ATE457977T1 - Biguanidderivate - Google Patents

Biguanidderivate

Info

Publication number
ATE457977T1
ATE457977T1 AT03789976T AT03789976T ATE457977T1 AT E457977 T1 ATE457977 T1 AT E457977T1 AT 03789976 T AT03789976 T AT 03789976T AT 03789976 T AT03789976 T AT 03789976T AT E457977 T1 ATE457977 T1 AT E457977T1
Authority
AT
Austria
Prior art keywords
biguanide
derivatives
disclosed
methods
dihydrotriazine derivatives
Prior art date
Application number
AT03789976T
Other languages
English (en)
Inventor
David Jacobus
Guy Alan Schiehser
Hong-Ming Shieh
Norman Jensen
Jacek Terpinski
Original Assignee
Jacobus Pharma Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jacobus Pharma Co Inc filed Critical Jacobus Pharma Co Inc
Application granted granted Critical
Publication of ATE457977T1 publication Critical patent/ATE457977T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/16Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24Y being a hetero atom
    • C07C279/26X and Y being nitrogen atoms, i.e. biguanides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D251/00Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/10Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/101,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/141,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/161,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/201,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555Hetero-N
    • Y10T436/147777Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Lubricants (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT03789976T 2002-11-22 2003-11-20 Biguanidderivate ATE457977T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42830602P 2002-11-22 2002-11-22
US10/716,283 US7256218B2 (en) 2002-11-22 2003-11-18 Biguanide and dihydrotriazine derivatives
PCT/US2003/037511 WO2004048320A1 (en) 2002-11-22 2003-11-20 Biguanide and dihydrotriazine derivatives

Publications (1)

Publication Number Publication Date
ATE457977T1 true ATE457977T1 (de) 2010-03-15

Family

ID=32397110

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03789976T ATE457977T1 (de) 2002-11-22 2003-11-20 Biguanidderivate

Country Status (10)

Country Link
US (2) US7256218B2 (de)
EP (1) EP1565430B1 (de)
AT (1) ATE457977T1 (de)
AU (1) AU2003294491B8 (de)
CA (1) CA2511505C (de)
DE (1) DE60331344D1 (de)
IL (2) IL168718A (de)
MY (1) MY138542A (de)
TW (1) TWI319399B (de)
WO (1) WO2004048320A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR053710A1 (es) 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
AR056968A1 (es) 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
ATE489370T1 (de) * 2005-06-14 2010-12-15 Schering Corp Herstellung und verwendung von verbindungen als aspartylproteasehemmer
JP4904947B2 (ja) * 2006-07-04 2012-03-28 住友化学株式会社 アルコール化合物の製造方法
JP4904948B2 (ja) * 2006-07-04 2012-03-28 住友化学株式会社 中間体アルコール化合物の製造方法
WO2008060789A2 (en) 2006-10-12 2008-05-22 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
KR101083300B1 (ko) * 2008-10-13 2011-11-14 한국화학연구원 N1-벤조[1,3]다이옥솔-5-일메틸-n2-치환된 바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물
JO3032B1 (ar) 2008-10-17 2016-09-05 Xenon Pharmaceuticals Inc مركبات سبيرو – اوكسندول وإستعمالاتها كعوامل علاجية.
CA2741024A1 (en) 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
KR20120099429A (ko) 2009-10-14 2012-09-10 제논 파마슈티칼스 인크. 스피로-옥스인돌 화합물의 합성 방법
WO2011106729A2 (en) 2010-02-26 2011-09-01 Xenon Pharmaceuticals Inc. Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
ES2464265T3 (es) * 2011-05-19 2014-06-02 Lohmann & Rauscher Gmbh & Co. Kg Apósito estéril para heridas que comprende un componente tri-bloque de elastómero sintético y un polímero hidrofobizado de biguanida
JP6454325B2 (ja) 2013-04-26 2019-01-16 バイオインタラクションズ・リミテッドBioInteractions Ltd 生物活性被覆
USRE49528E1 (en) 2013-04-26 2023-05-16 Biointeractions Ltd. Bioactive coatings
WO2016127068A1 (en) 2015-02-05 2016-08-11 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
AR108671A1 (es) * 2016-06-03 2018-09-12 Enlibrium Inc Análogos de diamida imidodicarbonimidica
WO2020179859A1 (ja) 2019-03-06 2020-09-10 第一三共株式会社 ピロロピラゾール誘導体
CN113621175B (zh) * 2021-08-13 2022-10-18 中国科学院化学研究所 一类高效等规聚丙烯β晶型成核剂及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1250531A (de) 1969-01-01 1971-10-20
US3723429A (en) * 1969-11-06 1973-03-27 Beecham Group Ltd Di-hydro triazine derivatives
GB1546937A (en) * 1976-07-29 1979-05-31 Beecham Group Ltd 2,4-diaminopyrimidine derivatives
CA2064664C (en) 1991-04-05 2000-01-11 Hiroshi Ishikawa Biguanide derivatives, manufacturing method thereof, and disinfectants containing the derivatives
US5300503A (en) * 1991-11-01 1994-04-05 Fmc Corporation Insecticidal 4,6-diamino-1,2-dihydro-1,3,5-triazine derivatives
US5322858A (en) * 1992-02-14 1994-06-21 Jacobus Pharmaceutical Co. Inc. N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines
US5538812A (en) * 1994-02-04 1996-07-23 Moltech Corporation Electrolyte materials containing highly dissociated metal ion salts

Also Published As

Publication number Publication date
EP1565430A1 (de) 2005-08-24
EP1565430B1 (de) 2010-02-17
CA2511505C (en) 2012-07-10
US20040116428A1 (en) 2004-06-17
IL200217A (en) 2013-07-31
US20080176852A1 (en) 2008-07-24
IL168718A (en) 2011-12-29
AU2003294491A1 (en) 2004-06-18
WO2004048320B1 (en) 2004-08-19
TW200500348A (en) 2005-01-01
CA2511505A1 (en) 2004-06-10
HK1088890A1 (en) 2006-11-17
US7563792B2 (en) 2009-07-21
DE60331344D1 (en) 2010-04-01
TWI319399B (en) 2010-01-11
US7256218B2 (en) 2007-08-14
AU2003294491B2 (en) 2010-02-18
WO2004048320A1 (en) 2004-06-10
AU2003294491B8 (en) 2010-03-25
MY138542A (en) 2009-06-30

Similar Documents

Publication Publication Date Title
ATE457977T1 (de) Biguanidderivate
BRPI0415449A (pt) combinações de compostos ativos fungicidas sinergìsticos
DE60334536D1 (de) Furylverbindungen
ATE270817T1 (de) Fungizide
ATE433447T1 (de) Pyrimiidinverbindungen
NO20044995L (no) Heterosykliske forbindelser
NO20041493L (no) Kjemiske forbindelser.
NO20034291D0 (no) 2-aminopropanolderivater
ATE477256T1 (de) Thienylverbindungen
ATE413388T1 (de) Muskarin antagonisten
NO20052884L (no) Substituerte indolpyridinforbindelser som anti-infeksjonsmidler.
SE0004245D0 (sv) Novel compounds and their use
SE0302139D0 (sv) Novel compounds
EA200301100A1 (ru) Новые фталазиноны
DK1531672T3 (da) Antimikrobielle sammensætninger
IN2012DN02609A (de)
ATE354622T1 (de) Flüssigkristallines medium
ATE308529T1 (de) Arylsulfonamide als antivirale mittel
SE9903290D0 (sv) Novel compounds
NO20034171D0 (no) Biguanidderivater
MXPA06003345A (es) Derivados de aminopiridina como inhibidores de la no-sintasa inducible.
ATE294154T1 (de) Apfelsäureadditionssalze von terbinafin
DE50311388D1 (de) Nicht-peptidische brs-3-agonisten
BRPI0413744A (pt) n-aril-2-ciano-oxazolidinonas e seus derivados
ATE374751T1 (de) 3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1565430

Country of ref document: EP