ATE452140T1 - Verbessertes verfahren zur herstellung von copolymer-1 - Google Patents

Verbessertes verfahren zur herstellung von copolymer-1

Info

Publication number: ATE452140T1
Authority: AT; Austria
Prior art keywords: copolymer; protected; carboxyanhydrides; treated; mixture
Prior art date: 2006-07-05

Application number

AT07799327T

Other languages

English (en)

Inventor

Mani Iyer

Corinne Bauer

Pat Oliver-Shaffer

Original Assignee

Momenta Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-05

Filing date

2007-07-05

Publication date

2010-01-15

2007-07-05 Application filed by Momenta Pharmaceuticals Inc filed Critical Momenta Pharmaceuticals Inc

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE452140T1 publication Critical patent/ATE452140T1/de

Links

238000000034 method Methods 0.000 title abstract 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
239000004472 Lysine Substances 0.000 abstract 2
239000004220 glutamic acid Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
235000004279 alanine Nutrition 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
-1 cyclic imide Chemical group 0.000 abstract 1
235000013922 glutamic acid Nutrition 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
239000003505 polymerization initiator Substances 0.000 abstract 1
238000006116 polymerization reaction Methods 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Polymers & Plastics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Polyamides (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

AT07799327T 2006-07-05 2007-07-05 Verbessertes verfahren zur herstellung von copolymer-1 ATE452140T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US80658506P	2006-07-05	2006-07-05
PCT/US2007/072865 WO2008006026A1 (en)	2006-07-05	2007-07-05	Improved process for the preparation of copolymer-1

Publications (1)

Publication Number	Publication Date
ATE452140T1 true ATE452140T1 (de)	2010-01-15

Family

ID=38658274

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07799327T ATE452140T1 (de)	2006-07-05	2007-07-05	Verbessertes verfahren zur herstellung von copolymer-1

Country Status (11)

Country	Link
US (1)	US20080021192A1 (de)
EP (2)	EP2143728A1 (de)
JP (1)	JP2009542864A (de)
CN (1)	CN101511862A (de)
AT (1)	ATE452140T1 (de)
AU (1)	AU2007269140A1 (de)
CA (1)	CA2656573A1 (de)
DE (1)	DE602007003848D1 (de)
ES (1)	ES2338488T3 (de)
SI (1)	SI2046817T1 (de)
WO (1)	WO2008006026A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7429374B2 (en)	2001-12-04	2008-09-30	Teva Pharmaceutical Industries, Ltd.	Process for the measurement of the potency of glatiramer acetate
HRP20160455T1 (hr)	2004-09-09	2016-07-15	Yeda Research And Development Co., Ltd.	Smjese polipeptida, sastavi koji ih sadrže i postupci za njihovu pripremu, te njihove primjene
US8993722B2 (en) *	2007-07-31	2015-03-31	Natco Pharma Limited	Process for the preparation glatiramer acetate (copolymer-1)
WO2009017775A2 (en) *	2007-08-02	2009-02-05	Scinopharm Taiwan Ltd.	Process for the preparation of a polypeptide
US8399600B2 (en) *	2008-08-07	2013-03-19	Sigma-Aldrich Co. Llc	Preparation of low molecular weight polylysine and polyornithine in high yield
US8455619B2 (en) *	2008-11-25	2013-06-04	Keith R. Latham	Polypeptide synthesis for drug delivery
AR074881A1 (es) *	2008-12-24	2011-02-16	Synthon Bv	Un proceso para purificar una mezcla de polimeros
NZ598661A (en)	2009-08-20	2013-02-22	Yeda Res & Dev	Low frequency glatiramer acetate therapy
EP2526420A4 (de) *	2009-11-17	2013-09-18	Ares Trading Sa	Verfahren zur verbesserung der gestalt, bioverfügbarkeit und effizienz von zufälligen sequenzpolymerzusammensetzungen mit serumproteinbasiertem nachweis von zufälligen sequenzpolymerzusammensetzungen
USRE49251E1 (en)	2010-01-04	2022-10-18	Mapi Pharma Ltd.	Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
US8759302B2 (en)	2010-03-16	2014-06-24	Teva Pharmaceutical Industries, Ltd.	Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis
JP2013529194A (ja) *	2010-04-27	2013-07-18	ドクターレディズラボラトリーズリミテッド	ポリペプチドおよびその塩の調製
CA2814500A1 (en)	2010-10-11	2012-04-19	Teva Pharmaceutical Industries Ltd	Cytokine biomarkers as predictive biomarkers of clinical response for glatiramer acetate
US20120123094A1 (en) *	2010-11-17	2012-05-17	Sigma-Aldrich Co. Llc.	Greener method for the production of copolymer 1
WO2013009885A2 (en)	2011-07-11	2013-01-17	Momenta Pharmaceuticals, Inc.	Evaluation of copolymer diethylamide
US8575198B1 (en)	2011-09-07	2013-11-05	Momenta Pharmaceuticals, Inc.	In-process control for the manufacture of glatiramer acetate
HK1200274A1 (en)	2011-10-10	2015-08-07	Teva Pharmaceutical Industries Ltd.	Single nucleotide polymorphisms useful to predict clinical response for glatiramer acetate
CN102617851B (zh) *	2012-03-31	2014-06-11	上海大学	分子量可控聚l-谷氨酸制备方法
US9155775B1 (en)	2015-01-28	2015-10-13	Teva Pharmaceutical Industries, Ltd.	Process for manufacturing glatiramer acetate product
EP3170836B1 (de)	2015-11-23	2018-10-24	Chemi SPA	Rp-hplc-analyse komplexer polypeptidmischungen
US12097292B2 (en)	2016-08-28	2024-09-24	Mapi Pharma Ltd.	Process for preparing microparticles containing glatiramer acetate
CN109982712A (zh)	2016-08-31	2019-07-05	Mapi医药公司	包含醋酸格拉替雷的储库系统
CN110382052A (zh)	2017-03-26	2019-10-25	Mapi医药公司	用于治疗进展型形式的多发性硬化症的格拉替雷储库系统
CN116355201B (zh) *	2023-06-01	2023-09-08	苏州大学	一种基于原位纯化的共聚氨基酸的一锅法制备方法
CN119431772A (zh) *	2023-07-31	2025-02-14	爱美客技术发展股份有限公司	一种超高分子量聚谷氨酸及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3349550A (en) *	1966-11-08	1967-10-31	Lourenco Anthony L	Plant compressing apparatus for mechanical pickers
CA2023176A1 (en) *	1989-08-25	1991-02-26	Margaret M. Bowers-Daines	Preparation and use of iodopropargyl esters of a-amino acid derivatives as antimicrobial agents
IL113812A (en) *	1994-05-24	2000-06-29	Yeda Res & Dev	Copolymer-1 pharmaceutical compositions containing it and its use
WO2004009665A2 (en) *	2002-07-19	2004-01-29	The Regents Of The University Of California	Dendrimers as molecular translocators
WO2004043995A2 (en) *	2002-11-13	2004-05-27	Apotex Pharmachem Inc.	Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine
CA2411786C (en) *	2002-11-13	2009-01-27	Brantford Chemicals Inc.	A process for the preparation of polypeptides from n-carboxyanhydrides of amino acids
AR052321A1 (es) *	2004-10-29	2007-03-14	Sandoz Ag	Procesos para la preparacion de un polipeptido
JP2009504885A (ja) *	2005-08-15	2009-02-05	チャン，ウェイ，ホン	コポリマー−１の製造方法

2007
- 2007-07-05 JP JP2009518630A patent/JP2009542864A/ja active Pending
- 2007-07-05 WO PCT/US2007/072865 patent/WO2008006026A1/en not_active Ceased
- 2007-07-05 AT AT07799327T patent/ATE452140T1/de active
- 2007-07-05 SI SI200730190T patent/SI2046817T1/sl unknown
- 2007-07-05 EP EP09174515A patent/EP2143728A1/de not_active Withdrawn
- 2007-07-05 ES ES07799327T patent/ES2338488T3/es active Active
- 2007-07-05 CA CA002656573A patent/CA2656573A1/en not_active Abandoned
- 2007-07-05 US US11/773,864 patent/US20080021192A1/en not_active Abandoned
- 2007-07-05 AU AU2007269140A patent/AU2007269140A1/en not_active Abandoned
- 2007-07-05 CN CNA2007800328809A patent/CN101511862A/zh active Pending
- 2007-07-05 DE DE602007003848T patent/DE602007003848D1/de active Active
- 2007-07-05 EP EP07799327A patent/EP2046817B1/de active Active

Also Published As

Publication number	Publication date
SI2046817T1 (sl)	2010-04-30
EP2143728A1 (de)	2010-01-13
CA2656573A1 (en)	2008-01-10
US20080021192A1 (en)	2008-01-24
JP2009542864A (ja)	2009-12-03
ES2338488T3 (es)	2010-05-07
EP2046817B1 (de)	2009-12-16
DE602007003848D1 (de)	2010-01-28
AU2007269140A1 (en)	2008-01-10
EP2046817A1 (de)	2009-04-15
WO2008006026A1 (en)	2008-01-10
CN101511862A (zh)	2009-08-19

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