ATE455113T1 - 3-triazolylthioalkyl-3-azabicyclo ä3.1.0ühexane und ihre verwendung als liganden des dopamin-d3- rezeptors - Google Patents

3-triazolylthioalkyl-3-azabicyclo ä3.1.0ühexane und ihre verwendung als liganden des dopamin-d3- rezeptors

Info

Publication number: ATE455113T1
Authority: AT; Austria
Prior art keywords: 4alkyl; group; haloc1; 4alkoxy; dopamine
Prior art date: 2005-04-14

Application number

AT06724410T

Other languages

English (en)

Inventor

Daniele Andreotti

Anna Checchia

Dieter Hamprecht

Fabrizio Micheli

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-04-14

Filing date

2006-04-12

Publication date

2010-01-15

2006-04-12 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2010-01-15 Application granted granted Critical

2010-01-15 Publication of ATE455113T1 publication Critical patent/ATE455113T1/de

Links

102000004073 Dopamine D3 Receptors Human genes 0.000 title abstract 2
108090000525 Dopamine D3 Receptors Proteins 0.000 title abstract 2
239000003446 ligand Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
HCMJWOGOISXSDL-UHFFFAOYSA-N (2-isothiocyanato-1-phenylethyl)benzene Chemical compound C=1C=CC=CC=1C(CN=C=S)C1=CC=CC=C1 HCMJWOGOISXSDL-UHFFFAOYSA-N 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
230000007278 cognition impairment Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
206010036596 premature ejaculation Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000001228 spectrum Methods 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT06724410T 2005-04-14 2006-04-12 3-triazolylthioalkyl-3-azabicyclo ä3.1.0ühexane und ihre verwendung als liganden des dopamin-d3- rezeptors ATE455113T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0507601.3A GB0507601D0 (en)	2005-04-14	2005-04-14	Compounds
PCT/EP2006/003553 WO2006108700A1 (en)	2005-04-14	2006-04-12	3-triazolylthioalkyl-3-azabicyclo (3 - 1 - o) hexanes and their use as dopamine d3 receptor ligands

Publications (1)

Publication Number	Publication Date
ATE455113T1 true ATE455113T1 (de)	2010-01-15

Family

ID=34611146

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06724410T ATE455113T1 (de)	2005-04-14	2006-04-12	3-triazolylthioalkyl-3-azabicyclo ä3.1.0ühexane und ihre verwendung als liganden des dopamin-d3- rezeptors

Country Status (8)

Country	Link
US (1)	US7803820B2 (de)
EP (1)	EP1869018B1 (de)
JP (1)	JP5150480B2 (de)
AT (1)	ATE455113T1 (de)
DE (1)	DE602006011725D1 (de)
ES (1)	ES2339274T3 (de)
GB (1)	GB0507601D0 (de)
WO (1)	WO2006108700A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE451364T1 (de) *	2004-02-23	2009-12-15	Glaxo Group Ltd	Als modulatoren des dopamin-d3-rezeptors geeignete azabicycloä3.1.0ühexanderivate
GB0507602D0 (en) *	2005-04-14	2005-05-18	Glaxo Group Ltd	Compounds
GB0507680D0 (en) *	2005-04-15	2005-05-25	Glaxo Group Ltd	Compounds
GB0512099D0 (en) *	2005-06-14	2005-07-20	Glaxo Group Ltd	Compounds
ATE484502T1 (de) *	2005-06-14	2010-10-15	Glaxo Group Ltd	Neue verbindungen
GB0517187D0 (en) *	2005-08-22	2005-09-28	Glaxo Group Ltd	Compounds
GB0517175D0 (en) *	2005-08-22	2005-09-28	Glaxo Group Ltd	Compounds
GB0517193D0 (en)	2005-08-22	2005-09-28	Glaxo Group Ltd	Novel use
ATE487715T1 (de) *	2005-08-22	2010-11-15	Glaxo Group Ltd	Triazolderivate als modulatoren von dopamin-d3- rezeptoren
GB0517191D0 (en) *	2005-08-22	2005-09-28	Glaxo Group Ltd	Compounds
WO2007113260A1 (en) *	2006-04-03	2007-10-11	Glaxo Group Limited	Azabicyclo [3. 1. o] hexyl derivatives as modulators of dopamine d3 receptors
WO2007113258A1 (en) *	2006-04-03	2007-10-11	Glaxo Group Limited	Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors
MX2012000231A (es)	2009-06-26	2012-03-07	Panacea Biotec Ltd	Nuevos aza-biciclo-hexanos.
CN104557646B (zh)	2011-02-15	2017-08-29	宇部兴产株式会社	生产芳基硫五氟化物的工业方法
WO2019146740A1 (ja)	2018-01-26	2019-08-01	塩野義製薬株式会社	ドーパミンｄ３受容体拮抗作用を有する環式化合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1254474C (zh) *	2000-11-14	2006-05-03	史密斯克莱·比奇曼公司	作为多巴胺D<sub>3</sub>受体调节剂(精神抑制药)的四氢苯并氮杂䓬衍生物
US6569887B2 (en) *	2001-08-24	2003-05-27	Dov Pharmaceuticals Inc.	(−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
ATE451364T1 (de) *	2004-02-23	2009-12-15	Glaxo Group Ltd	Als modulatoren des dopamin-d3-rezeptors geeignete azabicycloä3.1.0ühexanderivate
GB0507602D0 (en) *	2005-04-14	2005-05-18	Glaxo Group Ltd	Compounds
GB0507680D0 (en) *	2005-04-15	2005-05-25	Glaxo Group Ltd	Compounds
ATE484502T1 (de) *	2005-06-14	2010-10-15	Glaxo Group Ltd	Neue verbindungen
GB0512099D0 (en) *	2005-06-14	2005-07-20	Glaxo Group Ltd	Compounds
GB0517187D0 (en) *	2005-08-22	2005-09-28	Glaxo Group Ltd	Compounds
GB0517175D0 (en) *	2005-08-22	2005-09-28	Glaxo Group Ltd	Compounds
ATE487715T1 (de) *	2005-08-22	2010-11-15	Glaxo Group Ltd	Triazolderivate als modulatoren von dopamin-d3- rezeptoren
GB0517193D0 (en) *	2005-08-22	2005-09-28	Glaxo Group Ltd	Novel use
GB0517191D0 (en) *	2005-08-22	2005-09-28	Glaxo Group Ltd	Compounds
AU2007233715A1 (en) *	2006-04-03	2007-10-11	Glaxo Group Limited	Azabicyclo [3. 1. 0] hexyl derivatives as modulators of dopamine D3 receptors
GB0616574D0 (en) *	2006-08-21	2006-09-27	Glaxo Group Ltd	Compounds

2005
- 2005-04-14 GB GBGB0507601.3A patent/GB0507601D0/en not_active Ceased
2006
- 2006-04-12 EP EP06724410A patent/EP1869018B1/de not_active Expired - Lifetime
- 2006-04-12 ES ES06724410T patent/ES2339274T3/es not_active Expired - Lifetime
- 2006-04-12 JP JP2008505839A patent/JP5150480B2/ja not_active Expired - Fee Related
- 2006-04-12 US US11/911,035 patent/US7803820B2/en not_active Expired - Fee Related
- 2006-04-12 AT AT06724410T patent/ATE455113T1/de not_active IP Right Cessation
- 2006-04-12 WO PCT/EP2006/003553 patent/WO2006108700A1/en not_active Ceased
- 2006-04-12 DE DE602006011725T patent/DE602006011725D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2008535885A (ja)	2008-09-04
ES2339274T3 (es)	2010-05-18
US7803820B2 (en)	2010-09-28
JP5150480B2 (ja)	2013-02-20
US20080176917A1 (en)	2008-07-24
GB0507601D0 (en)	2005-05-18
EP1869018B1 (de)	2010-01-13
WO2006108700A1 (en)	2006-10-19
DE602006011725D1 (de)	2010-03-04
EP1869018A1 (de)	2007-12-26

Legal Events

Date	Code	Title	Description
2010-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602006006850D1 (de)	2009-06-25	Als modulatoren von dopamin-d3-rezeptoren geeignete azabicyclo-(3,1,0)-hexan-derivate
DE602006011725D1 (de)	2010-03-04	3-triazolylthioalkyl-3-azabicyclo ä3.1.0ühexane und ihre verwendung als liganden des dopamin-d3-rezeptors
PE20060599A1 (es)	2006-08-22	DERIVADOS PIRAZOLO-[3,4-d]-PIRIMIDINA COMO INHIBIDORES DE LA ACTIVIDAD DEL RECEPTOR CANNABINOIDE 1
EP2060570A3 (de)	2009-06-03	Azalbicyclo[3.1.0]Hexaderivate und ihre Verwendung als Modulatoren des Dopamin-D3-Rezeptors
AR075597A1 (es)	2011-04-20	Derivados de indol como antagonistas de receptores crth2, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento del asma y otras enfermedades alergicas .
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ATE429427T1 (de)	2009-05-15	Pyrimidinderivate als orexin-rezeptorantagonisten
TW200719886A (en)	2007-06-01	Dihydrobenzofuran derivatives and uses thereof
ATE487715T1 (de)	2010-11-15	Triazolderivate als modulatoren von dopamin-d3- rezeptoren
AR038419A1 (es)	2005-01-12	Derivados de piridina y quinolina
PE20091376A1 (es)	2009-09-25	Derivados de fenilamino como moduladores de beta-amiloide
IL177291A0 (en)	2006-12-10	Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists
UY30897A1 (es)	2008-09-30	Derivados de pentafluorotiobenzamidoacetonitrilo, composiciones conteniéndolos y aplicaciones
MXPA05010824A (es)	2005-12-05	Compuestos biciclicos como antagonistas del receptor nr2b.
TW200519096A (en)	2005-06-16	Quinazoline analogs as receptor tyrosine kinase inhibitors
DE602006019221D1 (de)	2011-02-10	Von dopamin-d3-rezeptoren
ATE534625T1 (de)	2011-12-15	Substituierte n-phenyl-bipyrrolidinharnstoffe und deren therapeutische verwendung
UY29204A1 (es)	2006-01-31	Compuestos de imidazo(1,2-a)piridina, composiciones, usos y métodos relacionados
DE602006006712D1 (de)	2009-06-18	Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
AR077534A1 (es)	2011-09-07	Derivados de isoxazol, un proceso para su obtencion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades relacionadas con el receptor gaba aalfa5
ATE532780T1 (de)	2011-11-15	Chinoline und ihre therapeutische verwendung
ATE512142T1 (de)	2011-06-15	Pyrimidin- und chinazolinderivate als modulatoren der somatostatin-rezeptor aktivität
ATE420859T1 (de)	2009-01-15	Azabicycloä3.1.0ühexylphenylderivate als modulatoren von dopamin-d3-rezeptoren
ATE429421T1 (de)	2009-05-15	Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonisten
MX2011007272A (es)	2011-08-08	Piperidinas de aroilamino y heteroaroilamino sustituidas como inhibidores de glyt-1.