisetzungssystem - Google Patents
Polyacetal-arzneimittelkonjugate als freisetzungssystemInfo
- Publication number
- ATE507845T1 ATE507845T1 AT04783400T AT04783400T ATE507845T1 AT E507845 T1 ATE507845 T1 AT E507845T1 AT 04783400 T AT04783400 T AT 04783400T AT 04783400 T AT04783400 T AT 04783400T AT E507845 T1 ATE507845 T1 AT E507845T1
- Authority
- AT
- Austria
- Prior art keywords
- linker
- occurrence
- succinamide
- polyacetal
- release system
- Prior art date
Links
- 229930182556 Polyacetal Natural products 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 229920006324 polyoxymethylene Polymers 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 239000003607 modifier Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- SNCZNSNPXMPCGN-UHFFFAOYSA-N butanediamide Chemical class NC(=O)CCC(N)=O SNCZNSNPXMPCGN-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L59/00—Compositions of polyacetals; Compositions of derivatives of polyacetals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Polymers & Plastics (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50057103P | 2003-09-05 | 2003-09-05 | |
| PCT/US2004/029130 WO2005023294A2 (en) | 2003-09-05 | 2004-09-04 | Polyacetal drug conjugates as release system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE507845T1 true ATE507845T1 (de) | 2011-05-15 |
Family
ID=34272970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04783400T ATE507845T1 (de) | 2003-09-05 | 2004-09-04 | Polyacetal-arzneimittelkonjugate als freisetzungssystem |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US7790150B2 (de) |
| EP (1) | EP1667726B1 (de) |
| JP (3) | JP5537763B2 (de) |
| AT (1) | ATE507845T1 (de) |
| AU (1) | AU2004270251B2 (de) |
| CA (1) | CA2537993C (de) |
| DE (1) | DE602004032553D1 (de) |
| ES (1) | ES2365918T3 (de) |
| WO (1) | WO2005023294A2 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8106098B2 (en) * | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| WO2003059988A2 (en) | 2002-01-14 | 2003-07-24 | The General Hospital Corporation | Biodegradable polyketal polymers and methods for their formation and use |
| CA2492803C (en) | 2002-07-19 | 2013-11-05 | The General Hospital Corporation | Oxime conjugates and methods for their formation and use |
| AU2004270251B2 (en) * | 2003-09-05 | 2011-03-31 | The General Hospital Corporation | Polyacetal drug conjugates as release system |
| JP2008540558A (ja) * | 2005-05-10 | 2008-11-20 | エモリー・ユニバーシティ | ミセルおよび粒子を用いた、活性物質の送達のための新規の戦略 |
| US8252846B2 (en) * | 2005-05-10 | 2012-08-28 | Emory University | Strategies for delivery of active agents using micelles and particles |
| WO2007098041A1 (en) | 2006-02-17 | 2007-08-30 | Medtronic, Inc. | Polyketal polymers, and methods of making and using same |
| JP2010523656A (ja) * | 2007-04-12 | 2010-07-15 | エモリー・ユニバーシティ | ミセルおよび粒子を用いた、活性物質の送達のための新規の戦略 |
| US20080255175A1 (en) * | 2007-04-16 | 2008-10-16 | Lam Marina K | Anti-cancer agents, compositions and methods of treating cancers |
| BRPI0820229A2 (pt) * | 2007-11-28 | 2017-05-09 | A Stevenson Cheri | conjugados de análogos de fumagilina biodegradáveis biocompatíveis |
| AR074584A1 (es) * | 2008-12-10 | 2011-01-26 | Mersana Therapeutics Inc | Formulaciones farmaceuticas de conjugados camtotecina-polimero biocompatibles biodegradables |
| US11090387B2 (en) | 2008-12-22 | 2021-08-17 | The Trustees Of The University Of Pennsylvania | Hydrolytically degradable polysaccharide hydrogels |
| JP2012528240A (ja) * | 2009-05-28 | 2012-11-12 | メルサナ セラピューティックス， インコーポレイテッド | 可変速度放出リンカーを含むポリアル−薬物コンジュゲート |
| WO2010144881A1 (en) * | 2009-06-12 | 2010-12-16 | The General Hospital Corporation | Treatment of meningeal and neural diseases |
| US8349308B2 (en) | 2010-03-26 | 2013-01-08 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| US9486404B2 (en) | 2011-03-28 | 2016-11-08 | The Trustees Of The University Of Pennsylvania | Infarction treatment compositions and methods |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| EP2717916B1 (de) | 2011-06-10 | 2017-03-08 | Mersana Therapeutics, Inc. | Protein-polymer-wirkstoffkonjugate |
| WO2014008375A1 (en) * | 2012-07-05 | 2014-01-09 | Mersana Therapeutics, Inc. | Terminally modified polymers and conjugates thereof |
| WO2014093394A1 (en) * | 2012-12-10 | 2014-06-19 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| US10226535B2 (en) | 2012-12-10 | 2019-03-12 | Mersana Therapeutics, Inc. | Auristatin compounds and conjugates thereof |
| US9872918B2 (en) | 2012-12-12 | 2018-01-23 | Mersana Therapeutics, Inc. | Hydroxyl-polymer-drug-protein conjugates |
| WO2014160360A1 (en) * | 2013-03-14 | 2014-10-02 | Mersana Therapeutics Inc. | Tubulysin compounds and conjugates thereof |
| WO2015054659A1 (en) | 2013-10-11 | 2015-04-16 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| CA2927022C (en) | 2013-10-11 | 2018-08-21 | Asana Biosciences, Llc | Protein-polymer-drug conjugates |
| KR20160142885A (ko) * | 2014-04-10 | 2016-12-13 | 에이에프 케미칼스, 엘엘씨 | 친화성 약제 컨쥬게이트 |
| JP6149810B2 (ja) * | 2014-06-13 | 2017-06-21 | 株式会社島津製作所 | 代謝物解析システム及び代謝物解析方法 |
| TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗ｈｅｒ２表位之單株抗體及其使用之方法 |
| CN104877127B (zh) | 2015-06-23 | 2017-11-10 | 厦门赛诺邦格生物科技股份有限公司 | 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质 |
| WO2016050210A1 (zh) | 2014-10-01 | 2016-04-07 | 厦门赛诺邦格生物科技有限公司 | 一种多官能化聚乙二醇衍生物及其制备方法 |
| EP3389720A1 (de) * | 2015-12-18 | 2018-10-24 | The General Hospital Corporation | Polyacetalpolymere, konjugate, partikel und verwendungen davon |
| BR112018068461A2 (pt) | 2016-03-15 | 2019-01-22 | Mersana Therapeutics Inc | conjugado, composição farmacêutica, métodos para preparação de um conjugado e para alívio de um sintoma de um câncer. |
| EP3464400B1 (de) * | 2016-06-03 | 2022-04-06 | Novacyte Therapeutics Company.,LTD | Polymervernetzer und deren verwendungen |
| TW201834697A (zh) | 2017-02-28 | 2018-10-01 | 美商梅爾莎納醫療公司 | Her2標靶抗體－藥物結合物之組合療法 |
| KR101875321B1 (ko) | 2017-03-15 | 2018-07-05 | 인하대학교 산학협력단 | 트리펩타이드 및 다이펩타이드 유도체, 이의 제조방법, 이를 포함하는 화학센서 및 이를 이용한 알루미늄 이온 및 3가 금속이온을 비례 형광형으로 검출하는 방법 |
| US10772971B2 (en) | 2017-06-22 | 2020-09-15 | Mersana Therpeutics, Inc. | Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates |
| EP4178955A1 (de) | 2020-07-11 | 2023-05-17 | Pfizer Inc. | Antivirale heteroarylketonderivate |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
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| US152790A (en) * | 1874-07-07 | Improvement in explosive compounds | ||
| US93951A (en) * | 1869-08-24 | Improved die fob forming- carriage-shaft shackles | ||
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| US4793986A (en) | 1987-02-25 | 1988-12-27 | Johnson Matthey, Inc. | Macromolecular platinum antitumor compounds |
| JPH01190636A (ja) | 1988-01-22 | 1989-07-31 | Green Cross Corp:The | 制癌作用物質複合体 |
| US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
| US6610841B1 (en) | 1997-12-18 | 2003-08-26 | Gilead Sciences, Inc. | Nucleotide-based prodrugs |
| EP0654973A4 (de) | 1992-07-21 | 1995-08-09 | Gen Hospital Corp | Anordnung zur abgabe von medikamenten an das lymphgewebe. |
| US5624803A (en) | 1993-10-14 | 1997-04-29 | The Regents Of The University Of California | In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom |
| US5965566A (en) * | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
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| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US6048837A (en) | 1994-08-17 | 2000-04-11 | The Rockefeller University | OB polypeptides as modulators of body weight |
| CA2216844A1 (en) | 1995-03-31 | 1996-10-03 | Drug Delivery System Institute, Ltd. | Amidite derivatives and oligonucleotide derivatives |
| US5811510A (en) | 1995-04-14 | 1998-09-22 | General Hospital Corporation | Biodegradable polyacetal polymers and methods for their formation and use |
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| US5817343A (en) | 1996-05-14 | 1998-10-06 | Alkermes, Inc. | Method for fabricating polymer-based controlled-release devices |
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| GB9814527D0 (en) * | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
| HK1047884A1 (zh) * | 1999-06-18 | 2003-03-14 | Ml Laboratories Plc | 生物活性材料 |
| IL131074A0 (en) | 1999-07-23 | 2001-03-19 | Polygene Ltd | A biodegradable polycation composition for delivery of an anionic macromolecule |
| US8106098B2 (en) | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| US6822086B1 (en) | 1999-08-09 | 2004-11-23 | The General Hospital Corporation | Drug-carrier complexes and methods of use thereof |
| JP4813712B2 (ja) * | 1999-08-09 | 2011-11-09 | ザ ジェネラル ホスピタル コーポレーション | 薬物−担体複合体およびその使用方法 |
| WO2002020663A2 (en) | 2000-09-06 | 2002-03-14 | Ap Pharma, Inc. | Degradable polyacetal polymers |
| WO2003059988A2 (en) | 2002-01-14 | 2003-07-24 | The General Hospital Corporation | Biodegradable polyketal polymers and methods for their formation and use |
| WO2003070823A2 (en) | 2002-02-20 | 2003-08-28 | The General Hospital Corporation | Conjugates comprising a biodegradable polymer and uses therefor |
| AU2003256613A1 (en) | 2002-07-19 | 2004-02-09 | Amgen Inc. | Protein conjugates with a water-soluble biocompatible, biogradable polymer |
| CA2492803C (en) | 2002-07-19 | 2013-11-05 | The General Hospital Corporation | Oxime conjugates and methods for their formation and use |
| KR20140070676A (ko) * | 2002-09-06 | 2014-06-10 | 인설트 테라페틱스, 인코퍼레이티드 | 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체 |
| JP2006522140A (ja) * | 2003-03-31 | 2006-09-28 | ベクトラメッド，インコーポレーテッド | 線維症の治療用ポリマー薬剤 |
| AU2004270251B2 (en) | 2003-09-05 | 2011-03-31 | The General Hospital Corporation | Polyacetal drug conjugates as release system |
| BRPI0820229A2 (pt) | 2007-11-28 | 2017-05-09 | A Stevenson Cheri | conjugados de análogos de fumagilina biodegradáveis biocompatíveis |
| WO2010144881A1 (en) | 2009-06-12 | 2010-12-16 | The General Hospital Corporation | Treatment of meningeal and neural diseases |
-
2004
- 2004-09-04 AU AU2004270251A patent/AU2004270251B2/en not_active Ceased
- 2004-09-04 AT AT04783400T patent/ATE507845T1/de not_active IP Right Cessation
- 2004-09-04 JP JP2006525524A patent/JP5537763B2/ja not_active Expired - Fee Related
- 2004-09-04 EP EP04783400A patent/EP1667726B1/de not_active Expired - Lifetime
- 2004-09-04 US US10/570,466 patent/US7790150B2/en not_active Expired - Fee Related
- 2004-09-04 WO PCT/US2004/029130 patent/WO2005023294A2/en not_active Ceased
- 2004-09-04 DE DE602004032553T patent/DE602004032553D1/de not_active Expired - Lifetime
- 2004-09-04 CA CA2537993A patent/CA2537993C/en not_active Expired - Fee Related
- 2004-09-04 ES ES04783400T patent/ES2365918T3/es not_active Expired - Lifetime
-
2010
- 2010-08-19 US US12/859,556 patent/US8101164B2/en not_active Expired - Fee Related
-
2011
- 2011-05-16 JP JP2011109935A patent/JP2011153159A/ja active Pending
- 2011-06-03 US US13/152,790 patent/US8247427B2/en not_active Expired - Fee Related
-
2012
- 2012-07-19 US US13/553,244 patent/US8546419B2/en not_active Expired - Fee Related
-
2014
- 2014-03-12 JP JP2014048757A patent/JP2014111657A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005023294A2 (en) | 2005-03-17 |
| CA2537993C (en) | 2012-08-28 |
| JP2014111657A (ja) | 2014-06-19 |
| US7790150B2 (en) | 2010-09-07 |
| US8101164B2 (en) | 2012-01-24 |
| AU2004270251A1 (en) | 2005-03-17 |
| EP1667726A2 (de) | 2006-06-14 |
| US20120289535A1 (en) | 2012-11-15 |
| HK1092708A1 (en) | 2007-02-16 |
| AU2004270251B2 (en) | 2011-03-31 |
| US8546419B2 (en) | 2013-10-01 |
| US20070190018A1 (en) | 2007-08-16 |
| ES2365918T3 (es) | 2011-10-13 |
| US20120004255A1 (en) | 2012-01-05 |
| DE602004032553D1 (de) | 2011-06-16 |
| WO2005023294A3 (en) | 2005-06-09 |
| CA2537993A1 (en) | 2005-03-17 |
| US20110059010A1 (en) | 2011-03-10 |
| JP5537763B2 (ja) | 2014-07-02 |
| JP2011153159A (ja) | 2011-08-11 |
| US8247427B2 (en) | 2012-08-21 |
| JP2007504253A (ja) | 2007-03-01 |
| EP1667726B1 (de) | 2011-05-04 |
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