ATE461279T1 - Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie - Google Patents

Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie

Info

Publication number
ATE461279T1
ATE461279T1 AT06772459T AT06772459T ATE461279T1 AT E461279 T1 ATE461279 T1 AT E461279T1 AT 06772459 T AT06772459 T AT 06772459T AT 06772459 T AT06772459 T AT 06772459T AT E461279 T1 ATE461279 T1 AT E461279T1
Authority
AT
Austria
Prior art keywords
nucleic acid
step synthesis
ordered multi
mediated chemistry
mediated
Prior art date
Application number
AT06772459T
Other languages
English (en)
Inventor
David R Liu
Thomas M Snyder
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE461279T1 publication Critical patent/ATE461279T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT06772459T 2005-06-07 2006-06-07 Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie ATE461279T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68793105P 2005-06-07 2005-06-07
PCT/US2006/022172 WO2006133312A2 (en) 2005-06-07 2006-06-07 Ordered multi-step synthesis by nucleic acid-mediated chemistry

Publications (1)

Publication Number Publication Date
ATE461279T1 true ATE461279T1 (de) 2010-04-15

Family

ID=37499107

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06772459T ATE461279T1 (de) 2005-06-07 2006-06-07 Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie

Country Status (5)

Country Link
US (1) US20090149347A1 (de)
EP (1) EP1888746B1 (de)
AT (1) ATE461279T1 (de)
DE (1) DE602006012971D1 (de)
WO (1) WO2006133312A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070928B2 (en) * 2001-03-19 2006-07-04 President And Fellows Of Harvard College Evolving new molecular function
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
DE60324778D1 (de) * 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
DK3299463T3 (da) 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
ATE450609T1 (de) 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
WO2005026387A1 (en) 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
EP1723255B1 (de) * 2004-02-17 2010-12-29 Nuevolution A/S Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung
US7968289B2 (en) * 2005-05-03 2011-06-28 Ensemble Therapeutics Corporation Turn over probes and use thereof for nucleic acid detection
US8183178B2 (en) * 2005-06-17 2012-05-22 President And Fellows Of Harvard College Iterated branching reaction pathways via nucleic acid-mediated chemistry
LT2336315T (lt) * 2005-12-01 2017-11-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti efektyviai didelių bibliotekų sintezei
EP2350031A2 (de) * 2008-08-20 2011-08-03 Ensemble Therapeutics Corporation Makrocyclische verbindungen zur inhibierung des tumornekrosefaktors alpha
CA2832672A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
US20180340174A1 (en) 2014-11-11 2018-11-29 Nanocore Aps Method for identification of molecules with desired characteristics
WO2016109808A1 (en) * 2014-12-31 2016-07-07 Ensemble Therapeutics Corporation Methods and compositions for nucleic acid-templated synthesis of large libraries of complex small molecules

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1539014A (zh) * 2001-06-20 2004-10-20 ŦΤ¬ɭ��˾ 模控分子和使用这种分子的方法
DE60324778D1 (de) * 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
ATE450609T1 (de) * 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
WO2004110964A2 (en) * 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)

Also Published As

Publication number Publication date
US20090149347A1 (en) 2009-06-11
EP1888746B1 (de) 2010-03-17
WO2006133312A2 (en) 2006-12-14
WO2006133312A3 (en) 2007-07-26
DE602006012971D1 (de) 2010-04-29
EP1888746A2 (de) 2008-02-20

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