ATE453639T1 - Phenylsubstituierte pyrimidinverbindungen zur verwendung als kinasehemmer - Google Patents
Phenylsubstituierte pyrimidinverbindungen zur verwendung als kinasehemmerInfo
- Publication number
- ATE453639T1 ATE453639T1 AT06734200T AT06734200T ATE453639T1 AT E453639 T1 ATE453639 T1 AT E453639T1 AT 06734200 T AT06734200 T AT 06734200T AT 06734200 T AT06734200 T AT 06734200T AT E453639 T1 ATE453639 T1 AT E453639T1
- Authority
- AT
- Austria
- Prior art keywords
- kinase inhibitors
- phenyl substituted
- pyrimidine compounds
- substituted pyrimidine
- kinase
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010089704 Lim Kinases Proteins 0.000 abstract 1
- 102000008020 Lim Kinases Human genes 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65007705P | 2005-02-04 | 2005-02-04 | |
| US11/344,881 US20060178388A1 (en) | 2005-02-04 | 2006-02-01 | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
| PCT/US2006/003659 WO2006084017A2 (en) | 2005-02-04 | 2006-02-02 | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453639T1 true ATE453639T1 (de) | 2010-01-15 |
Family
ID=36481437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06734200T ATE453639T1 (de) | 2005-02-04 | 2006-02-02 | Phenylsubstituierte pyrimidinverbindungen zur verwendung als kinasehemmer |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20060178388A1 (de) |
| EP (1) | EP1848714B1 (de) |
| JP (1) | JP4906738B2 (de) |
| AT (1) | ATE453639T1 (de) |
| DE (1) | DE602006011434D1 (de) |
| ES (1) | ES2336025T3 (de) |
| WO (1) | WO2006084017A2 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| DE102005048072A1 (de) * | 2005-09-24 | 2007-04-05 | Bayer Cropscience Ag | Thiazole als Fungizide |
| EP1981884B1 (de) * | 2006-01-18 | 2012-06-13 | Amgen, Inc | Thiazolverbindungen als proteinkinase b (pkb)-inhibitoren |
| US20080242694A1 (en) * | 2006-09-18 | 2008-10-02 | D Sidocky Neil R | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith |
| EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
| WO2009011871A2 (en) * | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of pkb |
| WO2009011880A2 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Heterocyclic modulators of pkb |
| AU2008285388B2 (en) | 2007-08-08 | 2013-09-19 | Lexicon Pharmaceuticals, Inc. | (7h-pyrrolo [2, 3-d] pyrimidin-4-yl) -piperazines as kinase inhibitors for the treatment of cancer and inflammation |
| BRPI0819976A2 (pt) | 2007-12-03 | 2019-02-12 | Signum Biosciences, Inc. | composto mimético de ácido para a inibição de isoprenil-s-cisteinil metiltransferase, composição compreedendo os mesmos, bem como uso dos ditos compostos. |
| WO2009093981A1 (en) * | 2008-01-23 | 2009-07-30 | S Bio Pte Ltd | Triazine compounds as kinase inhibitors |
| JPWO2009096198A1 (ja) * | 2008-02-01 | 2011-05-26 | 一般社団法人ファルマＩｐ | 新規ビアリール誘導体 |
| WO2009125870A1 (en) | 2008-04-09 | 2009-10-15 | Mitsubishi Tanabe Pharma Corporation | Pyrimidine, pyridine and triazine derivatives as maxi-k channel openers. |
| US8193202B2 (en) | 2008-04-21 | 2012-06-05 | Lexicon Pharmaceuticals, Inc. | LIMK2 inhibitors, compositions comprising them, and methods of their use |
| EP2528441A4 (de) * | 2010-01-25 | 2013-07-10 | Chdi Foundation Inc | Bestimmte kynurenin-3-monooxygenase-hemmer, pharmazeutische zusammensetzungen daraus und verwendungsverfahren dafür |
| JP2013107824A (ja) * | 2010-03-17 | 2013-06-06 | Dainippon Sumitomo Pharma Co Ltd | 新規単環ピリミジン誘導体 |
| WO2012078687A1 (en) * | 2010-12-06 | 2012-06-14 | Confluence Life Sciences, Inc. | Substituted pyrimidine urea compounds |
| JP2014525443A (ja) | 2011-08-30 | 2014-09-29 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | キヌレニン−３−モノオキシゲナーゼインヒビター、医薬組成物、およびこれらの使用方法 |
| US9981918B2 (en) | 2011-08-30 | 2018-05-29 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| US9532972B2 (en) * | 2012-02-07 | 2017-01-03 | University Of Central Florida Research Foundation, Inc. | Increasing taxane sensitivity in cancer cells |
| WO2013138456A1 (en) | 2012-03-14 | 2013-09-19 | University Of Central Florida Research Foundation, Inc. | Lim kinasemodulating agents for neurofibromatoses therapy and methods for screening for same |
| WO2015025172A1 (en) * | 2013-08-22 | 2015-02-26 | Mark David Charles | 5-aryl-thiazol-2-yl-amine compounds and their therapeutic use |
| SG11201604595VA (en) * | 2013-12-11 | 2016-07-28 | Biogen Ma Inc | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
| KR20170026633A (ko) | 2014-07-17 | 2017-03-08 | 씨에이치디아이 파운데이션, 인코포레이티드 | Hiv-관련 장애의 치료 방법 및 치료용 조성물 |
| EP3205157B1 (de) * | 2014-10-11 | 2021-01-13 | Telefonaktiebolaget LM Ericsson (publ) | Verfahren und zugangspunkt zur aufrechterhaltung der synchronisation zwischen zugangspunkten in einem funkzugriffsnetz |
| JP6616244B2 (ja) * | 2015-05-29 | 2019-12-04 | 北興化学工業株式会社 | 新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法 |
| WO2017007755A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| LT3319959T (lt) | 2015-07-06 | 2021-12-27 | Alkermes, Inc. | Histono deacetilazės hetero-halogeno inhibitoriai |
| AU2017300336B2 (en) * | 2016-07-18 | 2021-03-11 | National Institute Of Biological Sciences, Beijing | Apoptosis inhibitors |
| JP2019532944A (ja) | 2016-09-23 | 2019-11-14 | セルイプセ | Ｌｉｍｋ介在性疾患における、ｌｉｍキナーゼ阻害剤、医薬組成物および使用方法 |
| CN106727536B (zh) * | 2016-11-30 | 2019-05-31 | 东南大学 | LIM激酶抑制剂LIMKi3在制备治疗疼痛药物中的应用 |
| US10793567B2 (en) | 2017-01-11 | 2020-10-06 | Rodin Therapeutics, Inc. | Bicyclic inhibitors of histone deacetylase |
| JOP20190193A1 (ar) | 2017-02-09 | 2019-08-08 | Bayer Pharma AG | ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان |
| US11040947B2 (en) | 2017-03-22 | 2021-06-22 | The Research Foundation For The State University Of New York | Substituted quinazolines as matrix metalloproteinase-9 hemopexin domain inhibitors |
| EA039417B1 (ru) | 2017-08-07 | 2022-01-25 | Родин Терапеутикс, Инк. | Бициклические ингибиторы гистондеацетилазы |
| JP2021501130A (ja) | 2017-10-05 | 2021-01-14 | フルクラム セラピューティクス，インコーポレイテッド | ＤＵＸ４の発現を低減するためのｐ３８阻害剤の使用 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| CA3082855A1 (en) * | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 2-hetarylpyrimidine-4-carboxamides as aryl hydrocarbon receptor anatgonists |
| AU2019207517A1 (en) | 2018-01-15 | 2020-08-27 | Aucentra Therapeutics Pty Ltd | 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents |
| CA3240263A1 (en) | 2021-12-09 | 2023-06-15 | Daniel L. Flynn | Raf kinase inhibitors and methods of use thereof |
| CN117003730A (zh) * | 2022-04-29 | 2023-11-07 | 德明药泰生物技术（深圳）有限公司 | 取代嘧啶酰肼类化合物及其制备方法和应用 |
| CN117624135A (zh) * | 2022-08-19 | 2024-03-01 | 德明药泰生物技术（深圳）有限公司 | 2-氮取代嘧啶类化合物及其制备方法和应用 |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2201083A1 (en) * | 1972-09-28 | 1974-04-26 | Ferlux | 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics |
| US4200750A (en) | 1977-01-07 | 1980-04-29 | Westwood Pharmaceuticals Inc. | 4-Substituted imidazo [1,2-a]quinoxalines |
| CA1288433C (en) * | 1986-12-03 | 1991-09-03 | Tsuguhiro Katoh | Pyridinylpyrimidine derivatives, method for production thereof and a fungicide containing them as the active ingredient |
| DE3922735A1 (de) * | 1989-07-11 | 1991-01-24 | Hoechst Ag | Aminopyrimidin-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als fungizide |
| DE3940476A1 (de) * | 1989-12-07 | 1991-06-13 | Bayer Ag | Pyridinylpyrimidin-derivate |
| US5022915A (en) * | 1990-03-01 | 1991-06-11 | Ici Americas Inc. | Substituted 2,4-diarylpyrimidines and their use as herbicides |
| US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| HUP9603433A3 (en) * | 1995-04-13 | 1998-04-28 | Taiho Pharmaceutical Co Ltd | 4-6-diaryl-pyrimidine-derivatives, process for producing them and pharmaceutical compositions containing them |
| US5658903A (en) | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| ES2205167T3 (es) | 1996-01-11 | 2004-05-01 | Smithkline Beecham Corporation | Nuevos compuestos de imidazol sustituidos. |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| US6147080A (en) | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US5945418A (en) | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US6087496A (en) | 1998-05-22 | 2000-07-11 | G. D. Searle & Co. | Substituted pyrazoles suitable as p38 kinase inhibitors |
| PL336990A1 (en) | 1997-05-22 | 2000-07-31 | Searle & Co | 3(5)-heteroaryl group substituted pyrazoles as inhibitors of kinase p 38 |
| US6251914B1 (en) | 1997-07-02 | 2001-06-26 | Smithkline Beecham Corporation | Cycloalkyl substituted imidazoles |
| US6130235A (en) | 1998-05-22 | 2000-10-10 | Scios Inc. | Compounds and methods to treat cardiac failure and other disorders |
| IL141724A0 (en) | 1998-08-28 | 2002-03-10 | Scios Inc | INHIBITORS OF P38-α KINASE |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| AR023659A1 (es) * | 1998-09-18 | 2002-09-04 | Vertex Pharma | Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos |
| JP2002531549A (ja) | 1998-12-04 | 2002-09-24 | ブリストル−マイヤーズ スクイブ カンパニー | カリウムチャネル・モジュレーターとしての３−置換−４−アリールキノリン−２−オン誘導体 |
| GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
| US6548529B1 (en) | 1999-04-05 | 2003-04-15 | Bristol-Myers Squibb Company | Heterocyclic containing biphenyl aP2 inhibitors and method |
| JP2001089452A (ja) | 1999-09-22 | 2001-04-03 | Sankyo Co Ltd | ピリミジン誘導体 |
| GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
| MXPA01007019A (es) | 1999-11-10 | 2002-09-18 | Johnson & Johnson | 2-aril-3-(heteroaril)-imidazo[1,2-a]pirimidinas, sustituidas y composiciones farmaceuticas relacionados y metodos. |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| JP2001199982A (ja) * | 2000-01-14 | 2001-07-24 | Dainippon Pharmaceut Co Ltd | ６−ヘテロアリールピリミジン誘導体及びそれを含有する医薬組成物 |
| AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| HUP0300382A3 (en) | 2000-03-29 | 2006-11-28 | Cyclacel Ltd | 2-substituted 4-heteroaryl-pyrimidines and their use in the treatmetn of proliferative disorders and pharmaceutical compositions containing the compounds |
| DK1318997T3 (da) | 2000-09-15 | 2006-09-25 | Vertex Pharma | Pyrazolforbindelser der er nyttige som proteinkinase-inhibitorer |
| US6670357B2 (en) | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
| DE60208630T2 (de) | 2001-05-11 | 2006-08-17 | Pfizer Products Inc., Groton | Thiazolderivate und ihre Verwendung als cdk-Inhibitoren |
| EP1430051B1 (de) * | 2001-09-28 | 2006-12-27 | Cyclacel Limited | N-(4-(4-methylthiazol-5-yl)pyrimidin-2-yl)-n-phenylamine als antiproliferative verbindungen |
| AU2002357137A1 (en) * | 2001-12-10 | 2003-06-23 | Bristol-Myers Squibb Company | (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase |
| JP2003206230A (ja) | 2002-01-10 | 2003-07-22 | Yamanouchi Pharmaceut Co Ltd | シアノヘテロ環誘導体又はその塩 |
| TW200400034A (en) | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
| GB0217431D0 (en) | 2002-07-27 | 2002-09-04 | Astrazeneca Ab | Novel compounds |
| GB0226582D0 (en) | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Anti-viral compounds |
| ATE479667T1 (de) * | 2003-02-06 | 2010-09-15 | Bristol Myers Squibb Co | Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis |
| WO2004080979A1 (en) * | 2003-03-14 | 2004-09-23 | Lg Life Sciences Ltd. | Novel 3-(2-amino-4-pyrimidinyl)-4-hydroxyphenyl ketone derivatives |
| US20060293339A1 (en) | 2003-03-24 | 2006-12-28 | Chakravarty Prasun K | Biaryl substituted 6-membered heterocycles as sodium channel blockers |
| WO2004087679A1 (en) * | 2003-04-01 | 2004-10-14 | Aponetics Ag | 2, 4, 6-trisubstituted pyrimidine derivatives useful for the treatment of neoplastic and autoimmune diseases |
| TW200519106A (en) * | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| AU2004257289A1 (en) * | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
| GB0403155D0 (en) * | 2004-02-12 | 2004-03-17 | Vernalis Res Ltd | Chemical compounds |
| WO2005113514A2 (en) * | 2004-05-07 | 2005-12-01 | Janssen Pharmaceutica, N.V. | Substituted pyrimidines as inhibitors of bacterial type iii protein secretion systems |
| US20080132509A1 (en) * | 2004-12-13 | 2008-06-05 | Neurogen Corporation | Substituted Biaryl Analogues |
-
2006
- 2006-02-01 US US11/344,881 patent/US20060178388A1/en not_active Abandoned
- 2006-02-02 WO PCT/US2006/003659 patent/WO2006084017A2/en not_active Ceased
- 2006-02-02 DE DE602006011434T patent/DE602006011434D1/de not_active Expired - Lifetime
- 2006-02-02 EP EP06734200A patent/EP1848714B1/de not_active Expired - Lifetime
- 2006-02-02 AT AT06734200T patent/ATE453639T1/de not_active IP Right Cessation
- 2006-02-02 ES ES06734200T patent/ES2336025T3/es not_active Expired - Lifetime
- 2006-02-02 JP JP2007554206A patent/JP4906738B2/ja not_active Expired - Fee Related
-
2009
- 2009-09-30 US US12/570,010 patent/US7923556B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006011434D1 (de) | 2010-02-11 |
| WO2006084017A2 (en) | 2006-08-10 |
| WO2006084017A3 (en) | 2006-12-14 |
| US7923556B2 (en) | 2011-04-12 |
| EP1848714A2 (de) | 2007-10-31 |
| US20060178388A1 (en) | 2006-08-10 |
| EP1848714B1 (de) | 2009-12-30 |
| US20100029649A1 (en) | 2010-02-04 |
| JP2008530012A (ja) | 2008-08-07 |
| ES2336025T3 (es) | 2010-04-07 |
| JP4906738B2 (ja) | 2012-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE453639T1 (de) | Phenylsubstituierte pyrimidinverbindungen zur verwendung als kinasehemmer | |
| NO20070532L (no) | Substituerte 2-alkyl-kinazolinonderivater som PARP-inhibitorer | |
| ATE433981T1 (de) | Heterocyclische verbindungen | |
| ATE508747T1 (de) | C-kit kinase-hemmer | |
| GEP20074148B (en) | Pyrrolo-triazine aniline compounds useful as kinase inhibitors | |
| ATE469154T1 (de) | Pyrazolopyrimidine als zellzyklus-kinasehemmer | |
| SG154432A1 (en) | Quinazolinedione derivatives as parp inhibitors | |
| MY153727A (en) | Pyridazinone derivatives | |
| TW200610531A (en) | Phthalazine derivatives as PARP inhibitors | |
| MX2009012709A (es) | Derivados de arileter-piridazinona. | |
| DK1070056T3 (da) | Phthalazinon-PDE III/IV-inhibitorer | |
| IL185275A0 (en) | N-sulphonylpyrrole derivatives and pharmaceutical compositions containing the same | |
| EA200801291A1 (ru) | Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ | |
| EA200701257A1 (ru) | Пирролопиразолы в качестве сильнодействующих ингибиторов киназы | |
| IL181271A0 (en) | Triazolophthalazine derivatives and pharmaceutical compositions containing the same | |
| UA94570C2 (en) | Phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase | |
| SE0403171D0 (sv) | New compounds | |
| MX2011011764A (es) | Compuestos de carboxamida y su uso como inhibidores de calpaina. | |
| ATE355265T1 (de) | Biphenylcarboxamidderivate und ihre verwendung als p38 kinase inhibitoren | |
| MXPA05009151A (es) | Inhibidores de cinasa heterociclica. | |
| ATE553106T1 (de) | Heteroarylpyrrolopyridinone als kinaseinhibitoren | |
| ATE413392T1 (de) | Kondensierte heteroyralderivate und deren verwendung als p38-kinase-inhibitoren | |
| TW200716529A (en) | New compounds II | |
| TW200716118A (en) | Aminopyrimidines as kinase modulators | |
| DK1147088T3 (da) | 6-arylphenanthridiner med PDE-IV-inhiberende aktivitet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |