ATE296633T1 - Thiopyran-4-one als inhibitoren der dna protein kinase - Google Patents

Thiopyran-4-one als inhibitoren der dna protein kinase

Info

Publication number
ATE296633T1
ATE296633T1 AT02751427T AT02751427T ATE296633T1 AT E296633 T1 ATE296633 T1 AT E296633T1 AT 02751427 T AT02751427 T AT 02751427T AT 02751427 T AT02751427 T AT 02751427T AT E296633 T1 ATE296633 T1 AT E296633T1
Authority
AT
Austria
Prior art keywords
sub
sup
thiopyran
inhibitors
protein kinase
Prior art date
Application number
AT02751427T
Other languages
English (en)
Inventor
Roger John Griffin
Bernard Thomas Golding
David Richard Newell
Hilary Alan Calvert
Nicola Jane Curtin
Ian Robert Hardcastle
Niall Martin
Graeme Cameron Smith
Laurent Jean Martin Rigoreau
Paul Workman
Florence Irene Raynaud
Bernard Paul Nutley
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Application granted granted Critical
Publication of ATE296633T1 publication Critical patent/ATE296633T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
AT02751427T 2001-08-14 2002-08-14 Thiopyran-4-one als inhibitoren der dna protein kinase ATE296633T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119863.9A GB0119863D0 (en) 2001-08-14 2001-08-14 DNA-PK inhibitors
PCT/GB2002/003740 WO2003015790A1 (en) 2001-08-14 2002-08-14 Thiopyrane-4-ones as dna protein kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE296633T1 true ATE296633T1 (de) 2005-06-15

Family

ID=9920418

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02751427T ATE296633T1 (de) 2001-08-14 2002-08-14 Thiopyran-4-one als inhibitoren der dna protein kinase

Country Status (8)

Country Link
US (1) US7105518B2 (de)
EP (1) EP1416936B1 (de)
JP (1) JP4299666B2 (de)
AT (1) ATE296633T1 (de)
DE (1) DE60204468T2 (de)
ES (1) ES2243750T3 (de)
GB (1) GB0119863D0 (de)
WO (1) WO2003015790A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0119865D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0209891D0 (en) * 2002-04-30 2002-06-05 Glaxo Group Ltd Novel compounds
BRPI0413467A (pt) * 2003-08-13 2006-10-17 Kudos Pharm Ltd aminopironas e seu uso como inibidoras da atm
US7402607B2 (en) 2004-09-20 2008-07-22 Kudos Pharmaceuticals Limited DNA-PK inhibitors
JP2008529995A (ja) * 2005-02-09 2008-08-07 クドス ファーマシューティカルズ リミテッド Ａｔｍ阻害剤
AR053358A1 (es) * 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
WO2006126010A2 (en) * 2005-05-26 2006-11-30 Kudos Pharmaceuticals Limited Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
WO2020228649A1 (zh) * 2019-05-10 2020-11-19 上海海雁医药科技有限公司 取代的苯基丙烯基吡啶类衍生物，其制法与医药上的用途

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1303724A (de) 1969-05-14 1973-01-17
JPH0753725B2 (ja) 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
US5284856A (en) 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
HUT58310A (en) 1988-12-21 1992-02-28 Upjohn Co Anti-atherosclerotic and anti-thrombotic 1-benzopyran-4-one- and 2-amino-1,3-benzoxazin-4-one derivatives, process for producing them and pharmaceutical compositions containing them
US5703075A (en) 1988-12-21 1997-12-30 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
JPH03215423A (ja) 1990-01-18 1991-09-20 Kyowa Hakko Kogyo Co Ltd 血管拡張剤
EP0525123B1 (de) 1990-06-20 1997-09-17 PHARMACIA & UPJOHN COMPANY Antiatherosklerotische und antithrombotische 1-benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on-derivate
ATE128128T1 (de) 1990-06-29 1995-10-15 Upjohn Co Antiatherosclerotische und antithrombotische 2- amino-6-phenyl-4h-pyran-4-one.
US5252735A (en) 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
US5302613A (en) 1990-06-29 1994-04-12 The Upjohn Company Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
WO1993014504A1 (en) 1992-01-18 1993-07-22 The University Of Newcastle Upon Tyne Process for the preparation of conductive polymers
DE69327153T2 (de) 1992-09-02 2000-05-25 Kyowa Hakko Kogyo Co., Ltd. Anti-hiv-medikament
EP0695547B1 (de) 1993-04-09 2001-08-08 Toyama Chemical Co., Ltd. Immunomodulator, zelladhäsionsinhibitor und mittel zur behandlung und vorbeugung von autoimmunerkrankungen
US5378725A (en) 1993-07-19 1995-01-03 The Arizona Board Of Regents Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof
US5504103A (en) 1993-08-25 1996-04-02 Eli Lilly And Company Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
US5468773A (en) 1993-08-25 1995-11-21 Eli Lilly And Company Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs
US5441947A (en) 1993-08-25 1995-08-15 Eli Lilly And Company Methods of inhibiting vascular restenosis
CA2133815A1 (en) 1993-10-12 1995-04-13 Jeffrey Alan Dodge Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof
US6632789B1 (en) 1994-04-29 2003-10-14 The United States Of America As Represented By The Secretary Of The Navy Methods for modulating T cell responses by manipulating intracellular signal transduction
US5480906A (en) 1994-07-01 1996-01-02 Eli Lilly And Company Stereochemical Wortmannin derivatives
GB9521987D0 (en) 1995-10-26 1996-01-03 Ludwig Inst Cancer Res Phosphoinositide 3-kinase modulators
US5733920A (en) 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
PL322876A1 (en) 1995-11-16 1998-03-02 Icos Corp Pik type kinase of cellular cycle control point: materials and methods
GB2302021A (en) 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption
CA2292540A1 (en) 1997-06-06 1998-12-10 Jann N. Sarkaria Screening for phosphatidylinositol related-kinase inhibitors
AU8068198A (en) 1997-06-13 1998-12-30 President And Fellows Of Harvard College Methods for treating human cancers
FR2776291B1 (fr) 1998-03-18 2000-06-16 Pf Medicament Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament
US6348311B1 (en) 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
US6387640B1 (en) 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
EP1857443B1 (de) 2000-01-24 2012-03-28 AstraZeneca AB Therapeutische Morpholino-substituierte Verbindungen
EP1351946A2 (de) 2000-09-01 2003-10-15 Icos Corporation Materialien und methoden für krebs-therapie
EP1353693B1 (de) 2001-01-16 2005-03-16 Glaxo Group Limited Pharmazeutische mischung gegen krebs, die ein 4-chinazolinamin in kombination mit paclitaxel, carboplatin or vinorelbine enthält
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
AU2002349912A1 (en) 2001-10-24 2003-05-06 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
WO2003034997A2 (en) 2001-10-24 2003-05-01 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
ATE451365T1 (de) 2002-02-25 2009-12-15 Kudos Pharm Ltd Als atm-inhibitoren geeignete pyranone
US7196085B2 (en) 2002-04-30 2007-03-27 Kudos Pharmaceuticals Limited Phthalazinone derivatives

Also Published As

Publication number Publication date
EP1416936B1 (de) 2005-06-01
WO2003015790A1 (en) 2003-02-27
DE60204468D1 (de) 2005-07-07
JP2005502656A (ja) 2005-01-27
EP1416936A1 (de) 2004-05-12
JP4299666B2 (ja) 2009-07-22
ES2243750T3 (es) 2005-12-01
GB0119863D0 (en) 2001-10-10
US20050107367A1 (en) 2005-05-19
US7105518B2 (en) 2006-09-12
DE60204468T2 (de) 2006-04-27

Similar Documents

Publication Publication Date Title
DE60229531D1 (de) Dna-pk-inhibitoren
HRP20050533A2 (en) Aminoindazole derivatives and use thereof as kinase inhibitors
ATE406365T1 (de) Substituierte indazolyl(indolyl)maleimid-derivate als kinase inhibitoren
CO5700824A2 (es) Nuevos compuestos heterociclicos utiles para el tratamiento de desordenes inflamatorios y alergicos: proceso para su preparacion y composiciones farmaceuticas que los contienen
YU84603A (sh) Novi inhibitori tirozin kinaze
ATE371656T1 (de) Heteroaryl-pyrimidinderivate als jak-inhibitoren
ATE449099T1 (de) Derivate des 2-trifluormethyl-6-aminopurins als phosphodiesterase 4 inhibitoren
NO20070532L (no) Substituerte 2-alkyl-kinazolinonderivater som PARP-inhibitorer
ATE331519T1 (de) Pyridylpyrimidin-derivate als wirksame verbindungen gegen prionen-krankheiten
ATE461193T1 (de) Aminopyrone und ihre verwendung als atm inhibitoren
DE602005014804D1 (de) Substituierte 5-carboxyamidpyrazoles und ä1,2,4ütriazole als viruzide
PE20010751A1 (es) Quinolin-2-ona como inhibidores de las proteinas resistentes a multiples farmacos
DE602004005960D1 (de) Heteroaryl-substituierte pyrrolä2, 3- büpyridin-derivate als crf-rezeptor-antagonisten
EA200701779A1 (ru) Производные (1,5-дифенил-1н-пиразол-3-ил)оксадиазола, их получение и их применение в терапии
DE60204468D1 (de) Thiopyran-4-one als inhibitoren der dna protein kinase
DE60014394D1 (de) Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
DE60336735D1 (de) Neue biologischaktive molekü le
ATE480239T1 (de) Angiogeneseinhibitoren
ATE364384T1 (de) Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren
MY143245A (en) 4- 2-(cycloalkylamino)pyrimidin-4-yl-(phenyl)-imidazolin-2-one derivatives as p38 map-kinase inhibitors for the treatment of inflammatory diseases
HRP20050082A2 (en) 6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
ATE449773T1 (de) Homomorpholinoxazolidinone als antibakterielle mittel
MEP25308A (en) Aminoindazole derivatives and use thereof as kinase inhibitors
DE60223936D1 (de) Mittel zur anregung des appetits und mittel zur behandlung von anorexie
TW200619219A (en) Pharmaceutical compounds

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties