ATE498619T1 - Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren - Google Patents
Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptorenInfo
- Publication number
- ATE498619T1 ATE498619T1 AT07727587T AT07727587T ATE498619T1 AT E498619 T1 ATE498619 T1 AT E498619T1 AT 07727587 T AT07727587 T AT 07727587T AT 07727587 T AT07727587 T AT 07727587T AT E498619 T1 ATE498619 T1 AT E498619T1
- Authority
- AT
- Austria
- Prior art keywords
- dopamine
- modulators
- receptors
- derivatives
- treat
- Prior art date
Links
- 102000004073 Dopamine D3 Receptors Human genes 0.000 title abstract 2
- 108090000525 Dopamine D3 Receptors Proteins 0.000 title abstract 2
- 239000000164 antipsychotic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010036596 premature ejaculation Diseases 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0607896A GB0607896D0 (en) | 2006-04-03 | 2006-04-03 | Novel compounds |
| GB0703387A GB0703387D0 (en) | 2007-02-21 | 2007-02-21 | Novel compounds |
| PCT/EP2007/053115 WO2007113258A1 (en) | 2006-04-03 | 2007-03-30 | Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE498619T1 true ATE498619T1 (de) | 2011-03-15 |
Family
ID=38109652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07727587T ATE498619T1 (de) | 2006-04-03 | 2007-03-30 | Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8163927B2 (de) |
| EP (1) | EP2010518B1 (de) |
| AT (1) | ATE498619T1 (de) |
| DE (1) | DE602007012531D1 (de) |
| WO (1) | WO2007113258A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200870404A1 (ru) | 2006-04-03 | 2009-04-28 | Глэксо Груп Лимитед | Производные азабицикло[3.1.0.]гексила в качестве модуляторов рецепторов допамина d3 |
| RU2012102094A (ru) | 2009-06-26 | 2013-08-10 | Панацеа Биотек Лтд. | Новые азабициклогексаны |
| US11447484B2 (en) | 2018-01-26 | 2022-09-20 | Shionogi & Co., Ltd. | Cyclic compound having dopamine D3 receptor antagonistic effect |
| CR20200464A (es) | 2018-03-08 | 2021-04-14 | Incyte Corp | Compuestos diólicos de aminopirazina como inhibidores de pi3k-y |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0015562D0 (en) * | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
| ATE451364T1 (de) * | 2004-02-23 | 2009-12-15 | Glaxo Group Ltd | Als modulatoren des dopamin-d3-rezeptors geeignete azabicycloä3.1.0ühexanderivate |
| GB0507602D0 (en) | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| GB0507601D0 (en) * | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| GB0507680D0 (en) * | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
| GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
| JP5068747B2 (ja) * | 2005-06-14 | 2012-11-07 | グラクソ グループ リミテッド | ドーパミンｄ３受容体のモジュレーターとしてのアザビシクロ［３．１．０］ヘキサン誘導体 |
| GB0517175D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| GB0517187D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| ATE487715T1 (de) * | 2005-08-22 | 2010-11-15 | Glaxo Group Ltd | Triazolderivate als modulatoren von dopamin-d3- rezeptoren |
| GB0517193D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Novel use |
| GB0517191D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| EA200870404A1 (ru) * | 2006-04-03 | 2009-04-28 | Глэксо Груп Лимитед | Производные азабицикло[3.1.0.]гексила в качестве модуляторов рецепторов допамина d3 |
| GB0616574D0 (en) * | 2006-08-21 | 2006-09-27 | Glaxo Group Ltd | Compounds |
-
2007
- 2007-03-30 AT AT07727587T patent/ATE498619T1/de not_active IP Right Cessation
- 2007-03-30 EP EP07727587A patent/EP2010518B1/de active Active
- 2007-03-30 DE DE602007012531T patent/DE602007012531D1/de active Active
- 2007-03-30 WO PCT/EP2007/053115 patent/WO2007113258A1/en not_active Ceased
- 2007-03-30 US US12/295,024 patent/US8163927B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20100063097A1 (en) | 2010-03-11 |
| WO2007113258A1 (en) | 2007-10-11 |
| DE602007012531D1 (de) | 2011-03-31 |
| EP2010518B1 (de) | 2011-02-16 |
| US8163927B2 (en) | 2012-04-24 |
| EP2010518A1 (de) | 2009-01-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CR10138A (es) | 1h indoles sustituidos por sulfonilo como ligandos para los receptores 5-hidroxitriptamina | |
| SV2011003809A (es) | Derivados de heteroarilo como inhibidores de dgat1 | |
| EA200900828A1 (ru) | Соединения и композиции в качестве ингибиторов активности каннабиноидного рецептора 1 | |
| NO20084007L (no) | Spirokondenserte piperidiner som modulatorer av muskarinreseptorer | |
| EA200901166A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr 119 | |
| BRPI0410711A (pt) | novos compostos | |
| DE602007008524D1 (de) | Spiroimidazol-derivate als ppar-modulatoren | |
| GT200600197A (es) | Compuestos y composiciones como inhibidores de proteina quinasa | |
| EA200970337A1 (ru) | Ингибиторы котранспортера натрий-глюкозы 2 и способы их применения | |
| ECSP11010885A (es) | Heteroarilos sustituidos | |
| CR10060A (es) | 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas | |
| DK2212283T3 (da) | Substituerede N-phenylbipyrrolidincarboxamider og terapeutisk anvendelse deraf | |
| ECSP067121A (es) | 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas | |
| CY1112683T1 (el) | Υποκατεστημενες καρβοξαμιδες ν-φαινυλ-διπυρρολιδινης και θεραπευτικες χρησεις τους | |
| EA201000895A1 (ru) | Композиции и способы для лечения лизосомных болезней | |
| NO20061845L (no) | Fenyl-piperazinderivater som modulatorer for muskarine reseptorer | |
| SE0401465D0 (sv) | New substituted piperdines as modulators of dopamine neurotransmission | |
| EA200602242A1 (ru) | 3-аминоциклопентанкарбоксамиды в качестве модуляторов хемокиновых рецепторов | |
| EA200601895A1 (ru) | 3-(4-гетероарилциклогексиламино)циклопентанкарбоксамиды в качестве модуляторов хемокиновых рецепторов | |
| ATE466854T1 (de) | 1h-indol-6-ylpiperazin-1-ylmethanonderivate zur verwendung als h3-rezeptormodulatoren | |
| NO20073369L (no) | Modulatorer av muskarinreseptorer | |
| DK1948606T3 (da) | 3, 5-disubstituerede phenyl-piperidiner som modulatorer af dopaminneurotransmission | |
| DE602007012531D1 (de) | Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren | |
| ATE459620T1 (de) | Benzimidazolthiophenverbindungen als plk- modulatoren | |
| ATE421518T1 (de) | Dihydrochinazolinone als 5ht-modulatoren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |