ATE457308T1 - Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta - Google Patents
Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-betaInfo
- Publication number
- ATE457308T1 ATE457308T1 AT04759766T AT04759766T ATE457308T1 AT E457308 T1 ATE457308 T1 AT E457308T1 AT 04759766 T AT04759766 T AT 04759766T AT 04759766 T AT04759766 T AT 04759766T AT E457308 T1 ATE457308 T1 AT E457308T1
- Authority
- AT
- Austria
- Prior art keywords
- estrogen receptor
- receptor beta
- selective antagonists
- substituted benzopyrans
- substituted
- Prior art date
Links
- 150000001562 benzopyrans Chemical class 0.000 title abstract 2
- 102000000509 Estrogen Receptor beta Human genes 0.000 title 1
- 108010041356 Estrogen Receptor beta Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000000556 agonist Substances 0.000 abstract 2
- 102000015694 estrogen receptors Human genes 0.000 abstract 2
- 108010038795 estrogen receptors Proteins 0.000 abstract 2
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46440503P | 2003-04-21 | 2003-04-21 | |
| PCT/US2004/009271 WO2004094401A1 (en) | 2003-04-21 | 2004-04-08 | Substituted benzopyrans as selective estrogen receptor-beta agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE457308T1 true ATE457308T1 (de) | 2010-02-15 |
Family
ID=33310883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04759766T ATE457308T1 (de) | 2003-04-21 | 2004-04-08 | Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7279499B2 (de) |
| EP (1) | EP1618102B1 (de) |
| AT (1) | ATE457308T1 (de) |
| DE (1) | DE602004025460D1 (de) |
| ES (1) | ES2338119T3 (de) |
| WO (1) | WO2004094401A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100374444C (zh) * | 2003-04-21 | 2008-03-12 | 伊莱利利公司 | 作为选择性β-雌激素受体激动剂的取代的苯并吡喃化合物 |
| BRPI0514974A (pt) | 2004-09-07 | 2008-07-01 | Wyeth Corp | composto, composição, métodos de tratar ou inibir uma doença ou condição, estados de doença induzidos por radical livre em um mamìfero, dano à junta secundário aos procedimentos artroscópicos ou cirúrgicos em um mamìfero, infertilidade em um mamìfero, de diminuir os nìveis de colesterol, triglicerìdeos, lp(a), ou ldl, de fornecer realce na cognição ou neuroproteção, de contracepção em um mamìfero, e para preparar um composto, e, produto |
| WO2006044176A1 (en) * | 2004-10-18 | 2006-04-27 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor-beta agonists |
| GT200500317A (es) | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
| US8093302B2 (en) | 2005-02-15 | 2012-01-10 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-β agonists |
| AR054849A1 (es) | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
| AR056695A1 (es) * | 2005-10-17 | 2007-10-17 | Wyeth Corp | Tetrahidroquinolinas, su sintesis e intermediarios |
| WO2008091555A2 (en) | 2007-01-22 | 2008-07-31 | Gtx, Inc. | Nuclear receptor binding agents |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| BRPI0910850B1 (pt) | 2008-04-21 | 2022-06-14 | Otonomy, Inc. | Composição intratimpânica compreendendo fator neurotrófico de crescimento derivado do cérebro (bdnf) para o tratamento ou prevenção da perda auditiva |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| US8784870B2 (en) | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
| CN102105133B (zh) | 2008-07-21 | 2015-06-17 | 奥德纳米有限公司 | 控制释放型耳结构调节和先天性免疫系统调节组合物以及治疗耳部病症的方法 |
| WO2011014516A1 (en) | 2009-07-28 | 2011-02-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Estrogen antagonists as treatments for sclerosing disorders |
| CA2774373A1 (en) * | 2009-09-17 | 2011-03-24 | Vanderbilt University | Substituted heteroarylamide analogs as mglur5 negative allosteric modulators and methods of making and using the same |
| EP3071568A1 (de) | 2013-11-19 | 2016-09-28 | Vanderbilt University | Substituierte imidazopyridin- und triazolopyridinverbindungen als negative allosterische modulatoren von mglur5 |
| CN105916506B (zh) | 2013-11-20 | 2020-01-07 | 圣诺康生命科学公司 | 作为tam家族激酶抑制剂的喹唑啉衍生物 |
| EP3076964A1 (de) | 2013-12-05 | 2016-10-12 | Karo Pharma AB | Östrogenrezeptor-betaagonisten zur behandlung von mesotheliom |
| US9533982B2 (en) | 2014-03-20 | 2017-01-03 | Vanderbilt University | Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators |
| US9550778B2 (en) | 2014-10-03 | 2017-01-24 | Vanderbilt University | Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5 |
| KR20190024983A (ko) | 2016-06-29 | 2019-03-08 | 오토노미, 인코포레이티드 | 트리글리세라이드 귀 제제 및 이의 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE792292T1 (de) | 1995-09-08 | 1998-09-03 | Karo Bio Ab, Huddinge | Waisen-rezeptor |
| WO1999002512A1 (en) | 1997-07-09 | 1999-01-21 | Novo Nordisk A/S | Dl-2,3-diaryl-2h-1-benzopyrans |
| ATE289300T1 (de) | 1999-12-30 | 2005-03-15 | Signal Pharm Inc | Verbindungen und verfahren zur modulation von estrogen rezeptoren |
| US7214706B2 (en) * | 2000-03-01 | 2007-05-08 | Akzo Nobel N.V. | Chroman derivatives as estrogenic compounds |
| DE60130748T2 (de) | 2000-03-27 | 2008-07-17 | N.V. Organon | Nicht-steroidale tetracyclische verbindungen für östrogen-verwandte behandlungen |
| GB2361642A (en) | 2000-10-24 | 2001-10-31 | Karobio Ab | Estrogen receptor beta (ERbeta) agonists for use in cancer treatment |
| EA007382B1 (ru) * | 2001-11-19 | 2006-10-27 | Эли Лилли Энд Компани | Замещенные бензопираны в качестве селективных агонистов бета-рецептора эстрогена |
| TWI306450B (en) | 2001-12-13 | 2009-02-21 | Wyeth Corp | Substituted phenyl naphthalenes as estrogenic agents |
| US6630508B1 (en) | 2002-02-11 | 2003-10-07 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor β agonists |
-
2004
- 2004-04-08 AT AT04759766T patent/ATE457308T1/de not_active IP Right Cessation
- 2004-04-08 US US10/549,106 patent/US7279499B2/en not_active Expired - Fee Related
- 2004-04-08 ES ES04759766T patent/ES2338119T3/es not_active Expired - Lifetime
- 2004-04-08 DE DE602004025460T patent/DE602004025460D1/de not_active Expired - Lifetime
- 2004-04-08 EP EP04759766A patent/EP1618102B1/de not_active Expired - Lifetime
- 2004-04-08 WO PCT/US2004/009271 patent/WO2004094401A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2338119T3 (es) | 2010-05-04 |
| EP1618102A1 (de) | 2006-01-25 |
| US20060199858A1 (en) | 2006-09-07 |
| US7279499B2 (en) | 2007-10-09 |
| WO2004094401A1 (en) | 2004-11-04 |
| DE602004025460D1 (de) | 2010-03-25 |
| EP1618102B1 (de) | 2010-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |