ATE457308T1 - Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta - Google Patents
Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-betaInfo
- Publication number
- ATE457308T1 ATE457308T1 AT04759766T AT04759766T ATE457308T1 AT E457308 T1 ATE457308 T1 AT E457308T1 AT 04759766 T AT04759766 T AT 04759766T AT 04759766 T AT04759766 T AT 04759766T AT E457308 T1 ATE457308 T1 AT E457308T1
- Authority
- AT
- Austria
- Prior art keywords
- estrogen receptor
- receptor beta
- selective antagonists
- substituted benzopyrans
- substituted
- Prior art date
Links
- 150000001562 benzopyrans Chemical class 0.000 title abstract 2
- 102000000509 Estrogen Receptor beta Human genes 0.000 title 1
- 108010041356 Estrogen Receptor beta Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000000556 agonist Substances 0.000 abstract 2
- 102000015694 estrogen receptors Human genes 0.000 abstract 2
- 108010038795 estrogen receptors Proteins 0.000 abstract 2
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46440503P | 2003-04-21 | 2003-04-21 | |
| PCT/US2004/009271 WO2004094401A1 (en) | 2003-04-21 | 2004-04-08 | Substituted benzopyrans as selective estrogen receptor-beta agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE457308T1 true ATE457308T1 (de) | 2010-02-15 |
Family
ID=33310883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04759766T ATE457308T1 (de) | 2003-04-21 | 2004-04-08 | Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7279499B2 (de) |
| EP (1) | EP1618102B1 (de) |
| AT (1) | ATE457308T1 (de) |
| DE (1) | DE602004025460D1 (de) |
| ES (1) | ES2338119T3 (de) |
| WO (1) | WO2004094401A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1626974T1 (sl) * | 2003-04-21 | 2009-02-28 | Lilly Co Eli | Substituirani benzopirani kot selektivni agonistiestrogenskega receptorja beta |
| CA2578164A1 (en) | 2004-09-07 | 2006-03-16 | Wyeth | 6h-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents |
| US7354951B2 (en) | 2004-10-18 | 2008-04-08 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor-beta agonists |
| GT200500317A (es) | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
| US8093302B2 (en) | 2005-02-15 | 2012-01-10 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-β agonists |
| AR054849A1 (es) | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
| PE20070549A1 (es) * | 2005-10-17 | 2007-06-15 | Wyeth Corp | Tetrahidroquinolinas, su sintesis e intermediarios |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| EP2106212B1 (de) | 2007-01-22 | 2014-04-02 | GTX, Inc. | Nuklearrezeptor-bindende wirkstoffe |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| KR101449785B1 (ko) | 2008-04-21 | 2014-10-14 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
| EP2306975A4 (de) | 2008-07-21 | 2012-10-31 | Otonomy Inc | Zusammensetzungen mit gesteuerter freisetzung zur modulierung der ohrenstruktur und des angeborenen immunsystems sowie verfahren zur behandlung von ohrerkrankungen |
| US8784870B2 (en) * | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
| WO2011014516A1 (en) | 2009-07-28 | 2011-02-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Estrogen antagonists as treatments for sclerosing disorders |
| US8796295B2 (en) * | 2009-09-17 | 2014-08-05 | Vanderbilt University | Substituted benzamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same |
| CA2931097A1 (en) | 2013-11-19 | 2015-05-28 | Vanderbilt University | Substituted imidazopyridine and triazolopyridine compounds as negative allosteric modulators of mglur5 |
| CN105916506B (zh) | 2013-11-20 | 2020-01-07 | 圣诺康生命科学公司 | 作为tam家族激酶抑制剂的喹唑啉衍生物 |
| US9974776B2 (en) | 2013-12-05 | 2018-05-22 | Karo Pharma Ab | Estrogen receptor beta agonists for use in treating mesothelioma |
| US9533982B2 (en) | 2014-03-20 | 2017-01-03 | Vanderbilt University | Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators |
| US9550778B2 (en) | 2014-10-03 | 2017-01-24 | Vanderbilt University | Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5 |
| JP7033789B2 (ja) | 2016-06-29 | 2022-03-11 | オトノミー，インク． | トリグリセリド耳用製剤とその使用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0792292T4 (da) | 1995-09-08 | 2009-07-20 | Karobio Ab | Orphan-receptor |
| AU8102398A (en) | 1997-07-09 | 1999-02-08 | Central Drug Research Institute | (dl)-2,3-diaryl-2h-1-benzopyrans |
| EP1246814B1 (de) | 1999-12-30 | 2005-02-16 | Signal Pharmaceuticals, Inc. | Verbindungen und verfahren zur modulation von estrogen rezeptoren |
| WO2001064665A1 (en) | 2000-03-01 | 2001-09-07 | Akzo Nobel N.V. | Chroman derivatives as estrogenic compounds |
| WO2001072713A1 (en) | 2000-03-27 | 2001-10-04 | Akzo Nobel N.V. | Non-steroidal, tetracyclic compounds for estrogen-related treatments |
| GB2361642A (en) | 2000-10-24 | 2001-10-31 | Karobio Ab | Estrogen receptor beta (ERbeta) agonists for use in cancer treatment |
| ES2286322T3 (es) * | 2001-11-19 | 2007-12-01 | Eli Lilly And Company | Benzopirianos como agosnistas selectivos de receptores de estrogenos beta. |
| US6914074B2 (en) | 2001-12-13 | 2005-07-05 | Wyeth | Substituted phenyl naphthalenes as estrogenic agents |
| US6630508B1 (en) | 2002-02-11 | 2003-10-07 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor β agonists |
-
2004
- 2004-04-08 WO PCT/US2004/009271 patent/WO2004094401A1/en not_active Ceased
- 2004-04-08 EP EP04759766A patent/EP1618102B1/de not_active Expired - Lifetime
- 2004-04-08 AT AT04759766T patent/ATE457308T1/de not_active IP Right Cessation
- 2004-04-08 US US10/549,106 patent/US7279499B2/en not_active Expired - Fee Related
- 2004-04-08 DE DE602004025460T patent/DE602004025460D1/de not_active Expired - Lifetime
- 2004-04-08 ES ES04759766T patent/ES2338119T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2338119T3 (es) | 2010-05-04 |
| EP1618102B1 (de) | 2010-02-10 |
| DE602004025460D1 (de) | 2010-03-25 |
| US20060199858A1 (en) | 2006-09-07 |
| US7279499B2 (en) | 2007-10-09 |
| WO2004094401A1 (en) | 2004-11-04 |
| EP1618102A1 (de) | 2006-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |