ATE454900T1 - Stabilisierung von proteinen in lösung - Google Patents
Stabilisierung von proteinen in lösungInfo
- Publication number
- ATE454900T1 ATE454900T1 AT04734213T AT04734213T ATE454900T1 AT E454900 T1 ATE454900 T1 AT E454900T1 AT 04734213 T AT04734213 T AT 04734213T AT 04734213 T AT04734213 T AT 04734213T AT E454900 T1 ATE454900 T1 AT E454900T1
- Authority
- AT
- Austria
- Prior art keywords
- wall portion
- coated glass
- cycloolefin
- polymers
- protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
- UHBYWPGGCSDKFX-VKHMYHEASA-N gamma-carboxy-L-glutamic acid Chemical group OC(=O)[C@@H](N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-VKHMYHEASA-N 0.000 abstract 3
- 229920000089 Cyclic olefin copolymer Polymers 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000011521 glass Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- -1 cyclic olefins Chemical class 0.000 abstract 1
- 150000001925 cycloalkenes Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920001296 polysiloxane Polymers 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F110/00—Homopolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
- B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Ceramic Engineering (AREA)
- Mechanical Engineering (AREA)
- Polymers & Plastics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300788 | 2003-05-23 | ||
| US47628003P | 2003-06-05 | 2003-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE454900T1 true ATE454900T1 (de) | 2010-01-15 |
Family
ID=34973305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04734213T ATE454900T1 (de) | 2003-05-23 | 2004-05-21 | Stabilisierung von proteinen in lösung |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8536127B2 (de) |
| EP (1) | EP1628677B1 (de) |
| JP (2) | JP5627832B2 (de) |
| KR (1) | KR20060015574A (de) |
| CN (1) | CN1780638B (de) |
| AT (1) | ATE454900T1 (de) |
| AU (1) | AU2004241698A1 (de) |
| BR (1) | BRPI0409936A (de) |
| CA (1) | CA2525224A1 (de) |
| DE (1) | DE602004025100D1 (de) |
| MX (1) | MXPA05012476A (de) |
| RU (1) | RU2364609C2 (de) |
| WO (1) | WO2004103398A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2325653T3 (es) | 2001-12-21 | 2009-09-11 | Novo Nordisk Health Care Ag | Composicion liquida de polipeptidos del factor vii. |
| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| CA2490342C (en) | 2002-06-21 | 2015-06-16 | Novo Nordisk A/S | Stabilised solid compositions of factor vii polypeptides |
| US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| BRPI0409936A (pt) * | 2003-05-23 | 2006-04-25 | Novo Nordisk Healthcare Ag | uso de um material, recipiente pelo menos parcialmente cheio, e, kit médico |
| DE602004023848D1 (de) * | 2003-07-01 | 2009-12-10 | Novo Nordisk Healthcare Ag | Von factor vii polypeptiden |
| WO2005016365A2 (en) * | 2003-08-14 | 2005-02-24 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical composition of factor vii polypeptides |
| ES2676644T3 (es) * | 2003-12-19 | 2018-07-23 | Novo Nordisk Health Care Ag | Composiciones estabilizadas de polipéptidos de factor VII |
| US20070041905A1 (en) * | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
| WO2008135380A1 (en) * | 2007-05-02 | 2008-11-13 | F. Hoffmann-La Roche Ag | Method for stabilizing a protein |
| WO2008135500A1 (en) * | 2007-05-02 | 2008-11-13 | Novo Nordisk Health Care Ag | High concentration factor vii polypeptide formulations comprising an aromatic preservative and an antioxidant |
| CN106443002A (zh) * | 2007-10-22 | 2017-02-22 | 贝克顿·迪金森公司 | 评价在含有机基聚硅氧烷的悬浮液中蛋白质聚集的方法 |
| NZ622583A (en) * | 2007-11-30 | 2015-08-28 | Abbvie Biotechnology Ltd | Protein formulations and methods of making same |
| SG10201402265YA (en) * | 2008-02-07 | 2014-08-28 | Amgen Inc | Stabilized protein compositions |
| AU2009248885B2 (en) * | 2008-05-23 | 2015-02-05 | Hospira, Inc. | Packaged iron sucrose products |
| AU2010202125B1 (en) * | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
| US9993597B2 (en) * | 2012-05-29 | 2018-06-12 | Becton Dickinson France | Lubricant coating and medical injection device comprising such a coating |
| US8883979B2 (en) | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| ES2797298T3 (es) | 2016-02-10 | 2020-12-01 | Becton Dickinson France | Procedimiento para evaluar la estabilidad de una formulación a base de proteína |
| JPWO2018181531A1 (ja) | 2017-03-29 | 2020-02-06 | テルモ株式会社 | プレフィルドシリンジ包装体 |
| EP3760220B1 (de) | 2018-02-28 | 2025-02-19 | Seikagaku Corporation | Packung mit chondroitinase abc und verfahren zur herstellung davon |
| CN114980851A (zh) * | 2020-01-28 | 2022-08-30 | 日本瑞翁株式会社 | 预填充药剂包装和预填充药剂包装的制造方法 |
| EP4696321A1 (de) * | 2023-04-14 | 2026-02-18 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur stabilisierung einer proteinhaltigen pharmazeutischen zubereitung |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US577070A (en) * | 1897-02-16 | Machines | ||
| DE2916711A1 (de) | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
| US4956386A (en) | 1980-04-25 | 1990-09-11 | Gist-Brocades N.V. | Pharmaceutical compositions and process for their preparation |
| US4404132A (en) | 1980-05-27 | 1983-09-13 | Cutter Laboratories, Inc. | Blood coagulation promoting product |
| CA1182748A (en) | 1980-11-21 | 1985-02-19 | Gerard Marx | Method for synthesizing procoagulant factor viii activity |
| US4495278A (en) | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
| US4382083A (en) | 1981-06-25 | 1983-05-03 | Baxter Travenol Laboratories, Inc. | Therapeutic method for treating blood-clotting defects with factor VIIa |
| GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| US5180583A (en) | 1985-11-26 | 1993-01-19 | Hedner Ulla K E | Method for the treatment of bleeding disorders |
| EP0225160B1 (de) | 1985-11-26 | 1991-08-21 | Novo Nordisk A/S | Zubereitungen und Verfahren zur Behandlung von Blutungsstörungen |
| US5595886A (en) | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
| EP0272304B1 (de) | 1986-06-24 | 1994-01-26 | Novo Nordisk A/S | Verfahren zur herstellung eines koagulationsaktiven komplexes vom faktor viii-fragment |
| ES2045167T5 (es) | 1987-10-23 | 1996-07-01 | Centre Regional De Transfusion | Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas. |
| US5147638A (en) | 1988-12-30 | 1992-09-15 | Oklahoma Medical Research Foundation | Inhibition of tumor growth by blockade of the protein C system |
| US5472850A (en) * | 1991-04-10 | 1995-12-05 | Oklahoma Medical Research Foundation | Quantitative clotting assay for activated factor VII |
| JP2824430B2 (ja) | 1989-08-02 | 1998-11-11 | 財団法人化学及血清療法研究所 | 血液凝固第▲vii▼因子または活性型血液凝固第▲vii▼因子の調製方法 |
| DE3939346A1 (de) | 1989-11-29 | 1991-06-06 | Behringwerke Ag | Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide |
| DE4001451A1 (de) | 1990-01-19 | 1991-08-01 | Octapharma Ag | Stabile injizierbare loesungen von faktor viii und faktor ix |
| CA2074839C (en) | 1990-01-29 | 2000-11-14 | Kathleen L. Berkner | Modified factor vii anticoagulant proteins |
| JP3459416B2 (ja) | 1991-02-28 | 2003-10-20 | ザイモジェネティクス,インコーポレイティド | 修飾されたファクター▲vii▼ |
| US5788965A (en) | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
| US5997864A (en) | 1995-06-07 | 1999-12-07 | Novo Nordisk A/S | Modified factor VII |
| US5817788A (en) | 1991-02-28 | 1998-10-06 | Zymogenetics, Inc. | Modified factor VII |
| US5833982A (en) | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
| WO1993000807A1 (en) | 1991-07-03 | 1993-01-21 | Cryolife, Inc. | Method for stabilization of biomaterials |
| FR2684999A1 (fr) | 1991-12-16 | 1993-06-18 | Aquitaine Dev Transf Sanguine | Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag. |
| JP3155797B2 (ja) | 1991-12-26 | 2001-04-16 | 株式会社日立製作所 | 過電圧自己保護型半導体装置、及び、それを使用した半導体回路 |
| DE69333928T2 (de) | 1992-04-30 | 2006-08-17 | Probitas Pharma Inc., Los Angeles | Verbesserte solubilisierung und stabilisierung des faktor viii-komplexes |
| ES2152953T3 (es) | 1992-08-27 | 2001-02-16 | Sanquin Bloedvoorziening | Anticuerpos especificos para una proteina hemostatica, su utilizacion para aislar proteinas intactas, compuestos hemostaticos carentes de productos de segmentacion proteolitica de la proteina. |
| DK38293D0 (da) | 1993-03-31 | 1993-03-31 | Novo Nordisk As | Fremstilling af proteiner |
| SE9301581D0 (sv) | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Protein formulation |
| PT699075E (pt) | 1993-05-21 | 2002-05-31 | Novo Nordisk As | Factor vii modificado para inibicao de restenose vascular e de deposicao de plaquetas |
| WO1995003332A1 (en) | 1993-07-23 | 1995-02-02 | Baxter International Inc. | Activated human factor viii and method of preparation |
| US6277828B1 (en) | 1993-08-20 | 2001-08-21 | Syntex (U.S.A.) Inc. | Pharmaceutical formulations of nerve growth factor |
| US5576291A (en) | 1993-09-13 | 1996-11-19 | Baxter International Inc. | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
| IL113010A0 (en) | 1994-03-31 | 1995-10-31 | Pharmacia Ab | Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| US6372716B1 (en) | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
| DE4435520A1 (de) | 1994-10-04 | 1996-04-11 | Immuno Ag | Verfahren zur Trennung von rekombinantem pro-Faktor IX von rekombinantem Faktor IX |
| SE9403915D0 (sv) | 1994-11-14 | 1994-11-14 | Annelie Almstedt | Process A |
| US5649959A (en) | 1995-02-10 | 1997-07-22 | Sherwood Medical Company | Assembly for sealing a puncture in a vessel |
| DE19531637A1 (de) | 1995-08-28 | 1997-03-06 | Immuno Ag | Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung |
| DE19538715A1 (de) | 1995-10-18 | 1997-04-30 | Behringwerke Ag | Verfahren zur Reinigung von Faktor VII und aktiviertem Faktor VII |
| SE9503679D0 (sv) | 1995-10-20 | 1995-10-20 | Pharmacia Ab | Antioxidants |
| US5993795A (en) | 1995-11-09 | 1999-11-30 | Takemoto Yushi Kabushiki Kaisha | Protein composition derived from sesame seed and use thereof |
| US6320029B1 (en) | 1996-11-29 | 2001-11-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
| US5925738A (en) | 1995-12-01 | 1999-07-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
| US5830852A (en) | 1995-12-19 | 1998-11-03 | Cobra Therapeutics, Ltd. | Compositions for insulin-receptor mediated nucleic acid delivery |
| US5770700A (en) | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
| DE19903693A1 (de) | 1998-04-24 | 1999-10-28 | Centeon Pharma Gmbh | Protease zur Aktivierung des Gerinnungsfaktors VII |
| TW518219B (en) | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| US5910138A (en) * | 1996-05-13 | 1999-06-08 | B. Braun Medical, Inc. | Flexible medical container with selectively enlargeable compartments and method for making same |
| AT403989B (de) * | 1996-09-16 | 1998-07-27 | Immuno Ag | Verfahren zur herstellung eines plasmaprotein-hältigen arzneimittels |
| US6315995B1 (en) | 1996-09-27 | 2001-11-13 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
| KR101042660B1 (ko) | 1996-12-24 | 2011-06-20 | 바이오겐 아이덱 엠에이 인코포레이티드 | 안정한 액체 인터페론 제제 |
| US5804420A (en) | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| DE19730023A1 (de) | 1997-07-11 | 1999-01-14 | Bayer Ag | Hochreine Ciprofloxacin-Infusion |
| US6461610B1 (en) | 1997-07-18 | 2002-10-08 | Novo Nordisk A/S | Methods for modifying cell motility using factor VIIa or inactivated factor VIIa |
| US6310183B1 (en) | 1997-09-10 | 2001-10-30 | Novo Nordisk A/S | Coagulation factor VIIa composition |
| AT409334B (de) | 1997-09-19 | 2002-07-25 | Immuno Ag | Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren |
| JPH11335295A (ja) * | 1998-05-22 | 1999-12-07 | Towa Pharmaceutical Co Ltd | カルシウム調節ポリペプチドホルモンの安定な非経口投与用水溶液製剤 |
| DE19853033A1 (de) | 1998-11-18 | 2000-05-25 | Centeon Pharma Gmbh | Stabilisierte Proteinzubereitung für einen Gewebekleber |
| PT2193809E (pt) | 1999-02-22 | 2015-08-24 | Baxter Int | Formulações de fator viii livres de albumina |
| JP2000247903A (ja) | 1999-03-01 | 2000-09-12 | Chugai Pharmaceut Co Ltd | 長期安定化製剤 |
| US20010031721A1 (en) | 1999-05-05 | 2001-10-18 | Chandra Webb | Highly concentrated, lyophilized, and liquid factor IX formulations |
| JP4674021B2 (ja) | 1999-07-13 | 2011-04-20 | ビオヴィトルム・アクチボラゲット(プブリクト) | 安定第viii因子組成物 |
| DE19937218A1 (de) | 1999-08-06 | 2001-02-08 | Aventis Behring Gmbh | Verfahren zur Reindarstellung der den Blutgerinnungsfaktor VII aktivierenden Protease, ihres Proenzyms oder eines Gemisches beider Proteine mittels Affinitätschromatographie |
| US6586574B1 (en) | 1999-08-17 | 2003-07-01 | Nn A/S | Stabilization of freeze-dried cake |
| GB9920772D0 (en) * | 1999-09-03 | 1999-11-03 | Nycomed Amersham Plc | Improved container composition for radiopharmaceutical agents |
| GB9920758D0 (en) * | 1999-09-03 | 1999-11-03 | Nycomed Amersham Plc | Improved container composition for diagnostic agents |
| ATE389414T1 (de) * | 1999-09-08 | 2008-04-15 | Chugai Pharmaceutical Co Ltd | Stabile proteinlösung abgefüllt in einem behältnis aus hydrophobem harz und eine methode zur stabilisierung derselben |
| US6750053B1 (en) * | 1999-11-15 | 2004-06-15 | I-Stat Corporation | Apparatus and method for assaying coagulation in fluid samples |
| PL204285B1 (pl) | 2000-02-11 | 2009-12-31 | Bayer Healthcare Llc | Koniugat polipeptydowy, polipeptyd, sekwencja nukleotydowa, wektor ekspresyjny, komórka gospodarz, sposób wytwarzania koniugatu polipeptydowego, środek farmaceutyczny i zastosowanie koniugatu polipeptydowego |
| US7015194B2 (en) | 2000-05-10 | 2006-03-21 | Novo Nordisk A/S | Pharmaceutical composition comprising factor VIIa and anti-TFPI |
| AU9165201A (en) | 2000-10-02 | 2002-04-15 | Novo Nordisk As | Factor vii glycoforms |
| WO2002038162A1 (en) | 2000-11-09 | 2002-05-16 | The Scripps Research Institute | MODIFIED FACTOR VIIa |
| DE50114021D1 (de) | 2001-01-08 | 2008-07-24 | Csl Behring Gmbh | Stabilisierte Flüssigzubereitung der den Blutgerinnungsfaktor VII aktivierenden Protease oder ihres Proenzyms |
| US6825323B2 (en) | 2001-01-10 | 2004-11-30 | The United States Of America As Represented By The Secretary Of The Army | Compositions for treatment of hemorrhaging with activated factor VIIa in combination with fibrinogen and methods of using same |
| EP1232735A3 (de) | 2001-02-20 | 2004-03-03 | SCA Hygiene Products AB | Windeldeckblatt und Verfahren zu dessen Herstellung |
| US6858587B2 (en) | 2001-11-02 | 2005-02-22 | Novo Nordisk Pharmaceuticals, Inc. | Use of tissue factor agonist or tissue factor antagonist for treatment of conditions related to apoptosis |
| WO2003039585A1 (en) | 2001-11-09 | 2003-05-15 | Novo Nordisk Health Care Ag | Pharmaceutical composition comprising factor vii polypeptides and protein c inhibitors |
| US7078479B2 (en) | 2001-11-09 | 2006-07-18 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and alpha2-antiplasmin polypeptides |
| US7125846B2 (en) | 2001-11-09 | 2006-10-24 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides |
| US20030119743A1 (en) | 2001-11-09 | 2003-06-26 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and tissue plasminogen inhibitors |
| KR20040065278A (ko) | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
| JP2005530682A (ja) | 2001-12-21 | 2005-10-13 | ノボ ノルディスク アクティーゼルスカブ | 修飾第vii因子ポリペプチドの液体組成物 |
| ES2325653T3 (es) | 2001-12-21 | 2009-09-11 | Novo Nordisk Health Care Ag | Composicion liquida de polipeptidos del factor vii. |
| US20040009918A1 (en) | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| AT501088A2 (de) | 2002-12-18 | 2006-06-15 | Bio Prod & Bio Eng Ag | Stabile therapeutische proteine |
| CA2518327A1 (en) | 2003-03-18 | 2004-09-30 | Novo Nordisk Health Care Ag | Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides |
| US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| BRPI0409936A (pt) * | 2003-05-23 | 2006-04-25 | Novo Nordisk Healthcare Ag | uso de um material, recipiente pelo menos parcialmente cheio, e, kit médico |
-
2004
- 2004-05-21 BR BRPI0409936-2A patent/BRPI0409936A/pt not_active IP Right Cessation
- 2004-05-21 EP EP04734213A patent/EP1628677B1/de not_active Revoked
- 2004-05-21 AU AU2004241698A patent/AU2004241698A1/en not_active Abandoned
- 2004-05-21 CA CA002525224A patent/CA2525224A1/en not_active Abandoned
- 2004-05-21 CN CN2004800112247A patent/CN1780638B/zh not_active Expired - Fee Related
- 2004-05-21 RU RU2005140282/04A patent/RU2364609C2/ru active
- 2004-05-21 DE DE602004025100T patent/DE602004025100D1/de not_active Expired - Lifetime
- 2004-05-21 WO PCT/DK2004/000359 patent/WO2004103398A1/en not_active Ceased
- 2004-05-21 JP JP2006529638A patent/JP5627832B2/ja not_active Expired - Fee Related
- 2004-05-21 MX MXPA05012476A patent/MXPA05012476A/es unknown
- 2004-05-21 AT AT04734213T patent/ATE454900T1/de not_active IP Right Cessation
- 2004-05-21 KR KR1020057020807A patent/KR20060015574A/ko not_active Withdrawn
-
2005
- 2005-11-22 US US11/284,709 patent/US8536127B2/en not_active Expired - Fee Related
-
2012
- 2012-06-21 JP JP2012139978A patent/JP2012229230A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US8536127B2 (en) | 2013-09-17 |
| KR20060015574A (ko) | 2006-02-17 |
| CN1780638A (zh) | 2006-05-31 |
| CA2525224A1 (en) | 2004-12-02 |
| JP2007502310A (ja) | 2007-02-08 |
| US20060160720A1 (en) | 2006-07-20 |
| JP5627832B2 (ja) | 2014-11-19 |
| BRPI0409936A (pt) | 2006-04-25 |
| RU2364609C2 (ru) | 2009-08-20 |
| JP2012229230A (ja) | 2012-11-22 |
| EP1628677B1 (de) | 2010-01-13 |
| CN1780638B (zh) | 2010-04-14 |
| DE602004025100D1 (de) | 2010-03-04 |
| RU2005140282A (ru) | 2006-07-27 |
| WO2004103398A1 (en) | 2004-12-02 |
| AU2004241698A1 (en) | 2004-12-02 |
| MXPA05012476A (es) | 2006-02-22 |
| EP1628677A1 (de) | 2006-03-01 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |