ATE454910T1 - Zusammengesetzte strukturen mit hyaluronsäure und derivaten davon als neue knochensubstitute und transplantate - Google Patents

Zusammengesetzte strukturen mit hyaluronsäure und derivaten davon als neue knochensubstitute und transplantate

Info

Publication number: ATE454910T1
Authority: AT; Austria
Prior art keywords: hyaluronic acid; derivatives; transplants; composite structures; new bone
Prior art date: 2003-11-27

Application number

AT04804587T

Other languages

English (en)

Inventor

Andrea Pastorello

Daniele Pressato

Original Assignee

Fidia Advanced Biopolymers Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-27

Filing date

2004-11-26

Publication date

2010-01-15

2004-11-26 Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE454910T1 publication Critical patent/ATE454910T1/de

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 4
239000000316 bone substitute Substances 0.000 title abstract 2
239000002131 composite material Substances 0.000 title abstract 2
229920002674 hyaluronan Polymers 0.000 title abstract 2
229960003160 hyaluronic acid Drugs 0.000 title abstract 2
210000000988 bone and bone Anatomy 0.000 abstract 3
230000015572 biosynthetic process Effects 0.000 abstract 1
229910010293 ceramic material Inorganic materials 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
239000011159 matrix material Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
230000008929 regeneration Effects 0.000 abstract 1
238000011069 regeneration method Methods 0.000 abstract 1
238000001356 surgical procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3821—Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3847—Bones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Dermatology (AREA)
Medicinal Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Botany (AREA)
Cell Biology (AREA)
Orthopedic Medicine & Surgery (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Composite Materials (AREA)
Materials Engineering (AREA)
General Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Developmental Biology & Embryology (AREA)
Hematology (AREA)
Materials For Medical Uses (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT04804587T 2003-11-27 2004-11-26 Zusammengesetzte strukturen mit hyaluronsäure und derivaten davon als neue knochensubstitute und transplantate ATE454910T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT000286A ITPD20030286A1 (it)	2003-11-27	2003-11-27	Strutture composite multistrato contenenti acido ialuronico
PCT/EP2004/053129 WO2005051446A1 (en)	2003-11-27	2004-11-26	Composite structures containing hyaluronic acid the derivatives thereof as new bone substitutes and grafts

Publications (1)

Publication Number	Publication Date
ATE454910T1 true ATE454910T1 (de)	2010-01-15

Family

ID=34631181

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04804587T ATE454910T1 (de)	2003-11-27	2004-11-26	Zusammengesetzte strukturen mit hyaluronsäure und derivaten davon als neue knochensubstitute und transplantate

Country Status (9)

Country	Link
US (1)	US7709018B2 (de)
EP (1)	EP1715900B1 (de)
AT (1)	ATE454910T1 (de)
CA (1)	CA2547461C (de)
DE (1)	DE602004025145D1 (de)
DK (1)	DK1715900T3 (de)
ES (1)	ES2339667T3 (de)
IT (1)	ITPD20030286A1 (de)
WO (1)	WO2005051446A1 (de)

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ITPD20040312A1 (it) *	2004-12-15	2005-03-15	Fidia Advanced Biopolymers Srl	Protesi e o supporto per la sostituzione, riparazione, rigenerazione del menisco
ES2329329B1 (es) *	2008-05-23	2010-09-17	Institut Quimic De Sarria Cets, Fundacio Privada	Pasta termoplastica para la reparacion tejidos vivos.
AU2010207472B2 (en)	2009-01-23	2015-05-21	Royal College Of Surgeons In Ireland	Layered scaffold suitable for osteochondral repair
US9775721B2 (en)	2009-07-10	2017-10-03	Bio2 Technologies, Inc.	Resorbable interbody device
JP5711736B2 (ja)	2009-07-10	2015-05-07	バイオ２テクノロジーズ，インク．	生体組織工学のためのデバイスおよび方法
US20110206828A1 (en) *	2009-07-10	2011-08-25	Bio2 Technologies, Inc.	Devices and Methods for Tissue Engineering
IT1401218B1 (it) *	2010-07-14	2013-07-12	Mastelli S R L	Composizione ad attivita' bio-rigenerativa, riparativa ed eutrofizzante.
ITAN20110138A1 (it)	2011-10-12	2012-01-11	Regenyal Lab S R L	Sintesi di un gel iniettabile multifasico a base di acido ialuronico monofasico libero e reticolato e di acido ialuronico bifasico associato con idrossiapatite con inibitore della ialuronidasi microincapsulato.
SG11201407276RA (en) *	2012-05-30	2015-03-30	Klox Technologies Inc	Compositions and methods for biophotonic bone reconstruction
CN104853742B (zh) *	2012-10-08	2018-11-30	爱普蒂森股份公司	用于治疗用途的基于交联透明质酸和羟基磷灰石的可注射无菌水性制剂
US10172651B2 (en)	2012-10-25	2019-01-08	Warsaw Orthopedic, Inc.	Cortical bone implant
US9265609B2 (en)	2013-01-08	2016-02-23	Warsaw Orthopedic, Inc.	Osteograft implant
KR20150129717A (ko) *	2013-03-14	2015-11-20	젠자임 코포레이션	열-감수성 골 성장 조성물
CA3177726A1 (en)	2015-05-21	2016-11-24	Musculoskeletal Transplant Foundation	Modified demineralized cortical bone fibers
AU2018399962B2 (en)	2018-01-02	2024-11-14	Cartiheal (2009) Ltd.	Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth
JP7465876B2 (ja) *	2018-08-17	2024-04-11	スメラクシシュトフ	親油性化合物及び親水性化合物のカプセル化のためのナノカプセル・イン・ナノカプセルタイプのマルチコンパートメントシステム並びに関連する製造方法
US11369473B2 (en)	2019-04-08	2022-06-28	Loubert S. Suddaby	Extended release immunomodulatory implant to facilitate bone morphogenesis
US11779683B2 (en)	2019-04-08	2023-10-10	Loubert S. Suddaby	Extended release immunomodulatory implant to facilitate bone morphogenesis
US12447051B2 (en)	2020-08-24	2025-10-21	University Of Utah Research Foundation	Multi-functional analgesic-releasing wound dressing
DE202021004032U1 (de)	2020-08-29	2022-10-10	BioScientific Designs d.o.o	Ein steriles Medizinprodukt als Knochenersatz, Zubereitung und Verwendung
WO2022117567A1 (en) *	2020-12-02	2022-06-09	Anika Therapeutics S.R.L.	Bioabsorbable textiles and methods for joint function restoration
IT202100027047A1 (it) *	2021-10-21	2023-04-21	The Wave Innovation Group Srls	Composizione eterogenea a fasi stratificate di acido ialuronico e suo uso intrarticolare
CN115054728B (zh) *	2022-07-18	2023-11-07	中国科学院大学宁波华美医院	一种仿生骨组织工程支架材料及其制备方法
CN120053747B (zh) *	2025-04-28	2025-07-22	湖北双星药业股份有限公司	一种骨骼创伤修复骨泥及其制备方法

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ITPD20010032A1 (it)	2001-02-09	2002-08-09	Fidia Advanced Biopolymers Srl	Innesti ingegnerizzati per la riparazione di difetti osteocondrali

2003
- 2003-11-27 IT IT000286A patent/ITPD20030286A1/it unknown
2004
- 2004-11-26 DK DK04804587.6T patent/DK1715900T3/da active
- 2004-11-26 DE DE602004025145T patent/DE602004025145D1/de not_active Expired - Lifetime
- 2004-11-26 EP EP04804587A patent/EP1715900B1/de not_active Expired - Lifetime
- 2004-11-26 AT AT04804587T patent/ATE454910T1/de active
- 2004-11-26 ES ES04804587T patent/ES2339667T3/es not_active Expired - Lifetime
- 2004-11-26 US US10/580,659 patent/US7709018B2/en not_active Expired - Lifetime
- 2004-11-26 CA CA2547461A patent/CA2547461C/en not_active Expired - Lifetime
- 2004-11-26 WO PCT/EP2004/053129 patent/WO2005051446A1/en not_active Ceased

Also Published As

Publication number	Publication date
US7709018B2 (en)	2010-05-04
ITPD20030286A1 (it)	2005-05-28
US20070110819A1 (en)	2007-05-17
DE602004025145D1 (de)	2010-03-04
ES2339667T3 (es)	2010-05-24
WO2005051446A1 (en)	2005-06-09
CA2547461C (en)	2013-12-24
EP1715900B1 (de)	2010-01-13
CA2547461A1 (en)	2005-06-09
DK1715900T3 (da)	2010-05-25
EP1715900A1 (de)	2006-11-02

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