ATE461279T1 - Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie - Google Patents

Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie

Info

Publication number
ATE461279T1
ATE461279T1 AT06772459T AT06772459T ATE461279T1 AT E461279 T1 ATE461279 T1 AT E461279T1 AT 06772459 T AT06772459 T AT 06772459T AT 06772459 T AT06772459 T AT 06772459T AT E461279 T1 ATE461279 T1 AT E461279T1
Authority
AT
Austria
Prior art keywords
nucleic acid
step synthesis
ordered multi
mediated chemistry
mediated
Prior art date
Application number
AT06772459T
Other languages
English (en)
Inventor
David R Liu
Thomas M Snyder
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE461279T1 publication Critical patent/ATE461279T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT06772459T 2005-06-07 2006-06-07 Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie ATE461279T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68793105P 2005-06-07 2005-06-07
PCT/US2006/022172 WO2006133312A2 (en) 2005-06-07 2006-06-07 Ordered multi-step synthesis by nucleic acid-mediated chemistry

Publications (1)

Publication Number Publication Date
ATE461279T1 true ATE461279T1 (de) 2010-04-15

Family

ID=37499107

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06772459T ATE461279T1 (de) 2005-06-07 2006-06-07 Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie

Country Status (5)

Country Link
US (1) US20090149347A1 (de)
EP (1) EP1888746B1 (de)
AT (1) ATE461279T1 (de)
DE (1) DE602006012971D1 (de)
WO (1) WO2006133312A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE335754T1 (de) * 2001-03-19 2006-09-15 Harvard College Entwicklung neuer molekularer funktionen
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
WO2003078625A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S An improved method for synthesising templated molecules
EP1539980B1 (de) 2002-08-01 2016-02-17 Nuevolution A/S MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
WO2004039825A2 (en) 2002-10-30 2004-05-13 Nuevolution A/S Method for the synthesis of a bifunctional complex
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
EP1723255B1 (de) * 2004-02-17 2010-12-29 Nuevolution A/S Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung
CN101189347A (zh) * 2005-05-03 2008-05-28 通信探索公司 反转探针及其用于核酸检测的用途
DE602006013134D1 (de) * 2005-06-17 2010-05-06 Harvard College Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie
SI3305900T1 (sl) 2005-12-01 2022-02-28 Nuevolution A/S Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic
WO2010022249A2 (en) * 2008-08-20 2010-02-25 Ensemble Discovery Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha
EP3540059A1 (de) 2010-04-16 2019-09-18 Nuevolution A/S Bifunktionelle komplexe und verfahren zur herstellung sowie verwendung derartiger komplexe
EP3218479A1 (de) 2014-11-11 2017-09-20 Nanocore ApS Verfahren zur identifizierung von molekülen mit gewünschten eigenschaften
WO2016109808A1 (en) * 2014-12-31 2016-07-07 Ensemble Therapeutics Corporation Methods and compositions for nucleic acid-templated synthesis of large libraries of complex small molecules

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004535193A (ja) * 2001-06-20 2004-11-25 ヌエヴォリューション・アクティーゼルスカブ 鋳型化された分子およびかかる分子の使用方法
WO2003078625A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S An improved method for synthesising templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
WO2004056994A2 (en) * 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2004110964A2 (en) * 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)

Also Published As

Publication number Publication date
DE602006012971D1 (de) 2010-04-29
EP1888746A2 (de) 2008-02-20
EP1888746B1 (de) 2010-03-17
WO2006133312A2 (en) 2006-12-14
US20090149347A1 (en) 2009-06-11
WO2006133312A3 (en) 2007-07-26

Similar Documents

Publication Publication Date Title
ATE461279T1 (de) Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie
SG130152A1 (en) Process for producing lower olefins by using multiple reaction zones
WO2010031076A3 (en) Conversion of prenyl derivatives to isoprene
EA200801198A1 (ru) Способ производства внутренних олефинов
WO2005047523A3 (en) Short cycle methods for sequencing polynucleotides
ZA200903534B (en) Process for producing alkenes from oxygenates by using supported heteropolyacid catalysts
GB2457402B (en) Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
SG170802A1 (en) Systems and devices for sequence by synthesis analysis
PT1928882E (pt) (s)-n-metilnaltrexona, processo para a sua síntese e sua utilização farmacêutica
WO2008151170A3 (en) Process for the synthesis of ramelteon and its intermediates
IL184851A0 (en) Process of producing olefins
ATE462005T1 (de) Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie
NZ592432A (en) Antibodies that specifically block the biological activity of a tumor antigen Kidney associated antigen 1 (KAAG1)
EP3596099C0 (de) Verfahren zur nukleinsäuresequenzierung durch synthese (sbs), die sbs-zyklusschritte kombinieren
IL186279A0 (en) Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin
HK1245346A1 (zh) 多核苷酸的高通量测序
NO20080468L (no) Diazepinokinoliner, synteser av disse samt intermediater
NO20073460L (no) Fremgangsmåte til å produsere keramiske katalysatorer.
ITMI20050801A1 (it) Procedimento per la preparazione di telmisartan
WO2007108011A3 (en) Process for the preparation of highly pure donepezil
FR2978151B1 (fr) Composes organophosphores p-chirogeniques
WO2012082753A3 (en) Polymerization of nucleic acids using activation by polyphosphorolysis (app) reactions
DE602005022099D1 (de) Fluorisierungsverfahren zur synthese von 2-ä18fü fluoro-2-deoxy-d-glukose
GB0501253D0 (en) Process for the production of olefins
ATE419240T1 (de) Verfahren zum herstellen von 5-fluor-1,3-dialkyl- 1h-pyrazol-4-carbonsäurefluoriden

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties