BRPI0609392B8 - substituto cartilaginiforme e osteocondral compreendendo uma estrutura de múltiplas camadas e seu uso - Google Patents

substituto cartilaginiforme e osteocondral compreendendo uma estrutura de múltiplas camadas e seu uso

Info

Publication number
BRPI0609392B8
BRPI0609392B8 BRPI0609392A BRPI0609392A BRPI0609392B8 BR PI0609392 B8 BRPI0609392 B8 BR PI0609392B8 BR PI0609392 A BRPI0609392 A BR PI0609392A BR PI0609392 A BRPI0609392 A BR PI0609392A BR PI0609392 B8 BRPI0609392 B8 BR PI0609392B8
Authority
BR
Brazil
Prior art keywords
multilayer structure
substitute
osteochondral
cartilaginous
relates
Prior art date
Application number
BRPI0609392A
Other languages
English (en)
Inventor
Tampieri Anna
De Luca Claudio
Pressato Daniele
Landi Elena
Di Fede Sergio
Original Assignee
Fin Ceram Faenza Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fin Ceram Faenza Spa filed Critical Fin Ceram Faenza Spa
Publication of BRPI0609392A2 publication Critical patent/BRPI0609392A2/pt
Publication of BRPI0609392B1 publication Critical patent/BRPI0609392B1/pt
Publication of BRPI0609392B8 publication Critical patent/BRPI0609392B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/102—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Feedback Control In General (AREA)
  • Laminated Bodies (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Road Paving Structures (AREA)
  • Furnace Housings, Linings, Walls, And Ceilings (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Packages (AREA)

Abstract

substituto cartilaginiforme e osteocondral compreendendo uma estrutura de múltiplas camadas e seu uso. trata-se de uma estrutura de camadas múltiplas (1) que inclui uma primeira camada superior (2), que consiste em uma matriz orgânica incluindo colágeno e pelo menos uma camada inferior (3, 4, ..., 10), que consiste em uma matriz composta incluindo hidroxiapatita e colágeno. além disso, a presente invenção se refere a um substituto cartilaginoso incluindo a referida estrutura de múltiplas camadas (1) assim como um substituto osteocondral incluindo a referida estrutura de camadas múltiplas (1). finalmente, a presente invenção se refere ao uso da referida estrutura de múltiplas camadas (1) para o preparo do referido substituto cartilaginoso e do referido substituto osteocondral para o tratamento de defeitos cartilaginosos e de defeitos osteocondrais ou para a neoformação de um tecido cartilaginoso e/ou de um tecido ósseo subcondral.
BRPI0609392A 2005-03-04 2006-03-02 substituto cartilaginiforme e osteocondral compreendendo uma estrutura de múltiplas camadas e seu uso BRPI0609392B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2005A000343 2005-03-04
IT000343A ITMI20050343A1 (it) 2005-03-04 2005-03-04 Sostituto cartilagineo e osteocindrale comprendente una struttura multistrato e relativo impiego
PCT/IB2006/000452 WO2006092718A2 (en) 2005-03-04 2006-03-02 Cartilaginiform and osteochondral sustitute comprising a multilayer structure and use thereof

Publications (3)

Publication Number Publication Date
BRPI0609392A2 BRPI0609392A2 (pt) 2010-03-30
BRPI0609392B1 BRPI0609392B1 (pt) 2018-05-29
BRPI0609392B8 true BRPI0609392B8 (pt) 2021-06-22

Family

ID=36917317

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0609392A BRPI0609392B8 (pt) 2005-03-04 2006-03-02 substituto cartilaginiforme e osteocondral compreendendo uma estrutura de múltiplas camadas e seu uso

Country Status (13)

Country Link
US (1) US9155818B2 (pt)
EP (1) EP1858562B1 (pt)
JP (1) JP5289772B2 (pt)
CN (1) CN101163512B (pt)
AT (1) ATE447986T1 (pt)
BR (1) BRPI0609392B8 (pt)
CA (1) CA2600893C (pt)
DE (1) DE602006010341D1 (pt)
DK (1) DK1858562T3 (pt)
ES (1) ES2336359T3 (pt)
IT (1) ITMI20050343A1 (pt)
WO (1) WO2006092718A2 (pt)
ZA (1) ZA200707511B (pt)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858042B2 (en) 1999-12-15 2005-02-22 Zimmer Orthobiologics, Inc. Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
GB2424223C (en) * 2005-03-07 2011-02-02 Massachusetts Inst Technology Biomaterial.
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
EP1964583A1 (en) 2007-02-09 2008-09-03 Royal College of Surgeons in Ireland Process for producing a collagen/hydroxyapatite composite scaffold
CA2750605C (en) 2009-01-23 2019-01-22 Royal College Of Surgeons In Ireland Layered scaffold suitable for osteochondral repair
AU2010221089A1 (en) * 2009-03-05 2011-09-15 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of osteochondral defects
JP5545563B2 (ja) * 2009-09-08 2014-07-09 利江 土屋 軟骨用移植材
IT1396934B1 (it) * 2009-11-25 2012-12-20 Fin Ceramica Faenza Spa Materiali bio-mimetici compositi, relativo processo di preparazione e loro uso per la realizzazione di strutture mono-, bi- o multi-strato per la rigenerazione di tessuto osseo, cartilagineo o osteocartilagineo
US11786636B2 (en) * 2010-06-15 2023-10-17 Versitech Limited Methods for complex tissue engineering
US9693954B2 (en) * 2010-06-25 2017-07-04 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
DE102011052416A1 (de) * 2010-08-04 2012-02-09 Technische Universität Dresden Wachstumsinhibierter Hydroxylapatit, Verfahren zu dessen Herstellung und Verwendung
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
ITMI20102070A1 (it) 2010-11-08 2012-05-09 Consiglio Nazionale Ricerche Impianti per sostituzioni ossee "load bearing" ad architettura gerarchicamente organizzata derivante dalla trasformazione di strutture vegetali
AU2011329054B2 (en) 2010-11-15 2015-05-28 Zimmer Orthobiologics, Inc. Bone void fillers
KR101375828B1 (ko) * 2011-03-31 2014-03-17 인제대학교 산학협력단 골-연골 재생용 복합 지지체, 이의 제조 방법 및 이를 유효성분으로 함유하는 골-연골 질환 치료용 조성물
EP2786770B1 (en) * 2011-08-30 2017-04-19 Kyoto University Porous scaffold material, and method for producing same
JP6018477B2 (ja) * 2011-11-11 2016-11-02 Hoya株式会社 人工骨−軟骨複合体及びその製造方法
ES2869959T3 (es) * 2011-12-08 2021-10-26 Kai Stuckensen Producción de materiales que tienen estructura anisotrópica
US10576694B2 (en) 2011-12-08 2020-03-03 Julius-Maximilians-Universitaet Wuerzburg Production of materials having an anisotropic structure
CN102580156B (zh) * 2012-03-29 2014-10-08 陕西博鸿生物科技有限公司 一种组织工程软骨支架材料及其制备方法和装置
CN103920190B (zh) * 2013-01-14 2017-09-29 陕西博鸿生物科技集团有限公司 一种关节软骨移植物及其制备方法
ITMI20130636A1 (it) * 2013-04-18 2014-10-19 Novagenit S R L Metodo per la preparazione di biomateriali biocompatibili e biodegradabili a base di collagene e granuli di idrossiapatite/¿-tricalcio fosfato per uso in chirurgia ortopedica e biomateriali così ottenuti
EP2826495A1 (en) 2013-07-19 2015-01-21 Geistlich Pharma AG Biomimetic collagen-hydroxyapatite composite material
KR20150053606A (ko) * 2013-11-08 2015-05-18 세원셀론텍(주) 콜라겐과 히알루론산의 천연가교를 통한 고무성질의 물성이 강화된 생체재료물질 및 그 제조방법
CN104324418B (zh) * 2014-10-27 2016-04-06 东华大学 一种组织工程纳米纤维骨软骨修复支架及其制备方法
CN104307047B (zh) * 2014-10-29 2017-02-01 中国科学院长春应用化学研究所 一种双梯度仿生修复支架及其制备方法
CN106139255A (zh) * 2015-04-17 2016-11-23 天津市赛宁生物工程技术有限公司 一种胶原蛋白结合磷酸钙的医用海绵支架的新型材料和制备方法
CN106806940A (zh) * 2015-12-02 2017-06-09 中国科学院大连化学物理研究所 一种掺杂纳米羟基磷灰石的多孔仿生骨支架的制备方法
EP3175869A1 (en) 2015-12-04 2017-06-07 Geistlich Pharma AG Resorbable crosslinked formstable membrane
WO2018047785A1 (ja) * 2016-09-07 2018-03-15 ナガセケムテックス株式会社 コラーゲン様ポリペプチド
IT201600094601A1 (it) 2016-09-21 2018-03-21 Fin Ceram Faenza S P A “apparecchiatura e kit per la realizzazione di fori a profondità controllata e di diverso diametro su superfici condrali ed osteocondrali”
EP3409303A1 (en) * 2017-06-02 2018-12-05 Geistlich Pharma AG Use of a resorbable crosslinked form stable composition for preparing a membrane
CN107669371B (zh) * 2017-08-02 2018-08-03 中南大学湘雅医院 三相组织工程支架
CN107789668B (zh) * 2017-11-03 2020-10-27 华中科技大学同济医学院附属协和医院 具有多层结构的仿生胶原蛋白骨修复材料及其制备方法
CN108355174A (zh) * 2018-05-06 2018-08-03 西北工业大学 一种多功能分层关节软骨支架的制备方法
WO2020120805A2 (en) 2018-12-14 2020-06-18 Institut Químic De Sarrià Cets Fundació Privada Heterogeneous scaffolds and methods of functionalising surfaces
CN109628387A (zh) * 2018-12-28 2019-04-16 广州赛莱拉干细胞科技股份有限公司 组合物、含有该组合物的分化诱导培养液及诱导方法
CN110368529B (zh) * 2019-08-19 2021-08-31 江苏地韵医疗科技有限公司 软骨或软骨下骨全层修复支架及其制备方法
US11633879B2 (en) 2020-01-21 2023-04-25 United States Government As Represented By The Department Of Veterans Affairs Anatomic tissue-engineered osteochondral implant and method for fabrication thereof
CN111330080B (zh) * 2020-03-31 2021-12-07 江苏白衣缘生物工程有限公司 一种引导口腔骨再生的生物膜及其制备方法
CN115397920A (zh) * 2020-04-16 2022-11-25 南洋理工大学 复合支架材料
CN111375088B (zh) * 2020-04-29 2022-06-14 陕西巨子生物技术有限公司 双层骨软骨组织修复支架及其制备方法
CA3194691A1 (en) * 2020-11-05 2022-05-12 Ran Kapri Multi-layered collagen structure
CN113559329A (zh) * 2021-09-03 2021-10-29 北京大学口腔医学院 一种仿牙周有序双层结构支架材料及其制备方法和应用
CN114732957B (zh) * 2022-03-16 2022-12-23 武汉理工大学 一种具有预应力的矿化肌腱复合材料及其制备方法与应用
SK289409B6 (sk) 2022-12-05 2026-03-11 Ústav materiálového výskumu Slovenskej akadémie vied, verejná výskumná inštitúcia Kompozitný biocementový systém

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3082503B2 (ja) * 1993-02-26 2000-08-28 株式会社神戸製鋼所 人工骨製造用前駆体および人工骨の製法
US6117979A (en) * 1997-08-18 2000-09-12 Medtronic, Inc. Process for making a bioprosthetic device and implants produced therefrom
GB9727048D0 (en) * 1997-12-22 1998-02-18 Abonetics Ltd Process for the preparation of magnesium and carbonate substituted hydroxyapatite
US20030114936A1 (en) * 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
CN1169494C (zh) * 2001-05-23 2004-10-06 中国科学院化学研究所 组织工程用复合结构细胞支架及其制法和用途
US6626950B2 (en) * 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
GB0121985D0 (en) * 2001-09-11 2001-10-31 Isis Innovation Tissue engineering scaffolds
JP3727059B2 (ja) * 2002-05-01 2005-12-14 独立行政法人科学技術振興機構 多孔質複合材料の製造方法
JP4416152B2 (ja) * 2003-03-28 2010-02-17 独立行政法人物質・材料研究機構 生体組織補填材とその製造方法
US8039090B2 (en) * 2003-05-26 2011-10-18 Hoya Corporation Porous composite containing calcium phosphate and process for producing the same
US20050074877A1 (en) * 2003-07-28 2005-04-07 Mao Jeremy Jian Biological engineering of articular structures containing both cartilage and bone
US7217294B2 (en) * 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof

Also Published As

Publication number Publication date
CA2600893C (en) 2014-04-29
ITMI20050343A1 (it) 2006-09-05
DK1858562T3 (da) 2010-03-22
US20090232875A1 (en) 2009-09-17
ZA200707511B (en) 2008-11-26
BRPI0609392B1 (pt) 2018-05-29
WO2006092718A2 (en) 2006-09-08
JP5289772B2 (ja) 2013-09-11
EP1858562B1 (en) 2009-11-11
JP2008531171A (ja) 2008-08-14
CN101163512A (zh) 2008-04-16
ATE447986T1 (de) 2009-11-15
WO2006092718A3 (en) 2007-01-25
CA2600893A1 (en) 2006-09-08
EP1858562A2 (en) 2007-11-28
US9155818B2 (en) 2015-10-13
DE602006010341D1 (de) 2009-12-24
ES2336359T3 (es) 2010-04-12
BRPI0609392A2 (pt) 2010-03-30
CN101163512B (zh) 2010-11-17

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