ATE451366T1 - Sulphonamid benzoxazinonderivate. ihre herstellung und verwendung als medikamente - Google Patents

Sulphonamid benzoxazinonderivate. ihre herstellung und verwendung als medikamente

Info

Publication number
ATE451366T1
ATE451366T1 AT04741318T AT04741318T ATE451366T1 AT E451366 T1 ATE451366 T1 AT E451366T1 AT 04741318 T AT04741318 T AT 04741318T AT 04741318 T AT04741318 T AT 04741318T AT E451366 T1 ATE451366 T1 AT E451366T1
Authority
AT
Austria
Prior art keywords
sulphonamide
medications
production
benzoxazinone derivatives
benzoxazinone
Prior art date
Application number
AT04741318T
Other languages
English (en)
Inventor
Jover Antoni Torrens
Prio Josep Mas
Zueras Alberto Dordal
Escasany Maria Angeles Fisas
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Application granted granted Critical
Publication of ATE451366T1 publication Critical patent/ATE451366T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04741318T 2003-07-30 2004-07-29 Sulphonamid benzoxazinonderivate. ihre herstellung und verwendung als medikamente ATE451366T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200301812A ES2232292B1 (es) 2003-07-30 2003-07-30 Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos.
PCT/EP2004/008507 WO2005014589A1 (en) 2003-07-30 2004-07-29 Benzoxazinone-derived sulfonamide compounds, their preparation and use as medicaments

Publications (1)

Publication Number Publication Date
ATE451366T1 true ATE451366T1 (de) 2009-12-15

Family

ID=34130545

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04741318T ATE451366T1 (de) 2003-07-30 2004-07-29 Sulphonamid benzoxazinonderivate. ihre herstellung und verwendung als medikamente

Country Status (23)

Country Link
US (1) US20070032482A1 (de)
EP (1) EP1648886B1 (de)
JP (1) JP2007500161A (de)
KR (1) KR20060056355A (de)
CN (1) CN1860114A (de)
AR (1) AR045153A1 (de)
AT (1) ATE451366T1 (de)
AU (1) AU2004263300A1 (de)
BR (1) BRPI0413101A (de)
CA (1) CA2534095A1 (de)
CL (1) CL2004001929A1 (de)
DE (1) DE602004024538D1 (de)
EC (1) ECSP066331A (de)
ES (2) ES2232292B1 (de)
IL (1) IL173004A0 (de)
MX (1) MXPA06001228A (de)
NO (1) NO20060969L (de)
PE (1) PE20050724A1 (de)
PT (1) PT1648886E (de)
RU (1) RU2006105714A (de)
TW (1) TW200510354A (de)
WO (1) WO2005014589A1 (de)
ZA (1) ZA200600426B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1753421B1 (de) * 2004-04-20 2012-08-01 Amgen Inc. Arylsulfonamide und ihre verwendung als hydroxysteroid-dehydrogenase
AR058277A1 (es) 2005-12-09 2008-01-30 Solvay Pharm Gmbh N- sulfamoil - piperidin - amidas, composiciones farmaceuticas que las comprenden y procedimiento para su preparacion
GB2435825A (en) * 2006-03-09 2007-09-12 Esteve Labor Dr Benzimidazole-2- & pyrido[d]imidazole-2- sulphonamide derivatives for treatment of disorders mediated via 5-HT6 receptors, eg those related to food intake
EP2053052A1 (de) 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Verfahren zur Herstellung von 6-substituiertem Imidazo[2,1-b]thiazol-5-sulfonylhalogenid
ES2821877T3 (es) 2016-07-07 2021-04-28 Bristol Myers Squibb Co Espirolactamas como inhibidores de ROCK
ES2874628T3 (es) * 2017-08-07 2021-11-05 Suven Life Sciences Ltd Compuestos de fluoropiperidina como antagonistas puros del receptor 5-HT6
GB201713780D0 (en) * 2017-08-29 2017-10-11 E-Therapeutics Plc Modulators of hedgehog (Hh) signalling pathway
CN109232599B (zh) * 2018-10-08 2021-04-20 广西中医药大学 具有抗肿瘤活性的o-对三氟甲基苯甲酰基土甘草a及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344945A (en) * 1980-03-10 1982-08-17 Kyowa Hakko Kogyo Co., Ltd. Piperidine derivatives
TW199153B (de) * 1990-08-07 1993-02-01 Dtsuka Seiyaku Kk
EP0714299B1 (de) * 1993-07-16 2002-04-24 Merck & Co. Inc. Benzoxazinon- und Benzopyrimidinon- piperidinyl-Verbindungen als tokolytische Oxytocin-Rezeptor-Antagonisten
JP3989554B2 (ja) * 1996-03-29 2007-10-10 デユフアー・インターナシヨナル・リサーチ・ベー・ブイ ピペラジンおよびピペリジン化合物
KR20000016151A (ko) * 1996-05-29 2000-03-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 벤족사지논 도파민 d4 수용체 길항제
SE9904652D0 (sv) * 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
EP1283838B1 (de) * 2000-05-12 2003-12-03 Solvay Pharmaceuticals B.V. Piperazin- und piperidinverbindungen

Also Published As

Publication number Publication date
ES2232292B1 (es) 2006-11-01
ZA200600426B (en) 2007-03-28
PE20050724A1 (es) 2005-11-16
KR20060056355A (ko) 2006-05-24
ES2338008T3 (es) 2010-05-03
US20070032482A1 (en) 2007-02-08
DE602004024538D1 (de) 2010-01-21
CN1860114A (zh) 2006-11-08
ES2232292A1 (es) 2005-05-16
CA2534095A1 (en) 2005-01-27
EP1648886B1 (de) 2009-12-09
ECSP066331A (es) 2006-08-30
IL173004A0 (en) 2006-06-11
RU2006105714A (ru) 2007-09-20
BRPI0413101A (pt) 2006-10-03
WO2005014589A1 (en) 2005-02-17
JP2007500161A (ja) 2007-01-11
NO20060969L (no) 2006-04-11
CL2004001929A1 (es) 2005-06-03
MXPA06001228A (es) 2006-05-15
AU2004263300A1 (en) 2005-02-17
PT1648886E (pt) 2010-03-10
EP1648886A1 (de) 2006-04-26
TW200510354A (en) 2005-03-16
AR045153A1 (es) 2005-10-19

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