ATE458720T1 - Synthese von 2-cyanziridin-1-carbonsäureamid - Google Patents
Synthese von 2-cyanziridin-1-carbonsäureamidInfo
- Publication number
- ATE458720T1 ATE458720T1 AT02773466T AT02773466T ATE458720T1 AT E458720 T1 ATE458720 T1 AT E458720T1 AT 02773466 T AT02773466 T AT 02773466T AT 02773466 T AT02773466 T AT 02773466T AT E458720 T1 ATE458720 T1 AT E458720T1
- Authority
- AT
- Austria
- Prior art keywords
- cyanziridine
- synthesis
- acid amide
- carbonic acid
- formula
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- FFBZKUHRIXKOSY-UHFFFAOYSA-N aziridine-1-carboxamide Chemical compound NC(=O)N1CC1 FFBZKUHRIXKOSY-UHFFFAOYSA-N 0.000 abstract 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 abstract 1
- BIXBBIPTYBJTRY-UHFFFAOYSA-N imexon Chemical compound NC1=NC(=O)N2CC12 BIXBBIPTYBJTRY-UHFFFAOYSA-N 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
- C07D203/20—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carbonic acid, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/995,265 US6476236B1 (en) | 2001-11-26 | 2001-11-26 | Synthesis of 2-cyanoaziridine-1-carboxamide |
| PCT/US2002/029646 WO2003045906A2 (en) | 2001-11-26 | 2002-09-17 | Synthesis of 2-cyanoziridine-1-carboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE458720T1 true ATE458720T1 (de) | 2010-03-15 |
Family
ID=25541598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02773466T ATE458720T1 (de) | 2001-11-26 | 2002-09-17 | Synthese von 2-cyanziridin-1-carbonsäureamid |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6476236B1 (de) |
| EP (1) | EP1461316B1 (de) |
| JP (1) | JP4575666B2 (de) |
| AT (1) | ATE458720T1 (de) |
| AU (1) | AU2002336606B2 (de) |
| CA (1) | CA2468542C (de) |
| DE (1) | DE60235497D1 (de) |
| ES (1) | ES2348473T3 (de) |
| WO (1) | WO2003045906A2 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6476236B1 (en) * | 2001-11-26 | 2002-11-05 | The Arizona Board Of Regents | Synthesis of 2-cyanoaziridine-1-carboxamide |
| MXPA06006291A (es) * | 2003-12-08 | 2006-08-23 | Univ Arizona | Composiciones anti-cancer sinergisticas. |
| WO2008045686A2 (en) * | 2006-10-12 | 2008-04-17 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Enantiomerically enriched iminopyrrolidone azirdine compositions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE110492C (de) * | ||||
| DE2530398A1 (de) * | 1975-07-08 | 1977-01-27 | Boehringer Mannheim Gmbh | Organische verbindung |
| CA1092606A (en) * | 1976-10-05 | 1980-12-30 | Herbert Berger | 1-(n-acylcarbamoyl)-2-cyano-aziridines and the preparation thereof |
| AR218645A1 (es) * | 1976-12-11 | 1980-06-30 | Boehringer Mannheim Gmbh | Procedimiento para preparar derivados de esteres del acido 1-aziridina-carboxilico |
| US4376731A (en) | 1978-01-31 | 1983-03-15 | Boehringer Mannheim Gmbh | 1-Aziridine carboxylic acid derivatives with immunostimulant activity |
| US6476236B1 (en) * | 2001-11-26 | 2002-11-05 | The Arizona Board Of Regents | Synthesis of 2-cyanoaziridine-1-carboxamide |
-
2001
- 2001-11-26 US US09/995,265 patent/US6476236B1/en not_active Expired - Fee Related
-
2002
- 2002-09-17 WO PCT/US2002/029646 patent/WO2003045906A2/en not_active Ceased
- 2002-09-17 EP EP02773466A patent/EP1461316B1/de not_active Expired - Lifetime
- 2002-09-17 JP JP2003547358A patent/JP4575666B2/ja not_active Expired - Fee Related
- 2002-09-17 AT AT02773466T patent/ATE458720T1/de not_active IP Right Cessation
- 2002-09-17 CA CA2468542A patent/CA2468542C/en not_active Expired - Fee Related
- 2002-09-17 ES ES02773466T patent/ES2348473T3/es not_active Expired - Lifetime
- 2002-09-17 AU AU2002336606A patent/AU2002336606B2/en not_active Ceased
- 2002-09-17 DE DE60235497T patent/DE60235497D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6476236B1 (en) | 2002-11-05 |
| WO2003045906A3 (en) | 2003-08-21 |
| AU2002336606B2 (en) | 2008-05-22 |
| EP1461316A4 (de) | 2005-04-27 |
| CA2468542A1 (en) | 2003-06-05 |
| AU2002336606A1 (en) | 2003-06-10 |
| CA2468542C (en) | 2010-12-07 |
| EP1461316B1 (de) | 2010-02-24 |
| DE60235497D1 (de) | 2010-04-08 |
| WO2003045906A2 (en) | 2003-06-05 |
| EP1461316A2 (de) | 2004-09-29 |
| JP4575666B2 (ja) | 2010-11-04 |
| JP2005510561A (ja) | 2005-04-21 |
| ES2348473T3 (es) | 2010-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |