ATE461279T1 - Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie - Google Patents

Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie

Info

Publication number
ATE461279T1
ATE461279T1 AT06772459T AT06772459T ATE461279T1 AT E461279 T1 ATE461279 T1 AT E461279T1 AT 06772459 T AT06772459 T AT 06772459T AT 06772459 T AT06772459 T AT 06772459T AT E461279 T1 ATE461279 T1 AT E461279T1
Authority
AT
Austria
Prior art keywords
nucleic acid
step synthesis
ordered multi
mediated chemistry
mediated
Prior art date
Application number
AT06772459T
Other languages
English (en)
Inventor
David R Liu
Thomas M Snyder
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE461279T1 publication Critical patent/ATE461279T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT06772459T 2005-06-07 2006-06-07 Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie ATE461279T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68793105P 2005-06-07 2005-06-07
PCT/US2006/022172 WO2006133312A2 (en) 2005-06-07 2006-06-07 Ordered multi-step synthesis by nucleic acid-mediated chemistry

Publications (1)

Publication Number Publication Date
ATE461279T1 true ATE461279T1 (de) 2010-04-15

Family

ID=37499107

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06772459T ATE461279T1 (de) 2005-06-07 2006-06-07 Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie

Country Status (5)

Country Link
US (1) US20090149347A1 (de)
EP (1) EP1888746B1 (de)
AT (1) ATE461279T1 (de)
DE (1) DE602006012971D1 (de)
WO (1) WO2006133312A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1423400B2 (de) * 2001-03-19 2013-05-22 President and Fellows of Harvard College Entwicklung neuer molekularer funktionen
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
AU2003214031A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S An improved method for synthesising templated molecules
EP1539980B1 (de) * 2002-08-01 2016-02-17 Nuevolution A/S MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
EP2348124B1 (de) 2002-10-30 2013-12-11 Nuevolution A/S Synthese bifunktioneller Komplexe
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
US11118215B2 (en) * 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
WO2005078122A2 (en) * 2004-02-17 2005-08-25 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
WO2007008276A2 (en) * 2005-05-03 2007-01-18 Ensemble Discovery Corporation Turnover probes and use thereof for nucleic acid detection
US8183178B2 (en) * 2005-06-17 2012-05-22 President And Fellows Of Harvard College Iterated branching reaction pathways via nucleic acid-mediated chemistry
PT3305900T (pt) 2005-12-01 2021-10-27 Nuevolution As Métodos de codificação enzimática para síntese eficaz de bibliotecas grandes
US8338565B2 (en) * 2008-08-20 2012-12-25 Ensemble Therapeutics Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha
EP3540059A1 (de) 2010-04-16 2019-09-18 Nuevolution A/S Bifunktionelle komplexe und verfahren zur herstellung sowie verwendung derartiger komplexe
WO2016074683A1 (en) 2014-11-11 2016-05-19 Lundorf Pedersen Materials Aps Method for identification of molecules with desired characteristics
WO2016109808A1 (en) * 2014-12-31 2016-07-07 Ensemble Therapeutics Corporation Methods and compositions for nucleic acid-templated synthesis of large libraries of complex small molecules

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL159268A0 (en) * 2001-06-20 2004-06-01 Nuevolution As Templated molecules and methods for using such molecules
AU2003214031A1 (en) * 2002-03-15 2003-09-29 Nuevolution A/S An improved method for synthesising templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
WO2004056994A2 (en) * 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2004110964A2 (en) * 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)

Also Published As

Publication number Publication date
EP1888746B1 (de) 2010-03-17
EP1888746A2 (de) 2008-02-20
US20090149347A1 (en) 2009-06-11
WO2006133312A3 (en) 2007-07-26
DE602006012971D1 (de) 2010-04-29
WO2006133312A2 (en) 2006-12-14

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