ATE458042T1 - Verfahren zur herstellung von scyllo-inositol - Google Patents

Verfahren zur herstellung von scyllo-inositol

Info

Publication number: ATE458042T1
Authority: AT; Austria
Prior art keywords: inositol; scyllo; myo; complex; novel
Prior art date: 2003-10-14

Application number

AT04817164T

Other languages

English (en)

Inventor

Masanori Yamaguchi

Yuichi Kita

Tetsuya Mori

Kenji Kanbe

Akihiro Tomoda

Atsushi Takahashi

Wakako Ichikawa

Original Assignee

Hokko Chem Ind Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-14

Filing date

2004-10-14

Publication date

2010-03-15

2004-10-14 Application filed by Hokko Chem Ind Co filed Critical Hokko Chem Ind Co

2010-03-15 Application granted granted Critical

2010-03-15 Publication of ATE458042T1 publication Critical patent/ATE458042T1/de

Links

CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 title abstract 12
CDAISMWEOUEBRE-CDRYSYESSA-N scyllo-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-CDRYSYESSA-N 0.000 title abstract 10
238000004519 manufacturing process Methods 0.000 title 1
VYEGBDHSGHXOGT-HYFGLKJPSA-N 2,4,6/3,5-pentahydroxycyclohexanone Chemical compound O[C@H]1[C@H](O)[C@@H](O)C(=O)[C@@H](O)[C@@H]1O VYEGBDHSGHXOGT-HYFGLKJPSA-N 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 2
239000003929 acidic solution Substances 0.000 abstract 2
230000002378 acidificating effect Effects 0.000 abstract 2
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical class OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 2
239000004327 boric acid Substances 0.000 abstract 2
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract 2
229960000367 inositol Drugs 0.000 abstract 2
239000007788 liquid Substances 0.000 abstract 2
244000005700 microbiome Species 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 2
239000000725 suspension Substances 0.000 abstract 2
241000589220 Acetobacter Species 0.000 abstract 1
241001453380 Burkholderia Species 0.000 abstract 1
101710088194 Dehydrogenase Proteins 0.000 abstract 1
XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
239000002184 metal Chemical class 0.000 abstract 1
108010050450 myo-inositol 2-dehydrogenase Proteins 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
- C07C29/145—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT04817164T 2003-10-14 2004-10-14 Verfahren zur herstellung von scyllo-inositol ATE458042T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
JP2003353491		2003-10-14
JP2003353490		2003-10-14
JP2004018128		2004-01-27
JP2004194088		2004-06-30
PCT/JP2004/015174 WO2005035774A1 (ja)	2003-10-14	2004-10-14	シロ−イノシトールの製造方法

Publications (1)

Publication Number	Publication Date
ATE458042T1 true ATE458042T1 (de)	2010-03-15

Family

ID=34437726

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04817164T ATE458042T1 (de)	2003-10-14	2004-10-14	Verfahren zur herstellung von scyllo-inositol

Country Status (11)

Country	Link
US (4)	US7745671B2 (de)
EP (3)	EP2058390B1 (de)
JP (3)	JP4526485B2 (de)
KR (3)	KR101314079B1 (de)
AT (1)	ATE458042T1 (de)
CA (3)	CA2542560C (de)
DE (1)	DE602004025596D1 (de)
DK (2)	DK1674578T3 (de)
ES (2)	ES2341964T3 (de)
PT (2)	PT2058390E (de)
WO (1)	WO2005035774A1 (de)

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US7521481B2 (en)	2003-02-27	2009-04-21	Mclaurin Joanne	Methods of preventing, treating and diagnosing disorders of protein aggregation
US20060189582A1 (en) *	2004-11-17	2006-08-24	Mclaurin Joanne	Compositions and methods for treatment of disorders of protein aggregation
JP4761763B2 (ja) *	2004-12-16	2011-08-31	北興化学工業株式会社	ホウ酸選択的結合物質およびホウ酸の除去又は回収方法
JP4659545B2 (ja) *	2005-07-20	2011-03-30	北興化学工業株式会社	シロ−イノソースの製造方法
WO2007119108A2 (en) *	2005-10-13	2007-10-25	Waratah Pharmaceuticals Inc.	Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence
WO2007129221A2 (en) *	2006-02-17	2007-11-15	Waratah Parmaceuticals Inc	Compositions comprising an epi-inositol compounds and methods for treatment of disorders of protein aggregation
US20070197452A1 (en) *	2006-02-17	2007-08-23	Mclaurin Joanne	Treatment of amyloid-related diseases
EP1996175A4 (de) *	2006-03-09	2009-06-10	Waratah Pharmaceuticals Inc	Cyclohexan-polyalkohol-formulierung zur behandlung von störungen der proteinaggregation
CA2652449A1 (en) *	2006-05-19	2007-11-29	Waratah Pharmaceuticals Inc.	Screening methods for amyloid beta modulators
JP5101841B2 (ja) *	2006-06-15	2012-12-19	オルガノ株式会社	高分子多孔質体の製造方法
WO2008034244A1 (en) *	2006-09-21	2008-03-27	Waratah Pharmaceuticals Inc.	The combination of a cyclohexanehexol and a nsaid for the treatment of neurodegenerative diseases
WO2008061373A1 (en) *	2006-11-24	2008-05-29	Waratah Pharmaceuticals Inc.	Combination treatments for alzheimer's disease and similar diseases
MX2009009126A (es) *	2007-03-01	2009-10-28	Concourse Health Sciences Llc	Isomeros de niacinato de inositol y usos de los mismos.
US20100331267A1 (en) *	2007-04-12	2010-12-30	Mclaurin Joanne	Use of cyclohexanehexol derivatives in the treatment of alpha-synucleinopathies
WO2008124931A1 (en) *	2007-04-12	2008-10-23	Joanne Mclaurin	Use of cyclohexanehexol derivatives in the treatment of amyotrophic lateral sclerosis
CA2683548A1 (en) *	2007-04-12	2008-10-23	Joanne Mclaurin	Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases
EP2148667B1 (de) *	2007-04-12	2013-05-22	Waratah Pharmaceuticals, Inc.	Verwendung von cyclohexanhexol-derivaten bei der behandlung von augenerkrankungen
JP2012505162A (ja) *	2008-10-09	2012-03-01	ワラタファーマシューティカルズ，インコーポレイテッド	黄斑変性症関連障害を処置するためのｓｃｙｌｌｏ−イノシトールの使用
US8962287B2 (en) *	2008-10-31	2015-02-24	National University Corporation Kobe University	Scyllo-inositol-producing cell and scyllo-inositol production method using said cells
US8372367B2 (en) *	2009-10-26	2013-02-12	Emc Metals Corporation	System and method for recovering boron values from plant tailings
JP2013519380A (ja) *	2010-02-15	2013-05-30	アッヴィ・インコーポレイテッド	ｓｃｙｌｌｏ−イノシトールを調製するための方法
JP2013543513A (ja)	2010-10-13	2013-12-05	エランファーマシューティカルズ，インコーポレイテッド	シリトールおよび関連化合物の合成方法
CA2837926A1 (en)	2011-06-03	2012-12-20	Susan ABUSHAKRA	Scyllo - inositol for the treatment of behavioral and psychiatric disorders
US9505795B2 (en)	2012-02-02	2016-11-29	Asahi Kasei Chemicals Corporation	Method for producing scyllo-inositol
KR102017776B1 (ko) *	2012-12-17	2019-09-03	주식회사 디와이내츄럴	휴면 세포 전환법을 이용한 ｄ-카이로 이노시톨의 생산 방법
US10017537B2 (en) *	2013-04-15	2018-07-10	Korea Institute Of Science And Technology	Peptide selectively binding to graphitic materials and volatile organic compounds
US10000743B2 (en) *	2013-12-16	2018-06-19	Asahi Kasei Chemicals Corporation	2-deoxy-scyllo-inosose reductase
WO2017029353A1 (en)	2015-08-20	2017-02-23	Transition Therapeutics Ireland Limited	Treatment of behaviors in dementia patients
CN114181045B (zh) *	2021-12-02	2024-04-26	吉林海资生物工程技术有限公司	一种球形无水肌醇的制备方法
CN117550956A (zh) *	2023-09-16	2024-02-13	诸城市浩天药业有限公司	一种鲨肌醇晶体的制备方法
CN117752706B (zh) *	2023-12-20	2025-10-14	浙江天皇药业有限公司	西洋参炮制品在制备治疗甲状腺功能减退症药物中的应用
CN118851880B (zh) *	2024-07-19	2025-08-19	诸城市浩天药业有限公司	一种鲨肌醇制备中母液的回收利用方法
CN119842646B (zh) *	2024-11-08	2025-10-10	江南大学	一种双酶级联催化肌肉肌醇高效合成表肌醇的方法
CN119753034A (zh) *	2024-12-27	2025-04-04	诸城市浩天药业有限公司	一种鲨肌醇的分离制备方法
CN120590242A (zh) *	2025-08-01	2025-09-05	诸城市浩天药业有限公司	鲨肌醇晶型及其制备方法
CN121249612B (zh) *	2025-12-04	2026-02-13	诸城市浩天药业有限公司	一种肌醇脱氢酶突变体及其制备1l-表-2-肌糖的应用

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Publication number	Priority date	Publication date	Assignee	Title
DE3405663A1 (de)	1984-02-17	1985-08-22	Merck Patent Gmbh, 6100 Darmstadt	Verfahren zur herstellung von scyllo-inosit
DE3642999A1 (de)	1986-12-17	1988-06-30	Merck Patent Gmbh	Scyllo-inositverbindungen
JP2984043B2 (ja)	1990-09-18	1999-11-29	旭化成工業株式会社	ミオ・イノシトールデヒドロゲナーゼおよびその製造法
JPH05192163A (ja)	1991-09-30	1993-08-03	Suntory Ltd	イノシトールデヒドロゲナーゼ遺伝子
JP3251976B2 (ja)	1992-06-23	2002-01-28	旭化成株式会社	ミオ・イノシトールデヒドロゲナーゼを生産する実質上純粋な微生物
US5412080A (en)	1993-08-25	1995-05-02	President And Fellow Of Harvard College	Enterobactin compounds
JP3630344B2 (ja) *	1995-11-17	2005-03-16	北興化学工業株式会社	イノシトール立体異性体の製造方法
JP3944333B2 (ja) *	1999-06-25	2007-07-11	北興化学工業株式会社	Ｄ−キロ−イノシトールの新規製造方法
JP3981597B2 (ja) *	2001-06-25	2007-09-26	北興化学工業株式会社	シロ−イノソースの製造法及びシロ−イノシトールの製造法

2004
- 2004-10-14 PT PT80199870T patent/PT2058390E/pt unknown
- 2004-10-14 EP EP08019987A patent/EP2058390B1/de not_active Expired - Lifetime
- 2004-10-14 KR KR1020127019981A patent/KR101314079B1/ko not_active Expired - Fee Related
- 2004-10-14 CA CA2542560A patent/CA2542560C/en not_active Expired - Lifetime
- 2004-10-14 AT AT04817164T patent/ATE458042T1/de not_active IP Right Cessation
- 2004-10-14 KR KR1020067009224A patent/KR101191675B1/ko not_active Expired - Lifetime
- 2004-10-14 JP JP2005514651A patent/JP4526485B2/ja not_active Expired - Lifetime
- 2004-10-14 DE DE602004025596T patent/DE602004025596D1/de not_active Expired - Lifetime
- 2004-10-14 ES ES04817164T patent/ES2341964T3/es not_active Expired - Lifetime
- 2004-10-14 DK DK04817164.9T patent/DK1674578T3/da active
- 2004-10-14 PT PT04817164T patent/PT1674578E/pt unknown
- 2004-10-14 DK DK08019987.0T patent/DK2058390T3/da active
- 2004-10-14 EP EP04817164A patent/EP1674578B1/de not_active Expired - Lifetime
- 2004-10-14 ES ES08019987T patent/ES2404554T3/es not_active Expired - Lifetime
- 2004-10-14 WO PCT/JP2004/015174 patent/WO2005035774A1/ja not_active Ceased
- 2004-10-14 CA CA2774930A patent/CA2774930C/en not_active Expired - Lifetime
- 2004-10-14 KR KR1020107026017A patent/KR101173148B1/ko not_active Expired - Lifetime
- 2004-10-14 CA CA2852842A patent/CA2852842A1/en not_active Abandoned
- 2004-10-14 EP EP10182641A patent/EP2298870A1/de not_active Withdrawn
- 2004-10-14 US US10/576,030 patent/US7745671B2/en not_active Expired - Lifetime
2010
- 2010-02-25 US US12/712,635 patent/US8409833B2/en not_active Expired - Lifetime
- 2010-04-02 JP JP2010086459A patent/JP5122599B2/ja not_active Expired - Lifetime
2012
- 2012-07-19 JP JP2012160384A patent/JP5674724B2/ja not_active Expired - Fee Related
2013
- 2013-03-08 US US13/791,172 patent/US8715974B2/en not_active Expired - Lifetime
2014
- 2014-03-25 US US14/224,645 patent/US20140322775A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US8409833B2 (en)	2013-04-02
CA2542560C (en)	2012-07-10
JP2012228264A (ja)	2012-11-22
JPWO2005035774A1 (ja)	2006-12-21
US20140322775A1 (en)	2014-10-30
DK2058390T3 (da)	2013-05-06
KR20100127887A (ko)	2010-12-06
KR20120103731A (ko)	2012-09-19
WO2005035774A1 (ja)	2005-04-21
JP4526485B2 (ja)	2010-08-18
US8715974B2 (en)	2014-05-06
JP5674724B2 (ja)	2015-02-25
CA2542560A1 (en)	2005-04-21
US20100261238A1 (en)	2010-10-14
CA2774930A1 (en)	2005-04-21
EP2298870A1 (de)	2011-03-23
KR101314079B1 (ko)	2013-10-04
KR20060129187A (ko)	2006-12-15
EP2058390A1 (de)	2009-05-13
US20060240534A1 (en)	2006-10-26
ES2341964T3 (es)	2010-06-30
EP1674578A1 (de)	2006-06-28
EP1674578B1 (de)	2010-02-17
JP2010187688A (ja)	2010-09-02
CA2774930C (en)	2014-08-05
PT1674578E (pt)	2010-05-21
US7745671B2 (en)	2010-06-29
KR101173148B1 (ko)	2012-08-16
KR101191675B1 (ko)	2012-10-17
DE602004025596D1 (de)	2010-04-01
EP2058390B1 (de)	2013-01-23
CA2852842A1 (en)	2005-04-21
US20130196417A1 (en)	2013-08-01
DK1674578T3 (da)	2010-06-07
PT2058390E (pt)	2013-04-24
JP5122599B2 (ja)	2013-01-16
EP1674578A4 (de)	2007-03-14
ES2404554T3 (es)	2013-05-28

Legal Events

Date	Code	Title	Description
2010-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602004025596D1 (de)	2010-04-01	Verfahren zur herstellung von scyllo-inositol
Platen et al.	1990	Anaerobic degradation of acetone by Desulfococcus biacutus spec. nov.
ATE479758T1 (de)	2010-09-15	(r)-2-octanol dehydrogenasen, verfahren zur herstellung dieser enzyme, dna, welche für dieser enzyme kodiert, und verfahren zur herstellung von alkoholen durch anwendung der enzyme
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