ATE296633T1 - Thiopyran-4-one als inhibitoren der dna protein kinase - Google Patents

Thiopyran-4-one als inhibitoren der dna protein kinase

Info

Publication number
ATE296633T1
ATE296633T1 AT02751427T AT02751427T ATE296633T1 AT E296633 T1 ATE296633 T1 AT E296633T1 AT 02751427 T AT02751427 T AT 02751427T AT 02751427 T AT02751427 T AT 02751427T AT E296633 T1 ATE296633 T1 AT E296633T1
Authority
AT
Austria
Prior art keywords
sub
sup
thiopyran
inhibitors
protein kinase
Prior art date
Application number
AT02751427T
Other languages
English (en)
Inventor
Roger John Griffin
Bernard Thomas Golding
David Richard Newell
Hilary Alan Calvert
Nicola Jane Curtin
Ian Robert Hardcastle
Niall Martin
Graeme Cameron Smith
Laurent Jean Martin Rigoreau
Paul Workman
Florence Irene Raynaud
Bernard Paul Nutley
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Application granted granted Critical
Publication of ATE296633T1 publication Critical patent/ATE296633T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
AT02751427T 2001-08-14 2002-08-14 Thiopyran-4-one als inhibitoren der dna protein kinase ATE296633T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119863.9A GB0119863D0 (en) 2001-08-14 2001-08-14 DNA-PK inhibitors
PCT/GB2002/003740 WO2003015790A1 (en) 2001-08-14 2002-08-14 Thiopyrane-4-ones as dna protein kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE296633T1 true ATE296633T1 (de) 2005-06-15

Family

ID=9920418

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02751427T ATE296633T1 (de) 2001-08-14 2002-08-14 Thiopyran-4-one als inhibitoren der dna protein kinase

Country Status (8)

Country Link
US (1) US7105518B2 (de)
EP (1) EP1416936B1 (de)
JP (1) JP4299666B2 (de)
AT (1) ATE296633T1 (de)
DE (1) DE60204468T2 (de)
ES (1) ES2243750T3 (de)
GB (1) GB0119863D0 (de)
WO (1) WO2003015790A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0119865D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0209891D0 (en) * 2002-04-30 2002-06-05 Glaxo Group Ltd Novel compounds
JP2007501836A (ja) * 2003-08-13 2007-02-01 クドス ファーマシューティカルズ リミテッド アミノピロン類及びａｔｍ阻害剤としてのその使用
WO2006032869A1 (en) 2004-09-20 2006-03-30 Kudos Pharmaceuticals Limited Dna-pk inhibitors
WO2006085067A1 (en) * 2005-02-09 2006-08-17 Kudos Pharmaceuticals Limited Atm inhibitors
AR053358A1 (es) * 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
EP1895997A2 (de) * 2005-05-26 2008-03-12 Kudos Pharmaceuticals Ltd Verwendung von dna-pk-hemmung zur sensibilisierung von atm-defizienten krebsarten gegenüber dna-schädigenden krebstherapien
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
WO2020228649A1 (zh) * 2019-05-10 2020-11-19 上海海雁医药科技有限公司 取代的苯基丙烯基吡啶类衍生物，其制法与医药上的用途

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1303724A (de) 1969-05-14 1973-01-17
JPH0753725B2 (ja) * 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
FI912995A7 (fi) 1988-12-21 1991-06-19 Upjohn Co Antiateroskleroottisia ja antitromboottisia 1-bentsopyran-4-oneja ja 2 -amino-1,3-bentsoksatsin-4-oneja
US5703075A (en) * 1988-12-21 1997-12-30 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
JPH03215423A (ja) 1990-01-18 1991-09-20 Kyowa Hakko Kogyo Co Ltd 血管拡張剤
CA2081577A1 (en) 1990-06-20 1991-12-21 Ronald B. Gammill Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1, 3-benzoxazine-4-ones
US5252735A (en) * 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
US5302613A (en) * 1990-06-29 1994-04-12 The Upjohn Company Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
ATE128128T1 (de) 1990-06-29 1995-10-15 Upjohn Co Antiatherosclerotische und antithrombotische 2- amino-6-phenyl-4h-pyran-4-one.
US5527434A (en) 1992-01-18 1996-06-18 The University Of Newcastle Upon Tyne Process for the preparation of conductive polymers
EP0610519B1 (de) 1992-09-02 1999-12-01 Kyowa Hakko Kogyo Co., Ltd. Anti-hiv-medikament
US5922755A (en) * 1993-04-09 1999-07-13 Toyama Chemical Co., Ltd. Immunomodulator, cell adhesion inhibtor, and agent for treating, and preventing autoimmune diseases
US5378725A (en) 1993-07-19 1995-01-03 The Arizona Board Of Regents Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof
US5504103A (en) 1993-08-25 1996-04-02 Eli Lilly And Company Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
US5441947A (en) 1993-08-25 1995-08-15 Eli Lilly And Company Methods of inhibiting vascular restenosis
US5468773A (en) 1993-08-25 1995-11-21 Eli Lilly And Company Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs
CA2133815A1 (en) 1993-10-12 1995-04-13 Jeffrey Alan Dodge Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof
US6632789B1 (en) 1994-04-29 2003-10-14 The United States Of America As Represented By The Secretary Of The Navy Methods for modulating T cell responses by manipulating intracellular signal transduction
US5480906A (en) 1994-07-01 1996-01-02 Eli Lilly And Company Stereochemical Wortmannin derivatives
GB9521987D0 (en) 1995-10-26 1996-01-03 Ludwig Inst Cancer Res Phosphoinositide 3-kinase modulators
US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
CN1199420A (zh) 1995-11-16 1998-11-18 艾科斯有限公司 细胞周期关卡与pik相关的激酶材料和方法
GB2302021A (en) 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption
EP0990028A4 (de) 1997-06-06 2000-09-27 Mayo Foundation For Medical Screening auf inhibitoren der phosphatidylinositol verwandten kinase
WO1998056391A1 (en) 1997-06-13 1998-12-17 President And Fellows Of Harvard College Methods for treating human cancers
FR2776291B1 (fr) 1998-03-18 2000-06-16 Pf Medicament Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament
US6348311B1 (en) * 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
US6387640B1 (en) * 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
CN1891693A (zh) 2000-01-24 2007-01-10 基纳西亚股份有限公司 用于治疗的吗啉代基取代的化合物
WO2002020500A2 (en) 2000-09-01 2002-03-14 Icos Corporation Materials and methods to potentiate cancer treatment
EP1353693B1 (de) 2001-01-16 2005-03-16 Glaxo Group Limited Pharmazeutische mischung gegen krebs, die ein 4-chinazolinamin in kombination mit paclitaxel, carboplatin or vinorelbine enthält
GB0119865D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
AU2002357667A1 (en) 2001-10-24 2003-05-06 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
US6908932B2 (en) 2001-10-24 2005-06-21 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
US7049313B2 (en) * 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
EP2174939A1 (de) 2002-02-25 2010-04-14 Kudos Pharmaceuticals Limited Pyranone verwendbar als ATM Inhibitoren
AU2003229953A1 (en) 2002-04-30 2003-11-17 Kudos Pharmaceuticals Limited Phthalazinone derivatives

Also Published As

Publication number Publication date
US7105518B2 (en) 2006-09-12
DE60204468T2 (de) 2006-04-27
DE60204468D1 (de) 2005-07-07
GB0119863D0 (en) 2001-10-10
US20050107367A1 (en) 2005-05-19
JP2005502656A (ja) 2005-01-27
JP4299666B2 (ja) 2009-07-22
ES2243750T3 (es) 2005-12-01
WO2003015790A1 (en) 2003-02-27
EP1416936A1 (de) 2004-05-12
EP1416936B1 (de) 2005-06-01

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties