BRPI0615705A2 - processo para preparar um composto, e, composto - Google Patents
processo para preparar um composto, e, compostoInfo
- Publication number
- BRPI0615705A2 BRPI0615705A2 BRPI0615705A BRPI0615705A BRPI0615705A2 BR PI0615705 A2 BRPI0615705 A2 BR PI0615705A2 BR PI0615705 A BRPI0615705 A BR PI0615705A BR PI0615705 A BRPI0615705 A BR PI0615705A BR PI0615705 A2 BRPI0615705 A2 BR PI0615705A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparing
- formula
- provides
- present
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 2
- OHNAITIAQLQHJY-UHFFFAOYSA-N 1h-benzimidazole;thiophene Chemical class C=1C=CSC=1.C1=CC=C2NC=NC2=C1 OHNAITIAQLQHJY-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71430105P | 2005-09-06 | 2005-09-06 | |
| PCT/US2006/033793 WO2007030366A1 (en) | 2005-09-06 | 2006-08-28 | Regioselective process for preparing benzimidazole thiophenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0615705A2 true BRPI0615705A2 (pt) | 2016-08-23 |
Family
ID=37605702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0615705A BRPI0615705A2 (pt) | 2005-09-06 | 2006-08-28 | processo para preparar um composto, e, composto |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20080249301A1 (pt) |
| EP (1) | EP1924572B1 (pt) |
| JP (1) | JP2009507022A (pt) |
| KR (1) | KR20080045266A (pt) |
| CN (1) | CN101304986A (pt) |
| AT (1) | ATE453634T1 (pt) |
| AU (1) | AU2006287771A1 (pt) |
| BR (1) | BRPI0615705A2 (pt) |
| CA (1) | CA2621073A1 (pt) |
| DE (1) | DE602006011482D1 (pt) |
| EA (1) | EA200800549A1 (pt) |
| ES (1) | ES2338590T3 (pt) |
| IL (1) | IL189769A0 (pt) |
| MA (1) | MA29781B1 (pt) |
| MX (1) | MX2008003172A (pt) |
| NO (1) | NO20081101L (pt) |
| WO (1) | WO2007030366A1 (pt) |
| ZA (1) | ZA200801950B (pt) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009507020A (ja) * | 2005-09-06 | 2009-02-19 | スミスクライン ビーチャム コーポレーション | Ｐｌｋ調節物質としてのルベンゾイミダゾールチオフェン化合物 |
| MX2008003173A (es) * | 2005-09-06 | 2008-03-18 | Smithkline Beecham Corp | Compuestos de bencimidazol-tiofeno como inhibidores de plk. |
| EP2474546A1 (en) * | 2006-01-23 | 2012-07-11 | Vertex Pharmaceuticals Inc. | Thiophene-carboxamides useful as inhibitors of protein kinases |
| EP2007757B1 (en) | 2006-04-13 | 2012-10-03 | Vertex Pharmceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| CA2652816A1 (en) | 2006-05-23 | 2007-12-06 | Vertex Pharmaceuticals Incorporated | Thiophene-carboxamides useful as inhibitors of protein kinases |
| JP2009538305A (ja) | 2006-05-23 | 2009-11-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド |
| US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
| JP2010531887A (ja) * | 2007-06-26 | 2010-09-30 | グラクソスミスクライン エルエルシー | ベンズイミダゾールチオフェンの調製方法 |
| EP2100894A1 (en) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors |
| ES2552166T3 (es) * | 2010-04-12 | 2015-11-26 | Supernus Pharmaceuticals, Inc. | Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas |
| EP2588107A1 (en) | 2010-07-01 | 2013-05-08 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| EP2565186A1 (en) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| BR112014025201A2 (pt) | 2012-04-10 | 2017-07-11 | Sumitomo Dainippon Pharma Co Ltd | derivado de indazol 1-substituído |
| CA2876689C (en) | 2012-06-13 | 2022-04-26 | Incyte Corporation | Substituted tricyclic compounds as fgfr inhibitors |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| CA2976790C (en) | 2015-02-20 | 2024-02-27 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| WO2019126731A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| RS66310B1 (sr) | 2018-05-04 | 2025-01-31 | Incyte Corp | Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu |
| KR102956194B1 (ko) | 2018-05-04 | 2026-04-23 | 인사이트 코포레이션 | Fgfr 억제제의 염 |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| CN109988098A (zh) * | 2019-05-23 | 2019-07-09 | 常州工程职业技术学院 | 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法 |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| GEP20247679B (en) | 2019-10-14 | 2024-10-10 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| MX2022006691A (es) | 2019-12-04 | 2022-09-19 | Incyte Corp | Derivados de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr). |
| WO2021113479A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| EP4323405A1 (en) | 2021-04-12 | 2024-02-21 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| CA3220274A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| TW202313610A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之三環雜環 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5990146A (en) * | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| GB0005642D0 (en) * | 2000-03-10 | 2000-05-03 | Astrazeneca Uk Ltd | Chemical compounds |
| WO2003037890A2 (en) * | 2001-11-01 | 2003-05-08 | Icagen, Inc. | Piperidines |
| MXPA05001544A (es) * | 2002-08-08 | 2005-04-19 | Smithkline Beecham Corp | Compuestos de tiofeno. |
| JP2006508948A (ja) * | 2002-10-30 | 2006-03-16 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性のヘテロアリールピペリジンモジュレーター |
| EP1685128A1 (en) * | 2003-10-16 | 2006-08-02 | Smithkline Beecham Corporation | Process for preparing benzimidazole thiophenes |
-
2006
- 2006-08-28 EP EP06813938A patent/EP1924572B1/en active Active
- 2006-08-28 US US12/065,655 patent/US20080249301A1/en not_active Abandoned
- 2006-08-28 AU AU2006287771A patent/AU2006287771A1/en not_active Abandoned
- 2006-08-28 CN CNA2006800413629A patent/CN101304986A/zh active Pending
- 2006-08-28 AT AT06813938T patent/ATE453634T1/de not_active IP Right Cessation
- 2006-08-28 BR BRPI0615705A patent/BRPI0615705A2/pt not_active IP Right Cessation
- 2006-08-28 MX MX2008003172A patent/MX2008003172A/es not_active Application Discontinuation
- 2006-08-28 KR KR1020087008167A patent/KR20080045266A/ko not_active Withdrawn
- 2006-08-28 ES ES06813938T patent/ES2338590T3/es active Active
- 2006-08-28 CA CA002621073A patent/CA2621073A1/en not_active Abandoned
- 2006-08-28 WO PCT/US2006/033793 patent/WO2007030366A1/en not_active Ceased
- 2006-08-28 DE DE602006011482T patent/DE602006011482D1/de active Active
- 2006-08-28 EA EA200800549A patent/EA200800549A1/ru unknown
- 2006-08-28 JP JP2008529214A patent/JP2009507022A/ja not_active Ceased
-
2008
- 2008-02-26 IL IL189769A patent/IL189769A0/en unknown
- 2008-02-29 ZA ZA200801950A patent/ZA200801950B/xx unknown
- 2008-03-03 NO NO20081101A patent/NO20081101L/no not_active Application Discontinuation
- 2008-03-17 MA MA30750A patent/MA29781B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200801950B (en) | 2009-09-30 |
| ATE453634T1 (de) | 2010-01-15 |
| AU2006287771A1 (en) | 2007-03-15 |
| CA2621073A1 (en) | 2007-03-15 |
| US20080249301A1 (en) | 2008-10-09 |
| MX2008003172A (es) | 2008-03-18 |
| EA200800549A1 (ru) | 2008-08-29 |
| MA29781B1 (fr) | 2008-09-01 |
| IL189769A0 (en) | 2008-08-07 |
| ES2338590T3 (es) | 2010-05-10 |
| CN101304986A (zh) | 2008-11-12 |
| EP1924572A1 (en) | 2008-05-28 |
| WO2007030366A1 (en) | 2007-03-15 |
| NO20081101L (no) | 2008-04-04 |
| KR20080045266A (ko) | 2008-05-22 |
| DE602006011482D1 (de) | 2010-02-11 |
| EP1924572B1 (en) | 2009-12-30 |
| JP2009507022A (ja) | 2009-02-19 |
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| EA200870038A1 (ru) | Способ получения аминов |
Legal Events
| Date | Code | Title | Description |
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| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] |
Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 PAR 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO NO ORIGINAL, TRASLADO OU FOTOCOPIA AUTENTICADA. |
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| B11Z | Dismissal: petition dismissal - article 216, par 2 of industrial property law |
Free format text: REFERENTE A PETICAO NO 20080033280/RJ DE 05/03/2008. |
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| B06H | Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette] |
Free format text: O DESPACHO 6.7 ESTA SENDO ANULADO TENDO POR BASE A DETERMINACAO DO DIRETOR DE PATENTES, A QUAL E CALCADA NO PARECER NO 0003-2014 AGU/PGF/PFE/INPI/COOPHI-LBC-1.0. |
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| B11M | Decision cancelled [chapter 11.13 patent gazette] |
Free format text: O DESPACHO 11.6.1 ESTA SENDO ANULADO TENDO POR BASE A DETERMINACAO DO DIRETOR DE PATENTES, A QUAL E CALCADA NO PARECER NO 0003-2014 AGU/PGF/PFE/INPI/COOPHI-LBC-1.0. |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A,7A,8A,9A E 10A ANUIDADES |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] |