ATE453639T1 - Phenylsubstituierte pyrimidinverbindungen zur verwendung als kinasehemmer - Google Patents
Phenylsubstituierte pyrimidinverbindungen zur verwendung als kinasehemmerInfo
- Publication number
- ATE453639T1 ATE453639T1 AT06734200T AT06734200T ATE453639T1 AT E453639 T1 ATE453639 T1 AT E453639T1 AT 06734200 T AT06734200 T AT 06734200T AT 06734200 T AT06734200 T AT 06734200T AT E453639 T1 ATE453639 T1 AT E453639T1
- Authority
- AT
- Austria
- Prior art keywords
- kinase inhibitors
- phenyl substituted
- pyrimidine compounds
- substituted pyrimidine
- kinase
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010089704 Lim Kinases Proteins 0.000 abstract 1
- 102000008020 Lim Kinases Human genes 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65007705P | 2005-02-04 | 2005-02-04 | |
| US11/344,881 US20060178388A1 (en) | 2005-02-04 | 2006-02-01 | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
| PCT/US2006/003659 WO2006084017A2 (en) | 2005-02-04 | 2006-02-02 | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453639T1 true ATE453639T1 (de) | 2010-01-15 |
Family
ID=36481437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06734200T ATE453639T1 (de) | 2005-02-04 | 2006-02-02 | Phenylsubstituierte pyrimidinverbindungen zur verwendung als kinasehemmer |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20060178388A1 (de) |
| EP (1) | EP1848714B1 (de) |
| JP (1) | JP4906738B2 (de) |
| AT (1) | ATE453639T1 (de) |
| DE (1) | DE602006011434D1 (de) |
| ES (1) | ES2336025T3 (de) |
| WO (1) | WO2006084017A2 (de) |
Families Citing this family (41)
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| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| DE102005048072A1 (de) * | 2005-09-24 | 2007-04-05 | Bayer Cropscience Ag | Thiazole als Fungizide |
| WO2007084391A2 (en) * | 2006-01-18 | 2007-07-26 | Amgen Inc. | Thiazole compounds as protein kinase b ( pkb) inhibitors |
| US20080242694A1 (en) * | 2006-09-18 | 2008-10-02 | D Sidocky Neil R | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith |
| EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
| US7919504B2 (en) * | 2007-07-17 | 2011-04-05 | Amgen Inc. | Thiadiazole modulators of PKB |
| EP2173728A2 (de) | 2007-07-17 | 2010-04-14 | Amgen Inc. | Heterocyclische pkb-modulatoren |
| DK2188289T3 (en) | 2007-08-08 | 2016-01-25 | Lexicon Pharmaceuticals Inc | (7H-Pyrrolo [2,3-D] pyrimidin-4-yl) -piperazines as kinase inhibitors for the treatment of cancer and inflammation |
| BRPI0819976A2 (pt) * | 2007-12-03 | 2019-02-12 | Signum Biosciences, Inc. | composto mimético de ácido para a inibição de isoprenil-s-cisteinil metiltransferase, composição compreedendo os mesmos, bem como uso dos ditos compostos. |
| WO2009093981A1 (en) * | 2008-01-23 | 2009-07-30 | S Bio Pte Ltd | Triazine compounds as kinase inhibitors |
| WO2009096198A1 (ja) * | 2008-02-01 | 2009-08-06 | Pharma Ip Limited Liability Intermediary Corporations | 新規ビアリール誘導体 |
| TW200948362A (en) | 2008-04-09 | 2009-12-01 | Mitsubishi Tanabe Pharma Corp | New compounds and their uses |
| AU2009239500B2 (en) | 2008-04-21 | 2014-01-30 | Lexicon Pharmaceuticals, Inc. | LIMK2 inhibitors, compositions comprising them, and methods of their use |
| CA2787365A1 (en) * | 2010-01-25 | 2011-07-28 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| JP2013107824A (ja) * | 2010-03-17 | 2013-06-06 | Dainippon Sumitomo Pharma Co Ltd | 新規単環ピリミジン誘導体 |
| WO2012078687A1 (en) * | 2010-12-06 | 2012-06-14 | Confluence Life Sciences, Inc. | Substituted pyrimidine urea compounds |
| KR20140072037A (ko) | 2011-08-30 | 2014-06-12 | 씨에이치디아이 파운데이션, 인코포레이티드 | 키뉴레닌-3-모노옥시게나제 억제제, 약학적 조성물 및 이의 사용 방법 |
| SI2750677T1 (sl) | 2011-08-30 | 2017-10-30 | Chdi Foundation, Inc. | Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe |
| US9532972B2 (en) * | 2012-02-07 | 2017-01-03 | University Of Central Florida Research Foundation, Inc. | Increasing taxane sensitivity in cancer cells |
| WO2013138456A1 (en) | 2012-03-14 | 2013-09-19 | University Of Central Florida Research Foundation, Inc. | Lim kinasemodulating agents for neurofibromatoses therapy and methods for screening for same |
| WO2015025172A1 (en) * | 2013-08-22 | 2015-02-26 | Mark David Charles | 5-aryl-thiazol-2-yl-amine compounds and their therapeutic use |
| AU2014362231B2 (en) * | 2013-12-11 | 2019-04-04 | Biogen Ma Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
| AU2015289492B2 (en) | 2014-07-17 | 2020-02-20 | Chdi Foundation, Inc. | Methods and compositions for treating HIV-related disorders |
| WO2016054820A1 (en) * | 2014-10-11 | 2016-04-14 | Telefonaktiebolaget L M Ericsson (Publ) | Method and access point for maintaining synchronization among access points in radio access network |
| JP6616244B2 (ja) * | 2015-05-29 | 2019-12-04 | 北興化学工業株式会社 | 新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法 |
| EP3319968A1 (de) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclische n-aminophenyl-amide als inhibitoren der histondeacetylase |
| WO2017007756A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc | Hetero-halo inhibitors of histone deacetylase |
| KR102470130B1 (ko) * | 2016-07-18 | 2022-11-24 | 내셔널 인스티튜트 오브 바이올로지칼 사이언시스, 베이징 | 아폽토시스 억제제 |
| US20190263796A1 (en) | 2016-09-23 | 2019-08-29 | Cellipse | Lim kinase inhibitors, pharmaceutical composition and method of use in limk-mediated diseases |
| CN106727536B (zh) * | 2016-11-30 | 2019-05-31 | 东南大学 | LIM激酶抑制剂LIMKi3在制备治疗疼痛药物中的应用 |
| HUE057849T2 (hu) | 2017-01-11 | 2022-06-28 | Alkermes Inc | Hiszton deacetiláz biciklusos gátlói |
| HUE053191T2 (hu) | 2017-02-09 | 2021-06-28 | Bayer Ag | 2-Heteroaril-3-oxo-2,3-dihidropiridazin-4-karboxamidok rák kezelésére |
| US11040947B2 (en) | 2017-03-22 | 2021-06-22 | The Research Foundation For The State University Of New York | Substituted quinazolines as matrix metalloproteinase-9 hemopexin domain inhibitors |
| LT3664802T (lt) | 2017-08-07 | 2022-06-27 | Alkermes, Inc. | Bicikliniai histonų deacetilazės inhibitoriai |
| BR112020006677A2 (pt) | 2017-10-05 | 2020-10-06 | Fulcrum Therapeutics, Inc. | uso de inibidores p38 para reduzir a expressão de dux4 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| EP3713926B1 (de) | 2017-11-21 | 2023-06-07 | Bayer Aktiengesellschaft | 2-hetarylpyrimidine-4-carboxamide als aryl hydrocarbon receptor anatgonisten |
| EP3740484B1 (de) * | 2018-01-15 | 2024-09-11 | Aucentra Therapeutics Pty Ltd | 5-(pyrimidin-4-yl)thiazol-2-yl-harnstoffderivate als therapeutika |
| CA3240263A1 (en) | 2021-12-09 | 2023-06-15 | Daniel L. Flynn | Raf kinase inhibitors and methods of use thereof |
| CN117003730A (zh) * | 2022-04-29 | 2023-11-07 | 德明药泰生物技术（深圳）有限公司 | 取代嘧啶酰肼类化合物及其制备方法和应用 |
| CN117624135A (zh) * | 2022-08-19 | 2024-03-01 | 德明药泰生物技术（深圳）有限公司 | 2-氮取代嘧啶类化合物及其制备方法和应用 |
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| FR2201083A1 (en) * | 1972-09-28 | 1974-04-26 | Ferlux | 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics |
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| US6251914B1 (en) | 1997-07-02 | 2001-06-26 | Smithkline Beecham Corporation | Cycloalkyl substituted imidazoles |
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| PT1133474E (pt) | 1998-12-04 | 2007-04-30 | Bristol Myers Squibb Co | Derivados da 4-arilquinolin-2-ona substituidos em 3 posições utilizados como moduladores do canal de potássio. |
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| JP2003206230A (ja) | 2002-01-10 | 2003-07-22 | Yamanouchi Pharmaceut Co Ltd | シアノヘテロ環誘導体又はその塩 |
| TW200400034A (en) | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
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| GB0226582D0 (en) | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Anti-viral compounds |
| WO2004071440A2 (en) * | 2003-02-06 | 2004-08-26 | Bristol-Myers Squibb Company | Thiazolyl-based compounds useful as kinase inhibitors |
| WO2004080979A1 (en) * | 2003-03-14 | 2004-09-23 | Lg Life Sciences Ltd. | Novel 3-(2-amino-4-pyrimidinyl)-4-hydroxyphenyl ketone derivatives |
| JP2006521357A (ja) | 2003-03-24 | 2006-09-21 | メルク エンド カムパニー インコーポレーテッド | ナトリウムチャンネル遮断薬としてのビアリール置換６員複素環化合物 |
| EP1644338A1 (de) * | 2003-04-01 | 2006-04-12 | Aponetics AG | 2,4,6-trisubstituierte pyrimidinderivate, die sich für die behandlung von neoplastischen krankheiten und autoimmunkrankheiten eignen |
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| WO2005113514A2 (en) * | 2004-05-07 | 2005-12-01 | Janssen Pharmaceutica, N.V. | Substituted pyrimidines as inhibitors of bacterial type iii protein secretion systems |
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-
2006
- 2006-02-01 US US11/344,881 patent/US20060178388A1/en not_active Abandoned
- 2006-02-02 DE DE602006011434T patent/DE602006011434D1/de not_active Expired - Lifetime
- 2006-02-02 EP EP06734200A patent/EP1848714B1/de not_active Expired - Lifetime
- 2006-02-02 ES ES06734200T patent/ES2336025T3/es not_active Expired - Lifetime
- 2006-02-02 JP JP2007554206A patent/JP4906738B2/ja not_active Expired - Fee Related
- 2006-02-02 AT AT06734200T patent/ATE453639T1/de not_active IP Right Cessation
- 2006-02-02 WO PCT/US2006/003659 patent/WO2006084017A2/en not_active Ceased
-
2009
- 2009-09-30 US US12/570,010 patent/US7923556B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1848714A2 (de) | 2007-10-31 |
| JP4906738B2 (ja) | 2012-03-28 |
| JP2008530012A (ja) | 2008-08-07 |
| EP1848714B1 (de) | 2009-12-30 |
| DE602006011434D1 (de) | 2010-02-11 |
| ES2336025T3 (es) | 2010-04-07 |
| WO2006084017A3 (en) | 2006-12-14 |
| WO2006084017A2 (en) | 2006-08-10 |
| US20100029649A1 (en) | 2010-02-04 |
| US20060178388A1 (en) | 2006-08-10 |
| US7923556B2 (en) | 2011-04-12 |
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