ATE462005T1 - Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie - Google Patents
Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemieInfo
- Publication number
- ATE462005T1 ATE462005T1 AT06785057T AT06785057T ATE462005T1 AT E462005 T1 ATE462005 T1 AT E462005T1 AT 06785057 T AT06785057 T AT 06785057T AT 06785057 T AT06785057 T AT 06785057T AT E462005 T1 ATE462005 T1 AT E462005T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- iterated
- pathways via
- via nucleic
- mediated chemistry
- Prior art date
Links
- 230000037361 pathway Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000007806 chemical reaction intermediate Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69162805P | 2005-06-17 | 2005-06-17 | |
| PCT/US2006/023654 WO2006138666A2 (en) | 2005-06-17 | 2006-06-16 | Iterated branching reaction pathways via nucleic acid-mediated chemistry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE462005T1 true ATE462005T1 (de) | 2010-04-15 |
Family
ID=37571264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06785057T ATE462005T1 (de) | 2005-06-17 | 2006-06-16 | Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8183178B2 (de) |
| EP (1) | EP1899465B1 (de) |
| AT (1) | ATE462005T1 (de) |
| DE (1) | DE602006013134D1 (de) |
| WO (1) | WO2006138666A2 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE335754T1 (de) | 2001-03-19 | 2006-09-15 | Harvard College | Entwicklung neuer molekularer funktionen |
| WO2002102820A1 (en) | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| WO2003078625A2 (en) | 2002-03-15 | 2003-09-25 | Nuevolution A/S | An improved method for synthesising templated molecules |
| EP1539980B1 (de) | 2002-08-01 | 2016-02-17 | Nuevolution A/S | MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN |
| WO2004016767A2 (en) | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
| WO2004039825A2 (en) | 2002-10-30 | 2004-05-13 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
| WO2004056994A2 (en) | 2002-12-19 | 2004-07-08 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
| WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
| US8017323B2 (en) | 2003-03-26 | 2011-09-13 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
| ATE447626T1 (de) | 2003-09-18 | 2009-11-15 | Nuevolution As | Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen |
| CN101189347A (zh) * | 2005-05-03 | 2008-05-28 | 通信探索公司 | 反转探针及其用于核酸检测的用途 |
| DE602006013134D1 (de) | 2005-06-17 | 2010-05-06 | Harvard College | Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie |
| SI3305900T1 (sl) | 2005-12-01 | 2022-02-28 | Nuevolution A/S | Postopki encimskega kodiranja za učinkovito sintezo velikih knjižnic |
| WO2010022249A2 (en) * | 2008-08-20 | 2010-02-25 | Ensemble Discovery Corporation | Macrocyclic compounds for inhibition of tumor necrosis factor alpha |
| EP3540059A1 (de) | 2010-04-16 | 2019-09-18 | Nuevolution A/S | Bifunktionelle komplexe und verfahren zur herstellung sowie verwendung derartiger komplexe |
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| CA2956224A1 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3218479A1 (de) | 2014-11-11 | 2017-09-20 | Nanocore ApS | Verfahren zur identifizierung von molekülen mit gewünschten eigenschaften |
| IL294014B2 (en) | 2015-10-23 | 2024-07-01 | Harvard College | Nucleobase editors and uses thereof |
| WO2017218293A1 (en) | 2016-06-16 | 2017-12-21 | Richard Edward Watts | Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules |
| SG11201900907YA (en) | 2016-08-03 | 2019-02-27 | Harvard College | Adenosine nucleobase editors and uses thereof |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110662556A (zh) | 2017-03-09 | 2020-01-07 | 哈佛大学的校长及成员们 | 癌症疫苗 |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| US11795580B2 (en) | 2017-05-02 | 2023-10-24 | Haystack Sciences Corporation | Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| AU2018352592C1 (en) | 2017-10-16 | 2025-09-25 | Beam Therapeutics, Inc. | Uses of adenosine base editors |
| EP3724214A4 (de) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | Systeme und verfahren zur vorhersage von reparaturergebnissen in der gentechnik |
| EP3797160A1 (de) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Baseneditoren und verwendungen davon |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020124213A1 (en) | 2018-12-20 | 2020-06-25 | Krylov Sergey N | Binder selection using capillary electrophoresis |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| GB2601618B (en) | 2019-03-19 | 2024-11-06 | Broad Inst Inc | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2021072328A1 (en) | 2019-10-10 | 2021-04-15 | The Broad Institute, Inc. | Methods and compositions for prime editing rna |
| JP2023525304A (ja) | 2020-05-08 | 2023-06-15 | ザ ブロード インスティテュート，インコーポレーテッド | 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1318400A (en) | 1998-10-19 | 2000-05-08 | Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
| ATE335754T1 (de) | 2001-03-19 | 2006-09-15 | Harvard College | Entwicklung neuer molekularer funktionen |
| WO2004016767A2 (en) | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
| EP1539953A2 (de) | 2002-09-12 | 2005-06-15 | Nuevolution A/S | Durch nähe unterstützte synthese von mit matrizen versehenen molekülen |
| WO2004039825A2 (en) | 2002-10-30 | 2004-05-13 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
| US8017323B2 (en) | 2003-03-26 | 2011-09-13 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
| US20090163371A1 (en) | 2005-05-31 | 2009-06-25 | Stern Andrew M | Anchor-Assisted Fragment Selection and Directed Assembly |
| EP1888746B1 (de) | 2005-06-07 | 2010-03-17 | President And Fellows Of Harvard College | Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie |
| WO2006135654A2 (en) | 2005-06-07 | 2006-12-21 | President And Fellows Of Harvard College | Polymer evolution via templated synthesis related applications |
| WO2006138560A2 (en) | 2005-06-17 | 2006-12-28 | President And Fellows Of Harvard College | Nucleic acid-templated chemistry in organic solvents |
| DE602006013134D1 (de) | 2005-06-17 | 2010-05-06 | Harvard College | Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie |
| WO2009105657A1 (en) | 2008-02-22 | 2009-08-27 | Ensemble Discovery Corporation | Compositions and methods for catalyzing dna-programmed chemistry |
| WO2010022249A2 (en) | 2008-08-20 | 2010-02-25 | Ensemble Discovery Corporation | Macrocyclic compounds for inhibition of tumor necrosis factor alpha |
-
2006
- 2006-06-16 DE DE602006013134T patent/DE602006013134D1/de active Active
- 2006-06-16 AT AT06785057T patent/ATE462005T1/de not_active IP Right Cessation
- 2006-06-16 US US11/917,609 patent/US8183178B2/en active Active
- 2006-06-16 EP EP06785057A patent/EP1899465B1/de not_active Ceased
- 2006-06-16 WO PCT/US2006/023654 patent/WO2006138666A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1899465B1 (de) | 2010-03-24 |
| EP1899465A2 (de) | 2008-03-19 |
| WO2006138666A3 (en) | 2007-07-19 |
| US20080318807A1 (en) | 2008-12-25 |
| WO2006138666A2 (en) | 2006-12-28 |
| US8183178B2 (en) | 2012-05-22 |
| DE602006013134D1 (de) | 2010-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |