MA28687B1 - Composes organiques - Google Patents

Composes organiques

Info

Publication number
MA28687B1
MA28687B1 MA29571A MA29571A MA28687B1 MA 28687 B1 MA28687 B1 MA 28687B1 MA 29571 A MA29571 A MA 29571A MA 29571 A MA29571 A MA 29571A MA 28687 B1 MA28687 B1 MA 28687B1
Authority
MA
Morocco
Prior art keywords
quinolin
substituted oxy
organic compounds
halo
hydroxy
Prior art date
Application number
MA29571A
Other languages
English (en)
Inventor
Olivier Lohse
Caspar Vogel
Gerhard Penn
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32799952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA28687(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA28687B1 publication Critical patent/MA28687B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/04—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D251/06—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un procédé permettant de préparer des oxy-5-((R)-2-halo-l-hydroxy-éthyl)-(lH)-quinolin-2-ones substitués à la position 8 ou des solvates acceptables de ceux-ci. Le procédé susmentionné consiste à faire réagir un 5-($g(a)-haloacétyl)-8-substitué oxy-( lH)-quinolin-2-one avec un agent réducteur en présence d'un agent chiral et d'une base afin de former un 8-(substitué oxy)-5-((R)-2-halo-l-hydroxy-éthyl)-( lH)-quinolin-2-one; lequel agent chiral étant représenté par la formule (I) ou par la formule (II), dans ces formules. M, L, X, R1, R2 et R3 sont tels que définis dans la description.
MA29571A 2004-06-22 2006-12-28 Composes organiques MA28687B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0413960.6A GB0413960D0 (en) 2004-06-22 2004-06-22 Organic compounds

Publications (1)

Publication Number Publication Date
MA28687B1 true MA28687B1 (fr) 2007-06-01

Family

ID=32799952

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29571A MA28687B1 (fr) 2004-06-22 2006-12-28 Composes organiques

Country Status (32)

Country Link
US (2) US20090054653A1 (fr)
EP (1) EP1791820B1 (fr)
JP (1) JP5064214B2 (fr)
KR (1) KR101179302B1 (fr)
CN (1) CN1968927B (fr)
AR (2) AR049553A1 (fr)
AT (1) ATE450512T1 (fr)
AU (1) AU2005254698B2 (fr)
BR (1) BRPI0512298A (fr)
CA (1) CA2566388C (fr)
CY (1) CY1109884T1 (fr)
DE (1) DE602005018076D1 (fr)
DK (1) DK1791820T3 (fr)
EC (1) ECSP067100A (fr)
ES (1) ES2337273T3 (fr)
GB (1) GB0413960D0 (fr)
HR (1) HRP20100087T1 (fr)
IL (1) IL179600A (fr)
MA (1) MA28687B1 (fr)
MX (1) MXPA06014695A (fr)
MY (1) MY142051A (fr)
NO (1) NO339079B1 (fr)
NZ (1) NZ551276A (fr)
PE (1) PE20060304A1 (fr)
PL (1) PL1791820T3 (fr)
PT (1) PT1791820E (fr)
RU (1) RU2383534C2 (fr)
SI (1) SI1791820T1 (fr)
TN (1) TNSN06408A1 (fr)
TW (1) TWI347317B (fr)
WO (1) WO2005123684A2 (fr)
ZA (1) ZA200609257B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2044025T3 (da) 2006-06-30 2013-01-14 Novartis Ag Quinolinonderivater samt farmaceutiske sammensætninger deraf
EP1914227A1 (fr) * 2006-08-31 2008-04-23 Novartis AG Forme crystalline polymorphe d'une dérivé de indan-2-ylamino-hydroxyethyl-quinolinone maleate comme agoniste de 2-adrénorécepteur beta
WO2011056929A1 (fr) 2009-11-04 2011-05-12 Massachusetts Institute Of Technology Synthèse en flux continu d'alcools aminés à l'aide de microréacteurs
US8680303B2 (en) 2010-03-01 2014-03-25 Massachusetts Institute Of Technology Epoxidation catalysts
RS55856B1 (sr) 2010-07-14 2017-08-31 Novartis Ag Heterociklična jedinjenja agonisti ip receptora
JOP20120023B1 (ar) 2011-02-04 2022-03-14 Novartis Ag صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية
CN104053659B (zh) 2012-01-13 2016-11-09 诺华股份有限公司 用于治疗肺动脉高压(pah)及相关病症的作为ip 受体激动剂的稠合的吡咯类
ES2561353T3 (es) 2012-01-13 2016-02-25 Novartis Ag Sales de un agonista del receptor IP
WO2013105063A1 (fr) 2012-01-13 2013-07-18 Novartis Ag Pipéridines condensées utilisées comme agonistes du récepteur ip pour le traitement de l'hypertension artérielle pulmonaire (htap) et de troubles associés
EP2802581A1 (fr) 2012-01-13 2014-11-19 Novartis AG 7,8-dihydropyrido[3,4-b]pyrazines utilisées comme agonistes du récepteur ip pour le traitement de l'hypertension artérielle pulmonaire (htap) et des troubles associés
US20140357641A1 (en) 2012-01-13 2014-12-04 Novartis Ag IP receptor agonist heterocyclic compounds
EP2802585A1 (fr) 2012-01-13 2014-11-19 Novartis AG Pipéridines condensées utilisées comme agonistes du récepteur ip pour le traitement de l'htap et de troubles connexes
WO2014008640A1 (fr) * 2012-07-11 2014-01-16 上海威智医药科技有限公司 Intermédiaire d'indacatérol et procédé de synthèse d'indacatérol
WO2014044288A1 (fr) 2012-09-21 2014-03-27 Crystal Pharma Sa Procédés de préparation d'indacatérol et de ses sels pharmaceutiquement acceptables
EP2897937B1 (fr) 2012-09-21 2017-12-06 Crystal Pharma S.A.U Procédé de préparation d'indacatérol et intermédiaires de celle-ci
EP2935249B1 (fr) 2012-12-19 2018-12-12 Novartis AG Inhibiteurs d'autotaxine
EP2956455B1 (fr) 2013-02-13 2017-05-17 Novartis AG Composes heterocycliques a activite agoniste sur le recepteur ip
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
CN105209013B (zh) 2013-03-14 2019-04-26 诺华股份有限公司 喷雾干燥制剂经喷雾混合的脱非晶化
CZ306252B6 (cs) 2013-03-15 2016-10-26 Zentiva, K.S. Způsob přípravy 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-chinolin-2-onu (indacaterolu)
EP2978745B1 (fr) 2013-03-27 2017-03-15 Laboratorios Lesvi, S.L. Procédé de préparation de (r)-5-[2-(5,6-diéthylindan-2-ylamino)-1-hydroxyéthyl]-8-hydroxy-(1h)-quinolin-2-one
PT3022202T (pt) 2013-07-18 2019-09-03 Novartis Ag Inibidores da autotaxina compreendendo um núcleo beteroaromático anel-benzilo-amida-ciclo
EP3022201A1 (fr) 2013-07-18 2016-05-25 Novartis AG Inhibiteurs de l'autotaxine
ES2815123T3 (es) 2014-01-09 2021-03-29 Davuluri Ramamohan Rao Proceso novedoso para la preparación de indacaterol o sus sales aceptables farmacéuticamente
MX2016012641A (es) 2014-03-27 2016-12-14 Novartis Ag Dispersiones solidas secas en aceite en agua por aspersion para inhalacion de ingredientes farmaceuticos activos.
US20170037030A1 (en) 2014-04-24 2017-02-09 Novartis Ag Autotaxin inhibitors
CN105693603B (zh) * 2014-11-24 2019-11-29 上海医药工业研究院 改良的马来酸茚达特罗制备工艺
KR101769204B1 (ko) * 2015-08-04 2017-08-17 씨제이헬스케어 주식회사 크로마놀 유도체의 신규한 제조방법
ES2747905T3 (es) 2015-09-29 2020-03-12 Inke Sa Solvato mixto de L-tartrato de (R)-5-[2-(5,6-dietilindan-2-ilamino)-1-hidroxietil]-8-hidroxi-1H-quinolin-2-ona
KR102043331B1 (ko) 2016-05-17 2019-11-11 인더스트리얼 테크놀로지 리서치 인스티튜트 금속 이온 배터리
CN107868045A (zh) * 2016-09-28 2018-04-03 四川海思科制药有限公司 一种茚达特罗中间体的制备方法
CN114591236A (zh) * 2020-12-02 2022-06-07 四川海思科制药有限公司 一种茚达特罗的改进制备方法
CN113731406B (zh) * 2021-10-12 2023-07-28 南京工业大学 一种提高钯碳活性加氢脱除保护基的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9405019D0 (en) * 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
NZ332341A (en) * 1996-05-20 2000-05-26 Darwin Discovery Ltd Quinoline carboxamides as TNF inhibitors and as PDE-IV inhibitors
GB9913083D0 (en) * 1999-06-04 1999-08-04 Novartis Ag Organic compounds
TWI249515B (en) * 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
TWI324150B (en) * 2003-02-28 2010-05-01 Novartis Ag Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt
TWI324151B (en) * 2003-04-02 2010-05-01 Novartis Ag Process for the preparation of 5-(haloacetyl)-8-substituted oxy-(1h)-quinolin-2-ones

Also Published As

Publication number Publication date
KR101179302B1 (ko) 2012-09-03
AU2005254698B2 (en) 2008-09-25
US20120220775A1 (en) 2012-08-30
CN1968927A (zh) 2007-05-23
ECSP067100A (es) 2007-01-26
HK1105121A1 (en) 2008-02-01
MY142051A (en) 2010-08-30
MXPA06014695A (es) 2007-02-12
SI1791820T1 (sl) 2010-04-30
WO2005123684A3 (fr) 2006-06-01
CN1968927B (zh) 2010-07-21
CY1109884T1 (el) 2014-09-10
KR20070029752A (ko) 2007-03-14
ES2337273T3 (es) 2010-04-22
NO20070400L (no) 2007-03-21
NZ551276A (en) 2010-06-25
AR082981A2 (es) 2013-01-23
NO339079B1 (no) 2016-11-07
GB0413960D0 (en) 2004-07-28
ZA200609257B (en) 2008-07-30
DK1791820T3 (da) 2010-04-06
WO2005123684A2 (fr) 2005-12-29
RU2007102228A (ru) 2008-07-27
AR049553A1 (es) 2006-08-16
TNSN06408A1 (en) 2008-02-22
TWI347317B (en) 2011-08-21
IL179600A (en) 2011-11-30
PT1791820E (pt) 2010-02-23
CA2566388A1 (fr) 2005-12-29
ATE450512T1 (de) 2009-12-15
TW200615265A (en) 2006-05-16
US20090054653A1 (en) 2009-02-26
EP1791820A2 (fr) 2007-06-06
IL179600A0 (en) 2007-05-15
AU2005254698A1 (en) 2005-12-29
CA2566388C (fr) 2013-04-16
PL1791820T3 (pl) 2010-05-31
EP1791820B1 (fr) 2009-12-02
RU2383534C2 (ru) 2010-03-10
DE602005018076D1 (de) 2010-01-14
PE20060304A1 (es) 2006-05-19
BRPI0512298A (pt) 2008-03-25
JP5064214B2 (ja) 2012-10-31
HRP20100087T1 (hr) 2010-06-30
JP2008503526A (ja) 2008-02-07

Similar Documents

Publication Publication Date Title
TW200615265A (en) Organic compounds
Carta et al. Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII
UY28211A1 (es) Compuestos de hidroximetilo
NO20082719L (no) Aryl-isoksazol-4-yl-oksadiazolderivater
MA30991B1 (fr) Utilisation de dérivés du benzamide comme agonistes des récepteurs ep4
WO2008114819A1 (fr) Nouveau composé d'adénine
MA31763B1 (fr) Inhibiteurs de kinase de type polo
PE20121312A1 (es) Metodo para preparar compuestos macrociclicos inhibidores de serina proteasas de hepatitis c
MA30411B1 (fr) Derives de triazolopyrazine utiles comme agent anticancereux
WO2005092858A3 (fr) Composes alpha-aryle ou heteroaryle methyle beta piperidino propanamide en tant qu'antagoniste du recepteur orl1
ATE361916T1 (de) Pyrimidine verbindungen
TW200611907A (en) Fused heterocyclic compound
BRPI0407082A (pt) Composto, pró-droga, produto farmacêutico, método de antagonizar hormÈnio liberador de gonadotropina, e, uso do composto
AR060331A1 (es) Un proceso convergente para la sintesis de derivados de taxano
MA31832B1 (fr) Dérivés de quinazolinedione, leur préparation et leurs applications thérapeutiques
PE20061067A1 (es) Derivados de pirimidina
EP2036905A4 (fr) Dérivé de pyridylisoxazole
TNSN07400A1 (fr) Derives d'aminoacides
ATE276257T1 (de) Pyrazinonderivate
MA27930A1 (fr) Derives de nicotinamide utiles comme inhibiteurs de pde4
MA31015B1 (fr) Procede de fabrication de 4.4'- (1-methyl-1,2-ethandiyl)-bis -(2,6-piperazindione)
KR880013920A (ko) 디하이드로피리딘 화합물 및 이의 제조방법
GB0412314D0 (en) Compounds
EP1757610A4 (fr) Derivé de pyrimidine condensé et inhibiteur de la xanthine oxydase
EP1238977A4 (fr) Procede de preparation d'un compose pyridinemethanol