ATE453634T1 - Regioselektives verfahren zur zubereitung von benzimidazol-thiophenen - Google Patents
Regioselektives verfahren zur zubereitung von benzimidazol-thiophenenInfo
- Publication number
- ATE453634T1 ATE453634T1 AT06813938T AT06813938T ATE453634T1 AT E453634 T1 ATE453634 T1 AT E453634T1 AT 06813938 T AT06813938 T AT 06813938T AT 06813938 T AT06813938 T AT 06813938T AT E453634 T1 ATE453634 T1 AT E453634T1
- Authority
- AT
- Austria
- Prior art keywords
- thiophenes
- preparing benzimidazole
- regioselective process
- preparing
- benzimidazole
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 1
- 229930192474 thiophene Natural products 0.000 title 1
- OHNAITIAQLQHJY-UHFFFAOYSA-N 1h-benzimidazole;thiophene Chemical class C=1C=CSC=1.C1=CC=C2NC=NC2=C1 OHNAITIAQLQHJY-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71430105P | 2005-09-06 | 2005-09-06 | |
| PCT/US2006/033793 WO2007030366A1 (en) | 2005-09-06 | 2006-08-28 | Regioselective process for preparing benzimidazole thiophenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453634T1 true ATE453634T1 (de) | 2010-01-15 |
Family
ID=37605702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06813938T ATE453634T1 (de) | 2005-09-06 | 2006-08-28 | Regioselektives verfahren zur zubereitung von benzimidazol-thiophenen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20080249301A1 (de) |
| EP (1) | EP1924572B1 (de) |
| JP (1) | JP2009507022A (de) |
| KR (1) | KR20080045266A (de) |
| CN (1) | CN101304986A (de) |
| AT (1) | ATE453634T1 (de) |
| AU (1) | AU2006287771A1 (de) |
| BR (1) | BRPI0615705A2 (de) |
| CA (1) | CA2621073A1 (de) |
| DE (1) | DE602006011482D1 (de) |
| EA (1) | EA200800549A1 (de) |
| ES (1) | ES2338590T3 (de) |
| IL (1) | IL189769A0 (de) |
| MA (1) | MA29781B1 (de) |
| MX (1) | MX2008003172A (de) |
| NO (1) | NO20081101L (de) |
| WO (1) | WO2007030366A1 (de) |
| ZA (1) | ZA200801950B (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR055616A1 (es) * | 2005-09-06 | 2007-08-29 | Smithkline Beecham Corp | Compuestos de tiofeno bencimidazol |
| WO2007030359A1 (en) * | 2005-09-06 | 2007-03-15 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds as plk modulators |
| CA2637335A1 (en) | 2006-01-23 | 2007-08-02 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| US7829590B2 (en) | 2006-04-13 | 2010-11-09 | Guy Brenchley | Thiophene-carboxamides useful as inhibitors of protein kinases |
| WO2007139795A1 (en) | 2006-05-23 | 2007-12-06 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| AU2007267986A1 (en) | 2006-05-23 | 2007-12-06 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
| WO2009002916A2 (en) * | 2007-06-26 | 2008-12-31 | Smithkline Beecham Corporation | Processes for preparing benzimidazole thiophenes |
| EP2100894A1 (de) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidinone verwendbar als Plk1 (polo-like kinase) Hemmen |
| AU2011240773C1 (en) | 2010-04-12 | 2015-08-27 | Supernus Pharmaceuticals Inc. | Methods for producing viloxazine salts and novel polymorphs thereof |
| JP2013532627A (ja) | 2010-07-01 | 2013-08-19 | 武田薬品工業株式会社 | ｃＭＥＴ阻害剤とＨＧＦおよび／またはｃＭＥＴに対する抗体との組み合わせ |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| EP2565186A1 (de) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Spezifische und reversible Inhibitoren von ubiquitinspezifischer Protease 7 |
| BR112014025201A2 (pt) | 2012-04-10 | 2017-07-11 | Sumitomo Dainippon Pharma Co Ltd | derivado de indazol 1-substituído |
| LT3495367T (lt) | 2012-06-13 | 2021-02-25 | Incyte Holdings Corporation | Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| LT2986610T (lt) | 2013-04-19 | 2018-04-10 | Incyte Holdings Corporation | Bicikliniai heterociklai, kaip fgfr inhibitoriai |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| SG11201706287PA (en) | 2015-02-20 | 2017-09-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| EP3728228A1 (de) | 2017-12-22 | 2020-10-28 | Ravenna Pharmaceuticals, Inc. | Aminopyridinderivate als phosphatidylinositol-phosphatkinase-inhibitoren |
| ES3061844T3 (en) | 2018-05-04 | 2026-04-07 | Incyte Corp | Salts of an fgfr inhibitor |
| MX2020011718A (es) | 2018-05-04 | 2021-02-15 | Incyte Corp | Formas solidas de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr) y procesos para prepararlas. |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| CN109988098A (zh) * | 2019-05-23 | 2019-07-09 | 常州工程职业技术学院 | 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法 |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| TWI891666B (zh) | 2019-10-14 | 2025-08-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之雙環雜環 |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021113462A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法 |
| JP2024522189A (ja) | 2021-06-09 | 2024-06-11 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式ヘテロ環 |
| EP4352060A1 (de) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclische heterocyclen als fgfr-inhibitoren |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5990146A (en) * | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| GB0005642D0 (en) * | 2000-03-10 | 2000-05-03 | Astrazeneca Uk Ltd | Chemical compounds |
| EP1451173A4 (de) * | 2001-11-01 | 2005-10-26 | Icagen Inc | Piperidine |
| PL375532A1 (en) * | 2002-08-08 | 2005-11-28 | Smithkline Beecham Corporation | Benzimidazol-1-yl-thiophene compounds for the treatment of cancer |
| EP1558599A4 (de) * | 2002-10-30 | 2007-06-27 | Merck & Co Inc | Heteroarylpiperidinmodulatoren derchemokinrezeptoraktivitüt |
| WO2005037827A1 (en) * | 2003-10-16 | 2005-04-28 | Smithkline Beecham Corporation | Process for preparing benzimidazole thiophenes |
-
2006
- 2006-08-28 MX MX2008003172A patent/MX2008003172A/es not_active Application Discontinuation
- 2006-08-28 EA EA200800549A patent/EA200800549A1/ru unknown
- 2006-08-28 AT AT06813938T patent/ATE453634T1/de not_active IP Right Cessation
- 2006-08-28 EP EP06813938A patent/EP1924572B1/de active Active
- 2006-08-28 KR KR1020087008167A patent/KR20080045266A/ko not_active Withdrawn
- 2006-08-28 AU AU2006287771A patent/AU2006287771A1/en not_active Abandoned
- 2006-08-28 JP JP2008529214A patent/JP2009507022A/ja not_active Ceased
- 2006-08-28 CN CNA2006800413629A patent/CN101304986A/zh active Pending
- 2006-08-28 CA CA002621073A patent/CA2621073A1/en not_active Abandoned
- 2006-08-28 ES ES06813938T patent/ES2338590T3/es active Active
- 2006-08-28 BR BRPI0615705A patent/BRPI0615705A2/pt not_active IP Right Cessation
- 2006-08-28 WO PCT/US2006/033793 patent/WO2007030366A1/en not_active Ceased
- 2006-08-28 US US12/065,655 patent/US20080249301A1/en not_active Abandoned
- 2006-08-28 DE DE602006011482T patent/DE602006011482D1/de active Active
-
2008
- 2008-02-26 IL IL189769A patent/IL189769A0/en unknown
- 2008-02-29 ZA ZA200801950A patent/ZA200801950B/xx unknown
- 2008-03-03 NO NO20081101A patent/NO20081101L/no not_active Application Discontinuation
- 2008-03-17 MA MA30750A patent/MA29781B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101304986A (zh) | 2008-11-12 |
| ES2338590T3 (es) | 2010-05-10 |
| MX2008003172A (es) | 2008-03-18 |
| WO2007030366A1 (en) | 2007-03-15 |
| KR20080045266A (ko) | 2008-05-22 |
| EP1924572A1 (de) | 2008-05-28 |
| CA2621073A1 (en) | 2007-03-15 |
| US20080249301A1 (en) | 2008-10-09 |
| ZA200801950B (en) | 2009-09-30 |
| NO20081101L (no) | 2008-04-04 |
| AU2006287771A1 (en) | 2007-03-15 |
| MA29781B1 (fr) | 2008-09-01 |
| IL189769A0 (en) | 2008-08-07 |
| BRPI0615705A2 (pt) | 2016-08-23 |
| JP2009507022A (ja) | 2009-02-19 |
| EA200800549A1 (ru) | 2008-08-29 |
| EP1924572B1 (de) | 2009-12-30 |
| DE602006011482D1 (de) | 2010-02-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |