ATE456392T1 - Benzoädüisoxazol-derivate als c-kit-tyrosinkinase-hemmer zur behandlung von erkrankungen im zusammenhang mit der überproduktion von histamin - Google Patents

Benzoädüisoxazol-derivate als c-kit-tyrosinkinase-hemmer zur behandlung von erkrankungen im zusammenhang mit der überproduktion von histamin

Info

Publication number: ATE456392T1
Authority: AT; Austria
Prior art keywords: kit; treatment; benzoadiisoxazole; overproduction; histamine
Prior art date: 2006-07-20

Application number

AT07810594T

Other languages

English (en)

Inventor

Ning Chen

Essa Hu

Roxanne Kunz

Shannon Rumfelt

Andrew Tasker

Original Assignee

Amgen Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-20

Filing date

2007-07-18

Publication date

2010-02-15

2007-07-18 Application filed by Amgen Inc filed Critical Amgen Inc

2010-02-15 Application granted granted Critical

2010-02-15 Publication of ATE456392T1 publication Critical patent/ATE456392T1/de

Links

201000010099 disease Diseases 0.000 title abstract 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 title 2
229960001340 histamine Drugs 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
238000012261 overproduction Methods 0.000 title 1
102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 abstract 3
108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
230000001404 mediated effect Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
230000003176 fibrotic effect Effects 0.000 abstract 1
210000003630 histaminocyte Anatomy 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT07810594T 2006-07-20 2007-07-18 Benzoädüisoxazol-derivate als c-kit-tyrosinkinase-hemmer zur behandlung von erkrankungen im zusammenhang mit der überproduktion von histamin ATE456392T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US83230606P	2006-07-20	2006-07-20
PCT/US2007/016328 WO2008011080A2 (en)	2006-07-20	2007-07-18	Benzo(d) isoxazole derivatives as c-kit tyrosine kinase inhibitors for the treatment of disorders associated with the over production of histamine

Publications (1)

Publication Number	Publication Date
ATE456392T1 true ATE456392T1 (de)	2010-02-15

Family

ID=38941934

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07810594T ATE456392T1 (de)	2006-07-20	2007-07-18	Benzoädüisoxazol-derivate als c-kit-tyrosinkinase-hemmer zur behandlung von erkrankungen im zusammenhang mit der überproduktion von histamin

Country Status (8)

Country	Link
US (1)	US7872128B2 (de)
EP (1)	EP2069020B1 (de)
AT (1)	ATE456392T1 (de)
AU (1)	AU2007275653B2 (de)
CA (1)	CA2658359C (de)
DE (1)	DE602007004638D1 (de)
ES (1)	ES2338278T3 (de)
WO (1)	WO2008011080A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI504395B (zh)	2009-03-10	2015-10-21		Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier
CA2754934A1 (en)	2009-03-10	2010-09-16	Gruenenthal Gmbh	Substituted 3-aminoisoxazolopyridines as kcnq2/3 modulators
TWI475020B (zh)	2009-03-12	2015-03-01		The substituted nicotine amide as a KCNQ2 / 3 modifier
TW201038565A (en)	2009-03-12	2010-11-01	Gruenenthal Gmbh	Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators
TWI461197B (zh)	2009-03-12	2014-11-21		2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier
MX2012009377A (es) *	2010-02-11	2012-09-12	Univ Vanderbilt	Benzotiazoles y azabenzotiazoles como potenciadores alostericos mglur4, composiciones y metodos para tratar la disfuncion neurologica.
CA2805932A1 (en)	2010-08-27	2012-03-01	Gruenenthal Gmbh	Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators
RU2595894C2 (ru)	2010-08-27	2016-08-27	Грюненталь Гмбх	Замещенные 2-окси-хинолин-3-карбоксамиды в качестве модуляторов kcnq2/3
MX342459B (es)	2010-08-27	2016-09-29	Grünenthal Gmbh *	2-oxo- y 2-tioxo-dihidroquinolin-3-carboxamidas sustituidas, como moduladores de kcnq2/3.
CA2807886A1 (en)	2010-09-01	2012-03-08	Gruenenthal Gmbh	Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators
CN103717591B (zh)	2011-07-27	2016-08-24	Ab科学有限公司	作为选择性蛋白激酶(c-kit)抑制剂的噁唑和噻唑衍生物
SMT201800070T1 (it) *	2012-12-19	2018-03-08	Celgene Quanticel Res Inc	Inibiorti di istone demetilasi
JP2018523707A (ja) *	2015-08-12	2018-08-23	アクソバントサイエンシズゲーエムベーハー	α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換アミノベンゾイソオキサゾール化合物
EA202192575A1 (ru)	2019-03-21	2022-01-14	Онксео	Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN114761006A (zh)	2019-11-08	2022-07-15	Inserm(法国国家健康医学研究院)	对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6271233B1 (en)	1999-08-10	2001-08-07	Ciba Vision Corporation	Method for treating ocular neovascular diseases
US7202363B2 (en)	2003-07-24	2007-04-10	Abbott Laboratories	Thienopyridine and furopyridine kinase inhibitors

2007
- 2007-07-18 AU AU2007275653A patent/AU2007275653B2/en not_active Ceased
- 2007-07-18 EP EP07810594A patent/EP2069020B1/de active Active
- 2007-07-18 ES ES07810594T patent/ES2338278T3/es active Active
- 2007-07-18 CA CA2658359A patent/CA2658359C/en not_active Expired - Fee Related
- 2007-07-18 DE DE602007004638T patent/DE602007004638D1/de active Active
- 2007-07-18 WO PCT/US2007/016328 patent/WO2008011080A2/en not_active Ceased
- 2007-07-18 AT AT07810594T patent/ATE456392T1/de not_active IP Right Cessation
- 2007-07-18 US US11/879,831 patent/US7872128B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US7872128B2 (en)	2011-01-18
EP2069020B1 (de)	2010-01-27
CA2658359C (en)	2011-11-29
WO2008011080A2 (en)	2008-01-24
EP2069020A2 (de)	2009-06-17
ES2338278T3 (es)	2010-05-05
AU2007275653A1 (en)	2008-01-24
DE602007004638D1 (de)	2010-03-18
US20080227779A1 (en)	2008-09-18
AU2007275653B2 (en)	2010-12-23
WO2008011080A3 (en)	2008-04-24
CA2658359A1 (en)	2008-01-24

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Legal Events

Date	Code	Title	Description
2010-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties