ATE461279T1 - Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie - Google Patents

Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie

Info

Publication number
ATE461279T1
ATE461279T1 AT06772459T AT06772459T ATE461279T1 AT E461279 T1 ATE461279 T1 AT E461279T1 AT 06772459 T AT06772459 T AT 06772459T AT 06772459 T AT06772459 T AT 06772459T AT E461279 T1 ATE461279 T1 AT E461279T1
Authority
AT
Austria
Prior art keywords
nucleic acid
step synthesis
ordered multi
mediated chemistry
mediated
Prior art date
Application number
AT06772459T
Other languages
English (en)
Inventor
David R Liu
Thomas M Snyder
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE461279T1 publication Critical patent/ATE461279T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT06772459T 2005-06-07 2006-06-07 Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie ATE461279T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68793105P 2005-06-07 2005-06-07
PCT/US2006/022172 WO2006133312A2 (en) 2005-06-07 2006-06-07 Ordered multi-step synthesis by nucleic acid-mediated chemistry

Publications (1)

Publication Number Publication Date
ATE461279T1 true ATE461279T1 (de) 2010-04-15

Family

ID=37499107

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06772459T ATE461279T1 (de) 2005-06-07 2006-06-07 Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie

Country Status (5)

Country Link
US (1) US20090149347A1 (de)
EP (1) EP1888746B1 (de)
AT (1) ATE461279T1 (de)
DE (1) DE602006012971D1 (de)
WO (1) WO2006133312A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1423400E (pt) * 2001-03-19 2006-12-29 Harvard College Evolução de nova função molecular
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
DE60324778D1 (de) * 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
CN102838654B (zh) 2002-10-30 2016-05-18 纽韦卢森公司 合成双功能复合物的方法
DE60330406D1 (de) 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
US20090239211A1 (en) * 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
JP2008541698A (ja) * 2005-05-03 2008-11-27 アンサンブル ディスカバリー コーポレイション 核酸検出のためのターンオーバープローブおよびその使用
WO2006138666A2 (en) * 2005-06-17 2006-12-28 President And Fellows Of Harvard College Iterated branching reaction pathways via nucleic acid-mediated chemistry
LT3018206T (lt) * 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
CA2733790A1 (en) * 2008-08-20 2010-02-25 Ensemble Discovery Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
EP3218479A1 (de) 2014-11-11 2017-09-20 Nanocore ApS Verfahren zur identifizierung von molekülen mit gewünschten eigenschaften
WO2016109808A1 (en) * 2014-12-31 2016-07-07 Ensemble Therapeutics Corporation Methods and compositions for nucleic acid-templated synthesis of large libraries of complex small molecules

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1539014A (zh) * 2001-06-20 2004-10-20 ŦΤ¬ɭ��˾ 模控分子和使用这种分子的方法
DE60324778D1 (de) * 2002-03-15 2009-01-02 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
DE60330406D1 (de) * 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
WO2004110964A2 (en) * 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)

Also Published As

Publication number Publication date
US20090149347A1 (en) 2009-06-11
WO2006133312A3 (en) 2007-07-26
EP1888746B1 (de) 2010-03-17
EP1888746A2 (de) 2008-02-20
WO2006133312A2 (en) 2006-12-14
DE602006012971D1 (de) 2010-04-29

Similar Documents

Publication Publication Date Title
DE602006012971D1 (de) Vermittelter chemie
EA200801198A1 (ru) Способ производства внутренних олефинов
WO2005047523A3 (en) Short cycle methods for sequencing polynucleotides
ZA200903534B (en) Process for producing alkenes from oxygenates by using supported heteropolyacid catalysts
GB2457402B (en) Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
SG170802A1 (en) Systems and devices for sequence by synthesis analysis
PT1928882E (pt) (s)-n-metilnaltrexona, processo para a sua síntese e sua utilização farmacêutica
ATE462005T1 (de) Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie
HK1245346A1 (zh) 多核苷酸的高通量测序
NZ592432A (en) Antibodies that specifically block the biological activity of a tumor antigen Kidney associated antigen 1 (KAAG1)
EP3596099A4 (de) Verfahren zur nukleinsäuresequenzierung durch synthese (sbs), die sbs-zyklusschritte kombinieren
EA201101015A1 (ru) Способ получения бивалирудина
WO2009097626A3 (en) Paired-end reads in sequencing by synthesis
MX2010004546A (es) Nuevos intermedios de pregabalina y procedimiento para prepararlos y para preparar pregabalina.
NO20080468L (no) Diazepinokinoliner, synteser av disse samt intermediater
NO20073460L (no) Fremgangsmåte til å produsere keramiske katalysatorer.
WO2007057167A3 (en) A method for enhancing enzymatic dna polymerase reactions
WO2010079345A3 (en) Antibody-guided fragment growth
WO2007108011A3 (en) Process for the preparation of highly pure donepezil
WO2012082753A3 (en) Polymerization of nucleic acids using activation by polyphosphorolysis (app) reactions
WO2010151593A8 (en) Stereospecific carbonyl reductases
FR2978151B1 (fr) Composes organophosphores p-chirogeniques
DE112006003704A5 (de) DNA-Konstrukte zur spezifischen Hemmung der Genexpression durch RNA-Interferenz
DE602005022099D1 (de) Fluorisierungsverfahren zur synthese von 2-ä18fü fluoro-2-deoxy-d-glukose
WO2011066482A3 (en) Chiral synthesis of isoxazolines, isoxazoline compounds, and uses thereof

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties