ATE462005T1 - Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie - Google Patents
Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemieInfo
- Publication number
- ATE462005T1 ATE462005T1 AT06785057T AT06785057T ATE462005T1 AT E462005 T1 ATE462005 T1 AT E462005T1 AT 06785057 T AT06785057 T AT 06785057T AT 06785057 T AT06785057 T AT 06785057T AT E462005 T1 ATE462005 T1 AT E462005T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- iterated
- pathways via
- via nucleic
- mediated chemistry
- Prior art date
Links
- 230000037361 pathway Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000007806 chemical reaction intermediate Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69162805P | 2005-06-17 | 2005-06-17 | |
| PCT/US2006/023654 WO2006138666A2 (en) | 2005-06-17 | 2006-06-16 | Iterated branching reaction pathways via nucleic acid-mediated chemistry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE462005T1 true ATE462005T1 (de) | 2010-04-15 |
Family
ID=37571264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06785057T ATE462005T1 (de) | 2005-06-17 | 2006-06-16 | Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8183178B2 (de) |
| EP (1) | EP1899465B1 (de) |
| AT (1) | ATE462005T1 (de) |
| DE (1) | DE602006013134D1 (de) |
| WO (1) | WO2006138666A2 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7070928B2 (en) | 2001-03-19 | 2006-07-04 | President And Fellows Of Harvard College | Evolving new molecular function |
| EP1401850A1 (de) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nukleosidderivate zur herstellung einer verbindungsbibliothek |
| US10731151B2 (en) | 2002-03-15 | 2020-08-04 | Nuevolution A/S | Method for synthesising templated molecules |
| WO2004013070A2 (en) | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Multi-step synthesis of templated molecules |
| WO2004016767A2 (en) | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
| DK3299463T3 (da) | 2002-10-30 | 2020-12-07 | Nuevolution As | Enzymatisk kodning |
| ATE450609T1 (de) | 2002-12-19 | 2009-12-15 | Nuevolution As | Durch quasizufallsstrukturen und funktionen geführte synthesemethode |
| US20070026397A1 (en) | 2003-02-21 | 2007-02-01 | Nuevolution A/S | Method for producing second-generation library |
| US8017323B2 (en) | 2003-03-26 | 2011-09-13 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
| WO2005026387A1 (en) | 2003-09-18 | 2005-03-24 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
| US7968289B2 (en) * | 2005-05-03 | 2011-06-28 | Ensemble Therapeutics Corporation | Turn over probes and use thereof for nucleic acid detection |
| US8183178B2 (en) | 2005-06-17 | 2012-05-22 | President And Fellows Of Harvard College | Iterated branching reaction pathways via nucleic acid-mediated chemistry |
| LT2336315T (lt) | 2005-12-01 | 2017-11-10 | Nuevolution A/S | Fermentiniai kodavimo būdai, skirti efektyviai didelių bibliotekų sintezei |
| EP2350031A2 (de) * | 2008-08-20 | 2011-08-03 | Ensemble Therapeutics Corporation | Makrocyclische verbindungen zur inhibierung des tumornekrosefaktors alpha |
| CA2832672A1 (en) | 2010-04-16 | 2011-10-20 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| US20180340174A1 (en) | 2014-11-11 | 2018-11-29 | Nanocore Aps | Method for identification of molecules with desired characteristics |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| US11186836B2 (en) | 2016-06-16 | 2021-11-30 | Haystack Sciences Corporation | Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592381A1 (de) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Krebsimpfstoff |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| US11795580B2 (en) | 2017-05-02 | 2023-10-24 | Haystack Sciences Corporation | Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (de) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | Hocheffiziente baseneditoren mit gam |
| US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (de) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | Rna-programmierbare epigenetische rna-modifikatoren und deren verwendungen |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US12203130B2 (en) | 2018-12-20 | 2025-01-21 | Krylov Sergey N | Binder selection using capillary electrophoresis |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| EP3942043A2 (de) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| BR112022022603A2 (pt) | 2020-05-08 | 2023-01-17 | Broad Inst Inc | Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1318400A (en) * | 1998-10-19 | 2000-05-08 | Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
| US7070928B2 (en) | 2001-03-19 | 2006-07-04 | President And Fellows Of Harvard College | Evolving new molecular function |
| WO2004016767A2 (en) | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
| EP1539953A2 (de) | 2002-09-12 | 2005-06-15 | Nuevolution A/S | Durch nähe unterstützte synthese von mit matrizen versehenen molekülen |
| DK3299463T3 (da) | 2002-10-30 | 2020-12-07 | Nuevolution As | Enzymatisk kodning |
| US8017323B2 (en) | 2003-03-26 | 2011-09-13 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
| US20090163371A1 (en) | 2005-05-31 | 2009-06-25 | Stern Andrew M | Anchor-Assisted Fragment Selection and Directed Assembly |
| WO2006135654A2 (en) | 2005-06-07 | 2006-12-21 | President And Fellows Of Harvard College | Polymer evolution via templated synthesis related applications |
| WO2006133312A2 (en) | 2005-06-07 | 2006-12-14 | President And Fellows Of Harvard College | Ordered multi-step synthesis by nucleic acid-mediated chemistry |
| US8183178B2 (en) | 2005-06-17 | 2012-05-22 | President And Fellows Of Harvard College | Iterated branching reaction pathways via nucleic acid-mediated chemistry |
| US20090035824A1 (en) | 2005-06-17 | 2009-02-05 | Liu David R | Nucleic acid-templated chemistry in organic solvents |
| WO2009105657A1 (en) | 2008-02-22 | 2009-08-27 | Ensemble Discovery Corporation | Compositions and methods for catalyzing dna-programmed chemistry |
| EP2350031A2 (de) | 2008-08-20 | 2011-08-03 | Ensemble Therapeutics Corporation | Makrocyclische verbindungen zur inhibierung des tumornekrosefaktors alpha |
-
2006
- 2006-06-16 US US11/917,609 patent/US8183178B2/en active Active
- 2006-06-16 EP EP06785057A patent/EP1899465B1/de not_active Ceased
- 2006-06-16 DE DE602006013134T patent/DE602006013134D1/de active Active
- 2006-06-16 AT AT06785057T patent/ATE462005T1/de not_active IP Right Cessation
- 2006-06-16 WO PCT/US2006/023654 patent/WO2006138666A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006138666A3 (en) | 2007-07-19 |
| EP1899465A2 (de) | 2008-03-19 |
| US20080318807A1 (en) | 2008-12-25 |
| US8183178B2 (en) | 2012-05-22 |
| DE602006013134D1 (de) | 2010-05-06 |
| EP1899465B1 (de) | 2010-03-24 |
| WO2006138666A2 (en) | 2006-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |