ATE452125T1 - Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchlorid - Google Patents
Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchloridInfo
- Publication number
- ATE452125T1 ATE452125T1 AT07729664T AT07729664T ATE452125T1 AT E452125 T1 ATE452125 T1 AT E452125T1 AT 07729664 T AT07729664 T AT 07729664T AT 07729664 T AT07729664 T AT 07729664T AT E452125 T1 ATE452125 T1 AT E452125T1
- Authority
- AT
- Austria
- Prior art keywords
- dichlorobenzoyl chloride
- lamotrigine
- producing
- producing lamotrigine
- preparing
- Prior art date
Links
- PYZRQGJRPPTADH-UHFFFAOYSA-N lamotrigine Chemical compound NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl PYZRQGJRPPTADH-UHFFFAOYSA-N 0.000 title abstract 4
- 229960001848 lamotrigine Drugs 0.000 title abstract 3
- YBONBWJSFMTXLE-UHFFFAOYSA-N 2,3-dichlorobenzoyl chloride Chemical compound ClC(=O)C1=CC=CC(Cl)=C1Cl YBONBWJSFMTXLE-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- GKGPLSQWIBJJPC-UHFFFAOYSA-N 1,2-dichloro-3-(trichloromethyl)benzene Chemical compound ClC1=CC=CC(C(Cl)(Cl)Cl)=C1Cl GKGPLSQWIBJJPC-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06290888 | 2006-05-31 | ||
| PCT/EP2007/055251 WO2007138075A1 (en) | 2006-05-31 | 2007-05-30 | Method for preparing lamotrigine and its intermediate 2,3-dichlorobenzoyl chloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE452125T1 true ATE452125T1 (de) | 2010-01-15 |
Family
ID=36928567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07729664T ATE452125T1 (de) | 2006-05-31 | 2007-05-30 | Verfahren zur herstellung von lamotrigin und dessen zwischenprodukt 2,3-dichlorbenzoylchlorid |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090312544A1 (de) |
| EP (1) | EP2024345B1 (de) |
| JP (1) | JP2009538878A (de) |
| AT (1) | ATE452125T1 (de) |
| DE (1) | DE602007003830D1 (de) |
| ES (1) | ES2337415T3 (de) |
| WO (1) | WO2007138075A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120142919A1 (en) * | 2006-08-02 | 2012-06-07 | Medichem, S.A. | Method for synthesizing lamotrigine |
| CA2854621C (en) | 2011-11-07 | 2015-04-28 | Kaneka Corporation | Method for producing chlorinated vinyl chloride resin |
| CN104098464A (zh) * | 2013-04-15 | 2014-10-15 | 江苏新瀚有限公司 | 对氟苯甲酰氯的制备方法 |
| CN103570637A (zh) * | 2013-09-13 | 2014-02-12 | 盐城凯利药业有限公司 | 一种拉莫三嗪的制备方法 |
| CN103833660B (zh) * | 2014-03-26 | 2016-07-13 | 成都医路康医学技术服务有限公司 | 拉莫三嗪及其中间体的制备方法 |
| CN106277514B (zh) * | 2015-06-05 | 2019-02-15 | 西南大学 | 回收处理糖精钠废水的方法 |
| US12514860B2 (en) | 2021-04-16 | 2026-01-06 | Shanghai Aucta Pharmaceuticals Co., Ltd. | Composition containing lamotrigine, and preparation method and use thereof |
| CN114948868B (zh) | 2021-04-16 | 2023-04-14 | 上海奥科达医药科技股份有限公司 | 一种拉莫三嗪水合物的晶体形式、其制备方法及包含其的组合物 |
| CN114907232B (zh) * | 2022-04-28 | 2024-02-23 | 青岛和兴精细化学有限公司 | 2-硝基-4-三氟甲基苯腈的合成工艺 |
| CN116178139A (zh) * | 2023-02-22 | 2023-05-30 | 湖北丽康源化工有限公司 | 一种2,3-二氯苯甲酰氯的生产方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3691217A (en) * | 1970-03-16 | 1972-09-12 | Argus Chem | Process for the preparation of acyl chlorides and benzaldehydes |
| EP0021121B1 (de) * | 1979-06-01 | 1983-05-11 | The Wellcome Foundation Limited | 1,2,4-Triazin-Derivate, Verfahren zur Herstellung dieser Verbindungen und sie enthaltende pharmazeutische Zusammensetzungen |
| US4268457A (en) * | 1979-06-28 | 1981-05-19 | Hooker Chemicals & Plastics Corp. | Process for the preparation of paraphenoxybenzoylchloride |
| DE3142856A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoylchlorid |
| JPH0327334A (ja) * | 1989-06-23 | 1991-02-05 | Ihara Chem Ind Co Ltd | ２，５―ジハロゲン化ベンゾトリクロリド類の製造法 |
| DE4301247A1 (de) * | 1993-01-19 | 1994-07-21 | Bayer Ag | Verfahren zur Herstellung mehrfach halogenierter Benzotrichloride und Benzoylchloride sowie neue Trihalogenbenzotrichloride und -benzoylchloride |
| IT1263960B (it) * | 1993-02-24 | 1996-09-05 | Enichem Sintesi | Procedimento per la fotoclorurazione di composti alchilaromatici |
| JPH07330663A (ja) * | 1994-06-08 | 1995-12-19 | Nippon Light Metal Co Ltd | ２−クロロテレフタル酸クロライドの製造方法 |
| CZ20011949A3 (cs) * | 1998-12-14 | 2001-09-12 | Torrent Pharmacauticals Ltd | Zlepšený způsob výroby 3,5-diamino-6-(2,3-dichlorfenyl)-1,2,4-triazinu |
| HU225667B1 (en) * | 2002-09-20 | 2007-05-29 | Richter Gedeon Nyrt | Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
-
2007
- 2007-05-30 AT AT07729664T patent/ATE452125T1/de not_active IP Right Cessation
- 2007-05-30 US US12/301,747 patent/US20090312544A1/en not_active Abandoned
- 2007-05-30 DE DE602007003830T patent/DE602007003830D1/de active Active
- 2007-05-30 ES ES07729664T patent/ES2337415T3/es active Active
- 2007-05-30 JP JP2009512586A patent/JP2009538878A/ja active Pending
- 2007-05-30 WO PCT/EP2007/055251 patent/WO2007138075A1/en not_active Ceased
- 2007-05-30 EP EP07729664A patent/EP2024345B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20090312544A1 (en) | 2009-12-17 |
| WO2007138075A1 (en) | 2007-12-06 |
| DE602007003830D1 (de) | 2010-01-28 |
| ES2337415T3 (es) | 2010-04-23 |
| JP2009538878A (ja) | 2009-11-12 |
| EP2024345A1 (de) | 2009-02-18 |
| EP2024345B1 (de) | 2009-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |