ATE454900T1 - Stabilisierung von proteinen in lösung - Google Patents
Stabilisierung von proteinen in lösungInfo
- Publication number
- ATE454900T1 ATE454900T1 AT04734213T AT04734213T ATE454900T1 AT E454900 T1 ATE454900 T1 AT E454900T1 AT 04734213 T AT04734213 T AT 04734213T AT 04734213 T AT04734213 T AT 04734213T AT E454900 T1 ATE454900 T1 AT E454900T1
- Authority
- AT
- Austria
- Prior art keywords
- wall portion
- coated glass
- cycloolefin
- polymers
- protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
- UHBYWPGGCSDKFX-VKHMYHEASA-N gamma-carboxy-L-glutamic acid Chemical group OC(=O)[C@@H](N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-VKHMYHEASA-N 0.000 abstract 3
- 229920000089 Cyclic olefin copolymer Polymers 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000011521 glass Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- -1 cyclic olefins Chemical class 0.000 abstract 1
- 150000001925 cycloalkenes Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229920001296 polysiloxane Polymers 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F110/00—Homopolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
- B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Ceramic Engineering (AREA)
- Mechanical Engineering (AREA)
- Polymers & Plastics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300788 | 2003-05-23 | ||
| US47628003P | 2003-06-05 | 2003-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE454900T1 true ATE454900T1 (de) | 2010-01-15 |
Family
ID=34973305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04734213T ATE454900T1 (de) | 2003-05-23 | 2004-05-21 | Stabilisierung von proteinen in lösung |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8536127B2 (de) |
| EP (1) | EP1628677B1 (de) |
| JP (2) | JP5627832B2 (de) |
| KR (1) | KR20060015574A (de) |
| CN (1) | CN1780638B (de) |
| AT (1) | ATE454900T1 (de) |
| AU (1) | AU2004241698A1 (de) |
| BR (1) | BRPI0409936A (de) |
| CA (1) | CA2525224A1 (de) |
| DE (1) | DE602004025100D1 (de) |
| MX (1) | MXPA05012476A (de) |
| RU (1) | RU2364609C2 (de) |
| WO (1) | WO2004103398A1 (de) |
Families Citing this family (23)
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|---|---|---|---|---|
| EP1458408B1 (de) | 2001-12-21 | 2009-04-15 | Novo Nordisk Health Care AG | Flüssige zusammensetzung aus faktor vii polypeptiden |
| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| CN1671410B (zh) * | 2002-06-21 | 2010-05-12 | 诺和诺德医疗保健公司 | 因子ⅶ多肽的稳定化固体组合物 |
| US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| RU2364609C2 (ru) * | 2003-05-23 | 2009-08-20 | Ново Нордиск Хелт Кэр Аг | Стабилизация белка в растворе |
| WO2005002615A1 (en) * | 2003-07-01 | 2005-01-13 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical composition of factor vii polypeptides |
| JP5653572B2 (ja) * | 2003-08-14 | 2015-01-14 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第vii因子ポリペプチドの液状水性医薬組成物 |
| CN1917861B (zh) * | 2003-12-19 | 2012-03-21 | 诺和诺德医疗保健公司 | 因子vii多肽的稳定化固体组合物 |
| US20070041905A1 (en) * | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
| CN104887620A (zh) * | 2007-05-02 | 2015-09-09 | 诺沃—诺迪斯克保健股份有限公司 | 包括芳香族防腐剂和抗氧化剂的高浓度因子vii多肽制剂 |
| KR101140483B1 (ko) | 2007-05-02 | 2012-07-11 | 에프. 호프만-라 로슈 아게 | 단백질을 안정화시키는 방법 |
| EP2237038B1 (de) * | 2007-10-22 | 2015-04-29 | Becton Dickinson and Company | Medizinische Artikel mit Beschichtung aus Ogranopolysiloxan mit einer Proteinlösung und nichtionisches Tensid |
| US8420081B2 (en) * | 2007-11-30 | 2013-04-16 | Abbvie, Inc. | Antibody formulations and methods of making same |
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| WO2009143439A1 (en) * | 2008-05-23 | 2009-11-26 | Hospira, Inc. | Packaged iron sucrose products |
| AU2010202125B1 (en) * | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
| ES2897540T3 (es) * | 2012-05-29 | 2022-03-01 | Becton Dickinson France | Revestimiento lubricante y dispositivo médico de inyección que comprende dicho revestimiento |
| US8883979B2 (en) | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| CN107063940B (zh) | 2016-02-10 | 2019-10-18 | 贝克顿迪金森法国公司 | 用于评价基于蛋白质的制剂的稳定性的方法 |
| WO2018181531A1 (ja) | 2017-03-29 | 2018-10-04 | テルモ株式会社 | プレフィルドシリンジ包装体 |
| EP3760220B1 (de) | 2018-02-28 | 2025-02-19 | Seikagaku Corporation | Packung mit chondroitinase abc und verfahren zur herstellung davon |
| CN114980851A (zh) * | 2020-01-28 | 2022-08-30 | 日本瑞翁株式会社 | 预填充药剂包装和预填充药剂包装的制造方法 |
| WO2024214811A1 (ja) * | 2023-04-14 | 2024-10-17 | 中外製薬株式会社 | タンパク質含有医薬製剤の安定化方法 |
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| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| AT501088A2 (de) * | 2002-12-18 | 2006-06-15 | Bio Prod & Bio Eng Ag | Stabile therapeutische proteine |
| AU2004222625A1 (en) * | 2003-03-18 | 2004-09-30 | Novo Nordisk Health Care Ag | Liquid, aqueous, pharmaceutical compositions of factor VII polypeptides |
| US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| RU2364609C2 (ru) * | 2003-05-23 | 2009-08-20 | Ново Нордиск Хелт Кэр Аг | Стабилизация белка в растворе |
-
2004
- 2004-05-21 RU RU2005140282/04A patent/RU2364609C2/ru active
- 2004-05-21 DE DE602004025100T patent/DE602004025100D1/de not_active Expired - Lifetime
- 2004-05-21 WO PCT/DK2004/000359 patent/WO2004103398A1/en not_active Ceased
- 2004-05-21 MX MXPA05012476A patent/MXPA05012476A/es unknown
- 2004-05-21 CN CN2004800112247A patent/CN1780638B/zh not_active Expired - Fee Related
- 2004-05-21 BR BRPI0409936-2A patent/BRPI0409936A/pt not_active IP Right Cessation
- 2004-05-21 AU AU2004241698A patent/AU2004241698A1/en not_active Abandoned
- 2004-05-21 CA CA002525224A patent/CA2525224A1/en not_active Abandoned
- 2004-05-21 AT AT04734213T patent/ATE454900T1/de not_active IP Right Cessation
- 2004-05-21 EP EP04734213A patent/EP1628677B1/de not_active Revoked
- 2004-05-21 JP JP2006529638A patent/JP5627832B2/ja not_active Expired - Fee Related
- 2004-05-21 KR KR1020057020807A patent/KR20060015574A/ko not_active Withdrawn
-
2005
- 2005-11-22 US US11/284,709 patent/US8536127B2/en not_active Expired - Fee Related
-
2012
- 2012-06-21 JP JP2012139978A patent/JP2012229230A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN1780638A (zh) | 2006-05-31 |
| KR20060015574A (ko) | 2006-02-17 |
| JP2007502310A (ja) | 2007-02-08 |
| AU2004241698A1 (en) | 2004-12-02 |
| DE602004025100D1 (de) | 2010-03-04 |
| WO2004103398A1 (en) | 2004-12-02 |
| CA2525224A1 (en) | 2004-12-02 |
| RU2364609C2 (ru) | 2009-08-20 |
| MXPA05012476A (es) | 2006-02-22 |
| RU2005140282A (ru) | 2006-07-27 |
| JP2012229230A (ja) | 2012-11-22 |
| EP1628677B1 (de) | 2010-01-13 |
| US20060160720A1 (en) | 2006-07-20 |
| BRPI0409936A (pt) | 2006-04-25 |
| EP1628677A1 (de) | 2006-03-01 |
| CN1780638B (zh) | 2010-04-14 |
| US8536127B2 (en) | 2013-09-17 |
| JP5627832B2 (ja) | 2014-11-19 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |