ATE450512T1 - Enantioselektive herstellung von chinolin- derivaten - Google Patents

Enantioselektive herstellung von chinolin- derivaten

Info

Publication number
ATE450512T1
ATE450512T1 AT05770221T AT05770221T ATE450512T1 AT E450512 T1 ATE450512 T1 AT E450512T1 AT 05770221 T AT05770221 T AT 05770221T AT 05770221 T AT05770221 T AT 05770221T AT E450512 T1 ATE450512 T1 AT E450512T1
Authority
AT
Austria
Prior art keywords
quinoline derivatives
enantioselective production
enantioselective
production
quinoline
Prior art date
Application number
AT05770221T
Other languages
English (en)
Inventor
Olivier Lohse
Caspar Vogel
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32799952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE450512(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE450512T1 publication Critical patent/ATE450512T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/04—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D251/06—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT05770221T 2004-06-22 2005-06-21 Enantioselektive herstellung von chinolin- derivaten ATE450512T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0413960.6A GB0413960D0 (en) 2004-06-22 2004-06-22 Organic compounds
PCT/EP2005/006686 WO2005123684A2 (en) 2004-06-22 2005-06-21 Enantioselektive preparation of quinoline derivative

Publications (1)

Publication Number Publication Date
ATE450512T1 true ATE450512T1 (de) 2009-12-15

Family

ID=32799952

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05770221T ATE450512T1 (de) 2004-06-22 2005-06-21 Enantioselektive herstellung von chinolin- derivaten

Country Status (32)

Country Link
US (2) US20090054653A1 (de)
EP (1) EP1791820B1 (de)
JP (1) JP5064214B2 (de)
KR (1) KR101179302B1 (de)
CN (1) CN1968927B (de)
AR (2) AR049553A1 (de)
AT (1) ATE450512T1 (de)
AU (1) AU2005254698B2 (de)
BR (1) BRPI0512298A (de)
CA (1) CA2566388C (de)
CY (1) CY1109884T1 (de)
DE (1) DE602005018076D1 (de)
DK (1) DK1791820T3 (de)
EC (1) ECSP067100A (de)
ES (1) ES2337273T3 (de)
GB (1) GB0413960D0 (de)
HR (1) HRP20100087T1 (de)
IL (1) IL179600A (de)
MA (1) MA28687B1 (de)
MX (1) MXPA06014695A (de)
MY (1) MY142051A (de)
NO (1) NO339079B1 (de)
NZ (1) NZ551276A (de)
PE (1) PE20060304A1 (de)
PL (1) PL1791820T3 (de)
PT (1) PT1791820E (de)
RU (1) RU2383534C2 (de)
SI (1) SI1791820T1 (de)
TN (1) TNSN06408A1 (de)
TW (1) TWI347317B (de)
WO (1) WO2005123684A2 (de)
ZA (1) ZA200609257B (de)

Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
DK2044025T3 (da) 2006-06-30 2013-01-14 Novartis Ag Quinolinonderivater samt farmaceutiske sammensætninger deraf
EP1914227A1 (de) * 2006-08-31 2008-04-23 Novartis AG Kristalline Polymorphe Form von Indan-2-ylamino-hydroxyethyl-quinolinon-maleat Derivat als beta-Adrenorezeptor-Agonist
WO2011056929A1 (en) 2009-11-04 2011-05-12 Massachusetts Institute Of Technology Continuous flow synthesis of amino alcohols using microreactors
US8680303B2 (en) 2010-03-01 2014-03-25 Massachusetts Institute Of Technology Epoxidation catalysts
RS55856B1 (sr) 2010-07-14 2017-08-31 Novartis Ag Heterociklična jedinjenja agonisti ip receptora
JOP20120023B1 (ar) 2011-02-04 2022-03-14 Novartis Ag صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية
CN104053659B (zh) 2012-01-13 2016-11-09 诺华股份有限公司 用于治疗肺动脉高压(pah)及相关病症的作为ip 受体激动剂的稠合的吡咯类
ES2561353T3 (es) 2012-01-13 2016-02-25 Novartis Ag Sales de un agonista del receptor IP
WO2013105063A1 (en) 2012-01-13 2013-07-18 Novartis Ag Fused piperidines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
EP2802581A1 (de) 2012-01-13 2014-11-19 Novartis AG 7,8-dihydropyrido-[3,4, b-]pyrazine als ip-rezeptoragonisten zur behandlung von pulmonaler arterieller hypertonie (pah) und zugehörigen erkrankungen
US20140357641A1 (en) 2012-01-13 2014-12-04 Novartis Ag IP receptor agonist heterocyclic compounds
EP2802585A1 (de) 2012-01-13 2014-11-19 Novartis AG Kondensierte piperidine als ip-rezeptoragonisten zur behandlung von pah und verwandten erkrankungen
WO2014008640A1 (zh) * 2012-07-11 2014-01-16 上海威智医药科技有限公司 茚达特罗中间体及茚达特罗的合成方法
WO2014044288A1 (en) 2012-09-21 2014-03-27 Crystal Pharma Sa Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof
EP2897937B1 (de) 2012-09-21 2017-12-06 Crystal Pharma S.A.U Verfahren zur herstellung von indacaterol und zwischenprodukte davon
EP2935249B1 (de) 2012-12-19 2018-12-12 Novartis AG Autotaxinhemmer
EP2956455B1 (de) 2013-02-13 2017-05-17 Novartis AG Als ip-rezeptor-agonisten wirkende heterocyclische verbindungen
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
CN105209013B (zh) 2013-03-14 2019-04-26 诺华股份有限公司 喷雾干燥制剂经喷雾混合的脱非晶化
CZ306252B6 (cs) 2013-03-15 2016-10-26 Zentiva, K.S. Způsob přípravy 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-chinolin-2-onu (indacaterolu)
EP2978745B1 (de) 2013-03-27 2017-03-15 Laboratorios Lesvi, S.L. Verfahren zur herstellung von (r)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1h)-quinolin-2-on
PT3022202T (pt) 2013-07-18 2019-09-03 Novartis Ag Inibidores da autotaxina compreendendo um núcleo beteroaromático anel-benzilo-amida-ciclo
EP3022201A1 (de) 2013-07-18 2016-05-25 Novartis AG Autotaxinhemmer
ES2815123T3 (es) 2014-01-09 2021-03-29 Davuluri Ramamohan Rao Proceso novedoso para la preparación de indacaterol o sus sales aceptables farmacéuticamente
MX2016012641A (es) 2014-03-27 2016-12-14 Novartis Ag Dispersiones solidas secas en aceite en agua por aspersion para inhalacion de ingredientes farmaceuticos activos.
US20170037030A1 (en) 2014-04-24 2017-02-09 Novartis Ag Autotaxin inhibitors
CN105693603B (zh) * 2014-11-24 2019-11-29 上海医药工业研究院 改良的马来酸茚达特罗制备工艺
KR101769204B1 (ko) * 2015-08-04 2017-08-17 씨제이헬스케어 주식회사 크로마놀 유도체의 신규한 제조방법
ES2747905T3 (es) 2015-09-29 2020-03-12 Inke Sa Solvato mixto de L-tartrato de (R)-5-[2-(5,6-dietilindan-2-ilamino)-1-hidroxietil]-8-hidroxi-1H-quinolin-2-ona
KR102043331B1 (ko) 2016-05-17 2019-11-11 인더스트리얼 테크놀로지 리서치 인스티튜트 금속 이온 배터리
CN107868045A (zh) * 2016-09-28 2018-04-03 四川海思科制药有限公司 一种茚达特罗中间体的制备方法
CN114591236A (zh) * 2020-12-02 2022-06-07 四川海思科制药有限公司 一种茚达特罗的改进制备方法
CN113731406B (zh) * 2021-10-12 2023-07-28 南京工业大学 一种提高钯碳活性加氢脱除保护基的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9405019D0 (en) * 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
NZ332341A (en) * 1996-05-20 2000-05-26 Darwin Discovery Ltd Quinoline carboxamides as TNF inhibitors and as PDE-IV inhibitors
GB9913083D0 (en) * 1999-06-04 1999-08-04 Novartis Ag Organic compounds
TWI249515B (en) * 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
TWI324150B (en) * 2003-02-28 2010-05-01 Novartis Ag Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt
TWI324151B (en) * 2003-04-02 2010-05-01 Novartis Ag Process for the preparation of 5-(haloacetyl)-8-substituted oxy-(1h)-quinolin-2-ones

Also Published As

Publication number Publication date
KR101179302B1 (ko) 2012-09-03
AU2005254698B2 (en) 2008-09-25
US20120220775A1 (en) 2012-08-30
CN1968927A (zh) 2007-05-23
ECSP067100A (es) 2007-01-26
HK1105121A1 (en) 2008-02-01
MY142051A (en) 2010-08-30
MXPA06014695A (es) 2007-02-12
SI1791820T1 (sl) 2010-04-30
WO2005123684A3 (en) 2006-06-01
CN1968927B (zh) 2010-07-21
CY1109884T1 (el) 2014-09-10
KR20070029752A (ko) 2007-03-14
ES2337273T3 (es) 2010-04-22
NO20070400L (no) 2007-03-21
NZ551276A (en) 2010-06-25
AR082981A2 (es) 2013-01-23
NO339079B1 (no) 2016-11-07
GB0413960D0 (en) 2004-07-28
ZA200609257B (en) 2008-07-30
DK1791820T3 (da) 2010-04-06
WO2005123684A2 (en) 2005-12-29
RU2007102228A (ru) 2008-07-27
AR049553A1 (es) 2006-08-16
TNSN06408A1 (en) 2008-02-22
TWI347317B (en) 2011-08-21
IL179600A (en) 2011-11-30
PT1791820E (pt) 2010-02-23
CA2566388A1 (en) 2005-12-29
TW200615265A (en) 2006-05-16
US20090054653A1 (en) 2009-02-26
EP1791820A2 (de) 2007-06-06
IL179600A0 (en) 2007-05-15
MA28687B1 (fr) 2007-06-01
AU2005254698A1 (en) 2005-12-29
CA2566388C (en) 2013-04-16
PL1791820T3 (pl) 2010-05-31
EP1791820B1 (de) 2009-12-02
RU2383534C2 (ru) 2010-03-10
DE602005018076D1 (de) 2010-01-14
PE20060304A1 (es) 2006-05-19
BRPI0512298A (pt) 2008-03-25
JP5064214B2 (ja) 2012-10-31
HRP20100087T1 (hr) 2010-06-30
JP2008503526A (ja) 2008-02-07

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