ATE454404T1 - Intrazelluläre antikörper - Google Patents

Intrazelluläre antikörper

Info

Publication number
ATE454404T1
ATE454404T1 AT03776984T AT03776984T ATE454404T1 AT E454404 T1 ATE454404 T1 AT E454404T1 AT 03776984 T AT03776984 T AT 03776984T AT 03776984 T AT03776984 T AT 03776984T AT E454404 T1 ATE454404 T1 AT E454404T1
Authority
AT
Austria
Prior art keywords
intracellular
molecule
immunoglobulin
target
domain
Prior art date
Application number
AT03776984T
Other languages
English (en)
Inventor
Terence Howard Rabbitts
Tomoyuki Tanaka
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of ATE454404T1 publication Critical patent/ATE454404T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT03776984T 2002-11-15 2003-11-14 Intrazelluläre antikörper ATE454404T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0226729.2A GB0226729D0 (en) 2002-11-15 2002-11-15 Intracellular antibodies
PCT/GB2003/004942 WO2004046185A2 (en) 2002-11-15 2003-11-14 Intracellular antibodies

Publications (1)

Publication Number Publication Date
ATE454404T1 true ATE454404T1 (de) 2010-01-15

Family

ID=9947935

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03776984T ATE454404T1 (de) 2002-11-15 2003-11-14 Intrazelluläre antikörper

Country Status (10)

Country Link
US (2) US20050272107A1 (de)
EP (1) EP1560853B1 (de)
JP (1) JP2006518188A (de)
AT (1) ATE454404T1 (de)
AU (1) AU2003286241A1 (de)
CA (1) CA2506124A1 (de)
DE (1) DE60330893D1 (de)
ES (1) ES2337570T3 (de)
GB (1) GB0226729D0 (de)
WO (1) WO2004046185A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7662554B2 (en) * 2002-10-09 2010-02-16 The Trustees Of Boston University Nucleic acid supported protein complementation
AU2006305901A1 (en) * 2005-10-27 2007-05-03 Trustees Of Boston University Real time nucleic acid detection in vivo using protein complementation
KR20080070838A (ko) * 2005-10-27 2008-07-31 트러스티스 오브 보스턴 유니버시티 활성화된 분절­폴리펩티드 및 이의 생산 방법 및 이의 용도
RU2009120007A (ru) * 2006-10-27 2010-12-10 Трастиз Оф Бостон Юниверсити (Us) Направленные конъюгаты с разделенными биомолекулами для лечения заболеваний, злокачественных образований и нарушений и способы их получения
GB0911215D0 (en) 2009-06-29 2009-08-12 Univ Erasmus Medical Ct Gamma globin therapy
TWI450415B (zh) * 2010-03-23 2014-08-21 Ｌｇ伊諾特股份有限公司 發光裝置、發光裝置封裝件及照明系統
GB201103631D0 (en) * 2011-03-03 2011-04-13 Univ Leeds Identification of candidate therapeutics
AU2012347972B2 (en) 2011-12-05 2018-05-10 X-Body, Inc. PDGF receptor beta binding polypeptides
WO2014030780A1 (en) 2012-08-22 2014-02-27 Mogam Biotechnology Research Institute Screening and engineering method of super-stable immunoglobulin variable domains and their uses
CA2891510C (en) 2012-11-16 2022-10-18 Transposagen Biopharmaceuticals, Inc. Site-specific enzymes and methods of use
RS61778B1 (sr) 2013-05-06 2021-06-30 Scholar Rock Inc Kompozicije i postupci za modulaciju faktora rasta
US20170107541A1 (en) * 2014-06-17 2017-04-20 Poseida Therapeutics, Inc. A method for directing proteins to specific loci in the genome and uses thereof
US20160115247A1 (en) 2014-10-23 2016-04-28 Singh Biotechnology, Llc Single domain antibodies directed against intracellular antigens
US20170267784A1 (en) 2014-10-23 2017-09-21 Singh Molecular Medicine, Llc Single domain antibodies directed against intracellular antigens
FI3218005T3 (fi) 2014-11-12 2023-03-31 Seagen Inc Glykaanin kanssa vuorovaikutteisia yhdisteitä ja käyttömenetelmiä
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
US11473082B2 (en) 2015-06-17 2022-10-18 Poseida Therapeutics, Inc. Compositions and methods for directing proteins to specific loci in the genome
TWI746473B (zh) 2015-11-02 2021-11-21 美商辛分子醫藥有限公司 針對細胞內抗原之單域抗體
CA3002097A1 (en) 2015-11-12 2017-05-18 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
JP6293829B2 (ja) * 2016-08-05 2018-03-14 モガム インスティチュート フォー バイオメディカル リサーチＭＯＧＡＭ Ｉｎｓｔｉｔｕｔｅ ｆｏｒ Ｂｉｏｍｅｄｉｃａｌ Ｒｅｓｅａｒｃｈ 安定化された免疫グロブリン可変ドメイン選別方法及び選別されたドメインの応用
WO2018094143A1 (en) 2016-11-17 2018-05-24 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
WO2018160909A1 (en) 2017-03-03 2018-09-07 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919650A (en) * 1990-04-22 1999-07-06 Bristol-Myers Squibb Co. Method for inactivation of protein function
ES2176484T3 (es) * 1995-08-18 2002-12-01 Morphosys Ag Bancos de proteinas/(poli)peptidos.
GB2344886B (en) * 1999-03-10 2000-11-01 Medical Res Council Selection of intracellular immunoglobulins
WO2003077945A1 (en) * 2002-03-14 2003-09-25 Medical Research Council Intracellular antibodies
US6919650B2 (en) * 2002-05-31 2005-07-19 Ballard Power Systems Corporation Hybrid synchronization phase angle generation method

Also Published As

Publication number Publication date
US20100143939A1 (en) 2010-06-10
EP1560853A2 (de) 2005-08-10
US20050272107A1 (en) 2005-12-08
WO2004046185A2 (en) 2004-06-03
JP2006518188A (ja) 2006-08-10
DE60330893D1 (de) 2010-02-25
AU2003286241A1 (en) 2004-06-15
WO2004046185A3 (en) 2004-09-23
ES2337570T3 (es) 2010-04-27
GB0226729D0 (en) 2002-12-24
EP1560853B1 (de) 2010-01-06
CA2506124A1 (en) 2004-06-03

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