ATE452140T1 - Verbessertes verfahren zur herstellung von copolymer-1 - Google Patents
Verbessertes verfahren zur herstellung von copolymer-1Info
- Publication number
- ATE452140T1 ATE452140T1 AT07799327T AT07799327T ATE452140T1 AT E452140 T1 ATE452140 T1 AT E452140T1 AT 07799327 T AT07799327 T AT 07799327T AT 07799327 T AT07799327 T AT 07799327T AT E452140 T1 ATE452140 T1 AT E452140T1
- Authority
- AT
- Austria
- Prior art keywords
- copolymer
- protected
- carboxyanhydrides
- treated
- mixture
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- 239000004220 glutamic acid Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- -1 cyclic imide Chemical group 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000003505 polymerization initiator Substances 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polyamides (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80658506P | 2006-07-05 | 2006-07-05 | |
| PCT/US2007/072865 WO2008006026A1 (en) | 2006-07-05 | 2007-07-05 | Improved process for the preparation of copolymer-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE452140T1 true ATE452140T1 (de) | 2010-01-15 |
Family
ID=38658274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07799327T ATE452140T1 (de) | 2006-07-05 | 2007-07-05 | Verbessertes verfahren zur herstellung von copolymer-1 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080021192A1 (de) |
| EP (2) | EP2143728A1 (de) |
| JP (1) | JP2009542864A (de) |
| CN (1) | CN101511862A (de) |
| AT (1) | ATE452140T1 (de) |
| AU (1) | AU2007269140A1 (de) |
| CA (1) | CA2656573A1 (de) |
| DE (1) | DE602007003848D1 (de) |
| ES (1) | ES2338488T3 (de) |
| SI (1) | SI2046817T1 (de) |
| WO (1) | WO2008006026A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1459065B1 (de) | 2001-12-04 | 2010-07-28 | Teva Pharmaceutical Industries, Ltd. | Verfahren zur messung der wirkstärke von glatirameracetat |
| HRP20160455T1 (hr) | 2004-09-09 | 2016-07-15 | Yeda Research And Development Co., Ltd. | Smjese polipeptida, sastavi koji ih sadrže i postupci za njihovu pripremu, te njihove primjene |
| EP2173766A1 (de) * | 2007-07-31 | 2010-04-14 | Natco Pharma Limited | Verfahren zur herstellung von glatirameracetat (copolymer-1) |
| US20090035816A1 (en) * | 2007-08-02 | 2009-02-05 | Scinopharm Taiwan Ltd. | Process for the preparation of a polypeptide |
| PL2307448T3 (pl) * | 2008-08-07 | 2015-10-30 | Sigma Aldrich Co Llc | Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością |
| US8455619B2 (en) * | 2008-11-25 | 2013-06-04 | Keith R. Latham | Polypeptide synthesis for drug delivery |
| AR074881A1 (es) * | 2008-12-24 | 2011-02-16 | Synthon Bv | Un proceso para purificar una mezcla de polimeros |
| RS55607B1 (sr) | 2009-08-20 | 2017-06-30 | Yeda Research & Development Company Ltd | Niskofrekventna terapija glatiramer acetatom |
| MX2012005749A (es) * | 2009-11-17 | 2012-10-03 | Ares Trading Sa | Metodos para mejorar el diseño, la biodisponibilidad de composiciones de polimero de secuencia dirigida, por medio de la deteccion basada en proteinas del suero, de composiciones de polimero de secuencia dirigida. |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| US8759302B2 (en) | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
| MX2012012489A (es) * | 2010-04-27 | 2012-12-17 | Reddys Lab Ltd Dr | Preparacion de polipeptidos y sales de los mismos. |
| EA025780B1 (ru) | 2010-10-11 | 2017-01-30 | Тева Фармасьютикал Индастриз Лтд. | Цитокиновые биомаркеры в качестве биомаркеров, прогнозирующих клинический ответ на глатирамер ацетат |
| WO2012067974A1 (en) * | 2010-11-17 | 2012-05-24 | Sigma-Aldrich Co. Llc. | A greener method for the production of copolymer 1 |
| WO2013009885A2 (en) | 2011-07-11 | 2013-01-17 | Momenta Pharmaceuticals, Inc. | Evaluation of copolymer diethylamide |
| US8575198B1 (en) | 2011-09-07 | 2013-11-05 | Momenta Pharmaceuticals, Inc. | In-process control for the manufacture of glatiramer acetate |
| MX2014004309A (es) | 2011-10-10 | 2015-07-06 | Teva Pharma | Polimorfismos de nucleotidos individuales utiles para predecir una respuesta clinica para el acetato de glatiramer. |
| CN102617851B (zh) * | 2012-03-31 | 2014-06-11 | 上海大学 | 分子量可控聚l-谷氨酸制备方法 |
| US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
| ES2707500T3 (es) * | 2015-11-23 | 2019-04-03 | Chemi Spa | Análisis mediante RP-HPLC de mezclas de polipéptidos complejos |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| AU2017319728B2 (en) | 2016-08-31 | 2024-09-05 | Mapi Pharma Ltd | Depot systems comprising glatiramer acetate |
| IL316573A (en) | 2017-03-26 | 2024-12-01 | Mapi Pharma Ltd | Storage systems containing glatiramer acetate for the treatment of multiple sclerosis |
| CN116355201B (zh) * | 2023-06-01 | 2023-09-08 | 苏州大学 | 一种基于原位纯化的共聚氨基酸的一锅法制备方法 |
| CN119431772A (zh) * | 2023-07-31 | 2025-02-14 | 爱美客技术发展股份有限公司 | 一种超高分子量聚谷氨酸及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3349550A (en) * | 1966-11-08 | 1967-10-31 | Lourenco Anthony L | Plant compressing apparatus for mechanical pickers |
| CA2023176A1 (en) * | 1989-08-25 | 1991-02-26 | Margaret M. Bowers-Daines | Preparation and use of iodopropargyl esters of a-amino acid derivatives as antimicrobial agents |
| IL113812A (en) * | 1994-05-24 | 2000-06-29 | Yeda Res & Dev | Copolymer-1 pharmaceutical compositions containing it and its use |
| US20080221020A1 (en) * | 2002-07-19 | 2008-09-11 | The Regents Of The University Of California | Dendrimers as Molecular Translocators |
| CA2411786C (en) * | 2002-11-13 | 2009-01-27 | Brantford Chemicals Inc. | A process for the preparation of polypeptides from n-carboxyanhydrides of amino acids |
| WO2004043995A2 (en) * | 2002-11-13 | 2004-05-27 | Apotex Pharmachem Inc. | Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine |
| DE602005016292D1 (de) * | 2004-10-29 | 2009-10-08 | Sandoz Ag | Verfahren zur herstellung von glatiramer |
| CA2619123A1 (en) * | 2005-08-15 | 2007-02-22 | Wai Hong Chan | Process for the preparation of copolymer-1 |
-
2007
- 2007-07-05 SI SI200730190T patent/SI2046817T1/sl unknown
- 2007-07-05 AT AT07799327T patent/ATE452140T1/de active
- 2007-07-05 EP EP09174515A patent/EP2143728A1/de not_active Withdrawn
- 2007-07-05 EP EP07799327A patent/EP2046817B1/de active Active
- 2007-07-05 CA CA002656573A patent/CA2656573A1/en not_active Abandoned
- 2007-07-05 US US11/773,864 patent/US20080021192A1/en not_active Abandoned
- 2007-07-05 CN CNA2007800328809A patent/CN101511862A/zh active Pending
- 2007-07-05 WO PCT/US2007/072865 patent/WO2008006026A1/en not_active Ceased
- 2007-07-05 ES ES07799327T patent/ES2338488T3/es active Active
- 2007-07-05 JP JP2009518630A patent/JP2009542864A/ja active Pending
- 2007-07-05 DE DE602007003848T patent/DE602007003848D1/de active Active
- 2007-07-05 AU AU2007269140A patent/AU2007269140A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2046817B1 (de) | 2009-12-16 |
| EP2046817A1 (de) | 2009-04-15 |
| ES2338488T3 (es) | 2010-05-07 |
| US20080021192A1 (en) | 2008-01-24 |
| JP2009542864A (ja) | 2009-12-03 |
| CN101511862A (zh) | 2009-08-19 |
| AU2007269140A1 (en) | 2008-01-10 |
| DE602007003848D1 (de) | 2010-01-28 |
| SI2046817T1 (sl) | 2010-04-30 |
| CA2656573A1 (en) | 2008-01-10 |
| EP2143728A1 (de) | 2010-01-13 |
| WO2008006026A1 (en) | 2008-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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